| Gene Set | Leading Edge Genes |
|---|
| PUJANA CHEK2 PCC NETWORK | SYK, PCNA, POLA1, POLE3, KIAA0406, ABCE1, ILF2, BUB1, TAF11, NOLC1, TMPO, CCT3, DCP2, MRPL3, SLBP, RFC5, COX11, GINS1, ATP5O, MCM3, EXOSC8, ATP5S, C1D, GMPS, CDT1, CPT1A, MTERF, ABCB7, NUP88, SSRP1, SMARCA4, MELK, LMNB2, CPSF6, CTR9, CTCF, AGL, CAD, SKP2, SNRPD3, MPHOSPH6, UBE2G1, SUMO1, VRK1, KHSRP, UNG, PRKRA, GTF2A2, TAF4, MRE11A, EEF1E1, TUBGCP3, KIF2C, TCERG1, PRKRIR, C1QBP, ZWINT, DKC1, CCNB1, STMN1, AURKA, CDC2, ZNF131, NCBP2, ADSL, CPSF4, ORC5L, TOPBP1, CENPF, METAP2, TOE1, SMARCC1, RBBP8, CCT8, ZNF337, FRG1, POLR2H, DDX46, TINP1, CENPE, ZNF22, ZBTB33, KNTC1, LSM5, TIMELESS, CENPC1, PAICS, C12ORF24, SPAG5, FOXM1, ITGB3BP, ODC1, RFC4, TFAM, RPA3, OIP5, HMMR, CCNA2, PRKDC, ARD1A, TTF1, UCK2, NCBP1, DHX9 |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | PCNA, C1QBP, MLF1IP, ZWINT, PRPS2, STMN1, MRPS33, PTPLA, STOML2, CDC2, ADSL, NCAPG, COX11, TOP2A, EPRS, NEK4, GMPS, PPA1, CPNE3, RAD51, C21ORF45, LSM5, ZFAND1, TMEM97, LTA4H, PAICS, GPR125, MYH10, CAT, ITGB3BP, RRM1, RFC4, HMMR, PRKDC, DTL, RPP40, ACAT1, VRK1, UNG, HADH, NUP37, CEP57, POLE2, CACYBP, ALDH5A1, THOC7, ANP32A, IGFBP7, MYB, PRC1, RBMX, BIRC5 |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | KIF20A, CDKN3, PCNA, VANGL1, QSER1, NOLC1, BUB1, ZWINT, FGFR1OP, CCNB1, STMN1, AURKA, PBK, CDC2, CBX5, NCAPG, CENPF, CDCA3, FBXO5, GINS1, CDT1, CPT1A, NETO2, HIST1H2BJ, NEIL3, CENPE, KNTC1, CCNE1, CAD, TEAD4, TPRKB, PYGL, PAICS, CKAP2, C12ORF24, SPAG5, FOXM1, SRM, RFC4, OIP5, HMMR, PRKDC, CCNA2, COMMD8, R3HDM1, KIF4A, KIF18A, C12ORF11, DEPDC1, NUP37, CDC25C, NCAPG2, ACOT7, GPSM2, PRC1, TACC3, CDCA8 |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | CDKN3, PCNA, POLE3, BUB1, TMPO, DCP2, NCAPG, AASDHPPT, RFC5, CDCA3, FTSJ2, GINS1, MCM3, CDT1, MTERF, NUP88, PUS7, SSRP1, MELK, KIAA1704, NEIL3, TMEM97, HOOK1, DCLRE1B, C7ORF28A /// C7ORF28, BXDC2, KIF18A, HADH, GTF2A2, NSBP1, GPSM2, TACC3, TUBGCP3, PKP4, CASP8AP2, C1QBP, PRPS2, CCNB1, POGK, AURKA, CCDC99, NARS2, CLGN, CDC2, ORC5L, CENPF, METAP2, FBXO5, NEK4, WRB, NETO2, C1ORF109, KNTC1, TLK1, SH3GL3, TIMELESS, TPRKB, PHF20L1, FOXM1, ITGB3BP, THAP1, RFC4, HMMR, OIP5, PRKDC, COIL, TTF1, KIF4A, STEAP1, PRKD3, DEPDC1, CDC25C, CACYBP, NCAPG2, ANP32A, MYB, PRC1, CDCA8, KIAA1462 |
| WONG EMBRYONIC STEM CELL CORE | HDAC1, KIF20A, CDKN3, PCNA, HN1, BUB1, AURKA, STOML2, NCBP2, ADSL, CDCA3, HSPA14, ATP5O, MCM3, MRPL11, EBNA1BP2, ABCB7, KIF22, NIPSNAP1, RPS8, MRPL16, ZNF22, LSM5, SPAG5, RPA3, SUMO1, CCNA2, KIF4A, RPP40, VRK1, ACAD8, HADH, DHX9, POP7, CDCA8, EEF1E1, BIRC5 |
| KOBAYASHI EGFR SIGNALING 24HR DN | CDKN3, PCNA, ABCE1, NOLC1, BUB1, ZWINT, TMPO, CCNB1, AURKA, CCDC99, PBK, CDC2, NCAPG, FAM64A, RFC5, TOP2A, CDCA3, HSPA14, GINS1, MCM3, EXOSC8, MSH2, CDT1, HMGA2, NETO2, PUS7, MELK, TIMELESS, PAICS, C12ORF24, SPAG5, SRM, RFC4, HMMR, CCNA2, DTL, KIF4A, VRK1, STEAP1, TPX2, DEPDC1, UNG, NCAPG2, GPSM2, PRC1, CDCA8, EEF1E1 |
| MANALO HYPOXIA DN | CCNE1, BOLA2 /// BOLA2B, CAD, C1QBP, NOLC1, PAK1IP1, FANCG, NARS2, CCDC99, SRM, PBK, CDC2, TFAM, OIP5, AASDHPPT, CCNA2, RFC5, FBXO5, TOE1, GINS1, RPP40, MCM3, VRK1, NEK4, EXOSC8, EBNA1BP2, MELK, PRC1, EEF1E1 |
| ZHANG BREAST CANCER PROGENITORS UP | CASP8AP2, POLA1, BUB1, LRBA, TMPO, FGFR1OP, BMI1, PRPS2, MRPS33, STMN1, AURKA, PBK, NCAPG, ORC5L, TOPBP1, CENPF, METTL9, C1D, MELK, WDR3, LSM5, CPSF6, CTCF, NVL, HRSP12, PAICS, SKP2, HOOK1, TRRAP, AUTS2, RPA3, CCNA2, NEK1, ASXL1, CEP192, NCBP1, GPSM2, MYB, LRRC40, CDCA8, PKP4 |
| HORIUCHI WTAP TARGETS DN | KIF20A, CDKN3, C1QBP, BUB1, TMPO, CCNB1, AURKA, PBK, CDC2, NCAPG, FAM64A, RFC5, CDCA3, C1D, HMGA2, KIF22, MELK, TMEM97, PAICS, CKAP2, TAF10, SPAG5, FOXM1, OIP5, HMMR, CCNA2, KIF4A, VRK1, TSNAX, MBNL1, UNG, DEPDC1, PRC1, CDCA8 |
| WINNEPENNINCKX MELANOMA METASTASIS UP | CDKN3, PCNA, TIMELESS, PAICS, C12ORF24, BUB1, CCNB1, SPAG5, AURKA, RFC4, NCAPG, RPA3, RFC5, CENPF, GMPS, NCBP1, CACYBP, NCAPG2, CTNNAL1, MELK, PRC1, NEIL3, CDCA8, KNTC1, RBMX, BIRC5 |
| BLUM RESPONSE TO SALIRASIB DN | KIF20A, MYCBP, CDKN3, CASP8AP2, PCNA, TOP2B, BUB1, TMPO, STMN1, AURKA, PBK, CDC2, GALNT2, NCAPG, RFC5, TOPBP1, CENPF, HSPA14, FBXO5, GAMT, MCM3, KIF22, LSM5, PXMP2, TIMELESS, RAB40B, SPAG5, ITGB3BP, RFC4, HMMR, PRKDC, CCNA2, KIF4A, VRK1, ANP32A, MRE11A, GPSM2, PRC1, TACC3, MID1 |
| BIDUS METASTASIS UP | BUB1, CCNB1, CENPA, AURKA, RRM1, PBK, NCBP2, CDC2, RFC4, FBXO3, PRKDC, CCNA2, RFC5, CENPF, KIF4A, CAND1, WRB, CEP57, DEPDC1, C20ORF11, ZNF318, SSRP1, WDHD1, CBLL1, NF1 |
| ODONNELL TARGETS OF MYC AND TFRC DN | AURKA, FOXM1, CDC2, CCNA2, DEPDC1, CENPF, CCNB1 |
| FURUKAWA DUSP6 TARGETS PCI35 DN | DTL, CKAP2, EBNA1BP2, CCNB1, CTNNAL1, CENPA, AURKA, RRM1, PBK, PRC1, RFC4, NCAPG, CCNA2, WDR3, MAP7, PRIM1 |
| REACTOME CELL CYCLE MITOTIC | KIF20A, PCNA, BUB1, ZWINT, FGFR1OP, CCNB1, AURKA, NUP133, RFC5, CENPF, CP110, FBXO5, MCM3, CDT1, CENPE, KNTC1, CCNE1, SKP2, DCTN3, AZI1, ITGB3BP, RFC4, RPA3, CCNA2, MNAT1, KIF18A, CEP192, CDC25C, NUP37, ODF2, TUBGCP3, CDCA8, KIF2C, BIRC5 |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | KIF4A, DTL, KIF20A, C10ORF84, AQP3, TPX2, AURKA, KIAA1704, CDCA8, RFC5, KIF2C |
| REN BOUND BY E2F | MCM3, PCNA, MSH2, MLH1, UNG, RRM1, CBX5, RFC4, CENPE, RPA3, CCNA2, TOP2A, PRKDC |
| REACTOME METABOLISM OF RNA | EXOSC8, NUP37, NCBP1, DCPS, DCP2, NUP88, NUP133, LSM5 |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN | SKP2, POLR3B, TMPO, C16ORF53, AURKA, TACC3, NEIL3, CCNA2 |
| CHANG CYCLING GENES | FOXM1, AURKA, CDKN3, PBK, TACC3, ILF2, CDC25C |
| AMUNDSON GAMMA RADIATION RESPONSE | BUB1, CCNB1, TSN, AURKA, TACC3, CENPE, CCNA2, CENPF |
| NCI TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON CONTAINING TRANSCRIPT | NUP88, NCBP2, NUP133, NUP37, NCBP1, U2AF2 |
| PUJANA BRCA1 PCC NETWORK | |
| LI WILMS TUMOR VS FETAL KIDNEY 1 DN | |
| RHODES UNDIFFERENTIATED CANCER | CDKN3, MCM3, PCNA, ILF2, CCNB1, FOXM1, RFC4, RPA3, CCNA2, BIRC5 |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| REACTOME RNA POLYMERASE II TRANSCRIPTION | |
| NCI PLK1 PATHWAY | |
| CORUM MRNA DECAY COMPLEX UPF1 UPF2 UPF3B DCP2 XRN1 XRN2 EXOSC2 EXOSC4 EXOSC10 PARN | |
| REACTOME CENTROSOME MATURATION | |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | |
| MOREAUX B LYMPHOCYTE MATURATION BY TACI DN | |
| ODONNELL TFRC TARGETS DN | |
| MARKEY RB1 ACUTE LOF DN | |
| REACTOME G2 M TRANSITION | SSNA1, FGFR1OP, DCTN3, CCNB1, AZI1, CKAP5, CCNA2, MNAT1, CP110, CEP192, CDC25C, CEP72, PCNT, ODF2, CEP152, CDC25A, TUBGCP3, NDE1 |
| REACTOME REV MEDIATED NUCLEAR EXPORT OF HIV1 RNA | |
| KEGG SPLICEOSOME | |
| NCI MITOTIC PROMETAPHASE | CLASP2, KIF18A, NUP107, CENPC1, BUB1, ZWINT, NUP37, CCDC99, NUP133, CENPE, CDCA8 |
| LE EGR2 TARGETS UP | |
| CORUM EMERIN COMPLEX 52 | |
| REACTOME DNA REPAIR | |
| REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON CONTAINING TRANSCRIPT | NUP88, NCBP2, NUP133, NUP37, NCBP1, U2AF2 |
| NCI TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA | |
| SCHLOSSER MYC TARGETS REPRESSED BY SERUM | |
| TANG SENESCENCE TP53 TARGETS DN | KIF4A, FBXO5, MRE11A, PRC1, TFAM, CENPE, CCNA2, SPAG5 |
| KAUFFMANN DNA REPAIR GENES | |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | NUP107, MAGOH, SF3A2, SNRPD3, SLBP, NCBP2, POLR2K, NUP133, U2AF2, NUDT21, SNRPB2, POLR2F, NCBP1, NUP37, DDX23, DHX9, POLR2H, NUP88 |
| MORI EMU MYC LYMPHOMA BY ONSET TIME UP | |
| NCI BARD1PATHWAY | |
| REACTOME G2 M CHECKPOINTS | |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | RDBP, TAF11, TAF10, NCBP2, NUP133, MNAT1, POLR2G, TAF12, POLR2F, NCBP1, NUP37, GTF2A2, TAF4, POLR2H, NUP88, SSRP1 |
| REACTOME MRNA 3 END PROCESSING | |
| BENPORATH CYCLING GENES | |
| REACTOME ELECTRON TRANSPORT CHAIN | |
| CORUM MLL1-WDR5 COMPLEX | |
| CORUM RC COMPLEX REPLICATION COMPETENT COMPLEX | |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | |
| NCI SNRNP ASSEMBLY | SNRPD3, NUP88, NCBP2, NUP133, NUP37 |
| KAUFFMANN DNA REPLICATION GENES | |
| REACTOME TELOMERE MAINTENANCE | |
| REACTOME MITOTIC PROMETAPHASE | KIF18A, CLASP2, NUP107, CENPC1, BUB1, ZWINT, NUP37, CCDC99, ITGB3BP, NUP133, CENPE, CDCA8, KNTC1, MIS12, CENPF |
| SCHUHMACHER MYC TARGETS UP | |
| REACTOME MICRORNA BIOGENESIS | |
| TOYOTA TARGETS OF MIR34B AND MIR34C | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| RIZ ERYTHROID DIFFERENTIATION | |
| NCI ACTIVATION OF THE PRE REPLICATIVE COMPLEX | |
| SUNG METASTASIS STROMA DN | |
| FINETTI BREAST CANCER BASAL VS LUMINAL | |
| NCI RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | |
| NCI TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | |
| YU MYC TARGETS UP | |
| NCI REV MEDIATED NUCLEAR EXPORT OF HIV 1 RNA | |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | |
| NCI MRNA SPLICING MAJOR PATHWAY | |
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | KIF4A, CCNE1, FBXO5, KIF20A, DEPDC1, CCNB1, FOXM1, PBK, PRC1, RFC4, FHOD3, OIP5, CENPE, CCNA2, CENPF |
| REACTOME SNRNP ASSEMBLY | SNRPD3, NUP88, NCBP2, NUP133, NUP37 |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | |
| NCI ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | |
| REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| FINETTI BREAST CANCER KINOME RED | |
| CORUM SPLICEOSOME | |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | |
| CORUM TFTC COMPLEX TATA-BINDING PROTEIN-FREE TAF-II-CONTAINING COMPLEX | |
| CORUM DNMT3B COMPLEX | |
| CORUM ALL-1 SUPERCOMPLEX | |
| PUJANA BREAST CANCER WITH BRCA1 MUTATED UP | |
| REACTOME HIV LIFE CYCLE | RDBP, TAF11, TAF10, NCBP2, NUP133, MNAT1, POLR2G, TAF12, POLR2F, NCBP1, NUP37, GTF2A2, TAF4, POLR2H, NUP88, SSRP1 |
| REACTOME MITOTIC M M G1 PHASES | KIF20A, NUP107, CENPC1, MLF1IP, ZWINT, BUB1, CCDC99, ITGB3BP, CKAP5, NUP133, ORC5L, CENPF, FBXO5, MCM3, KIF18A, MCM5, CDT1, NUP37, CENPE, CDCA8, KNTC1, NUP43, KIF2C, NDE1, BIRC5 |
| REACTOME FORMATION AND MATURATION OF MRNA TRANSCRIPT | |
| DODD NASOPHARYNGEAL CARCINOMA DN | |
| BENPORATH PROLIFERATION | |