BICLUSTER_ID : UPREG-28
PATHOGENS /2/ : c. albicans,a. fumigatus
KNOWN DRUG TARGETS /7/ : FYN, CCL20, PTGS2, JUN, PIM1, IL8, PLAUR

Gene Set	Leading Edge Genes
NETPATH IL 1 PATHWAY UP	NR4A3, CCL20, LIF, JUN, CXCL1, DUSP3, NFKBIE, FOSL1, JMJD3, CXCL3, NFKBIA, PTGS2, ZFP36, IL8, CXCL2
NETPATH TNF ALPHA PATHWAY DOWN	CCL20, JUN, CXCL3, NFKBIA, ZNF131, EGR1, FOSL2, CXCL2, BHLHB2, IER3, KLF6, REL, NR4A1, CXCL1, KLF10, PPP1R15A, JUNB, FOSB, MAPK6, VEGF, DDX3X, GTF2H1, MAFF, PTGS2, TNFAIP3, ZFP36
NCI NFAT TFPATHWAY	FOSL1, EGR1, PTGS2, JUN, JUNB, IL8, FOS
NETPATH WNT PATHWAY UP	JUN, SIAH2, KLF10, MAPK6, FOS, IL8, CREM, DUSP1, PLAUR
NETPATH IL 3 PATHWAY UP	NFIL3, PIM1, IL8, FOS
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	CXCL3, CCL20, CXCL1, EDN1, CXCL2, IL8
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	CXCL3, CCL20, CXCL1, EDN1, CXCL2, IL8
CYTOKINE ACTIVITY	CXCL3, CCL20, CXCL1, IL8, CXCL2
NETPATH IL 7 PATHWAY UP	CXCL3, KLF2, CXCL1, JUN, IL8, CXCL2
CHEMOKINE ACTIVITY	CXCL3, CCL20, CXCL1, CXCL2, IL8
G PROTEIN COUPLED RECEPTOR BINDING	CXCL3, CCL20, CXCL1, CXCL2, IL8
CHEMOKINE RECEPTOR BINDING	CXCL3, CCL20, CXCL1, CXCL2, IL8
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	CXCL3, CCL20, CXCL1, CXCL2, IL8
BIOCARTA STEM PATHWAY	IL8
FEEDING BEHAVIOR	FYN
STRUCTURAL CONSTITUENT OF RIBOSOME	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPS8, RPL29, RPL13A, RPS20, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL31, RPS27, RPS24, RPS15
NCI FORMATION OF A POOL OF FREE 40S SUBUNITS	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
REACTOME PEPTIDE CHAIN ELONGATION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
NCI VIRAL MRNA TRANSLATION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
REACTOME VIRAL MRNA TRANSLATION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
DEVELOPMENTAL MATURATION	EREG
REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL29, RPL13A, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
NCI GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
NCI CAP DEPENDENT TRANSLATION INITIATION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
NCI EUKARYOTIC TRANSLATION TERMINATION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
NCI PEPTIDE CHAIN ELONGATION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
KEGG RIBOSOME	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL8, RPLP2, RPL31, RPL35A, RPS27, RPS24, RPS15
REACTOME GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
REACTOME REGULATION OF BETA CELL DEVELOPMENT	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL29, RPL13A, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL29, RPL13A, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, POLR2F, RPS29, RPS13, RPL19, RPL9, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
REACTOME FORMATION OF A POOL OF FREE 40S SUBUNITS	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
REACTOME TRANSLATION	RPL27, EEF1B2, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL29, RPL13A, RPL10A, RPS20, RPL36, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
CORUM RIBOSOME CYTOPLASMIC	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15
NCI L13A MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION	RPL27, RPL24, RPL38, RPS17, RPS16, RPS28, RPL18, RPL22, RPL12, UBA52, RPS8, RPL13A, RPL29, RPS20, RPL36, RPL10A, RPS15A, RPS18, RPLP1, RPS10, RPS14, RPS5, RPS21, RPL13, RPS12, RPL30, RPS29, RPL19, RPL9, RPS13, RPL8, RPLP2, RPL35A, RPL31, RPS24, RPS27, RPS15

Color legend
q-value	1	0.2	0.05	0.01	0.001	0.0001
Color

TABLE OF Q-VALUES

aspergillus fumigatus conidia a549	candida albicans neutrophils	Gene Set
1.5328516E-5	0.19693953	NETPATH_IL_1_PATHWAY_UP
0.0	0.10874915	NETPATH_TNF_ALPHA_PATHWAY_DOWN
1.4434879E-4	0.035003204	NCI_NFAT_TFPATHWAY
6.440544E-4	0.18667124	NETPATH_WNT_PATHWAY_UP
2.8740968E-5	0.10933371	NETPATH_IL_3_PATHWAY_UP
0.0015525026	0.17791544	REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
1.9160645E-5	0.10786476	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
2.0902522E-5	7.5262925E-4	CYTOKINE_ACTIVITY
3.284682E-5	0.061718952	NETPATH_IL_7_PATHWAY_UP
2.8400484E-5	0.091335885	CHEMOKINE_ACTIVITY
1.8933655E-5	0.1173318	G_PROTEIN_COUPLED_RECEPTOR_BINDING
0.0	0.08899127	CHEMOKINE_RECEPTOR_BINDING
0.0	0.17955464	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.02162187	0.18127525	BIOCARTA_STEM_PATHWAY
0.028019777	0.034272384	FEEDING_BEHAVIOR
-0.0	9.2519214E-4	STRUCTURAL_CONSTITUENT_OF_RIBOSOME
-0.0	4.3731768E-4	NCI_FORMATION_OF_A_POOL_OF_FREE_40S_SUBUNITS
-0.0	5.686901E-4	REACTOME_PEPTIDE_CHAIN_ELONGATION
-0.0	3.7892838E-4	NCI_VIRAL_MRNA_TRANSLATION
-0.0	5.190721E-4	REACTOME_VIRAL_MRNA_TRANSLATION
0.072709754	0.07456012	DEVELOPMENTAL_MATURATION
-0.0	0.0031905666	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS
-0.0	4.0424606E-4	NCI_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT
-0.0	3.6774037E-4	NCI_CAP_DEPENDENT_TRANSLATION_INITIATION
-0.0	4.7714828E-4	NCI_EUKARYOTIC_TRANSLATION_TERMINATION
-0.0	3.8171865E-4	NCI_PEPTIDE_CHAIN_ELONGATION
-0.0	4.142596E-4	KEGG_RIBOSOME
-0.0	4.919824E-4	REACTOME_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT
-0.0	0.017057288	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT
-0.0	0.049720928	REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
-0.0	4.377411E-4	REACTOME_FORMATION_OF_A_POOL_OF_FREE_40S_SUBUNITS
-0.0	6.10188E-4	REACTOME_TRANSLATION
-0.0	3.4322432E-4	CORUM_RIBOSOME_CYTOPLASMIC
-0.0	3.8062505E-4	NCI_L13A_MEDIATED_TRANSLATIONAL_SILENCING_OF_CERULOPLASMIN_EXPRESSION