BICLUSTER_ID : UPREG-18
PATHOGENS /4/ : p. jirovecii,a. alternata,a. fumigatus,c. albicans
KNOWN DRUG TARGETS /11/ : CCL2, CD40, TFPI, IL6, SERPINE1, F3, IL1B, CCL5, PTGER2, CXCL10, PLAUR
Gene SetLeading Edge Genes
RESPONSE TO EXTERNAL STIMULUSIL1RAP, CXCL1, CCL2, CD40, TFPI, SERPINE1, CCL5, CXCL2, CXCL10, PLAUR
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTIONCSF1, CXCL1, CCL2, CD40, IL6, IL1B, CCL5, CXCL2, CXCL10
RESPONSE TO WOUNDINGIL1RAP, CXCL1, CD40, TFPI, SERPINE1, CCL5, CXCL2, CXCL10
KEGG CYTOSOLIC DNA SENSING PATHWAYNFKBIA, IL6, IL1B, CCL5, CXCL10, IRF7
BEHAVIORCXCL1, CCL5, CCL2, CXCL2, CXCL10, PLAUR
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORSCXCL1, CCL5, CCL2, PTGER2, CXCL2, CXCL10
LOCOMOTORY BEHAVIORCXCL1, CCL5, CCL2, CXCL2, CXCL10, PLAUR
REACTOME GPCR LIGAND BINDINGCXCL1, CCL5, CCL2, PTGER2, CXCL2, CXCL10
CHEMOKINE ACTIVITYCXCL1, CCL5, CCL2, CXCL2, CXCL10
KEGG COMPLEMENT AND COAGULATION CASCADESF3, SERPINE1, PLAUR
G PROTEIN COUPLED RECEPTOR BINDINGCXCL1, CCL5, CCL2, CXCL2, CXCL10
DEFENSE RESPONSEMX2, IL1RAP, CXCL1, CD40, CCL5, CXCL2, CXCL10, MX1
REACTOME PEPTIDE LIGAND BINDING RECEPTORSCXCL1, CCL5, CCL2, CXCL2, CXCL10
CHEMOKINE RECEPTOR BINDINGCXCL1, CCL5, CCL2, CXCL2, CXCL10
CYTOKINE ACTIVITYCXCL1, CSF1, CCL5, CCL2, CXCL2, CXCL10
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINESCXCL1, CCL5, CCL2, CXCL2, CXCL10
REACTOME G ALPHA I SIGNALLING EVENTSCXCL1, CCL5, CXCL2, CXCL10
KEGG GRAFT VERSUS HOST DISEASEIL6, IL1B
INFLAMMATORY RESPONSECXCL1, CCL5, CXCL2, CXCL10
EXTRACELLULAR SPACEIL1B, CXCL1, CCL2, CXCL2
EXTRACELLULAR REGION PARTIL1B, CXCL1, CCL2, CXCL2
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTIONIL6, CD40
NCI IL23PATHWAYNFKBIA, IL1B, CXCL1, CCL2
NETPATH WNT PATHWAY DOWNIL1B, CXCL1
HUMORAL IMMUNE RESPONSECCL2
KEGG ALLOGRAFT REJECTIONCD40
BIOCARTA FIBRINOLYSIS PATHWAYSERPINE1
KEGG TYPE I DIABETES MELLITUSIL1B
KEGG AUTOIMMUNE THYROID DISEASECD40
BIOCARTA INFLAM PATHWAYCSF1
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
candida albicans moddc135alternaria alternata beas2bpneumocystis carinnii macrophageaspergillus fumigatus dendriticGene Set
2.43421E-4 1.715488E-5 0.14160725 0.024326107RESPONSE_TO_EXTERNAL_STIMULUS
0.0 4.8502272E-5 0.016364018 0.0KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
2.1165008E-6 6.9193807E-6 0.04277774 0.0047411146RESPONSE_TO_WOUNDING
1.3989894E-4 4.208835E-4 0.16132888 0.15817112KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
2.2250392E-6 1.2214923E-5 0.15872823 0.023901414BEHAVIOR
1.4066127E-4 7.181068E-4 1.738751E-4 0.003579989REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
3.2139455E-6 0.0 0.108142614 0.04213685LOCOMOTORY_BEHAVIOR
0.0016598669 0.023852112 0.014167708 0.023223832REACTOME_GPCR_LIGAND_BINDING
0.0 0.0 0.041768454 3.546737E-5CHEMOKINE_ACTIVITY
0.0020074716 0.0 0.0145290345 0.03170033KEGG_COMPLEMENT_AND_COAGULATION_CASCADES
0.0 9.6749085E-5 0.017283333 6.563468E-5G_PROTEIN_COUPLED_RECEPTOR_BINDING
2.1694132E-6 0.0 0.04436318 0.106237434DEFENSE_RESPONSE
0.0 0.0 2.594948E-4 0.0REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.0 0.0 0.04107923 2.8777304E-5CHEMOKINE_RECEPTOR_BINDING
0.0 0.0 1.1591674E-4 0.0CYTOKINE_ACTIVITY
0.0 0.0 0.016418632 0.0REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.009618234 4.58652E-5 0.030884687 0.13351512REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.0 0.020532541 0.044786237 0.036907617KEGG_GRAFT_VERSUS_HOST_DISEASE
4.0434443E-6 0.0 0.048219085 0.015176189INFLAMMATORY_RESPONSE
0.0 0.0027369289 0.033668406 0.0EXTRACELLULAR_SPACE
4.004787E-5 0.18083072 0.062482 6.125904E-5EXTRACELLULAR_REGION_PART
1.4610786E-4 0.0061623864 0.14613497 0.08491679KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
0.0 6.501296E-4 0.19927236 0.003802986NCI_IL23PATHWAY
0.002521776 0.16622809 0.14159183 0.15058221NETPATH_WNT_PATHWAY_DOWN
4.1889373E-4 0.033842232 0.09870169 0.13597828HUMORAL_IMMUNE_RESPONSE
0.0 0.0072650104 0.04673168 0.035359737KEGG_ALLOGRAFT_REJECTION
0.009271151 0.18600726 0.17358682 0.07972296BIOCARTA_FIBRINOLYSIS_PATHWAY
0.0 0.09067089 0.041445535 0.018020527KEGG_TYPE_I_DIABETES_MELLITUS
6.802776E-4 0.0031133108 0.041329965 0.09974431KEGG_AUTOIMMUNE_THYROID_DISEASE
0.0 0.024269812 0.14592804 5.4974487E-5BIOCARTA_INFLAM_PATHWAY