| Gene Set | Leading Edge Genes |
|---|
| MOOTHA MITOCHONDRIA | MYCBP, ACADL, NDUFA3, ACADSB, MRPL49, MRPL20, ATP5O, FIBP, FECH, MUT, ECHS1, CPT1A, SLC25A10, NDUFV2, SLC25A3, CAD, MRPL41, DLAT, PYGB, FARS2, IMMT, GLUD1, APAF1, CYB5A, ACAT1, PECI, HADH, ANXA7, NDUFA4, BCKDK, ACADS, PRDX3, SLC25A13, MKRN2, IDH2, MRPS35, PCK2, NNT, ATP5I, UQCR, ATP5G2, UQCRH, GNAS, MRPS33, PTPRA, CROT, TST, UQCRFS1, IVD, SLC25A4, MBD3, TUFM, ATP5J2, BCAT2, ATP5J, MTCH1, BAK1, BCKDHA, MRPL46, SLC25A15, ATP5C1, SARDH, OXA1L, TOMM22, ACAA2, ACADM, MRPS15, SLC25A1, SLC9A6, NFKBIL2, SLC25A17, ALDH2, SLC25A5, SUCLG1, OAT, CS, SLC25A23, ERBB2, MRPS14, ENDOG, MPST |
| BERENJENO TRANSFORMED BY RHOA DN | SHC1, ITM2C, SEC23A, GSTA4, NAB2, PLCD1, LRBA, NRBP2, MGST3, HSPA2, CASK, DAP, SPNB2, FZD1, FIBP, MXD4, CPT1A, WDR6, MAN2A1, PKD2, KAZALD1, APOA1BP, VKORC1, MOSC2, NUCB2, PYGB, ZFP637, RABAC1, LMO7, ANXA6, PTOV1, LIMA1, IDH1, RNASE4, RCN1, TM7SF3, VPS28, DHCR7, HCFC1R1, YPEL3, TBL1XR1, TTC3, COL4A5, S100A13, TSPYL4, SEC31A, AIM1, GSN, AES, GAMT, TCEA3, GAS6, ANXA4, MAGED1, LXN, F2R, CTDSP2, CAV1, ALDH1A1, SARDH, FKBP10, SMARCA2, RAB11A, GALK2, ACADM, GSTM5, COL6A1, PIAS3, SSPN, HES6, SLC25A17, PCOLCE, RRAS, RAB3D, FKBP7, CORO1B, THRA, GNAI2, ECH1, 1110003E01RIK, LAPTM4A |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | DYNLT3, EMP1, NPDC1, BACE1, PRDX4, IDS, ATOX1, IQGAP1, ARPC5, FZD1, WIPI1, CST3, NTAN1, UGDH, MAN2A1, PITPNA, CREB3L2, TMOD3, VAMP3, CD81, CAPG, CD151, CLIC1, TMEM50A, CTTN, VKORC1, LEPROT, PAPSS1, SEC24D, FZD2, PARVA, NUCB2, CNN2, RABAC1, PRKCA, TMEM43, TXNDC5, LRP1, SFXN3, LIMA1, ARPC3, IDH1, TLN1, ANXA7, TUSC3, SH3BGRL3, ELK3, SEMA3C, TGFBR2, SEC61B, PTRF, PRPS2, S100A13, GALNT1, WDR45, PEA15, EPHX1, ADAM10, GSN, S100A6, NQO1, CDR2, EFEMP2, TRAM2, GAS6, DAB2, PDLIM2, LXN, EBP, NUCB1, CAV1, DOK1, FKBP14, CMTM6, PLSCR3, CCND1, FXYD5, ACTR2, CAST, SLC25A1, LBH, PCOLCE, ERP29, MBNL1, RRAS, CORO1B, GNAI2, SKAP2, ELOVL5 |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | SET, EMP1, CETN2, PFKM, HSP90AB1, MLF1IP, PRDX4, PRPS2, MRPS33, SPARC, ADSL, CANX, HMGB3, SH3BGRL, TBCA, MDH1, APEX1, PDIA6, TUBB, CPNE3, UGP2, ATP5J, WASF1, MELK, FHL1, ISOC1, MAGED1, RAB13, DPYSL2, LXN, ZFAND1, MPP1, RSU1, RTN3, LTA4H, GPR125, PAICS, CD9, NUCB2, CCNG1, CYFIP1, ACADM, ACAA2, CYB5A, PSIP1, CCNB2, GMNN, ACAT1, TTK, RACGAP1, PIGP, PECI, ALDH6A1, HADH, PXDN, POLE2, CACYBP, PRDX3, RPL31, SNRPD2, IDH2, MRPS35 |
| PAL PRMT5 TARGETS UP | KIF20A, PROS1, SET, NNT, HN1, PRKCDBP, CALM3, CETN2, TMPO, STMN1, 1110002B05RIK, DOCK7, FKBP4, NCBP2, IVD, MRPL20, APEX1, LEPREL2, ECHS1, CPT1A, GUSB, PKD2, TUBB2A, LSM2, CAPG, ARL2BP, H2AFX, TSEN34, ABCG2, PSIP1, CCNB2, TTK, RACGAP1, GMNN, CTPS2, PTOV1, PSMD6, CDC25C, KIF23, POLE2, NONO, H2AFV, TARDBP, TACC3, ECH1, EHMT2, NDE1, ERH |
| KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION | ACAT1, AUH, ACAT2, ACADSB, HADH, BCAT2, MUT, MCCC2, ACADS, BCKDHA, ACAA2, IVD, ACADM |
| KEGG GLUTATHIONE METABOLISM | GSTA4, MGST1, GSTM1, MGST3, IDH1, LAP3, IDH2, GSTM5, GSTM2 |
| KEGG PROPANOATE METABOLISM | ACAT1, HIBCH, ACAT2, ACADM, MUT, ECHS1, ALDH6A1, ALDH2, SUCLG1 |
| JI RESPONSE TO FSH UP | FCGRT, CTTN, PPL, FADS1, BRD3, RBP1, PIR, NT5C2, FADS2, CTNNB1, IDI1, FASN, EBP |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | SSNA1, 2010107E04RIK, UQCR, NDUFA3, AU022870, MRPS33, UBL5, MTMR9, NCBP2, PIGX, LY6A, DAP, DBI, S100A6, ATP5O, HDDC2, FIBP, ATP5J, GUK1, 1810046J19RIK, PPIB, PPP2R5C, EBP, 2410015M20RIK, CCND1, LGALS1, PRDX2, GSTM5, DGCR6, TSEN34, ILVBL, PAFAH1B3, CHMP2A, COX6A1, 1810063B05RIK, CD320, ECH1, SNRPD2, 0610007P14RIK |
| BIOCARTA CREB PATHWAY | AKT1, MAPK3, PRKCA, RAC1, HRAS, GNAS, MAPK14 |
| BIOCARTA TFF PATHWAY | AKT1, BAD, SHC1, MAPK3, PIK3CA, HRAS, CTNNB1, APAF1 |
| SMITH TERT TARGETS DN | TUBB3, CCNG1, RAB11A, TST, GSN, NSDHL, AKT1, GAMT, TRADD, UGP2, DHCR24, GM2A, FAH, IDI1, PON2, UNC119 |
| KEGG PATHOGENIC ESCHERICHIA COLI INFECTION | ARPC5, ARPC4, CTTN, TUBB, NCK2, ARPC3, TUBB2B, TUBB3, ARPC1A, TUBB2C, PRKCA, CTNNB1, TUBB2A, TUBB6, ROCK2 |
| REACTOME CHOLESTEROL BIOSYNTHESIS | FDFT1, IDI1, HMGCS1, DHCR7, EBP, DHCR24, NSDHL |
| BIOCARTA MPR PATHWAY | ARPC5, ARPC4, CDC25C, ARPC3, CCNB1, PAQR7, ARPC1A, MAPK3, HRAS, ACTR2 |
| CHEN HOXA5 TARGETS 9HR DN | SLC29A1, GEMIN4, FZD2, UBTF, GM2A, G6PC3, DDT, H2AFX, CKAP4, HMGB3, KDELR1, GLG1, PPAP2C |
| MORI PLASMA CELL UP | BPGM, SPCS3, TMED2, LMAN1, MGAT2, RPN1, GMPPB, CRELD2, BET1, EBP |
| BIOCARTA CDC42RAC PATHWAY | ARPC1A, ARPC5, RAC1, ARPC4, ACTR2, ARPC3 |
| KEGG CITRATE CYCLE TCA CYCLE | |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | |
| KEGG FATTY ACID METABOLISM | |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | |
| BIOCARTA RHO PATHWAY | |
| HUANG DASATINIB RESISTANCE DN | |
| SHEPARD BMYB TARGETS | |
| BOYAULT LIVER CANCER SUBCLASS G3 DN | |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | |
| SENESE HDAC1 TARGETS DN | |
| BIOCARTA TRKA PATHWAY | |
| WOO LIVER CANCER RECURRENCE DN | |
| CHAUHAN RESPONSE TO METHOXYESTRADIOL DN | |
| KEGG BUTANOATE METABOLISM | |
| CORUM GCN5-TRRAP HISTONE ACETYLTRANSFERASE COMPLEX | |
| REACTOME INSULIN SYNTHESIS AND SECRETION | |
| BIOCARTA LONGEVITY PATHWAY | |
| CORUM BRM-SIN3A COMPLEX | |
| RAGHAVACHARI PLATELET SPECIFIC GENES | |
| LUI THYROID CANCER CLUSTER 5 | |
| BIOCARTA BAD PATHWAY | |
| OUELLET OVARIAN CANCER INVASIVE VS LMP DN | |
| REACTOME TRANSFORMATION OF LANOSTEROL TO CHOLESTEROL | |
| REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | |
| REACTOME GLUTATHIONE CONJUGATION | |
| NCI BETA OXIDATION OF DECANOYL COA TO OCTANOYL COA COA | |
| SENESE HDAC1 AND HDAC2 TARGETS DN | |
| NCI TRANSFORMATION OF LANOSTEROL TO CHOLESTEROL | |
| REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | |
| NCI CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 | |
| CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN | |
| OHASHI AURKB TARGETS | |
| NCI NCADHERINPATHWAY | |
| GRABARCZYK BCL11B TARGETS UP | |
| STEIN ESRRA TARGETS DN | |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | |
| LEE LIVER CANCER SURVIVAL DN | |
| NCI BETA OXIDATION OF OCTANOYL COA TO HEXANOYL COA | |
| BIOCARTA MCALPAIN PATHWAY | |
| PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN | |
| PYEON HPV POSITIVE TUMORS DN | |
| MOOTHA FFA OXYDATION | |
| SENESE HDAC2 TARGETS DN | |
| NCI BETA OXIDATION OF HEXANOYL COA TO BUTANOYL COA | |
| SIG CHEMOTAXIS | |
| NCI MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS | |
| BOYLAN MULTIPLE MYELOMA D CLUSTER DN | |
| BIOCARTA NOS1 PATHWAY | |
| REACTOME RNA POLYMERASE I PROMOTER OPENING | |
| CHANG CYCLING GENES | GMNN, CCNB2, LMNB1, ILF2, KIF23, CDC25C, TSN, CCNF, CENPA, ASF1B, MELK, TACC3, MBOAT1 |
| BOYLAN MULTIPLE MYELOMA PCA3 DN | |
| OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP | |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | |
| REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | |
| REACTOME PHASE II CONJUGATION | |
| BIOCARTA ECM PATHWAY | |