| Gene Set | Leading Edge Genes |
|---|
| MOOTHA HUMAN MITODB 6 2002 | NDUFA3, MRPS18A, MRPL49, MRPL12, NDUFA1, CYC1, NDUFS8, NDUFA8, ATP5O, NDUFS6, FIBP, ALDH4A1, ECHS1, CPT1A, PDHA1, NDUFS2, TK1, SLC25A10, IDH3B, DECR1, NDUFC1, TIMM8B, NDUFS5, SLC25A3, ATPIF1, MTHFD1, MRPS16, VDAC3, MRPS11, COX4NB, FPGS, MRPS28, DCI, DGUOK, CYB5A, MRPL18, ETFB, PCCB, NDUFS4, HADHA, NDUFA4, NDUFB6, BCKDK, COX8A, COX7C, IDH2, MRPS35, MRPL48, PCK2, UQCR, MRPL2, MRPS34, TK2, ATP5G2, UQCRH, NDUFB8, MRPL17, SDHA, MRPS33, PTPRA, BDH1, VDAC2, TST, UQCRFS1, NDUFS1, NGFRAP1, UQCRC1, ATP5G1, MBD3, TUFM, ATP5J2, MRP63, ATP5E, CYB5R3, MTCH1, NDUFB2, COX6C, NDUFS3, MFN2, ABAT, PDHB, IDH3G, NDUFA2, NDUFB3, PYCR1, COX4I1, SUCLG1, COX6A1, CS, ATP5G3, GCAT, MRPS14, ENDOG, ATP5L |
| MOOTHA MITOCHONDRIA | NDUFA3, MRPS18A, MRPL49, MRPL12, NDUFA1, HSPE1, NDUFA8, ATP5O, NDUFS6, FIBP, ALDH4A1, ECHS1, CPT1A, PDHA1, NDUFS2, SLC25A10, IDH3B, DECR1, NDUFC1, TIMM8B, NDUFS5, SLC25A3, CAD, ATPIF1, MRPS16, PYGB, VDAC3, MRPS11, COX4NB, FPGS, MRPS28, DCI, DGUOK, CYB5A, MRPL18, ETFB, PCCB, NDUFS4, HADHA, NDUFA4, NDUFB6, BCKDK, COX8A, COX7C, SLC25A12, IDH2, MRPS35, PCK2, UQCR, MRPL2, MRPS34, TK2, ATP5G2, UQCRH, NDUFB8, MRPL17, SDHA, MRPS33, APP, CROT, PTPRA, BDH1, VDAC2, TST, UQCRFS1, NDUFS1, NGFRAP1, UQCRC1, ATP5G1, MBD3, TUFM, ATP5J2, MRP63, ATP5E, CYB5R3, MTCH1, NDUFB2, COX6C, NDUFS3, MFN2, ABAT, HTRA2, MRPL35, NDUFB3, PYCR1, COX4I1, SUCLG1, COX6A1, CS, ATP5G3, MRPS14, ENDOG, ATP5L |
| WONG MITOCHONDRIA GENE MODULE | PCK2, MRPS18A, NDUFA3, ATP5G2, ATOX1, MRPS33, MCCC2, VDAC2, MRPL49, MRPL12, NDUFA1, UQCRFS1, NDUFA8, NDUFA6, ATP5O, NDUFS6, FIBP, ATP5G1, ATP5J2, TUFM, ECHS1, CPT1A, NQO1, PDHA1, ATP5E, NDUFS2, COX6C, NDUFB2, NDUFS3, SURF1, DECR1, NDUFC1, TIMM8B, NDUFS5, VDAC3, MRPS16, MRPL40, DBT, MRPS28, DCI, CYB5A, MRPL18, NDUFB3, GSTZ1, PCCB, NDUFS4, COX4I1, SUCLG1, ATP1B1, ATP1B3, NDUFB6, NDUFA4, ATP5G3, COX8A, GCAT, IDH2, ATP5L |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | PEX6, PIN1, SNAP29, NDUFA3, ACY1, YBX1, CSNK1G2, MRPL23, VAMP2, NDUFA1, WWP2, NDUFS8, BLOC1S1, DBI, PSMB5, NDUFS6, APRT, GMPS, CST3, FDPS, NDUFB11, NDUFS5, CTTN, ATPIF1, VDAC3, NENF, NARF, S100A11, FKBP2, ARPC4, CDC20, NUDT1, SMARCD2, RALY, PHKA2, NUBP2, TACC3, PCK2, ATP5G2, VASP, POLR2I, NDUFB8, AHCY, UBL5, ICMT, TOP2A, CENPF, UQCRC1, LDB1, RPS27L, CD2BP2, CDK2AP2, MBD3, DPAGT1, UBE2C, ATP5J2, CYB5R3, LSM4, B4GALT1, ARHGAP1, CCHCR1, COX6C, GOLGA2, HMBS, EBP, CD97, CDK5, MAP2K2, H2AFX, NDUFA2, PGLS, PRDX2, TADA3L, MEA1, FBN1, COX4I1, SNRPD1, ETV5, COX6A1, ATP5G3, H2AFV, POLE, KCNK1 |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | TXNDC14, RAD23A, MRPS18A, MGST3, ATOX1, DYNLRB1, RPL18, HSPE1, BRP44, NDUFS8, CYC1, NDUFA8, AHSA1, MCTS1, NDUFS6, DDX1, NTAN1, GUK1, FDPS, CREB3, NUP88, COPS3, LRPAP1, GLG1, TIMM8B, PDCD6, ATPIF1, VDAC3, PSMB6, KPNA1, MRPS11, NENF, MRPL40, ASNA1, MRPS28, TMEM147, SAC3D1, FKBP2, PDE6D, RPL36AL, NDUFS4, ACAT2, CCT5, IDH1, SMYD2, STAU1, TPD52L1, UQCR, TUSC4, SEC61B, MRPL17, VDAC2, TST, UQCRFS1, NDUFS1, DNAJC15, S100A6, ATP5J2, SSR4, MRP63, ATP5E, NDUFB2, NDUFS3, GOLGA2, CDK5, PFDN5, NAGK, IDH3G, B3GNT1, GRLF1, PRDX2, MEA1, CBR1, TUBG1, DGCR2, SNRPD2, CCDC56, SPSB3, ATP5L, PSMB4, UFD1L |
| KEGG HUNTINGTONS DISEASE | SLC25A31, NDUFA3, HIP1, NDUFB8, POLR2I, UQCRH, SDHA, NDUFA1, AP2A2, NDUFS1, NDUFA7, UQCRFS1, NDUFS8, CYC1, AP2S1, NDUFA8, UQCRC1, ATP5O, NDUFS6, ATP5E, NDUFS2, CREB3L2, CREB3, NDUFB2, NDUFS3, NDUFC1, NDUFS5, POLR2L, NDUFA2, NDUFB3, AP2B1, NDUFS4, COX4I1, COX6A1, NDUFB6, NDUFA4, ATP5G3, COX8A, DCTN2, ITPR1, COX7C, DCTN1 |
| KEGG ALZHEIMERS DISEASE | NDUFA3, NDUFB8, UQCRH, SDHA, APP, NDUFA1, NDUFS1, UQCRFS1, NDUFS8, NDUFA8, UQCRC1, ATP5O, NDUFS6, ATP5E, PSEN2, NDUFS2, NDUFB2, NDUFS3, NDUFC1, NDUFS5, CDK5, NDUFB3, ITPR3, NDUFS4, PPP3CB, COX4I1, NDUFA4, NDUFB6, COX6A1, ATP5G3, COX8A, COX7C, ITPR1 |
| TIEN INTESTINE PROBIOTICS 24HR UP | ESPL1, MGST3, POLDIP2, ATOX1, FARP1, HSPE1, UBAP2L, LMAN2L, HSPA14, NUP85, NDUFA8, DBI, AHSA1, NTAN1, ECHS1, PLXNA1, SYNGR2, FDPS, MCM6, LRPAP1, GM2A, TK1, VAMP3, LMNB2, NDUFC1, TIMM8B, DYNLT1, TPCN1, POLR2L, MYH10, PSMB7, MRPS28, SAC3D1, ACAT2, NUDT1, SMYD2, TBL1X, NDUFB6, DNAJC9, NUP93, UBL5, TAGLN2, NUDC, FKBP4, ADSL, SHCBP1, ICMT, CENPF, GLRX5, DNAJC15, ERCC3, ATP5J2, UROD, SPAST, THYN1, LSM4, DPP3, NDUFB2, SAMM50, NUP205, EBP, PXMP2, PDHB, FOXM1, RPA3, PRDX2, NDUFB3, CKLF, NSF, TUBG1, MSH6, SNRPD1, POLE2, ATP5G3, DGCR2, H2AFV, PRC1, TRAPPC4, CCDC56, QDPR, ATP5L |
| HSIAO HOUSEKEEPING GENES | SET, RPS3A, YBX1, ATOX1, RPN2, RPL18, RPS9, IQGAP1, HMGN2, ATP5O, PSMB5, CST3, ECHS1, GUSB, SSR2, HSPB1, CIRBP, CD81, COPA, NDUFV2, SLC25A3, CLIC1, IRAK1, PDLIM1, POLR2L, PSMB6, PSMC1, RPL36AL, NDUFA4, COX8A, DCTN2, CSNK2B, COX7C, RPL7, CAP1, TRAF4, SEC61B, EEF1B2, ATP5G2, UQCRH, GNAS, PLP2, TAGLN2, ANXA11, VDAC2, COMT, FKBP4, ABLIM1, APEX1, MDH1, ATP5G1, UBE2C, GDI2, NCOR2, CYB5R3, COX6C, ARHGAP1, CTDSP2, PFDN5, GNB1, LTA4H, TMED10, PSMB2, PTDSS1, COX4I1, PSMD8, COX6A1, MGP, ATP5G3, RPL31, SNRPD2, PSMB4 |
| REACTOME CELL CYCLE MITOTIC | POLD4, KIF20A, CDC16, CEP110, TK2, PLK1, ORC3L, CDK4, PSMB1, NUDC, CDC25B, PSMD4, CENPF, NUP85, PSMB5, MCM3, PPP2R5A, UBE2C, CDC6, ANAPC1, MCM6, LIG1, KNTC1, TUBGCP2, GORASP1, CCNE1, PPP2R5D, POLA2, CDK5RAP2, DCTN3, PSMB6, SMC1A, E2F1, PSMC1, PSMB7, PRKACA, PSMD9, RPA3, ANAPC2, SMC3, PSMA7, CENPJ, PSMB2, CCNB2, GMNN, TUBG1, CDC20, CDC25C, POLE2, PSMD8, POLE, DCTN2, ODF2, FZR1, KIF2C, BIRC5, PSMB4 |
| WONG EMBRYONIC STEM CELL CORE | SET, HN1, UQCRH, NDUFB8, CDK4, MRPL12, PRPS1, ADSL, HSPE1, TOP2A, HSPA14, MID1IP1, ATP5O, PSMB5, MCM3, CDC6, ECHS1, EBNA1BP2, CDC34, PDHA1, FDPS, NDUFS2, PDIA4, AMOTL2, LSM4, DPP3, TIMM8B, PSMB6, COX4NB, RPA3, PPM1G, MRPS28, PSMA7, RPS19, KIF4A, CCNB2, CDC20, ERP29, SNRPD1, POLE2, CCT5, GLO1, NT5DC2, BIRC5 |
| MISSIAGLIA REGULATED BY METHYLATION DN | ESPL1, CAD, FOXM1, ITGB4, MSH6, GMPS, ACAT2, UBE2C, CDC25C, LIG1, RNASEH2A, TK1, PRC1, NDUFS3, FASN, KNTC1, EBP |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | UQCR, MRPS18A, NDUFA3, NDUFB8, TMED3, MRPL23, MRPS33, UBL5, DYNLRB1, TAGLN2, DAP, DBI, DNAJC15, S100A6, ATP5O, HDDC2, FIBP, SF3B5, GUK1, ATP5E, NDUFS2, EBP, TIMM8B, NDUFC1, MRPL35, PRDX2, TSEN34, PAFAH1B3, CHMP2A, COX6A1, SNRPD2, CCDC56 |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | ANXA5, CLPB, PLK1, ITGA3, MRPL17, C16ORF61, GLT25D1, FKBP4, PRPS1, PREB, SCD, NUP85, CDCA3, AKT1, MCM3, EXOSC8, CDC6, MCM6, TIPIN, PRMT5, RNASEH2A, NUP205, HMBS, ASPM, IRAK1, CAD, GNB1, MTHFD1, CDC45L, FOXM1, RPA3, TXNDC5, KIF4A, PSMB2, TUBG1, MSH6, RAP1GDS1, DNAJC9, ARHGDIA, H2AFV, PRC1, CAP1, NT5DC2, KIF2C, BIRC5 |
| NCI REMOVAL OF LICENSING FACTORS FROM ORIGINS | PSMD7, ORC3L, PSMA2, PSMB6, PSMB1, PSMC1, PSMB7, PSMD9, PSMA7, PSMB2, PSMB5, MCM3, GMNN, CDC6, PSMD8, MCM6, PSMB4 |
| NCI ORC1 REMOVAL FROM CHROMATIN | PSMB2, PSMB5, MCM3, PSMD7, CDC6, ORC3L, PSMA2, PSMB6, PSMD8, PSMB1, MCM6, PSMC1, PSMB7, PSMD9, PSMA7, PSMB4 |
| KANG DOXORUBICIN RESISTANCE UP | CDKN3, PLK1, CENPA, FOXM1, RRM1, ASF1B, HMMR, TOP2A, MCM4, KIF4A, CDC20, TPX2, CDC6, NQO1, TK1, PRC1, ASPM, BIRC5 |
| CORUM 20S PROTEASOME | PSMB2, PSMB5, PSMB7, PSMA7, PSMB6, PSMB4, PSMB1 |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP | CCNE1, ESPL1, PDLIM1, CDC45L, H2AFX, TST, RPA3, MRPS28, TOP2A, PRDX2, NUP85, HSPA14, SAC3D1, KIF4A, CCNB2, CDC20, MICAL2, NUDT1, SNRPD1, UBE2C, CDC6, POLE2, ATP5G3, RNASEH2A, TK1, PRC1, SAMM50, NT5DC2, KIF2C, ASPM, BIRC5 |
| WHITEFORD PEDIATRIC CANCER MARKERS | ESPL1, HN1, CDK4, H2AFX, TOP2A, CENPF, TWIST1, CCNB2, PAFAH1B3, TPX2, NUDT1, UBE2C, POLE2, TK1, RNASEH2A, PRC1, MFN2, LMNB2, BIRC5 |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | ESPL1, ORMDL2, HN1, CDC45L, FOXM1, C16ORF61, MRPL12, TOP2A, PSMA7, KIF4A, CCNB2, CDC20, GMPS, TPX2, NUDT1, UBE2C, PFDN6, CCT5, MCM6, NUP93, DNAJC9, H2AFV, RNASEH2A, PRC1, TACC3, KIF2C, ASPM, BIRC5 |
| REACTOME G2 M TRANSITION | CCNB2, TUBG1, CEP110, CDC25C, PLK1, DCTN3, AZI1, CDC25B, DCTN2, PRKACA, ODF2, NDE1, DYNLL1, TUBGCP2, CENPJ |
| CROONQUIST NRAS SIGNALING DN | CCNB2, MCM3, MYBL2, CDC20, TPX2, CDC25C, CDC6, UBE2C, PLK1, CSE1L, FOXM1, TK1, H2AFX, TOP2A, KIF2C |
| CHEN HOXA5 TARGETS 9HR DN | MYL9, FZD2, SYNGR2, AP1S1, GM2A, G6PC3, H2AFX, CCDC56, KDELR1, GLG1 |
| ROSTY CERVICAL CANCER PROLIFERATION CLUSTER | KIF20A, ESPL1, HN1, PLK1, E2F1, FOXM1, H2AFX, SHCBP1, RPA3, TOP2A, CENPF, CDCA3, SAC3D1, KIF4A, CCNB2, GMNN, PAFAH1B3, CDC20, TPX2, UBE2C, CDC6, LSM4, TK1, PRC1, DPP3, TACC3, KIF2C, EBP, ASPM, BIRC5 |
| AMUNDSON GAMMA RADIATION RESPONSE | ESPL1, CCNB2, KIFC1, CDC25C, UBE2C, PLK1, CENPA, CDC25B, TACC3, H2AFX |
| LOPEZ MESOTELIOMA SURVIVAL TIME UP | |
| GRADE COLON CANCER UP | |
| NCI MITOCHONDRIAL FATTY ACID BETA OXIDATION OF UNSATURATED FATTY ACIDS | |
| MONTERO THYROID CANCER POOR SURVIVAL UP | CCNB2, PRC1, UBE2C, ASPM, BIRC5, CENPA |
| MITSIADES RESPONSE TO APLIDIN DN | |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | |
| CHUNG BLISTER CYTOTOXICITY UP | |
| ODONNELL TARGETS OF MYC AND TFRC DN | |
| GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN | |
| REACTOME NUCLEOTIDE EXCISION REPAIR | |
| CORUM F1F0-ATP SYNTHASE EC 3.6.3.14 MITOCHONDRIAL | ATP5O, ATP5A1, ATP5I, ATP5C1, ATPIF1, ATP5G1, ATP5J2, ATP5J, ATP5E, ATP5H, ATP5B, ATP5L |
| ODONNELL TFRC TARGETS DN | |
| FRASOR RESPONSE TO SERM OR FULVESTRANT DN | |
| BASAKI YBX1 TARGETS UP | |
| REACTOME GLUCOSE REGULATION OF INSULIN SECRETION | |
| CORUM PA28-20S PROTEASOME | |
| KEGG DNA REPLICATION | |
| REACTOME TRANSCRIPTION COUPLED NER | |
| MULLIGHAN MLL SIGNATURE 2 UP | |
| CORUM RESPIRATORY CHAIN COMPLEX I GAMMA SUBUNIT MITOCHONDRIAL | |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | ATP5O, ATP5A1, ATP5I, ATP5C1, ATP5G1, ATP5J2, ATP5J, ATP5E, ATP5H, ATP5B, ATP5L |
| KEGG BUTANOATE METABOLISM | |
| NUTT GBM VS AO GLIOMA DN | |
| REACTOME INSULIN SYNTHESIS AND SECRETION | |
| CORUM PA28GAMMA-20S PROTEASOME | |
| BIOCARTA LONGEVITY PATHWAY | |
| CAIRO HEPATOBLASTOMA CLASSES UP | |
| PENG LEUCINE DEPRIVATION DN | |
| REACTOME DNA REPAIR | |
| WELCSH BRCA1 TARGETS 1 DN | |
| ZHANG RESPONSE TO CANTHARIDIN DN | |
| TANG SENESCENCE TP53 TARGETS DN | |
| REACTOME SYNTHESIS OF DNA | |
| KAUFFMANN DNA REPAIR GENES | |
| TAKAO RESPONSE TO UVB RADIATION UP | |
| SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP | |
| NCI PLK3 PATHWAY | |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | |
| CORUM RESPIRATORY CHAIN COMPLEX I INCOMPLETE INTERMEDIATE MITOCHONDRIAL | |
| ZHAN V2 LATE DIFFERENTIATION GENES | |
| CORUM RESPIRATORY CHAIN COMPLEX I INTERMEDIATE VII/650KD MITOCHONDRIAL | |
| HONMA DOCETAXEL RESISTANCE | |
| MORI IMMATURE B LYMPHOCYTE DN | |
| KEGG PARKINSONS DISEASE | |
| PRAMOONJAGO SOX4 TARGETS DN | |
| HEDENFALK BREAST CANCER BRCA1 VS BRCA2 | |
| BIOCARTA CDK5 PATHWAY | |
| CORUM DYNACTIN COMPLEX DCTN1 DCTN2 DCTN3 DCTN4 DCTN6 CAPZA1 CAPZB ACTR1A | |
| CORUM RESPIRATORY CHAIN COMPLEX I BETA SUBUNIT MITOCHONDRIAL | |
| REACTOME INTEGRATION OF ENERGY METABOLISM | |
| REACTOME DIABETES PATHWAYS | |
| LUI THYROID CANCER CLUSTER 3 | |
| LOPEZ MESOTHELIOMA SURVIVAL WORST VS BEST UP | |
| POMEROY MEDULLOBLASTOMA PROGNOSIS DN | |
| REACTOME MRNA SPLICING MINOR PATHWAY | |
| REACTOME REGULATION OF INSULIN SECRETION | |
| MORI MATURE B LYMPHOCYTE DN | PAFAH1B3, NUDT1, CDC25C, PSMD8, PRPS1, IDH2, PGLS, KIF2C |
| CORUM RESPIRATORY CHAIN COMPLEX I LAMBDA SUBUNIT MITOCHONDRIAL | |
| SCHLOSSER MYC AND SERUM RESPONSE SYNERGY | |
| CROONQUIST IL6 DEPRIVATION DN | |
| CORUM KINASE MATURATION COMPLEX 1 | |
| CORUM 55S RIBOSOME MITOCHONDRIAL | MRPL2, MRPS18A, MRPS34, MRPS16, MRPL17, MRPL23, MRPL35, MRPS11, MRPS33, MRPL49, MRPL12, MRPL40, MRPS28, MRPS22, MRPL18, MRPS10, MRPS35, MRPS14, MRPL48 |
| REACTOME S PHASE | |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| KEGG BASE EXCISION REPAIR | |
| CHANG CYCLING GENES | FOXM1, GMNN, CCNB2, TACC3, CDC25C, UBE2C, ZNHIT2 |
| KEGG LYSINE DEGRADATION | |
| FONTAINE FOLLICULAR THYROID ADENOMA UP | |
| NCI FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | |
| NCI SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE | |
| NCI MRNA SPLICING MINOR PATHWAY | |
| MOOTHA PGC | |
| KEGG NUCLEOTIDE EXCISION REPAIR | |
| TIEN INTESTINE PROBIOTICS 6HR DN | |