BICLUSTER_ID : UPREG-24
PATHOGENS /2/ : p. jirovecii,s. chartarum
KNOWN DRUG TARGETS /31/ : ORM1, MMP8, CCR5, MMP12, CTSD, CCL2, CD40, LGALS3, PLAU, SFTPD, CCL5, IFNG, CXCL10, FCGR2B, APOE, ANXA1, C1QB, MMP9, IFNGR1, CFD, CTSB, CTSS, IL6, F10, IL1B, ACSL4, F3, CASP1, PTGER2, CXCR4, PLAUR
Gene SetLeading Edge Genes
RESPONSE TO EXTERNAL STIMULUSCCR5, ORM1, CDKN1A, CCL2, CD40, PLAU, SFTPD, CCL5, CXCL2, CXCL10, CCL4, ANXA1, CXCL1, IL1A, CCR1, F10, CCL3, PGLYRP1, CXCR4, PLAUR
BEHAVIORAPOE, CCR5, CXCL1, CCL2, PLAU, SFTPD, ACSL4, CCL3, CCL5, CXCL2, CXCR4, CXCL10, PLAUR
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTIONCCR5, IL1RAP, CCL2, CD40, CCL5, CXCL2, CXCL10, CCL4, CXCL1, IFNGR1, IL1A, CCR1, IL6, CCL3, IL1B, CXCR4
LOCOMOTORY BEHAVIORCCR5, CXCL1, CCL2, PLAU, SFTPD, CCL3, CCL5, CXCL2, CXCL10, CXCR4, PLAUR
ENDOPEPTIDASE ACTIVITYC1R, CTSD, MMP12, MMP14, MMP9, CFD, CTSE, CTSK, CTSB, CTSS, F10, CASP1, PDIA3
RESPONSE TO WOUNDINGANXA1, CCR5, ORM1, CXCL1, CD40, IL1A, CCR1, F10, CCL3, CCL5, CXCL2, CXCR4, CXCL10, CCL4
PEPTIDASE ACTIVITYC1R, CTSD, MMP12, MMP14, CFD, CTSK, CTSS, CTSB, F10, CASP1, PDIA3
DEFENSE RESPONSECCR5, ORM1, SFTPD, CCL5, CXCL2, CXCL10, CCL4, ANXA1, CXCL1, IL1A, CCR1, LGALS3BP, CCL3, PGLYRP1, CXCR4, MX1
INFLAMMATORY RESPONSEANXA1, CCR5, ORM1, CXCL1, CD40, IL1A, CCR1, CCL3, CCL5, CXCL2, CXCR4, CXCL10, CCL4
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORSCCR5, CXCL1, P2RY6, CCL2, CCR1, C3, CCL3, CCL5, PTGER2, CXCL2, CXCR4, CXCL10, CCL4
REACTOME GPCR LIGAND BINDINGCCR5, CXCL1, P2RY6, CCL2, CCR1, C3, CCL3, CCL5, PTGER2, CXCL2, CXCR4, CXCL10, CCL4
REACTOME PEPTIDE LIGAND BINDING RECEPTORSCCR5, CXCL1, CCL2, CCR1, C3, CCL3, C3AR1, CCL5, CXCL2, CXCR4, CXCL10, CCL4
KEGG COMPLEMENT AND COAGULATION CASCADESPLAU, C1QB, F10, C3, C1R, C3AR1, F3, PLAUR
EXTRACELLULAR SPACEC1QB, MMP8, ORM1, CXCL1, CCL2, IL1A, LGALS3BP, IL1RN, IL1B, CXCL2, CCL4
REACTOME G ALPHA I SIGNALLING EVENTSCCR5, CXCL1, CCR1, C3, CCL5, CXCL2, CXCR4, CXCL10
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINESCXCL1, CCL2, CCR1, CCL3, CCL5, CXCL2, CXCL10, CXCR4, CCL4
KEGG GRAFT VERSUS HOST DISEASEIL6, IL1B, IFNG, IL1A
CYTOKINE ACTIVITYIL1RN, CCL3, CXCL1, CCL5, CCL2, CXCL2, CXCL10, CCL4
BIOCARTA NKT PATHWAYCCR5, CCL3, IFNG, CXCR4, CCL4, CCR1
CHEMOKINE ACTIVITYCCL3, CXCL1, CCL2, CCL5, CXCL2, CXCL10, CCL4
G PROTEIN COUPLED RECEPTOR BINDINGCCL3, CXCL1, CCL2, CCL5, CXCL2, CXCL10, CCL4
CHEMOKINE RECEPTOR BINDINGCCL3, CXCL1, CCL2, CCL5, CXCL2, CXCL10, CCL4
KEGG SYSTEMIC LUPUS ERYTHEMATOSUSFCGR2B, C1QB, C3, C1R, CD40
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTIONIL6, CD40, PIGR, CXCR4, ITGB7
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELLFCGR2B, C3, CD40, ITGB7
KEGG HEMATOPOIETIC CELL LINEAGEIL6, ITGAM, IL1B, CD14, IL1A
BIOCARTA EXTRINSIC PATHWAYF10, F3
SUGAR BINDINGSFTPD, LGALS3
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADEF10, F3
HUMORAL IMMUNE RESPONSECCL2
HEMOSTASISF10
BIOCARTA ASBCELL PATHWAYCD40
NCI IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELLCD200, CD8B, C3, CD40, CD3D, ITGB7
COAGULATIONF10
BLOOD COAGULATIONF10
REGULATION OF BODY FLUID LEVELSF10
HEMATOPOIETIN INTERFERON CLASSD200 DOMAIN CYTOKINE RECEPTOR ACTIVITYIFNGR1
KEGG ASTHMA
EXCITATORY EXTRACELLULAR LIGAND GATED ION CHANNEL ACTIVITYP2RX4
EXTRACELLULAR LIGAND GATED ION CHANNEL ACTIVITYP2RX4
DIGESTIONCTSE
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
pneumocystis carinnii macrophagestachybotrys chartarum lungGene Set
0.14160725 0.0030316834RESPONSE_TO_EXTERNAL_STIMULUS
0.15872823 0.004897092BEHAVIOR
0.016364018 8.667609E-4KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.108142614 8.301471E-4LOCOMOTORY_BEHAVIOR
0.040358678 0.030025851ENDOPEPTIDASE_ACTIVITY
0.04277774 0.003132014RESPONSE_TO_WOUNDING
0.13859202 0.107635975PEPTIDASE_ACTIVITY
0.04436318 4.4228967E-5DEFENSE_RESPONSE
0.048219085 3.9669833E-4INFLAMMATORY_RESPONSE
1.738751E-4 2.021267E-4REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.014167708 0.068581946REACTOME_GPCR_LIGAND_BINDING
2.594948E-4 8.2969455E-5REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.0145290345 5.516338E-5KEGG_COMPLEMENT_AND_COAGULATION_CASCADES
0.033668406 0.17841046EXTRACELLULAR_SPACE
0.030884687 0.0064382344REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.016418632 5.5177166E-5REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.044786237 0.16922897KEGG_GRAFT_VERSUS_HOST_DISEASE
1.1591674E-4 0.012438191CYTOKINE_ACTIVITY
0.106201544 0.10779688BIOCARTA_NKT_PATHWAY
0.041768454 7.375062E-5CHEMOKINE_ACTIVITY
0.017283333 1.8657849E-4G_PROTEIN_COUPLED_RECEPTOR_BINDING
0.04107923 7.93557E-5CHEMOKINE_RECEPTOR_BINDING
0.034138743 0.005506665KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.14613497 0.0012814513KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
0.025689289 0.0013304139REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
0.14391063 0.012549701KEGG_HEMATOPOIETIC_CELL_LINEAGE
0.17286684 0.1152361BIOCARTA_EXTRINSIC_PATHWAY
0.15740086 0.19939512SUGAR_BINDING
0.03150514 0.17213066REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE
0.09870169 3.5422304E-4HUMORAL_IMMUNE_RESPONSE
0.18397155 0.17265753HEMOSTASIS
0.1606871 0.14346233BIOCARTA_ASBCELL_PATHWAY
0.08373454 0.003889722NCI_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
0.19515085 0.13898392COAGULATION
0.18718082 0.15122637BLOOD_COAGULATION
0.15098336 0.12395742REGULATION_OF_BODY_FLUID_LEVELS
0.17504902 0.15185583HEMATOPOIETIN_INTERFERON_CLASSD200_DOMAIN_CYTOKINE_RECEPTOR_ACTIVITY
0.0478591 0.09246591KEGG_ASTHMA
0.18625905 1.3019271E-4EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY
0.1777229 1.4321198E-4EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY
0.08366786 0.08851697DIGESTION