| Gene Set | Leading Edge Genes |
|---|
| NETPATH TGFBETA RECEPTOR PATHWAY UP | BDNF, HBEGF, ASNS, NFKBIA, EIF2C2, INHBA, ZNF143, TDG, STAM, RGS2, APBB2, PTPRK, PDGFA, GOLGA4, JUNB, MAPK6, TNFRSF12A, TMEPAI, NFIL3, JAG1, HIVEP2, RELA, FOSL1, PTHLH, PLAU, IER3, FGF2, GDF15, RAPGEF2, DUSP5, NUP153, KLF10, SPRY2, ATP6V0A2, SMAD3, IL6, ATF3, PTGS2, PMP22, JUP, SLC7A5, SERPINB8, DDX21, TRIB3, MAP3K8, CHST11, PHLDA2, CYP1B1, GTPBP2, EXT1, PTPN2, RELB, BHLHB2, MAP2K1, EGFR, CAB39, SGK, SMAD2, GARS, CBFB, VEGF, TOPORS, FYN, RYBP, FOXO1A, FST, CRY1, SMURF2, ICAM1, MYC, MXI1, GADD45B, UAP1, DVL3, CASP3, VEGFC, SLC7A1, MAP3K2, SRPX2, NEDD9, DSCR1, KIAA0247, NRIP1, DDIT4, ATP1B1, ETS2, CLK1, TANK, SNF1LK, SMURF1, MAPKAPK2, DAXX, PLAUR |
| NETPATH IL 2 PATHWAY UP | DDX21, PFKFB3, ABCE1, NOLC1, BTG3, DUSP6, PMAIP1, ASNS, RRAS2, FOS, CREM, BHLHB2, CFLAR, NFKB1, SGK, APBB2, MFHAS1, GARS, CBFB, MAP3K7IP2, DENND3, OXSR1, VEGF, NFIL3, FYN, ICAM1, IRF1, MYC, AHR, ZNF267, LDLR, JUN, PDE4B, MMD, FRMD4B, SOS1, CASP3, SLC2A3, RELA, NR4A2, PLAU, PRKCD, PIM1, FOSL2, PPRC1, IER3, TTK, DUSP5, ATP1B1, ETS2, USP15, SAMHD1, JUND, IL6, MAPKAPK2, DAXX, IL8, SLC7A5, CHSY1, PLAUR |
| NCI LYSOPHOSPHOLIPID PATHWAY | NFKB1, JUN, HBEGF, GSK3B, CASP3, RELA, NFKBIA, IL6, PRKCD, PTK2, IL8, FOS, GNAI1, EGFR |
| RESPONSE TO EXTERNAL STIMULUS | CCL20, CCL2, RELA, STC1, PLAU, FOSL1, STC2, RIPK2, FOS, CXCL2, FGF2, MAP2K1, NFKB1, CXCL1, CEBPB, IL1A, IL8, ADM, PLAUR |
| KEGG CHEMOKINE SIGNALING PATHWAY | CCL20, CCL2, SOS1, RELA, CXCL3, NFKBIA, PIK3CA, PRKCD, PTK2, CXCL2, ADRBK1, GNAI1, MAP2K1, GNB5, NFKB1, CXCL1, GSK3B, PLCB1, IL8 |
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | TNFRSF10B, CCL20, CCL2, VEGFC, CXCL3, LEPR, INHBA, CXCL2, EGFR, PDGFB, PDGFA, CXCL1, IFNGR1, TNFRSF12A, IL1A, IFNGR2, IL6, IL8 |
| NEGATIVE REGULATION OF PROGRAMMED CELL DEATH | MCL1, CCL2, CASP3, RELA, BCL2L2, PIM1, IER3, CFLAR, NFKB1, BIRC3, IGF1R, BCL3, IL1A, ANGPTL4, GSK3B, BCL10, TNFAIP8, IL6, SFRP1, TAX1BP1, PSEN1, BNIP3 |
| NEGATIVE REGULATION OF APOPTOSIS | MCL1, CCL2, CASP3, RELA, BCL2L2, PIM1, IER3, CFLAR, NFKB1, BIRC3, IGF1R, BCL3, IL1A, ANGPTL4, GSK3B, BCL10, TNFAIP8, IL6, SFRP1, TAX1BP1, PSEN1, BNIP3 |
| KEGG MAPK SIGNALING PATHWAY | GADD45B, BDNF, MAP3K8, SOS1, DUSP6, CASP3, RELA, RASA2, MAP4K3, RRAS2, MAP3K2, RELB, FOS, FGF2, EGFR, MAP2K1, PDGFB, NFKB1, DUSP5, RAPGEF2, PDGFA, NR4A1, STK3, PPP3CB, IL1A, JUND, PPM1B, MAPKAPK2, DAXX, MYC, DUSP1 |
| NETPATH IL 4 PATHWAY DOWN | PDGFB, CCL20, GADD45B, KLHL18, CCL2, DDIT4, NFKBIA, IL6, GEM, PTGS2, IRF1, IL8, CXCL2, EGFR |
| BEHAVIOR | CCL20, CXCL1, FOSB, CCL2, PLAU, FOSL1, IL8, CXCL2, PLAUR, FGF2 |
| NETPATH TNF ALPHA PATHWAY DOWN | JMJD1A, NFKBIA, ZNF131, EGR1, CXCL2, BHLHB2, NFKB1, CXCL1, ZHX2, JUNB, FOSB, MAPK6, GSK3B, TIPARP, VEGF, MAFF, TNFAIP2, GEM, TNFAIP3, IRF1, CCL20, MTMR2, CXCL3, SDC4, FOSL2, IER3, REL, NR4A1, PPP1R15A, KLF10, MNT, DDX3X, IL6, CLK1, PTGS2, ZFP36 |
| LOCOMOTORY BEHAVIOR | CCL20, CXCL1, CCL2, PLAU, FOSL1, IL8, CXCL2, PLAUR, FGF2 |
| NETPATH IL 5 PATHWAY UP | IRF2, PDE4B, MMD, CCL2, NFKBIE, HBEGF, DUSP6, RELA, EGR1, MAP3K2, FOSL2, CD55, RELB, IER3, SGK, NFKB1, BIRC3, DUSP5, REL, TRAF3, MAPK6, IL1A, RAB21, NFIL3, PMP22, ICAM1, IL8, IER2 |
| NETPATH IL 1 PATHWAY UP | NR4A3, CCL20, NFKBIE, CCL2, DUSP6, RELA, FOSL1, CXCL3, NFKBIA, PRKCD, CXCL2, SOD2, NFKB1, TTK, BIRC3, CXCL1, JMJD3, IL6, PTGS2, ZFP36, IL8, MYC |
| TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | RB1, SNW1, NFAT5, ELL2, E2F3, ZNF143, INHBA, TAF2, KLF7, FOS, SOD2, NFKB1, SMAD2, KLF11, CEBPZ, CBFB, RBBP8, TAF1A, FOSB, ELF4, CEBPB, JUNB, CDK7, NFIL3, MAFF, HSF2, FST, RYBP, ZBTB38, IRF1, MYC, IRF2, AHR, ETV1, TIAL1, COPS2, CREB5, ABL1, TCEB3, SQSTM1, FOSL1, PLAGL1, FOXK2, VEZF1, ELF2, FOSL2, E2F6, CEBPD, CHD1, SP2, KLF10, MNT, NRIP1, SMAD3, GTF2H1, RNF4, TAF5, PBX3, JUND, ARID4A, ZMYND11 |
| NETPATH IL 4 PATHWAY UP | AHR, SLC38A1, CCL2, ELL2, SOS1, DUSP6, FJX1, CASP3, RELA, CYP1B1, RASA2, ARL4C, RIPK2, FOS, CREM, GNAI1, PMCH, GATA6, RGS2, NFKB1, REL, PSCD1, CEBPB, BCL3, NFIL3, IL6, JAG1, MYC |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | JUN, NFAT5, NFKBIE, MAP3K8, SOS1, RELA, NFKBIA, PIK3CA, PDK1, CBLB, FOS, MAP2K1, NFKB1, PPP3CB, GSK3B, BCL10, FYN |
| NCI MET PATHWAY | MAP3K5, JUN, SOS1, PDPK1, PIK3CA, PTK2, FOS, MAP2K1, GRB2 |
| NETPATH IL 2 PATHWAY | NFKB1, IRS2, SHB, SOS1, RELA, ETS2, FYN, PIK3CA, CREB1, PLCB1, GAB2, GRB2, STAM, MAP2K1 |
| EXTRACELLULAR SPACE | CCL20, CXCL1, CCL2, FJX1, CXCL3, TNFAIP2, IL6, ADM, IL8, CXCL2, FGF2 |
| BIOCARTA MET PATHWAY | PIK3CA, PTK2, JUN, FOS, SOS1, MAP2K1, GRB2 |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | NFKB1, BIRC3, CXCL1, CCL2, BIRC2, RELA, NFKBIA, IL6, TNFAIP3, CXCL2, IL8, RIPK2 |
| REACTOME TOLL LIKE RECEPTOR 3 CASCADE | NFKB1, ATF1, JUN, NFKB2, DUSP3, RIPK1, DUSP6, TBK1, RELA, NFKBIA, PPP2R1B, MAPKAPK2, FOS, TICAM1, MAP2K1 |
| KEGG B CELL RECEPTOR SIGNALING PATHWAY | NFKB1, JUN, NFAT5, NFKBIE, PPP3CB, GSK3B, SOS1, BCL10, RELA, NFKBIA, PIK3CA, FOS, MAP2K1 |
| NCI REG GR PATHWAY | NFKB1, SGK, NR4A1, GSK3B, EGR1, IL6, IRF1, FOS, IL8 |
| NETPATH EGFR1 PATHWAY UP | EMP1, NR4A3, DUSP6, PHLDA2, PTHLH, PLAU, EGR1, SDC4, IER3, NAV3, SPRY2, VEGF, TNFAIP3, PPAT, PTGS2, MYC, PLAUR, DUSP1 |
| NCI AMB2 NEUTROPHILS PATHWAY | PLAU, NFKB1, IL6, PLAUR |
| NCI IL2 1PATHWAY | IRS2, JUN, SOS1, PIK3CA, FYN, MAPKAPK2, FOS, MYC, MAP2K1, STAM |
| BIOCARTA EGF PATHWAY | SRF, JUN, SOS1, PIK3CA, FOS, EGFR, GRB2, MAP2K1 |
| BIOCARTA KERATINOCYTE PATHWAY | NFKB1, JUN, RELA, ETS2, NFKBIA, PRKCD, DAXX, FOS, EGFR, MAP2K1 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | CXCL3, CCL20, CXCL1, CCL2, CXCL2, IL8 |
| BIOCARTA IL1R PATHWAY | NFKB1, NFKBIA, IL6, JUN, IL1A, RELA |
| NCI MAPKTRKPATHWAY | SRF, NRAS, EHD4, PRKCD, EGR1, KRAS, MAPKAPK2, CREB1, FOS, MAP3K2, MAP2K1 |
| NCI FGF PATHWAY | SOS1, SPRY2, PLAU, PIK3CA, FOS, SSH1, FGF2, PLAUR |
| BIOCARTA CDMAC PATHWAY | NFKB1, NFKBIA, JUN, FOS, MYC, MAP2K1, RELA |
| CYTOKINE ACTIVITY | CXCL3, GDF15, CCL20, CXCL1, CCL2, CXCL2, IL8 |
| BIOCARTA IGF1 PATHWAY | SRF, PIK3CA, IGF1R, JUN, FOS, SOS1, MAP2K1 |
| CHEMOKINE ACTIVITY | CXCL3, CCL20, CXCL1, CCL2, IL8, CXCL2 |
| DEFENSE RESPONSE | CD83, CCL20, RELA, FOSL1, VEZF1, INHBA, RIPK2, FOS, CXCL2, NFKB1, TNIP1, CXCL1, CEBPB, IL1A, BCL10, IL8, BNIP3 |
| CHEMOKINE RECEPTOR BINDING | CXCL3, CCL20, CXCL1, CCL2, IL8, CXCL2 |
| REACTOME TRAF6 MEDIATED INDUCTION OF THE ANTIVIRAL CYTOKINE IFN ALPHA BETA CASCADE | NFKB1, ATF1, JUN, DUSP3, DUSP6, RELA, NFKBIA, FOS, TICAM1, MAP2K1 |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL3, CCL20, CXCL1, CCL2, CXCL2, IL8 |
| BIOCARTA CARDIACEGF PATHWAY | NFKB1, JUN, FOS, MYC, EGFR, RELA |
| NCI IL23PATHWAY | NFKB1, NFKBIA, IL6, PIK3CA, CXCL1, CCL2, RELA |
| BIOCARTA PDGF PATHWAY | SRF, PDGFA, JUN, SOS1, PIK3CA, FOS, GRB2, MAP2K1 |
| G PROTEIN COUPLED RECEPTOR BINDING | CXCL3, CCL20, CXCL1, CCL2, IL8, CXCL2 |
| NCI AVB3 OPN PATHWAY | PLAU, NFKB1, NFKBIA, PIK3CA, JUN, FOS, RELA |
| INFLAMMATORY RESPONSE | NFKB1, CCL20, CXCL1, CEBPB, IL1A, CXCL2, RIPK2, IL8, FOS |
| BIOCARTA TPO PATHWAY | PIK3CA, JUN, FOS, SOS1, MAP2K1, GRB2 |
| NETPATH WNT PATHWAY UP | SIAH2, KLF10, BTG3, MAPK6, DUSP6, TRRAP, GJA1, IL8, FOS, CREM, DUSP1, PLAUR |
| ST B CELL ANTIGEN RECEPTOR | NFKB1, NFKBIA, PIK3CA, NFAT5, NFKBIE, SOS1, MAP2K1 |
| NCI ATF2 PATHWAY | PLAU, JUND, IL6, ATF3, DUSP5, FOS, DUSP1 |
| BIOCARTA STEM PATHWAY | IL6, IL8 |
| BIOCARTA INSULIN PATHWAY | SRF, PIK3CA, JUN, FOS, SOS1, MAP2K1 |
| BIOCARTA NKT PATHWAY | IFNGR1, CSF2, IFNGR2 |
| NCI IL6 7PATHWAY | JUN, MCL1, JUNB, CEBPB, SOS1, MITF, IL6, PRKCD, PIK3CA, IRF1, FOS, MYC |
| NCI DISSOLUTION OF FIBRIN CLOT | PLAU, PLAUR |
| NETPATH KIT RECEPTOR PATHWAY UP | GDF15, MCL1, JUNB, CCL2, PPP3CB, ETV5, VEGF, JUND, IL6, EGR1, FOS, MYC, IER3 |
| ST ERK1 ERK2 MAPK PATHWAY | NFKB1, ATF1, TRAF3, MAP3K8, DUSP6, SOS1, CREB5, MAP2K1 |
| BIOCARTA NTHI PATHWAY | SMAD3, NFKB1, NFKBIA, IL8, SMAD4, DUSP1, RELA |
| NCI NFAT TFPATHWAY | FOSL1, EGR1, CBLB, PTGS2, JUNB, IL8, FOS |
| NETPATH IL 3 PATHWAY UP | NFIL3, MCL1, CCL2, FOS, IL8, MYC |
| BIOCARTA INFLAM PATHWAY | IL6, PDGFA, IL8, CSF2, IL1A |
| BIOCARTA IL17 PATHWAY | IL6, IL8 |
| REACTOME G ALPHA I SIGNALLING EVENTS | CXCL3, OPN3, CCL20, CXCL1, CXCL2, IL8, GNAI1, GNB5 |
| BIOCARTA GRANULOCYTES PATHWAY | ICAM1, IL8, IL1A |
| BIOCARTA GLEEVEC PATHWAY | PIK3CA, JUN, FOS, MYC, SOS1, MAP2K1 |
| NCI TCRCALCIUMPATHWAY | FOSL1, PTGS2, JUNB, FOS, PPP3CB |
| NETPATH IL 9 PATHWAY UP | CCL2, JUNB, BCL3, MYC |
| NCI PDGFRAPATHWAY | PDGFB, SRF, PDGFA, JUN, SHB, SOS1, PIK3CA, FOS |
| NCI NFKAPPABATYPICALPATHWAY | NFKB1, REL, BCL3, CSNK2A2, RELA, NFKBIA, PIK3CA, FBXW11 |
| FEEDING BEHAVIOR | FYN, PMCH |
| CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 COMPLEX | NFKB1, NFKBIA, SPAG9, REL, TNIP1, NFKBIE, RELA |
| BIOCARTA CD40 PATHWAY | NFKB1, NFKBIA, TNFAIP3, TRAF3, DUSP1, RELA |
| BIOCARTA ERYTH PATHWAY | IL6, CSF2, IL1A |
| BIOCARTA RANKL PATHWAY | FOSL1, NFKB1, FOS, FOSL2, RELA |
| NCI CHEMOKINE RECEPTORS BIND CHEMOKINES | CCL20 |
| SIG CD40PATHWAYMAP | NFKB1, NFKBIA, PIK3CA, NFKBIE, TRAF3, DUSP1 |
| NETPATH IL 6 PATHWAY UP | SGK, GADD45B, CXCL1, LDLR, MCL1, JUNB, CEBPB, BCL3, SLC2A3, MAFF, ZFP36, IRF1, FOS, BHLHB2 |
| NCI CD40 PATHWAY | NFKB1, BIRC3, TRAF3, BIRC2, RELA, NFKBIA, TNFAIP3, CBLB, MYC |
| ST T CELL SIGNAL TRANSDUCTION | NFKB1, NFKBIA, NFAT5, NFKBIE, SOS1 |
| BIOCARTA IL2 PATHWAY | FOS, SOS1, MAP2K1 |
| POSITIVE REGULATION OF TRANSLATION | IL6, BCL3, SAMD4A, BCL10 |
| NCI CD8TCRDOWNSTREAMPATHWAY | FOSL1, EGR1, JUNB, FOS, PPP3CB, MAP2K1 |
| SPHINGOLIPID BIOSYNTHETIC PROCESS | UGCG |
| BIOCARTA TNFR2 PATHWAY | NFKB1, NFKBIA, TNFAIP3, TANK, TRAF3, DUSP1, RELA |
| NCI IL12 2PATHWAY | NFKB1, GADD45B, RIPK2, RELB, FOS, PPP3CB |
| NCI NFKAPPABCANONICALPATHWAY | NFKB1, CYLD, MALT1, BIRC2, BCL10, RELA, NFKBIA, TNFAIP3, RIPK2, FBXW11 |
| LEUKOCYTE ACTIVATION | |
| BIOCARTA IL6 PATHWAY | |
| BIOCARTA SPRY PATHWAY | |
| NETPATH IL 1 PATHWAY | |
| PROTEIN AMINO ACID DEPHOSPHORYLATION | PPM1D, PPM1B, DUSP5, DUSP3, PTPN12, MTMR3, DUSP6, SSH1 |
| NETPATH IL 7 PATHWAY | |
| TISSUE MORPHOGENESIS | SMAD2 |
| BIOCARTA LAIR PATHWAY | |
| BIOCARTA LYM PATHWAY | |
| PHOSPHOPROTEIN PHOSPHATASE ACTIVITY | PPM1D, DUSP5, PTPRK, PPAP2B, DUSP3, MTMR3, DUSP6, PPM1B, PTPN2, PTPN12, DUSP1 |
| PROTEIN TYROSINE PHOSPHATASE ACTIVITY | DUSP5, DUSP3, PTPN12, MTMR3, DUSP6, DUSP1 |
| CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2 | |
| NETPATH HEDGEHOG PATHWAY UP | VEGF, NR4A1, PMP22, MYC |
| NEGATIVE REGULATION OF RNA METABOLIC PROCESS | IRF2, E2F6, SMAD2, SIRT1, KLF11, ZHX2, FOSB, KLF10, NRIP1, SMAD3, FST, RYBP, DAXX, SMAD4, ARID4A, ZMYND11 |
| LEUKOCYTE MIGRATION | |
| LEUKOCYTE CHEMOTAXIS | |
| BIOCARTA 41BB PATHWAY | |
| CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX RPL6 RPL30 RPS13 CHUK DDX3X NFKB2 NFKBIB REL IKBKG NFKB1 MAP3K8 RELB GLG1 NFKBIA RELA TNIP2 GTF2I | |
| NCI IL12 STAT4PATHWAY | FOS, IRF1, PPP3CB, ETV5 |
| NCI PDGFRBPATHWAY | |
| NEGATIVE REGULATION OF TRANSCRIPTION DNA DEPENDENT | IRF2, E2F6, SMAD2, SIRT1, KLF11, ZHX2, FOSB, KLF10, NRIP1, SMAD3, FST, RYBP, DAXX, SMAD4, ARID4A, ZMYND11 |