BICLUSTER_ID : UPREG-26
PATHOGENS /2/ : a. fumigatus,c. albicans
KNOWN DRUG TARGETS /16/ : THBS1, CCL20, SERPINB2, GPR109B, PRNP, CCL5, PIM1, ADORA2A, PTGER4, NP, IL1B, PTGS2, ICAM1, IL8, PTGER2, TNF
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPNR4A3, CCL20, SERPINB2, FOSL1, CXCL3, PRNP, NFKBIA, CXCL2, CCL4, PTX3, CXCL1, LIF, NP, CKS2, IL1B, PTGS2, ICAM1, IL8
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORSPTGER4, CCL20, CXCL1, C5AR1, EDN1, GPR109B, CXCL3, CCL5, IL8, PTGER2, CXCL2, CCL4, ADORA2A
NETPATH IL 3 PATHWAY UPCSF1, USP36, SOCS3, TGFA, IL1B, OSM, PIM1, IL8, TNF, CCL4
CYTOKINE ACTIVITYCCL20, CXCL1, CSF1, CXCL3, IL1RN, CCL5, OSM, CXCL2, IL8, CSF2, TNF, CCL4
CHEMOKINE ACTIVITYCXCL3, CCL20, CXCL1, CCL5, IL8, CXCL2, CCL4
NETPATH TNF ALPHA PATHWAY DOWNTHBS1, CCL20, CXCL3, NFKBIA, EGR1, CXCL2, IER3, REL, INSIG1, KLF6, CXCL1, PPP1R15A, KLF10, FOSB, MAPK6, EGR3, DDX3X, MAFF, DUSP2, PTGS2, TNFAIP3
NCI NFAT TFPATHWAYEGR3, FOSL1, EGR1, PTGS2, IL8, FOS, TNF
G PROTEIN COUPLED RECEPTOR BINDINGCXCL3, CCL20, CXCL1, CCL5, IL8, CXCL2, CCL4
REACTOME PEPTIDE LIGAND BINDING RECEPTORSCCL20, CXCL1, C5AR1, EDN1, CXCL3, CCL5, IL8, CXCL2, CCL4
CHEMOKINE RECEPTOR BINDINGCXCL3, CCL20, CXCL1, CCL5, IL8, CXCL2, CCL4
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINESCXCL3, CCL20, CXCL1, CCL5, IL8, CXCL2, CCL4
NETPATH IL 7 PATHWAY UPCXCL1, TFRC, BCL2L1, TNFSF8, CXCL3, CCL5, IL8, CXCL2, CCL4
NETPATH WNT PATHWAY DOWNIL1B, CXCL1
BIOCARTA STEM PATHWAYCSF1, IL8, CSF2
BIOCARTA FIBRINOLYSIS PATHWAYSERPINB2
REACTOME UNFOLDED PROTEIN RESPONSEERN1, DDIT3, DNAJB9, EIF2AK3, HERPUD1, EDEM1, ATF3, XBP1
HORMONE ACTIVITYEDN1
NEGATIVE REGULATION OF CELLULAR BIOSYNTHETIC PROCESS
HORMONE SECRETIONLIF, OSM
GENERATION OF A SIGNAL INVOLVED IN CELL CELL SIGNALING
BIOCARTA PLATELETAPP PATHWAY
GROWTH FACTOR ACTIVITYTGFA, IL1RN, CSF1, CSF2
HEMATOPOIETIN INTERFERON CLASSD200 DOMAIN CYTOKINE RECEPTOR BINDINGOSM, CSF2
REGULATION OF HORMONE SECRETIONLIF, OSM
NETPATH WNT PATHWAY UP
REACTOME STEROID HORMONES
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
candida albicans moddc135candida albicans neutrophilsaspergillus fumigatus dendriticGene Set
0.0 0.19693953 0.0NETPATH_IL_1_PATHWAY_UP
1.4066127E-4 0.17791544 0.003579989REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.0 0.10933371 5.743034E-5NETPATH_IL_3_PATHWAY_UP
0.0 7.5262925E-4 0.0CYTOKINE_ACTIVITY
0.0 0.091335885 3.546737E-5CHEMOKINE_ACTIVITY
2.3453117E-6 0.10874915 0.0036943294NETPATH_TNF_ALPHA_PATHWAY_DOWN
5.8961764E-4 0.035003204 1.962291E-4NCI_NFAT_TFPATHWAY
0.0 0.1173318 6.563468E-5G_PROTEIN_COUPLED_RECEPTOR_BINDING
0.0 0.10786476 0.0REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.0 0.08899127 2.8777304E-5CHEMOKINE_RECEPTOR_BINDING
0.0 0.17955464 0.0REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.0 0.061718952 0.0NETPATH_IL_7_PATHWAY_UP
0.002521776 0.053037744 0.15058221NETPATH_WNT_PATHWAY_DOWN
3.7597125E-5 0.18127525 0.016043266BIOCARTA_STEM_PATHWAY
0.009271151 0.17570677 0.07972296BIOCARTA_FIBRINOLYSIS_PATHWAY
0.013748358 0.13336742 0.025169797REACTOME_UNFOLDED_PROTEIN_RESPONSE
0.011306912 0.0028156147 7.06835E-5HORMONE_ACTIVITY
0.06449941 0.025412852 0.01092913NEGATIVE_REGULATION_OF_CELLULAR_BIOSYNTHETIC_PROCESS
0.013864454 0.064871006 0.0033732688HORMONE_SECRETION
0.095168166 7.8165246E-4 0.0021141812GENERATION_OF_A_SIGNAL_INVOLVED_IN_CELL_CELL_SIGNALING
0.098546006 0.1780624 0.13522168BIOCARTA_PLATELETAPP_PATHWAY
0.0 0.02203862 5.1121856E-4GROWTH_FACTOR_ACTIVITY
8.233354E-5 0.037406106 1.621935E-5HEMATOPOIETIN_INTERFERON_CLASSD200_DOMAIN_CYTOKINE_RECEPTOR_BINDING
0.020191431 0.10907822 0.009836641REGULATION_OF_HORMONE_SECRETION
0.066257045 0.18667124 0.16470632NETPATH_WNT_PATHWAY_UP
0.15807852 0.09484979 0.020148115REACTOME_STEROID_HORMONES