| Gene Set | Leading Edge Genes |
|---|
| KEGG MAPK SIGNALING PATHWAY | NFKB2, BDNF, SOS1, DUSP6, PPP5C, MAPK8IP3, CASP3, RELA, NRAS, MAPKAPK5, PRKCA, RPS6KA1, RASA2, RRAS2, MAP3K2, RELB, FGF2, EGFR, MAP2K1, DUSP5, PDGFA, PPP3CB, CHUK, MAPKAPK2, DAXX, MAP4K4, CDC42, DUSP1 |
| NCI LYSOPHOSPHOLIPID PATHWAY | NFKB1, GNA11, GNB1, JUN, HBEGF, GSK3B, GNA13, CASP3, RELA, NFKBIA, PTK2, IL8, CRK, EGFR |
| KEGG CHEMOKINE SIGNALING PATHWAY | NFKBIB, GNB1, PARD3, CCL2, RAF1, SOS1, RELA, NRAS, CXCL3, PIK3CD, NFKBIA, PIK3CA, PTK2, GRK5, CXCL2, CRK, MAP2K1, NFKB1, CXCL1, GSK3B, CHUK, IL8, CDC42 |
| LOCOMOTORY BEHAVIOR | CXCL1, CCL2, PLAU, FOSL1, IL8, PLAUR, MAP2K1, FGF2 |
| NETPATH EGFR1 PATHWAY UP | EMP1, RRM2, CDKN1A, HBEGF, DUSP6, PHLDA2, CCND1, PTHLH, PLAU, SDC4, ARL4C, IER3, NAV3, NP, SPRY2, PTGS2, PPAT, TNFAIP3, NUP205, PLAUR, DUSP1 |
| NCI MET PATHWAY | JUN, RAF1, SOS1, PDPK1, PIK3CA, PTK2, STAT3, CRK, MAP2K1, GRB2 |
| BIOCARTA MET PATHWAY | JUN, RAF1, SOS1, PIK3CA, PTK2, STAT3, CRK, GRB2, MAP2K1 |
| BIOCARTA CDMAC PATHWAY | PRKCA, NFKBIA, JUN, RAF1, MAP2K1, RELA |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | NFKBIB, JUN, NCK2, NFKBIE, RAF1, SOS1, NRAS, RELA, PIK3CD, NFKBIA, PIK3CA, CBLB, MAP2K1, PPP3CB, CHUK, GSK3B, CDC42 |
| REACTOME TOLL LIKE RECEPTOR 3 CASCADE | NFKB1, NFKBIB, JUN, NFKB2, DUSP3, CHUK, DUSP6, RELA, RPS6KA1, NFKBIA, PPP2R1B, MAPKAPK2, TICAM1, MAP2K1 |
| KEGG B CELL RECEPTOR SIGNALING PATHWAY | NFKBIB, JUN, NFKBIE, PPP3CB, RAF1, GSK3B, SOS1, NRAS, RELA, PIK3CD, NFKBIA, PIK3CA, MAP2K1 |
| REACTOME TRAF6 MEDIATED INDUCTION OF THE ANTIVIRAL CYTOKINE IFN ALPHA BETA CASCADE | NFKB1, NFKBIB, JUN, NFKB2, DUSP3, CHUK, DUSP6, RELA, RPS6KA1, NFKBIA, PPP2R1B, MAPKAPK2, TICAM1, MAP2K1 |
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | TNFRSF10B, PDGFA, CXCL1, CCL2, TNFRSF12A, VEGFC, CXCL3, IL8, CXCL2, EGFR |
| NCI NFAT TFPATHWAY | FOSL1, PTGS2, JUNB, IL8, ITCH, CASP3 |
| ATPASE ACTIVITY COUPLED TO TRANSMEMBRANE MOVEMENT OF IONS | ATP1B1, ATP2C1, ATP2B1, FXYD2, ATP1A1, ATP6V1B2, ATP6V1C1 |
| NCI AVB3 OPN PATHWAY | PLAU, NFKBIA, ITGAV, PIK3CA, JUN, CD44, CDC42, RELA |
| BIOCARTA GLEEVEC PATHWAY | PIK3CA, JUN, RAF1, SOS1, MAP2K1 |
| NETPATH IL 1 PATHWAY | NFKB1, NFKBIB, CHUK, MAP3K7IP2, RELA, SQSTM1, NFKBIA, IL1R1 |
| CHEMOKINE ACTIVITY | CXCL3, CXCL1, CCL2, IL8 |
| NCI DISSOLUTION OF FIBRIN CLOT | PLAU, PLAUR |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | NFKBIB, BIRC3, CXCL1, CCL2, BIRC2, RELA, NFKBIA, TNFAIP3, CXCL2, IL8 |
| CHEMOKINE RECEPTOR BINDING | CXCL3, CXCL1, CCL2, IL8 |
| ATPASE ACTIVITY COUPLED TO TRANSMEMBRANE MOVEMENT OF IONS PHOSPHORYLATIVE MECHANISM | ATP1B1, ATP2C1, ATP2B1, ATP1A1 |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL3, CXCR7, CXCL1, CCL2, IL8 |
| ST B CELL ANTIGEN RECEPTOR | PIK3CD, NFKBIA, NFKBIB, PIK3CA, NFKB2, NFKBIE, SOS1, MAP2K1 |
| BIOCARTA STEM PATHWAY | IL8 |
| NCI PDGFRAPATHWAY | PIK3CA, ITGAV, PDGFA, JUN, SHB, CRK, SOS1 |
| REACTOME ENDOGENOUS STEROLS | CYP1B1 |
| LEUKOCYTE CHEMOTAXIS | IL8 |
| BIOCARTA INFLAM PATHWAY | PDGFA, IL8 |
| BIOCARTA IL17 PATHWAY | CD58, IL8 |
| CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 COMPLEX | NFKB1, SPAG9, REL, TNIP1, NFKB2, NFKBIE, CHUK, RELA, NFKBIA |
| BIOCARTA LYM PATHWAY | IL8 |
| NCI ENDOGENOUS STEROLS | CYP1B1 |
| BIOCARTA CD40 PATHWAY | NFKBIA, TNFAIP3, TRAF3, DUSP1, RELA |
| POSITIVE REGULATION OF DEFENSE RESPONSE | |
| BIOCARTA ERYTH PATHWAY | |
| SIG CD40PATHWAYMAP | NFKBIB, NFKB2, NFKBIE, TRAF3, MAPK8IP3, PIK3CD, MAPKAPK5, NFKBIA, PIK3CA, DUSP1 |
| CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2 | |
| NCI CD40 PATHWAY | NFKBIA, BIRC3, TNFAIP3, TRAF3, BIRC2, RELA |
| ST T CELL SIGNAL TRANSDUCTION | NFKBIA, NFKB2, NFKBIE, SOS1 |
| TISSUE MORPHOGENESIS | ERCC3, KLF4 |
| REACTOME SPHINGOLIPID METABOLISM | COL4A3BP, PPAP2B, SPHK1, SGPP1, LASS2 |
| CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX RPL6 RPL30 RPS13 CHUK DDX3X NFKB2 NFKBIB REL IKBKG NFKB1 MAP3K8 RELB GLG1 NFKBIA RELA TNIP2 GTF2I | |
| BIOCARTA TNFR2 PATHWAY | NFKBIA, TNFAIP3, TRAF3, DUSP1, RELA |