BICLUSTER_ID : UPREG-34
PATHOGENS /2/ : p. jirovecii,a. fumigatus
KNOWN DRUG TARGETS /9/ : PLAU, NFKB1, STAT1, IL6, SERPINE1, IFNGR1, CCL2, TFPI, PLAUR
Gene SetLeading Edge Genes
RESPONSE TO EXTERNAL STIMULUSNFKB1, IL1RAP, CXCL1, PIK3CB, CCL2, TFPI, IL1A, PLAU, SERPINE1, CXCL2, PLAUR
NCI IL23PATHWAYNFKB1, NFKBIA, STAT1, IL6, CXCL1, CCL2
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTIONIL6, IFNGR1, IL1RAP, CXCL1, CCL2, CXCL2, IL1A
BEHAVIORPLAU, CXCL1, CCL2, CXCL2, PLAUR
LOCOMOTORY BEHAVIORPLAU, CXCL1, CCL2, CXCL2, PLAUR
RESPONSE TO WOUNDINGNFKB1, SERPINE1, CXCL1, IL1RAP, CXCL2, IL1A, TFPI
CHEMOKINE ACTIVITYCXCL1, CCL2, CXCL2
PEPTIDYL TYROSINE PHOSPHORYLATIONSTAT1
G PROTEIN COUPLED RECEPTOR BINDINGCXCL1, CCL2, CXCL2
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORSCXCL1, CCL2, EDN1, CXCL2
DEFENSE RESPONSENFKB1, CXCL1, IL1RAP, CXCL2, IL1A
INFLAMMATORY RESPONSENFKB1, CXCL1, IL1RAP, CXCL2, IL1A
REACTOME PEPTIDE LIGAND BINDING RECEPTORSCXCL1, CCL2, EDN1, CXCL2
PEPTIDYL TYROSINE MODIFICATIONSTAT1, TPST2
REACTOME GPCR LIGAND BINDINGCXCL1, EDN1, CCL2, CXCL2
EXTRACELLULAR SPACECXCL1, CCL2, EDN1, CXCL2
CHEMOKINE RECEPTOR BINDINGCXCL1, CCL2, CXCL2
CYTOKINE ACTIVITYCXCL1, CCL2, CXCL2
BIOCARTA INFLAM PATHWAYIL6, IL1A
BIOCARTA NKT PATHWAYIFNGR1
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINESCXCL1, CCL2, CXCL2
HEART DEVELOPMENT
KEGG HEMATOPOIETIC CELL LINEAGE
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS
REACTOME G ALPHA I SIGNALLING EVENTSCXCL1, CXCL2
PROTEIN TYROSINE KINASE ACTIVITY
EXTRACELLULAR REGION PART
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
aspergillus fumigatus conidia a549pneumocystis carinnii macrophageGene Set
6.960372E-4 0.14160725RESPONSE_TO_EXTERNAL_STIMULUS
1.4370484E-5 0.19927236NCI_IL23PATHWAY
2.5672338E-5 0.016364018KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
1.642341E-5 0.15872823BEHAVIOR
2.2720385E-5 0.108142614LOCOMOTORY_BEHAVIOR
0.0013995847 0.04277774RESPONSE_TO_WOUNDING
2.8400484E-5 0.041768454CHEMOKINE_ACTIVITY
0.0517779 0.15985331PEPTIDYL_TYROSINE_PHOSPHORYLATION
1.8933655E-5 0.017283333G_PROTEIN_COUPLED_RECEPTOR_BINDING
0.0015525026 1.738751E-4REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.005702261 0.04436318DEFENSE_RESPONSE
6.0851693E-5 0.048219085INFLAMMATORY_RESPONSE
1.9160645E-5 2.594948E-4REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.04039933 0.10861157PEPTIDYL_TYROSINE_MODIFICATION
0.06493268 0.014167708REACTOME_GPCR_LIGAND_BINDING
0.07053614 0.033668406EXTRACELLULAR_SPACE
0.0 0.04107923CHEMOKINE_RECEPTOR_BINDING
2.0902522E-5 1.1591674E-4CYTOKINE_ACTIVITY
0.01884623 0.14592804BIOCARTA_INFLAM_PATHWAY
0.11278513 0.106201544BIOCARTA_NKT_PATHWAY
0.0 0.016418632REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.13906007 0.14578117HEART_DEVELOPMENT
0.14205706 0.14391063KEGG_HEMATOPOIETIC_CELL_LINEAGE
0.13590625 0.046032816REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS
0.017489815 0.030884687REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.08512424 0.1764927PROTEIN_TYROSINE_KINASE_ACTIVITY
0.13260934 0.062482EXTRACELLULAR_REGION_PART