| Gene Set | Leading Edge Genes |
|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | CCL22, IL7R, CCL24, OSMR, INHBA, CXCL2, TNFRSF18, CXCL10, CCR7, CXCL1, CCL8, IL1A, TNFSF9, IL10RA, IL1B, CCL3, TNFRSF9, CCR5, CCL20, CCL1, CCL2, CD40, TNFRSF1B, TNFRSF4, CXCR3, IL3RA, CCL7, TNFRSF11B, CCL5, CXCL11, CSF2, CCL4, TNFSF14, IL12B, CXCL5, IL6 |
| REACTOME GPCR LIGAND BINDING | GPR68, NMB, CCL22, CCR5, CCL20, CXCR6, CCL2, PTGIR, CXCR3, CCL7, CCL5, ADORA2B, CXCL2, CXCL10, CCL4, PTGER4, CCR7, CXCL1, P2RY1, GPR109A, CXCL5, CCL3, PTGER2, CXCR4 |
| NETPATH IL 1 PATHWAY UP | ACPP, CCL20, MMP12, CCL2, SERPINB2, CCL7, NFKBIA, AMPD3, PIM2, TNFRSF11B, MT2A, INHBA, CXCL2, CSF2, SOD2, CCL4, CFB, BIRC3, BMP1, CXCL1, CCL8, NP, IL1A, TNFAIP6, CKS2, CXCL5, IL6, IL1B, MYC |
| RESPONSE TO EXTERNAL STIMULUS | GPR68, CCL22, ELF3, CCR5, CCL20, PLA2G7, CXCL14, CCL2, CCL1, CD40, CCL24, CXCR3, CCL7, CCL5, INHBA, FOS, CXCL2, CXCL11, CXCL10, CCL4, ANXA1, CCR7, CXCL1, CCL8, PPARG, IL1A, TNFAIP6, CXCL5, F5, CCL3, PLAUR |
| RESPONSE TO CHEMICAL STIMULUS | ABCG1, CCL22, CCR5, CCL20, CTPS, CCL2, CCL1, CCL24, HERPUD1, CXCR3, PMAIP1, CCL7, CCL5, CXCL2, CLEC7A, CXCL11, SOD2, CXCL10, CCR7, CXCL1, CCL8, PPARG, AQP9, CXCL5, CCL3, PLAUR |
| NETPATH IL 2 PATHWAY UP | PTPN22, STAT5A, IRF4, PMAIP1, IFI44, FOS, CREM, B4GALT5, GADD45G, LCP2, RGS1, IL1B, CCL3, MYC, SOCS2, SACS, CCR5, CTPS, STAT4, LDLR, TNFRSF1B, TNFRSF4, SOCS3, PIM1, CYP7B1, SLAMF1, CSF2, CCL4, PPRC1, EZH2, KLF6, IL2RG, IL6, ID2, PTGER2, PLAUR, MX1 |
| IMMUNE SYSTEM PROCESS | CCL22, CST7, IL7R, CCL24, INHBA, LAT, CLEC7A, CD86, EBI3, IRF8, PTGER4, CD274, PDCD1, AQP9, SEMA4D, LCP2, RGS1, GEM, CD83, CCR5, CCL20, CCL2, TNFRSF4, CCL5, CCL4, ICOSLG, IL12B, MMP9, CTSE, MALT1, SEMA7A, TM7SF4, IL6 |
| REACTOME SIGNALING IN IMMUNE SYSTEM | OLR1, NFKB2, CD40, MAP3K8, CD80, IRAK3, VCAM1, SLC7A11, NFKBIA, LAT, FOS, CD86, RPS6KA3, CFB, PRKCQ, CTLA4, IFITM1, ICOSLG, CD48, C1R, CD84, ITGB7, CD274, MALT1, PDCD1, LCP2, TLR2, TICAM1 |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | CD40, MAP3K8, CD80, NFKBIA, CCL5, CD86, CXCL10, CXCL11, CCL4, IL12B, TRAF3, PIK3R5, IL6, CCL3, IL1B, TICAM1, TLR2 |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | GPR68, NMB, CCL22, CCR5, CCL20, CCL2, CXCR3, CCL7, CCL5, CXCL2, CXCL10, CCL4, PTGER4, CCR7, CXCL1, P2RY1, GPR109A, CXCL5, CCL3, PTGER2 |
| NETPATH T CELL RECEPTOR PATHWAY UP | CCR5, IL1RAP, DDIT3, CH25H, NFKBIA, EGR1, PIM2, CCL5, IFNG, CD86, CSF2, PSTPIP1, NFKB1, IL27RA, NP, TAP1, IL1A, TAF9, SLC5A3, IQGAP2, TNFAIP8, SEMA4D, IL6, RHOC, TFPI2, MYC |
| DEFENSE RESPONSE | CD83, ELF3, GPR68, TCIRG1, CCL22, CCR5, CCL20, PLA2G7, CCL24, NCF1, CCL5, INHBA, CXCL2, FOS, CXCL10, CCL4, CD48, ANXA1, IL12B, CCR7, TNIP1, CXCL1, CD84, IL1A, TNFAIP6, KCNN4, CCL3, MX1 |
| NETPATH IL 4 PATHWAY UP | CCL22, ETV3, CCL2, ELL2, CH25H, SOCS3, VCAM1, IL1RN, INHBA, FOS, CD86, AIM1, CREM, RGS2, SLC22A4, RASGRP1, IL6, IL10RA, EBI2, F3, PTGER2, MYC |
| EXTRACELLULAR SPACE | CCL22, CCL20, CCL2, CCL1, CCL7, IL1RN, INHBA, RBP4, CXCL2, EBI3, CCL4, IL12B, MMP9, CXCL1, IL1A, TNFAIP2, IL6, IL1B |
| BEHAVIOR | CCL22, CCR5, CCR7, CCL20, CXCL1, CCL8, CCL1, CCL2, CCL24, CXCR3, CXCL5, CCL7, CCL3, CCL5, CXCL2, CXCL10, PLAUR |
| RESPONSE TO WOUNDING | GPR68, CCL22, ELF3, CCR5, CCL20, PLA2G7, CD40, CCL24, CCL5, FOS, CXCL2, CXCL11, CXCL10, CCL4, ANXA1, CCR7, CXCL1, IL1A, TNFAIP6, F5, CCL3 |
| LOCOMOTORY BEHAVIOR | CCL22, CCR5, CCL20, CCL1, CCL2, CCL24, CXCR3, CCL7, CCL5, CXCL2, CXCL10, CXCL11, CCR7, CXCL1, CCL8, CXCL5, CCL3, PLAUR |
| IMMUNE RESPONSE | CD83, CCL22, CCL20, CST7, IL7R, CCL2, CCL24, TNFRSF4, CCL5, LAT, CD86, EBI3, CCL4, IRF8, PTGER4, IL12B, MALT1, SEMA7A, CD274, PDCD1, AQP9, LCP2, IL6, RGS1, GEM |
| CYTOKINE ACTIVITY | CCL22, CCL20, CCL2, CCL1, CCL24, CCL7, IL1RN, TNFRSF11B, CCL5, INHBA, CXCL2, CXCL11, CSF2, CXCL10, CCL4, IL12B, CXCL1, CCL8, CXCL5, CCL3 |
| REACTOME G ALPHA I SIGNALLING EVENTS | CCR5, CCL20, CCR7, CXCL1, CXCR6, GPR109A, CXCR3, CXCL5, CXCL16, CCL5, CXCL2, CXCL10, CXCR4, CXCL13 |
| REACTOME HEMOSTASIS | PTPN1, OLR1, CD48, P2RY1, PLEK, CD84, SERPINB2, SLC7A11, PIK3R5, LCP2, F5, F3, PLAUR |
| NETPATH IL 5 PATHWAY UP | NFKBIB, NFKB2, CCL2, GADD45A, IL3RA, EGR1, PIM1, CD55, RELB, REL, PPIF, TRAF3, IL1A, EGR3, LCP2, IDI1, IL1B, CCL3 |
| KEGG CHEMOKINE SIGNALING PATHWAY | CCL22, CCR5, CCL20, CXCL14, CXCR6, CCL2, CCL1, CCL24, CXCR3, NCF1, CCL7, NFKBIA, CCL5, CXCL2, CXCL11, CXCL10, CCL4, CCR7, CXCL1, CCL8, FGR, TIAM1, CXCL5, PIK3R5, CCL3 |
| INFLAMMATORY RESPONSE | GPR68, CCL22, ELF3, CCR5, CCL20, PLA2G7, CD40, CCL24, CCL5, FOS, CXCL2, CXCL11, CXCL10, CCL4, ANXA1, CCR7, CXCL1, IL1A, TNFAIP6, CCL3 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | CCL22, NMB, CCR5, CCR7, CCL20, CXCL1, CCL2, CXCR3, CXCL5, CCL7, CCL3, CCL5, CXCL2, CXCL10, CCL4 |
| CHEMOKINE ACTIVITY | CCL22, CCL20, CXCL1, CCL8, CCL1, CCL2, CCL24, CXCL5, CCL7, CCL3, CCL5, CXCL2, CXCL10, CXCL11, CCL4 |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | CXCL1, CCL8, CCL2, NFKBIA, CCL7, IL6, TNFAIP3, IL1B, CCL5, CXCL2 |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CCL22, CCR5, CCR7, CCL20, CXCL1, CCL2, CXCR3, CXCL5, CCL7, CCL3, CCL5, CXCL2, CXCL10, CCL4 |
| NCI NFAT TFPATHWAY | CTLA4, PRKCQ, PTPN1, PPARG, IRF4, EGR3, EGR1, IFNG, FOS, CSF2 |
| KEGG JAK STAT SIGNALING PATHWAY | IL12B, STAT4, IL7R, STAT5A, IL2RG, IL3RA, SOCS3, OSMR, PIK3R5, IL6, IL10RA, PIM1, CSF2, SOCS2, MYC |
| HOMEOSTATIC PROCESS | ABCG1, CCR5, CCR7, CCL2, CCL1, FXN, CXCR3, CCL7, IL6, CCL3, MT2A, CCL5, INHBA, MYC |
| CHEMOKINE RECEPTOR BINDING | CCL22, CCL20, CXCL1, CCL8, CCL1, CCL2, CCL24, CXCL5, CCL7, CCL3, CCL5, CXCL2, CXCL10, CXCL11, CCL4 |
| G PROTEIN COUPLED RECEPTOR BINDING | CCL22, CCL20, CXCL1, CCL8, CCL1, CCL2, CCL24, CXCL5, CCL7, CCL3, CCL5, CXCL2, CXCL10, CXCL11, CCL4 |
| KEGG GRAFT VERSUS HOST DISEASE | IL6, IL1B, CD86, CD80, IL1A |
| NETPATH IL 7 PATHWAY UP | CCL22, CXCL1, CCL8, TRAF3, STAT5A, CD80, CXCL5, CCL3, CCL5, CXCL2, CD86, MYC, CCL4 |
| KEGG COMPLEMENT AND COAGULATION CASCADES | F5, C1R, F3, CFB, PLAUR |
| CHEMICAL HOMEOSTASIS | ABCG1, CCR5, CCR7, CCL1, CCL2, FXN, CXCR3, CCL7, CCL3, CCL5, MT2A, MYC |
| KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION | ICOSLG, IL6, CD86, CD40, CD80 |
| CELLULAR CATION HOMEOSTASIS | CCR5, CCR7, CCL1, CCL2, FXN, CXCR3, CCL7, CCL3, MT2A, CCL5, CXCR4, MYC |
| NCI IL12 2PATHWAY | CCR5, IL12B, NFKB2, STAT4, STAT5A, GADD45G, IL2RG, IL1B, CCL3, RELB, FOS, CCL4 |
| CATION HOMEOSTASIS | CCR5, CCR7, CCL1, CCL2, FXN, CXCR3, CCL7, CCL3, MT2A, CCL5, CXCR4, MYC |
| NETPATH IL 3 PATHWAY UP | CCL2, SOCS3, MATK, CCL7, CCL3, IL1B, PIM1, CD86, MYC, SOCS2 |
| NETPATH IL 6 PATHWAY UP | MUC5AC, MMP9, CXCL1, LDLR, MAP3K8, SLC39A14, PPARG, SOCS3, MAFF, TNFRSF11B, PIM2, ID2, FOS, PIM1, SOCS2, MX1 |
| KEGG HEMATOPOIETIC CELL LINEAGE | IL3RA, ANPEP, IL6, IL1B, IL7R, IL1A, CSF2 |
| NCI CD8TCRPATHWAY | PRKCQ, MAP3K8, MALT1, CD80, LCP2, RASSF5, CD86, LAT |
| RESPONSE TO BIOTIC STIMULUS | CCL22, IL12B, CCL8, FGR, HERPUD1, IFI44, CCL5, CCL4 |
| ION HOMEOSTASIS | CCR5, CCR7, CCL1, CCL2, FXN, CXCR3, CCL7, CCL3, MT2A, CCL5, MYC |
| CELLULAR HOMEOSTASIS | CCR5, CCR7, CCL1, CCL2, FXN, CXCR3, CCL7, CCL3, MT2A, CCL5, MYC |
| CYTOKINE BINDING | IL7R, TNFRSF1B, TNFRSF4, IL2RG, IL3RA, IL10RA, TNFRSF18, EBI3 |
| KEGG PRION DISEASES | IL6, IL1B, CCL5, IL1A |
| BIOCARTA DC PATHWAY | IL12B, CD40, CSF2, TLR2 |
| KEGG LEISHMANIA INFECTION | IL12B, IL1A, NCF1, NFKBIA, IL1B, FOS, MARCKSL1, TLR2 |
| NETPATH IL 9 PATHWAY UP | MUC5AC, CCL2, SOCS3, CCL7, CCL3, PIM1, SOCS2, MYC |
| BIOCARTA NO2IL12 PATHWAY | CCR5, IL12B, STAT4, CXCR3 |
| INTERLEUKIN BINDING | IL3RA, IL2RG, IL10RA, IL7R, EBI3 |
| BIOCARTA NKT PATHWAY | CCR5, CCR7, IL12B, CCL3, CSF2, CCL4, CXCR3 |
| RESPONSE TO OTHER ORGANISM | CCL22, IFI44, CCL5, CCL8, CCL4 |
| NCI CD8TCRDOWNSTREAMPATHWAY | IL2RG, PRKCQ, TNFRSF9, STAT4, FOS, TNFRSF18, TNFRSF4 |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | CTLA4, PRKCQ, TEC, MALT1, RASGRP1, PDCD1, LCP2, PIK3R5, NFKBIA, PPP3CC, LAT, FOS, CSF2 |
| CYTOKINE BIOSYNTHETIC PROCESS | IL6, IL12B, INHBA, EBI3, IRF4 |
| REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | F5, F3 |
| HUMORAL IMMUNE RESPONSE | CD83, IL6, CCL2, EBI3, PDCD1 |
| BIOCARTA IL12 PATHWAY | CCR5, IL12B, STAT4, CXCR3 |
| RESPONSE TO VIRUS | CCL22, IFI44, CCL5, CCL8, CCL4 |
| BIOCARTA IL5 PATHWAY | IL6, IL1B |
| CYTOKINE METABOLIC PROCESS | IL6, IL12B, INHBA, EBI3, IRF4 |
| INTERLEUKIN RECEPTOR ACTIVITY | IL3RA, IL2RG, IL10RA, IL7R |
| REACTOME COSTIMULATION BY THE CD28 FAMILY | ICOSLG, CD86, MAP3K8, CD274, CD80, PDCD1 |
| MULTI ORGANISM PROCESS | CCL22, MAFF, TNIP1, IFI44, CCL5, CCL8, CCL4 |
| POSITIVE REGULATION OF TRANSLATION | IL6, IL12B, EBI3, IRF4 |
| BIOCARTA ASBCELL PATHWAY | CD40, CD80 |
| REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | IL6, IL12B, INHBA, EBI3, IRF4 |
| BIOCARTA IL10 PATHWAY | IL6, IL10RA, STAT4, STAT3, STAT5A, IL1A |
| NEGATIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | IL6, INHBA |
| LEUKOCYTE ACTIVATION | ICOSLG, IL12B, INHBA, CLEC7A, LAT, EBI3 |
| BIOCARTA LAIR PATHWAY | IL6, IL1A |
| REGULATION OF T CELL PROLIFERATION | ICOSLG, IL12B, EBI3 |
| NCI CHEMOKINE RECEPTORS BIND CHEMOKINES | CCL20, CCR7 |
| REGULATION OF LYMPHOCYTE ACTIVATION | ICOSLG, IL12B, INHBA, LAT, EBI3 |
| REGULATION OF IMMUNE SYSTEM PROCESS | ICOSLG, IL12B, INHBA, LAT, EBI3, MALT1 |
| NCI IL2 1PATHWAY | IL2RG, SOCS3, FOS, STAT5A, SOCS2, MYC |
| BIOCARTA IL17 PATHWAY | IL6 |
| COAGULATION | F5 |
| T CELL PROLIFERATION | ICOSLG, IL12B, EBI3 |
| REGULATION OF T CELL ACTIVATION | ICOSLG, IL12B, LAT, EBI3 |
| CELL ACTIVATION | ICOSLG, IL12B, INHBA, CLEC7A, LAT, EBI3 |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | OLR1, CD48, SLC7A11, CD84 |
| NCI DOWNSTREAM TCR SIGNALING | PRKCQ, NFKBIA, MALT1 |
| REGULATION OF INTERFERON GAMMA BIOSYNTHETIC PROCESS | IL12B, INHBA, EBI3 |
| LYMPHOCYTE ACTIVATION | ICOSLG, IL12B, INHBA, CLEC7A, LAT, EBI3 |
| NCI CD40 PATHWAY | BIRC3, TRAF3, CD40, STAT5A, BIRC2, TRAF1, NFKBIA, TNFAIP3, MYC |
| BIOCARTA TNFR2 PATHWAY | TRAF1, NFKBIA, TNFAIP3, TANK, TRAF3, TNFRSF1B |
| BLOOD COAGULATION | F5 |
| T CELL ACTIVATION | ICOSLG, IL12B, CLEC7A, LAT, EBI3 |
| REACTOME PD1 SIGNALING | CD274, PDCD1 |
| HEMOSTASIS | |
| VACUOLAR PART | |
| REACTOME ENDOGENOUS STEROLS | |
| NCI PD 1 SIGNALING | PDCD1 |
| NETPATH T CELL RECEPTOR PATHWAY DOWN | |
| NCI CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | OLR1, CD48 |
| BIOCARTA EXTRINSIC PATHWAY | |
| POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | |
| BIOCARTA IL22BP PATHWAY | SOCS3, IL10RA, STAT4, STAT5A |
| HEMATOPOIETIN INTERFERON CLASSD200 DOMAIN CYTOKINE RECEPTOR ACTIVITY | |
| NCI ENDOGENOUS STEROLS | |
| GLYCOLIPID METABOLIC PROCESS | |
| BIOCARTA HIVNEF PATHWAY | |
| REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | |
| NEGATIVE REGULATION OF CELLULAR BIOSYNTHETIC PROCESS | |
| CELLULAR DEFENSE RESPONSE | |
| KEGG SYSTEMIC LUPUS ERYTHEMATOSUS | |
| NCI SYNTHESIS OF BILE ACIDS AND BILE SALTS | CH25H, CYP7B1, HSD3B7 |
| KEGG ASTHMA | |
| NCI TRYPTOPHAN CATABOLISM | |
| REACTOME DOWNSTREAM EVENTS IN GPCR SIGNALING | |
| CYTOKINE PRODUCTION | |
| REGULATION OF TRANSLATION | |
| KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY | CD48, SH3BP2, PIK3R5, LCP2, PPP3CC, LAT, CSF2, BID |
| REGULATION OF BIOLOGICAL QUALITY | |
| NCI TCR PATHWAY | |
| REGULATION OF BODY FLUID LEVELS | |
| REGULATION OF HORMONE SECRETION | SCG5, INHBA |
| SPHINGOLIPID METABOLIC PROCESS | |
| LIPID RAFT | |
| REACTOME DOWNSTREAM TCR SIGNALING | |
| ACTIVATION OF IMMUNE RESPONSE | |
| BIOCARTA IL7 PATHWAY | |
| NEGATIVE REGULATION OF BIOSYNTHETIC PROCESS | |