BICLUSTER_ID : UPREG-42
PATHOGENS /2/ : c. albicans,a. fumigatus
KNOWN DRUG TARGETS /27/ : LDLR, BCL2, SLC1A4, CCL2, GLA, CDK4, SLC1A3, IL3RA, SLC7A11, UGCG, PIM1, IL2RA, IFNG, CXCL10, PTPN1, STAT1, IL12B, MMP9, ABCC1, CCL8, IL6R, PPARG, SMPD1, IL1B, MET, IL8, TNF
Gene SetLeading Edge Genes
NETPATH IL 3 PATHWAY UPBCL2, BCL2L1, CCL2, SPP1, SOCS3, IL3RA, MATK, CCL7, PIM1, CCL4, CSF1, IL6R, USP36, IL1B, OSM, IL8, SOCS2, TNF
NCI NFAT TFPATHWAYPTPN1, GBP3, PPARG, CDK4, FOSL1, CBLB, IL8, IFNG, IL2RA, CSF2, TNF
NETPATH IL 6 PATHWAY UPGADD45B, LDLR, SPP1, HBEGF, SLC39A14, SOCS3, RHOBTB3, PIM1, STAT1, ABCC1, MMP9, PPARG, MAFF, STAT3, EIF5, IRF1, SOCS2, TNF
CYTOKINE ACTIVITYSDCBP, CCL2, CXCL3, CCL7, IL1RN, INHBA, CXCL2, CSF2, CXCL10, CCL4, CSF1, IL1F5, CCL8, CXCL5, OSM, IL8, TNF
KEGG SPHINGOLIPID METABOLISMSMPD1, SPHK1, UGCG, NEU4, GLA, SGPP2
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERSSLC1A3, SLC7A11, SLC6A6, SLC16A10, SLC1A4, SLC15A4
BIOCARTA INFLAM PATHWAYIL12B, PDGFA, CSF1, IL8, CSF2, IL1A, TNF
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTIONATP6V1H, TCIRG1, HBEGF, ATP6V1D, ADAM17, SRC, ATP6V0A1, MET, MAPK13, IL8, ATP6V0D2, MAPK8
HEMATOPOIETIN INTERFERON CLASSD200 DOMAIN CYTOKINE RECEPTOR BINDINGSDCBP, IL12B, IFNG, OSM, CSF2
MONOOXYGENASE ACTIVITY
AMINO ACID TRANSMEMBRANE TRANSPORTER ACTIVITY
BIOCARTA PLATELETAPP PATHWAY
REACTOME ENDOGENOUS STEROLS
AMINO SUGAR METABOLIC PROCESS
AMINO ACID TRANSPORT
AMINE TRANSMEMBRANE TRANSPORTER ACTIVITY
NCI ENDOGENOUS STEROLS
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
aspergillus fumigatus monocytescandida albicans moddc135Gene Set
0.009785512 0.0NETPATH_IL_3_PATHWAY_UP
0.19765195 5.8961764E-4NCI_NFAT_TFPATHWAY
0.11932011 0.0NETPATH_IL_6_PATHWAY_UP
0.010335351 0.0CYTOKINE_ACTIVITY
0.10197773 0.048068393KEGG_SPHINGOLIPID_METABOLISM
0.08670611 0.01380212REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS
0.11185193 0.0BIOCARTA_INFLAM_PATHWAY
0.15699872 0.002267632KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION
0.04804973 8.233354E-5HEMATOPOIETIN_INTERFERON_CLASSD200_DOMAIN_CYTOKINE_RECEPTOR_BINDING
0.09482384 0.07396551MONOOXYGENASE_ACTIVITY
0.092043035 0.117709376AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY
0.14451481 0.098546006BIOCARTA_PLATELETAPP_PATHWAY
0.1503794 0.1172772REACTOME_ENDOGENOUS_STEROLS
0.11079641 0.055010613AMINO_SUGAR_METABOLIC_PROCESS
0.16387926 0.13234565AMINO_ACID_TRANSPORT
0.15825975 0.061027322AMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY
0.16779399 0.19913463NCI_ENDOGENOUS_STEROLS