| Gene Set | Leading Edge Genes |
|---|
| STEIN ESRRA TARGETS | NNT, TGFBR2, PFKM, ACADSB, ASPH, MGST3, PRPS2, ST3GAL5, PEA15, AK1, TRIM2, USP4, ATP5O, MDH1, CAV2, WIPI1, PPL, MXD4, MUT, GAS2L1, UGP2, ATP5J, GAS6, TRAM2, DECR1, EBP, ARL2BP, ATP5C1, FZD2, DLAT, OXA1L, MYO6, B3GNT1, ACAA2, ACADM, NQO2, ANXA6, ACAT1, MSH6, HEXIM1, TACC1, CS, ATP5G3, PDCL, RABIF |
| STEIN ESRRA TARGETS UP | NNT, ARL2BP, ATP5C1, PFKM, DLAT, ACADSB, MGST3, OXA1L, ST3GAL5, AK1, ACADM, ACAA2, NQO2, TRIM2, USP4, ATP5O, ANXA6, MDH1, ACAT1, WIPI1, MUT, GAS2L1, ATP5J, UGP2, CS, PLEKHB2, ATP5G3, GAS6, DECR1, EBP |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | SET, ILF2, CETN2, RPS25, HSP90AB1, ELOVL6, MGST3, PEA15, ANKMY2, CASK, NCBP2, CANX, BLVRA, IGBP1, WRB, TOM1L1, PDIA6, WIPI1, PPL, CREB3L2, DDX46, COPB2, ARL2BP, SEC24D, PAPSS1, OXA1L, FARS2, CAP2, PIR, GNPAT, MRPL40, YIPF1, MAPRE1, NDUFB3, SLC9A6, CCT2, RPL30, MSH6, PARP1, IDH1, SPCS2, ZMPSTE24, ACLY, RPA1 |
| KEGG PROPANOATE METABOLISM | ACAT1, PCCB, ACAT2, ALDH3A2, ALDH6A1, HADHA, MUT, ACADM |
| WONG EMBRYONIC STEM CELL CORE | BUB1B, HDAC1, SET, LMNB1, MAD2L1, ELOVL6, DLAT, CTNNA1, NCBP2, ADSL, ANP32E, LYPLA1, ATP5O, CCNB2, TTK, PSMB5, MSH2, PARP1, KIF23, UGDH, HADH, POLE2, SLC25A5, CCT5, ATP5J, NONO, ZNF22, LSM2, CHEK2 |
| KEGG FATTY ACID METABOLISM | ACSL3, ACAT1, ALDH9A1, ACAT2, ACADM, ACAA2, ACADSB, HADH |
| HORIUCHI WTAP TARGETS DN | BUB1B, ATP2C1, LMNB1, SEPHS1, PAICS, MAD2L1, DLAT, TMPO, PLP2, CCNB1, CENPA, CANX, SEPT10, CCNB2, TTK, MBNL1, ANKRD46, TPX2, ACAT2, KIF23, SLC25A5, EDEM1, GSR, FDFT1, H2AFV, MELK, KIF2C |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | MYCBP, TGFBR2, SEPHS1, ELOVL6, PEX11B, AK1, ICMT, CAV2, CDKN2C, VCL, ITGB3, IRS1, TRAM2, SLC5A6, ZNF22, OSTF1, LSM2, EBP, MDM1, TEX261, LMNB1, ZMYM3, UCP2, UBTF, MAPK14, MRPL40, B3GNT1, CTDSPL, PTDSS1, UBQLN2, ID1, HEXIM1, HADH, POLE2, ANAPC13, INHBB, ARF3, TARDBP, EHMT2, PON2, RABIF |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | ATP5C1, ASPH, MGST3, PPT1, PRPS2, MRPL40, B3GNT1, BLVRA, CCT2, PDGFA, SRP9, ACAT2, SLC25A5, ATP5J, UGP2, CCT5, IDH1, TCP1, COX7A2, OAT, NONO, PRDX3, DCTN6, EIF2B4, SNRPD2, PPP2R5C, GLG1, ATP5L |
| REACTOME ELECTRON TRANSPORT CHAIN | NDUFB3, NDUFA9, NDUFS4, COX4I1, UQCRH, ETFDH, COX7A2L, COX6C, UQCRC2, NDUFB5, SDHD, SDHC |
| NUYTTEN EZH2 TARGETS DN | ATP2C1, SET, ACADSB, TMPO, PRPS2, CCNB1, CENPA, GLT8D1, SYPL1, CANX, CENPF, DAZAP2, AUH, PPARG, LMNB1, CASP6, ITGA6, HSBP1, DDHD2, GNPAT, GALK2, TCF7L2, TTK, CCT2, FBXO21, CCNB2, TPX2, KIF23, CDC25C, FADS1, EDEM1, INHBB, H2AFV, TRAIP, KIF2C |
| MOOTHA VOXPHOS | ATP5I, ATP5C1, UQCRH, ATP5H, NDUFB5, SDHC, NDUFB3, ATP5O, NDUFA9, COX4I1, ATP5J, COX7A2, ATP5G3, COX7A2L, UQCRC2, COX6C, ATP5L |
| PAL PRMT5 TARGETS UP | SET, NNT, ARL2BP, CETN2, TMPO, STMN1, NCBP2, FKBP4, ANAPC5, ABCG2, PSIP1, TTK, CCNB2, CDC25C, KIF23, POLE2, SPCS2, PKD2, NONO, H2AFV, TARDBP, EHMT2, LSM2, ERH |
| SASAKI ADULT T CELL LEUKEMIA | ANXA6, CAV1, BUB1B, ATP2C1, MYCBP, CCNB2, PARP1, IDH1, CCNB1, SMARCA2, ATP5G3, ICMT, GALK2, KIF2C, LSM2 |
| REACTOME REGULATION OF APC ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE | BUB1B, PSMB5, MAD2L1, UBE2D1, CDC23, CCNB1, PSMD1, PSMA4, CDK2, PSMF1 |
| KEGG PARKINSONS DISEASE | NDUFB3, ATP5O, ATP5C1, VDAC1, ATP5J, COX7A2L, ATP5G3, COX6C |
| BLUM RESPONSE TO SALIRASIB DN | HDAC1, MYCBP, TMPO, GALNT1, STMN1, CENPA, CENPF, MSH2, CBFB, CDKN2C, IRS1, EBP, BUB1B, FZD2, MAPRE2, B3GNT1, PLS3, TTK, CCNB2, PIAS3, SRP9, MSH6, ID1, TPX2, PARP1, CDC25C, KIF23, POLE2, PRDX3, ATP5G3, H2AFV, GPSM2, ACLY, KIF2C |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | BUB1B, CCNB2, TTK, LMNB1, MAD2L1, TPX2, CCT5, CCNB1, CENPA, STMN1, H2AFV, MELK, CDK2, KIF2C |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | DYNLT3, TMPO, PRPS2, CCNB1, STMN1, CENPA, GNPAT, ALDH9A1, MAPRE1, CENPF, CCNB2, INSIG1, MSH2, TOM1L1, CDKN2C, KIF23, H2AFV, MELK, ANXA4, COPB2, KIF2C, EBP |
| REACTOME CELL CYCLE MITOTIC | |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP | |
| SCIAN CELL CYCLE TARGETS OF TP53 AND TP73 DN | |
| BHATTACHARYA EMBRYONIC STEM CELL | |
| RHODES UNDIFFERENTIATED CANCER | MELK, GAS6, KIF23, KIF2C, CCNB1, CENPA |
| ALONSO METASTASIS UP | |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| LEE EARLY T LYMPHOCYTE UP | BUB1B, CCNB2, TTK, MELK, KIF2C, CCNB1, CENPA |
| NCI AURORA B PATHWAY | |
| NCI PHOSPHORYLATION OF THE APC C | |
| ODONNELL TARGETS OF MYC AND TFRC DN | |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | |
| NCI PLK1 PATHWAY | |
| ZHAN MULTIPLE MYELOMA PR UP | |
| SANA RESPONSE TO IFNG DN | |
| REACTOME PEROXISOMAL LIPID METABOLISM | |
| CORUM F1F0-ATP SYNTHASE EC 3.6.3.14 MITOCHONDRIAL | ATP5O, ATP5I, ATP5C1, ATP5J, ATP5L |
| NCI APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | |
| LI WILMS TUMOR VS FETAL KIDNEY 1 UP | |
| NCI APC C CDC20 MEDIATED DEGRADATION OF SECURIN | |
| WONG MITOCHONDRIA GENE MODULE | |
| MARKEY RB1 ACUTE LOF DN | |
| CORUM CTBP CORE COMPLEX | |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | |
| CORUM PA28-20S PROTEASOME | |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | |
| CROONQUIST NRAS SIGNALING DN | |
| REACTOME CHOLESTEROL BIOSYNTHESIS | |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | ATP5O, ATP5I, ATP5C1, ATP5J, ATP5L |
| CORUM BRM-SIN3A COMPLEX | |
| BIOCARTA SALMONELLA PATHWAY | |
| NCI RNA POLYMERASE I PROMOTER OPENING | |
| PUIFFE INVASION INHIBITED BY ASCITES UP | |
| REACTOME INACTIVATION OF APC VIA DIRECT INHIBITION OF THE APCOMPLEX | |
| JEON SMAD6 TARGETS DN | |
| REACTOME APCDC20 MEDIATED DEGRADATION OF CYCLIN B | |
| SCIBETTA KDM5B TARGETS DN | |
| NCI REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE | |
| REACTOME TRANSFORMATION OF LANOSTEROL TO CHOLESTEROL | |
| APPIERTO RESPONSE TO FENRETINIDE DN | |
| VANTVEER BREAST CANCER ESR1 UP | |
| GOLDRATH ANTIGEN RESPONSE | |
| NCI AUTODEGRADATION OF CDH1 BY CDH1 APC C | |
| NCI TRANSFORMATION OF LANOSTEROL TO CHOLESTEROL | |
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | |
| KEGG PEROXISOME | |
| REACTOME CDC20 PHOSPHO APC MEDIATED DEGRADATION OF CYCLIN A | |
| FERRANDO T ALL WITH MLL ENL FUSION DN | |
| BENPORATH CYCLING GENES | |
| MORI IMMATURE B LYMPHOCYTE DN | CKAP5, TTK, H2AFV, LMNB1, CDKN2C, CCNB1, CENPA |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | |
| STEIN ESRRA TARGETS DN | |
| KAPOSI LIVER CANCER POOR SURVIVAL UP | |
| BIOCARTA ACTINY PATHWAY | |
| LEE LIVER CANCER SURVIVAL DN | |
| KEGG OOCYTE MEIOSIS | |
| KAYO AGING MUSCLE DN | |
| NCI APC CDC20 MEDIATED DEGRADATION OF NEK2A | |
| MUELLER PLURINET | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| BIOCARTA CDC42RAC PATHWAY | ARPC1A, ARPC5, ACTR2 |
| NCI CDC20 PHOSPHO APC C MEDIATED DEGRADATION OF CYCLIN A | |
| CORUM BRM-SIN3A-HDAC COMPLEX | |
| FINETTI BREAST CANCER BASAL VS LUMINAL | |
| KAAB FAILED HEART ATRIUM DN | |
| NCI CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | |
| LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE UP | |
| YU MYC TARGETS UP | |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | |
| CROONQUIST IL6 DEPRIVATION DN | BUB1B, CCNB2, SEPHS1, MAD2L1, TPX2, POLE2, CCNB1, CENPA, FOXM1, KIF2C |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | BUB1B, TTK, CCNB2, LMNB1, MMD, KIF23, PLP2, CCNB1, WASF1, GPD1L, KIF2C |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| FINETTI BREAST CANCER KINOME RED | |
| CHANG CYCLING GENES | CCNB2, MELK, LMNB1, ILF2, CDC25C, KIF23, CENPA |
| ROSTY CERVICAL CANCER PROLIFERATION CLUSTER | BUB1B, CCNB2, TTK, LMNB1, MAD2L1, TPX2, TMPO, KIF23, CCNB1, CENPA, MELK, KIF2C, ANP32E, CENPF, EBP |
| NCI APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | |
| NCI INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX | |
| NUYTTEN NIPP1 TARGETS DN | |
| FARMER BREAST CANCER CLUSTER 2 | |
| OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP | |
| CORUM YWHAQ-CALM1-CABIN1 COMPLEX | |
| NCI FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | |
| KEGG PROGESTERONE MEDIATED OOCYTE MATURATION | |
| REACTOME PHOSPHORYLATION OF THE APC | |
| BENPORATH PROLIFERATION | |