| Gene Set | Leading Edge Genes |
|---|
| NETPATH IL 2 PATHWAY UP | DDX21, PFKFB3, SRD5A1, TARS, PMAIP1, ASNS, FOS, CREM, BHLHB2, CFLAR, B4GALT5, MFHAS1, GARS, DENND3, VEGF, NFIL3, BAG1, ATF4, ICAM1, IRF1, MYC, UPP1, ZNF267, MMD, FRMD4B, CCND1, SLC2A3, RELA, OPCML, PLAU, PRKCD, PIM1, IER3, DUSP5, ETS2, USP15, SAMHD1, JUND, IL8, SLC7A5, CHSY1, PLAUR, MX1 |
| RESPONSE TO EXTERNAL STIMULUS | CCL2, PLAT, RELA, STC1, PLAU, FOSL1, ASNS, STC2, RIPK2, FOS, CXCL2, PTX3, FGF2, HDAC9, CXCL1, CEBPB, CXCL6, TNFRSF1A, CHST2, IL8, PLAUR |
| NETPATH TNF ALPHA PATHWAY UP | EMP1, TP53BP2, OPTN, BDNF, PMAIP1, NFKBIA, EGR1, SMG1, GCH1, SF3A3, RIPK2, CXCL2, KLF7, RELB, SOD2, CFLAR, CASP4, TNIP1, CXCL1, CSF1, TRAF3, JUNB, BCL3, ATF4, EFNA1, TNFAIP2, TNFAIP8, TNFAIP3, PTRH2, ICAM1, IRF1, TFPI2, IER2, GALNAC4S-6ST, SMOX, CCL2, NFKBIE, IL32, BIRC2, RRS1, PLAU, VEGFC, SDC4, PTX3, IER3, AFF1, BIRC3, NR4A1, KLF10, PPP1R15A, NRIP1, SMAD3, ETS2, ZFP36, IL8, PLAUR, MX1 |
| NETPATH IL 1 PATHWAY UP | NFKBIE, CCL2, RELA, FOSL1, NFKBIA, PRKCD, SLC25A28, CXCL2, SOD2, CFB, BIRC3, CXCL1, GARS, NP, ICAM1, ZFP36, IL8, MYC |
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | PDGFB, PDGFA, IFNGR1, CXCL1, CCL2, CXCL6, VEGFC, IL11, TNFSF15, IL6, TNFRSF1A, IL8, CXCL2 |
| LOCOMOTORY BEHAVIOR | CXCL1, CCL2, CXCL6, PLAU, FOSL1, IL8, CXCL2, PLAUR, FGF2 |
| KEGG COMPLEMENT AND COAGULATION CASCADES | PLAU, F3, CD55, PLAUR, CFB |
| BEHAVIOR | CXCL1, FOSB, CCL2, CXCL6, PLAU, FOSL1, CXCL2, IL8, PLAUR, FGF2 |
| NETPATH IL 5 PATHWAY UP | IRF2, MMD, CCL2, NFKBIE, RELA, EGR1, CD55, RELB, IER3, CASP4, BIRC3, DUSP5, TRAF3, NFIL3, ATF4, ICAM1, IL8, UPP1, IER2 |
| NETPATH EGFR1 PATHWAY UP | DDX21, EMP1, ZFP36L2, IL32, NP, CXCL6, CCND1, PLAU, VEGF, EGR1, TNFAIP3, SDC4, MYC, PLAUR, IER3 |
| NETPATH IL 4 PATHWAY DOWN | LITAF, CCL2, DDIT4, NFKBIA, ICAM1, IRF1, CXCL2, BCL6, IL8 |
| NETPATH KIT RECEPTOR PATHWAY UP | GDF15, MCL1, JUNB, CCL2, ETV5, CCND1, VEGF, JUND, ATF4, TNFRSF1A, EGR1, FOS, MYC, IER3 |
| KEGG CHEMOKINE SIGNALING PATHWAY | CXCL1, JAK2, CCL2, CXCL6, RELA, NFKBIA, PRKCD, IL8, CXCL2, GRK5 |
| DEFENSE RESPONSE | MICB, IL32, RELA, FOSL1, VEZF1, RIPK2, FOS, CXCL2, PTX3, HDAC9, TNIP1, CXCL1, CEBPB, CXCL6, TNFRSF1A, CHST2, IL8, MX1, HLA-G, BNIP3 |
| INFLAMMATORY RESPONSE | HDAC9, CXCL1, CEBPB, CXCL6, TNFRSF1A, RIPK2, IL8, CXCL2 |
| EXTRACELLULAR SPACE | LOXL2, CXCL1, CCL2, IL32, TNFAIP2, CXCL2, IL8, FGF2 |
| NETPATH TNF ALPHA PATHWAY DOWN | CCND1, TARS, JMJD1A, NFKBIA, EGR1, EXT1, SDC4, CXCL2, BHLHB2, IER3, NR4A1, CXCL1, KLF10, PPP1R15A, JUNB, FOSB, MNT, VEGF, DDX3X, TNFAIP2, MAFF, TNFAIP3, ZFP36, IRF1 |
| NETPATH IL 3 PATHWAY UP | NFIL3, MCL1, CCL2, FOS, IL8, MYC |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | CXCR7, CXCL1, CCL2, CXCL2, IL8, CXCL6 |
| CYTOKINE ACTIVITY | GDF15, CXCL1, CCL2, CXCL2, IL8, CXCL6 |
| CHEMOKINE ACTIVITY | CXCL1, CCL2, IL8, CXCL2, CXCL6 |
| NCI DISSOLUTION OF FIBRIN CLOT | PLAU, PLAUR |
| BIOCARTA LAIR PATHWAY | ICAM1, IL8 |
| G PROTEIN COUPLED RECEPTOR BINDING | CXCL1, CCL2, IL8, CXCL2, CXCL6 |
| BIOCARTA GRANULOCYTES PATHWAY | ICAM1, IL8 |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | BIRC3, CXCL1, CCL2, BIRC2, RELA, NFKBIA, TNFAIP3, CXCL2, RIPK2, IL8 |
| BIOCARTA LYM PATHWAY | ICAM1, IL8 |
| CHEMOKINE RECEPTOR BINDING | CXCL1, CCL2, IL8, CXCL2, CXCL6 |
| NCI REG GR PATHWAY | POU2F1, EGR1, NR4A1, ICAM1, IRF1, IL8, FOS |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL1, CCL2, CXCL2, IL8, CXCL6 |
| POSITIVE REGULATION OF DEFENSE RESPONSE | TNFRSF1A |
| NCI NFAT TFPATHWAY | FOSL1, EGR1, POU2F1, PTPRK, JUNB, IL8, FOS |
| BIOCARTA STEM PATHWAY | IL8 |
| NETPATH HEDGEHOG PATHWAY UP | VEGF, NR4A1, MYC, CCND1 |
| LEUKOCYTE MIGRATION | IL8 |
| BIOCARTA FIBRINOLYSIS PATHWAY | PLAU |
| REACTOME PHASE 1 FUNCTIONALIZATION OF COMPOUNDS | SMOX |
| LEUKOCYTE CHEMOTAXIS | IL8 |
| NCI IL23PATHWAY | NFKBIA, CXCL1, CCL2, RELA |
| BIOCARTA INFLAM PATHWAY | PDGFA, IL8 |
| REACTOME G ALPHA I SIGNALLING EVENTS | CXCR7, CXCL1, CXCL2, IL8, CXCL6 |
| HORMONE ACTIVITY | STC2, STC1 |
| NCI CHEMOKINE RECEPTORS BIND CHEMOKINES | |
| REGULATION OF INTERFERON GAMMA BIOSYNTHETIC PROCESS | |
| HORMONE SECRETION | IL11 |
| NETPATH IL 6 PATHWAY UP | CXCL1, CEBPD, MCL1, JUNB, CEBPB, BCL3, SLC2A3, MAFF, ZFP36, IRF1, BHLHB2 |
| INTERFERON GAMMA PRODUCTION | |
| NCI CD40 PATHWAY | NFKBIA, BIRC3, TNFAIP3, TRAF3, MYC, BIRC2, RELA |
| POSITIVE REGULATION OF TRANSLATION | BCL3 |
| RESPONSE TO VIRUS | FOSL1, TRIM22, BCL3, BNIP3 |
| REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | BCL3 |
| NCI IL12 2PATHWAY | RIPK2, RELB, FOS |
| REACTOME VIRAL DSRNA TLR3 TRIF COMPLEX ACTIVATES RIP1 | NFKBIA, TICAM1, RELA |
| CYTOKINE METABOLIC PROCESS | TNFSF15, BCL3 |
| CYTOKINE BIOSYNTHETIC PROCESS | BCL3 |