| Gene Set | Leading Edge Genes |
|---|
| SIGNAL TRANSDUCTION | BAI1, RRAGC, EREG, OPTN, HOMER1, PMAIP1, OSMR, HIPK2, MC1R, IRAK2, CXCL10, CFLAR, PDGFA, CXCL1, IL6R, IFI6, CD274, CHRNB2, RRAD, TNFAIP3, IL15RA, IL12A, MAP4K4, NBN, BID, HGS, BNIP3, SPHK1, EPHA2, DUSP10, CCL2, TNFRSF10A, RELA, CASP7, SQSTM1, TRIP10, AKAP12, CCL5, GP1BA, CXCL11, STAT1, KLF10, INPP1, TGFA, IFNB1, IL6, TICAM1, MX1, SCG2, TRAF4, SIAH2, TP53BP2, GTPBP2, EXT1, RIPK2, CREM, GNG4, IFITM1, GPRC5A, IL27RA, TRAF3, RIT1, RGS20, SRC, SERPINB9, IL1B, MRAS, DUSP4, CD40, BIRC2, NOTCH2, BIRC3, NRP1, NR3C1, LY6E, CXCL5, SKIL, IL8, PTGER2 |
| NETPATH TNF ALPHA PATHWAY UP | ELF3, EMP1, TRAF4, TP53BP2, OPTN, IFIT5, PMAIP1, GFPT2, NFKBIA, EGR1, PDLIM4, RIPK2, CXCL2, KLF7, RELB, SOD2, CXCL10, CFLAR, IFITM1, TNIP1, CXCL1, CSF1, TRAF3, SLC22A4, GBP2, IFITM3, EFNA1, TNFAIP2, TNFAIP8, SERPINB9, IL1B, WDR4, TNFAIP3, IL15RA, ICAM1, IRF1, BID, SMOX, CCL2, CASP7, DEXI, CCL5, SDC4, CXCL11, IFIT2, PTX3, IER3, BIRC3, WARS, KLF10, PPP1R15A, TRIM21, ADAM17, ETS2, SLCO3A1, IFNB1, IFI27, IL8, PLAUR, MX1 |
| NETPATH IL 2 PATHWAY UP | DDX21, PFKFB3, PMAIP1, IFI44, FOS, CREM, CFLAR, IFIT1, B4GALT5, MFHAS1, CSF1, DENND3, IFITM3, IL1B, SERPINE1, ICAM1, IRF1, MYC, UPP1, DUSP4, GBP1, RELA, CCND1, PIM1, IER3, STAT1, DUSP5, KLF6, LIF, WARS, TOP1, TRIM21, ETS2, IL8, PTGER2, SLC7A5, CHSY1, PLAUR, MX1 |
| NETPATH IL 1 PATHWAY UP | CCL2, RELA, FOSL1, NFKBIA, MT2A, CXCL2, SOD2, PTX3, CFB, BMP1, BIRC3, LIF, CXCL1, WARS, NP, TFPI, CXCL5, IL1B, SERPINE1, ICAM1, IL8, MYC |
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | CCL2, CD40, OSMR, IL28RA, CCL5, CXCL2, CXCL11, CXCL10, PDGFB, PDGFA, CXCL1, CSF1, CXCL5, IFNB1, IL6, IL15RA, IL1B, MET, IL12A, IL8 |
| RESPONSE TO EXTERNAL STIMULUS | ELF3, IL1RAP, EREG, CCL2, PLAT, CD40, RELA, FOSL1, CCL5, RIPK2, IRAK2, FOS, CXCL2, CXCL11, ITGA2, CXCL10, PTX3, CXCL1, TFPI, CXCL5, SERPINE1, CHST2, IL8, PLAUR, SCG2 |
| CELL PROLIFERATION GO 0008283 | BAI1, EMP1, EREG, BCAT1, SPEG, ISG20, RUNX3, CXCL10, IFITM1, LAMP3, PDGFA, CXCL1, CSF1, CD274, IL1B, IL15RA, MYC, HGS, TCIRG1, SPHK1, TRIB1, EIF2AK2, CD276, FOSL1, NOTCH2, PIM1, ICOSLG, NRP1, ARHGEF2, LIF, WARS, KLF10, TGFA, CXCL5, IL8, SCG2 |
| POSITIVE REGULATION OF BIOLOGICAL PROCESS | EREG, TP53BP2, BCL2L11, PMAIP1, EGR1, HIPK2, RIPK2, TGM2, RUNX3, CXCL10, CFLAR, CDC42EP1, PDGFA, PML, CSF1, ELF4, TRAF3, HIVEP3, IL12A, BID, MYC, BNIP3, TCIRG1, SPHK1, CD40, BIRC2, CCND1, CD276, RELA, SQSTM1, FOSL1, NUFIP1, NOTCH2, NRP1, LIF, NRIP1, TGFA, IFNB1, CXCL5, IL8, TICAM1, SCG2, MX1 |
| KEGG COMPLEMENT AND COAGULATION CASCADES | BDKRB1, SERPINA1, PLAT, SERPINE1, F3, CD55, PLAUR, CFB |
| RESPONSE TO WOUNDING | ELF3, IL1RAP, EREG, PLAT, CD40, RELA, CCL5, RIPK2, IRAK2, FOS, CXCL2, CXCL11, ITGA2, CXCL10, PTX3, CXCL1, TFPI, SERPINE1, CHST2, IL8, SCG2 |
| NETPATH IL 5 PATHWAY UP | PLSCR1, DUSP5, PPIF, CCL2, TRAF3, RELA, EGR1, IL1B, ICAM1, IL8, PIM1, CD55, RELB, UPP1, IER3 |
| REACTOME GPCR LIGAND BINDING | BDKRB1, CXCL1, CCL2, CXCL5, CCL5, PTGER2, IL8, ADORA2B, FZD7, CXCL2, GNG4, CXCL10, CXCL11 |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | TRAF3, CD40, MAP3K8, RELA, IFNB1, NFKBIA, IL1B, IL12A, CCL5, IL8, IRF7, TICAM1, CXCL10, CXCL11 |
| POSITIVE REGULATION OF CELLULAR PROCESS | EREG, TP53BP2, BCL2L11, PMAIP1, EGR1, HIPK2, RIPK2, TGM2, RUNX3, CXCL10, CDC42EP1, CFLAR, PDGFA, CSF1, ELF4, TRAF3, HIVEP3, IL12A, MYC, BID, BNIP3, TCIRG1, SPHK1, CD40, BIRC2, CCND1, CD276, RELA, SQSTM1, FOSL1, NUFIP1, NOTCH2, NRP1, LIF, TGFA, CXCL5, IFNB1, TICAM1, SCG2, MX1 |
| KEGG JAK STAT SIGNALING PATHWAY | STAT1, LIF, IL6R, CCND1, OSMR, IL28RA, IFNB1, IL6, IL15RA, IL12A, OSM, PIM1, SPRY1, MYC |
| NETPATH EGFR1 PATHWAY UP | DDX21, EMP1, EREG, CCND1, PDLIM4, EGR1, AKAP12, SDC4, MT1M, TGM2, ITGA2, IER3, GPRC5A, LIF, NP, TGFA, CXCL5, TNFAIP3, MET, TFPI2, MYC, PLAUR |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | CXCL1, CCL2, CXCL5, CCL5, IL8, CXCL2, PTGER2, CXCL10, CXCL11 |
| DEFENSE RESPONSE | ELF3, TCIRG1, MX2, IL1RAP, EREG, CD40, RELA, FOSL1, VEZF1, CCL5, RIPK2, CXCL2, IRAK2, FOS, CXCL11, CXCL10, PTX3, TNIP1, CXCL1, KCNN4, CHST2, RSAD2, IL12A, IL8, MX1, SCG2, BNIP3 |
| NETPATH KIT RECEPTOR PATHWAY UP | DUSP4, CCL2, TAP1, CCND1, RELA, EGR1, CCL5, PIM1, FOS, MYC, IER3 |
| BEHAVIOR | CXCL1, FOSB, CCL2, FOSL1, CXCL5, CCL5, IL8, CXCL2, CXCL11, CXCL10, PLAUR, SCG2 |
| NETPATH B CELL RECEPTOR PATHWAY UP | EPHA2, EREG, CCL2, DDIT3, TP53BP2, BCL2L11, EIF2AK2, EGR1, CCL5, PIM1, FOS, CFLAR, IFITM1, BIRC3, ELF4, TNFAIP3, ICAM1, MYC |
| LOCOMOTORY BEHAVIOR | CXCL1, CCL2, FOSL1, CXCL5, CCL5, CXCL2, IL8, CXCL11, CXCL10, PLAUR, SCG2 |
| KEGG CHEMOKINE SIGNALING PATHWAY | STAT1, CXCL1, CCL2, RELA, CXCL5, NFKBIA, CCL5, IL8, CXCL2, CXCL11, GNG4, CXCL10 |
| KEGG CYTOSOLIC DNA SENSING PATHWAY | RELA, NFKBIA, IFNB1, IL6, IL1B, CCL5, IRF7, CXCL10, DDX58 |
| IMMUNE SYSTEM PROCESS | EREG, CCL2, CD276, IL28RA, NOTCH2, CCL5, ICOSLG, CSF1, IFI6, CD274, GBP2, IFITM3, SEMA4D, IL6, RSAD2, IFITM2, IL12A, IL8, SCG2 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | CXCL1, CCL2, CXCL5, CCL5, CXCL2, IL8, CXCL11, CXCL10 |
| EXTRACELLULAR REGION PART | SERPINA1, CXCL1, EREG, CCL2, TNFAIP2, IL1B, IL12A, CXCL2, IL8, SCG2 |
| CYTOKINE ACTIVITY | CXCL1, CSF1, CCL2, CXCL5, IL12A, CCL5, IL8, CXCL2, CXCL10, CXCL11, SCG2 |
| CHEMOKINE ACTIVITY | CXCL1, CCL2, CXCL5, CCL5, CXCL2, IL8, CXCL11, CXCL10 |
| REACTOME SIGNALING IN IMMUNE SYSTEM | DUSP4, TRIB3, CD40, MAP3K8, RELA, MAP3K14, SLC7A11, NFKBIA, RIPK2, FOS, HLA-C, CFB, IFITM1, ICOSLG, CD58, CD274, PVRL2, ICAM1, SLC7A5, IRF7, TICAM1, HLA-G |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | CXCL1, CCL2, NFKBIA, IL1B, TNFAIP3, CCL5, IL8, RIPK2, CXCL2 |
| REGULATION OF CELL PROLIFERATION | TCIRG1, SPHK1, EREG, EIF2AK2, CD276, FOSL1, SPEG, NOTCH2, CXCL10, IFITM1, ICOSLG, ARHGEF2, NRP1, PDGFA, CSF1, CXCL1, KLF10, TGFA, CXCL5, IL1B, IL8, MYC, SCG2 |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL1, CCL2, CXCL5, CCL5, CXCL2, IL8, CXCL11, CXCL10 |
| CELL CELL SIGNALING | NRP1, PDGFA, LIF, EREG, KLF10, CXCL5, EFNA1, IL1B, CCL5, CXCL10, CXCL11 |
| EXTRACELLULAR REGION | SERPINA1, CXCL1, EREG, CCL2, TNFAIP2, IL1B, IL12A, DMD, IL8, CXCL2, SCG2, PTX3 |
| EXTRACELLULAR SPACE | SERPINA1, CXCL1, EREG, CCL2, TNFAIP2, IL1B, IL12A, CXCL2, IL8, SCG2 |
| RECEPTOR BINDING | CSF1, CXCL1, EREG, CCL2, TGFA, CXCL5, EFNA1, OASL, IL12A, CCL5, IL8, CXCL2, CXCL11, CXCL10, SCG2 |
| CHEMOKINE RECEPTOR BINDING | CXCL1, CCL2, CXCL5, CCL5, CXCL2, IL8, CXCL11, CXCL10 |
| NETPATH IL 3 PATHWAY UP | TGFA, IL1B, CSF1, CCL2, IL8, PIM1, MYC |
| G PROTEIN COUPLED RECEPTOR BINDING | CXCL1, CCL2, CXCL5, CCL5, CXCL2, IL8, CXCL11, CXCL10 |
| NCI DISSOLUTION OF FIBRIN CLOT | SERPINE1, PLAT, PLAUR |
| CHEMICAL HOMEOSTASIS | BDKRB1, CCL5, MT2A, CCL2, IFI6, CD55, MYC, BNIP3 |
| NCI REG GR PATHWAY | STAT1, EGR1, ICAM1, IRF1, IL8, FOS, RELA |
| CELLULAR CATION HOMEOSTASIS | BDKRB1, CCL5, MT2A, CCL2, CD55, MYC |
| NCI IL23PATHWAY | STAT1, NFKBIA, IL1B, CXCL1, CCL2, RELA |
| REACTOME G ALPHA I SIGNALLING EVENTS | BDKRB1, CXCL1, CXCL5, CXCL16, CCL5, CXCL2, IL8, GNG4, CXCL10, CXCL11 |
| ION HOMEOSTASIS | BDKRB1, CCL5, MT2A, CCL2, IFI6, CD55, MYC, BNIP3 |
| CELLULAR HOMEOSTASIS | BDKRB1, CCL5, MT2A, CCL2, DDIT3, IFI6, CD55, MYC, BNIP3 |
| NETPATH IL 4 PATHWAY DOWN | TNS1, CCL2, GBP2, NFKBIA, NINJ1, ICAM1, IRF1, CXCL2, IL8, MX1 |
| CATION HOMEOSTASIS | BDKRB1, CCL5, MT2A, CCL2, CD55, MYC |
| NETPATH B CELL RECEPTOR PATHWAY DOWN | TRAF4, DUSP5, ARHGEF2, PDGFA, CXCL1, GBP2, CASP7, EIF2AK2, MAP3K14, NFKBIA, ISG20, IL8, IRF1, IRF7, MYC |
| KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY | ISG15, IFIH1, TRAF3, DDX3Y, AZI2, RELA, DDX3X, IFNB1, TRIM25, NFKBIA, IL12A, IL8, IRF7, CXCL10, DDX58 |
| NCI IL27PATHWAY | STAT1, IL6, IL1B, IL27RA, IL12A |
| POSITIVE REGULATION OF CELL PROLIFERATION | ICOSLG, TCIRG1, NRP1, SPHK1, PDGFA, LIF, CSF1, EREG, CD276, TGFA, FOSL1, CXCL5, IL6, CXCL10, MYC, SCG2 |
| INFLAMMATORY RESPONSE | ELF3, CXCL1, RELA, CCL5, IL8, RIPK2, IRAK2, CXCL2, CXCL10, CXCL11, SCG2, PTX3 |
| KEGG GRAFT VERSUS HOST DISEASE | IL6, IL1B |
| NETPATH IL 7 PATHWAY UP | CXCL5, CXCL1, TRAF3, CCL5, IL8, CXCL2, MYC |
| BIOCARTA LAIR PATHWAY | ICAM1, IL8 |
| VIRAL REPRODUCTION | TNIP1, CCL2, IL8 |
| BIOCARTA LYM PATHWAY | ICAM1, IL8 |
| KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION | MAP3K14, ICOSLG, IL6, IL15RA, CD40 |
| RESPONSE TO OTHER ORGANISM | FOSL1, IFI44, RSAD2, IL12A, CCL5, ISG20, IRF7 |
| BIOCARTA FIBRINOLYSIS PATHWAY | SERPINE1, PLAT |
| KEGG CELL ADHESION MOLECULES CAMS | CD58, ICOSLG, CD40, CD274, CD276, PVRL2, ICAM1, SDC4, PTPRF, HLA-C, CLDN3, CLDN1, HLA-G |
| RESPONSE TO BIOTIC STIMULUS | FOSL1, RSAD2, IFI44, IL12A, CCL5, ISG20, IRF7 |
| NCI IL12 2PATHWAY | STAT1, IL1B, IL12A, FOS, RELB, RIPK2, RELA |
| KEGG APOPTOSIS | BIRC3, IL1RAP, BIRC2, TNFRSF10A, CASP7, RELA, MAP3K14, NFKBIA, IL1B, IRAK2, BID, CFLAR |
| RESPONSE TO VIRUS | FOSL1, IFI44, RSAD2, CCL5, ISG20, IRF7 |
| VIRAL GENOME REPLICATION | TNIP1, CCL2, IL8 |
| JAK STAT CASCADE | STAT1, IL12A, CCL2, HGS |
| PROTEIN KINASE CASCADE | DUSP4, CCL2, BIRC2, RELA, SQSTM1, HIPK2, RIPK2, IRAK2, CFLAR, STAT1, TGFA, TNFAIP3, IL12A, MAP4K4, TICAM1, HGS, SCG2 |
| KEGG LEISHMANIA INFECTION | STAT1, NFKBIA, IL1B, IL12A, FOS, RELA |
| NETPATH IL 6 PATHWAY UP | MAFF, STAT1, CXCL1, IRF1, PIM1, MX1 |
| REGULATION OF CELL ADHESION | IL12A, IL8, TGM2, ALOX12 |
| IMMUNE RESPONSE | EREG, CCL2, IFI6, CD274, GBP2, IFITM3, RSAD2, IFITM2, IL12A, CCL5 |
| MULTI ORGANISM PROCESS | TNIP1, FOSL1, MAFF, RSAD2, IFI44, ISG20, CCL5, IL12A, IRF7 |
| BIOCARTA GRANULOCYTES PATHWAY | ICAM1, IL8 |
| BIOCARTA STEM PATHWAY | CSF1, IL8 |
| NCI TNFPATHWAY | SQSTM1, STAT1, BIRC3, TNFAIP3, MAP4K4, BIRC2, ADAM17, RELA |
| BIOCARTA IL22BP PATHWAY | STAT1 |
| NCI NFAT TFPATHWAY | FOSL1, EGR1, GBP3, IL8, FOS |
| NCI CHEMOKINE RECEPTORS BIND CHEMOKINES | CCL5 |
| NETPATH HEDGEHOG PATHWAY UP | MYC, CCND1 |
| TYROSINE PHOSPHORYLATION OF STAT PROTEIN | STAT1, IL12A, SOCS1 |
| KEGG TYPE I DIABETES MELLITUS | IL1B, IL12A |
| NETPATH EGFR1 PATHWAY DOWN | IFITM1, IFIT1, IFI44L, CSF1, EREG, SQSTM1, TIMP3, NINJ1, IFI27, SPOCD1, CLDN1, CXCL10, IFIT2, IER3 |
| HUMORAL IMMUNE RESPONSE | CCL2 |
| SA MMP CYTOKINE CONNECTION | CSF1, IL1B |
| RECEPTOR SIGNALING PROTEIN ACTIVITY | IFITM1, SKIL, STAT1, IRAK2 |
| BIOCARTA CYTOKINE PATHWAY | IL12A, IL8 |
| KEGG AUTOIMMUNE THYROID DISEASE | HLA-C, CD40, HLA-G |
| NETPATH TNF ALPHA PATHWAY DOWN | IFIT5, CCND1, MAP3K14, NFKBIA, EGR1, EXT1, SDC4, CXCL2, IER3, KLF6, CXCL1, PPP1R15A, FOSB, KLF10, DDX3X, TNFAIP2, MAFF, TNFAIP3, IRF1, SYNJ2 |
| NETPATH WNT PATHWAY DOWN | IL1B, CXCL1, FZD7 |
| BIOCARTA CTL PATHWAY | ICAM1 |
| NCI CD40 PATHWAY | BIRC3, TRAF3, CD40, BIRC2, RELA, MAP3K14, NFKBIA, TNFAIP3, MYC |
| KEGG ALLOGRAFT REJECTION | IL12A, HLA-C, CD40, HLA-G |
| POSITIVE REGULATION OF CELL ADHESION | IL12A, TGM2, ALOX12 |
| REGULATION OF RESPONSE TO STIMULUS | EREG, IL12A, IL8, SCG2 |
| BIOCARTA INFLAM PATHWAY | PDGFA, CSF1, IL12A, IL8 |
| BIOCARTA NFKB PATHWAY | MAP3K14, NFKBIA, TNFAIP3, RELA |
| BIOCARTA NO2IL12 PATHWAY | IL12A |
| REGULATION OF DEFENSE RESPONSE | EREG, IL12A |
| INTERFERON GAMMA PRODUCTION | IL12A, CD276 |
| HEMOPOIETIC OR LYMPHOID ORGAN DEVELOPMENT | |
| IMMUNE EFFECTOR PROCESS | RSAD2, IL12A |
| I KAPPAB KINASE NF KAPPAB CASCADE | |
| LEUKOCYTE DIFFERENTIATION | CSF1 |
| REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN | IL12A, SOCS1 |
| POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | |
| REGULATION OF I KAPPAB KINASE NF KAPPAB CASCADE | |
| MYELOID CELL DIFFERENTIATION | |
| POSITIVE REGULATION OF RESPONSE TO STIMULUS | |
| PATTERN RECOGNITION RECEPTOR ACTIVITY | |
| REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION | IL12A |
| INNATE IMMUNE RESPONSE | |
| CALCIUM MEDIATED SIGNALING | |
| NETPATH TGFBETA RECEPTOR PATHWAY DOWN | |
| REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | |
| CELLULAR DEFENSE RESPONSE | |
| ST TUMOR NECROSIS FACTOR PATHWAY | |
| POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION | IL12A |
| REACTOME VIRAL DSRNA TLR3 TRIF COMPLEX ACTIVATES RIP1 | NFKBIA, TICAM1, RELA |
| POSITIVE REGULATION OF SIGNAL TRANSDUCTION | |
| CYTOKINE BIOSYNTHETIC PROCESS | EREG, CD276 |
| HORMONE SECRETION | LIF, OSM |
| REACTOME PHASE 1 FUNCTIONALIZATION OF COMPOUNDS | |
| DEFENSE RESPONSE TO VIRUS | RSAD2 |
| CYTOKINE PRODUCTION | |
| CYTOKINE METABOLIC PROCESS | EREG, CD276 |
| REGULATION OF JAK STAT CASCADE | IL12A, SOCS1, HGS |
| NEGATIVE REGULATION OF CELL PROLIFERATION | |
| REACTOME STEROID HORMONES | |
| POSITIVE REGULATION OF DEFENSE RESPONSE | |
| INTRACELLULAR SIGNALING CASCADE | |
| HORMONE ACTIVITY | |
| IMMUNE SYSTEM DEVELOPMENT | |
| REGULATION OF INTERFERON GAMMA BIOSYNTHETIC PROCESS | CD276 |
| HEMOPOIESIS | |
| GENERATION OF A SIGNAL INVOLVED IN CELL CELL SIGNALING | |
| BIOCARTA DEATH PATHWAY | |
| POSITIVE REGULATION OF TRANSLATION | EREG, CD276 |
| REACTOME TOLL RECEPTOR CASCADES | |
| REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | EREG, CD276 |
| REACTOME P75NTR SIGNALS VIA NFKB | SQSTM1, NFKBIA, RIPK2, RELA |
| BIOCARTA TOLL PATHWAY | |