| Gene Set | Leading Edge Genes |
|---|
| PUJANA CHEK2 PCC NETWORK | HDAC1, SYK, PCNA, NCAPD2, RRM2, POLE3, HMGCR, BUB1, ZWINT, TMPO, PLK1, DBF4, CCNB1, STMN1, DCP2, AURKB, SLBP, CDC2, ZNF131, COX11, TFDP2, CENPF, ICT1, POLR2G, GINS1, RECQL4, ATP5S, LSM3, UBE2C, GSR, CKS2, NRL, COPS3, DDX46, RNASEH2A, CENPE, CTR9, AGL, MKI67, CEBPG, LSM7, OXA1L, SPAG5, CCNF, FOXM1, ITGB3BP, ODC1, RPA3, OIP5, PIAS2, HMMR, CCNA2, CDC20, PPIG, PTTG1, UNG, CCNE2, GTF2A2, POLE, H2AFV, IDI1, KIF2C |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | CDKN3, PCNA, NCAPD2, POLE3, BUB1, TMPO, DCP2, AURKB, SLBP, NCAPG, CDCA3, NUP85, GINS1, OSBPL3, COPS3, RNASEH2A, LIAS, NEIL3, HRSP12, MKI67, MBD4, CCNF, GGA2, ASRGL1, PPP2R2D, PPP1R8, SHMT1, TMEM70, NUDT21, YWHAH, KIF18A, CDC20, GTF2A1, PTTG1, GTF2A2, NSBP1, PRKAA1, MRPL48, PXN, BIRC5, PPP1R7, RRM2, ZNF76, PLK1, DBF4, CCNB1, PAK2, GINS2, CCDC99, ASF1B, CDC2, UCHL5, CENPF, FBXO5, WRB, CYB5B, EXOC5, TPRKB, PHF20L1, MAPKAP1, FOXM1, ITGB3BP, CMAS, HMMR, PIAS2, OIP5, KIF4A, EIF2B1, DEPDC1, CDC25C, CCNE2, NCAPG2, ANP32A, PRC1, CDC25A, CDCA8 |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | PCNA, KIFC1, BUB1, TMPO, PLK1, DBF4, CCNB1, GINS2, STMN1, AURKA, SHMT1, ALDH9A1, ACADM, RPA3, CENPF, TYMS, KIF4A, PIGC, DEPDC1, UBE2C, PTTG1, NCAPG2, CKS2, C21ORF45, RNASEH2A, PRC1, TACC3, CDC25A, CENPE, IDH2, CDCA8, BIRC5 |
| BLUM RESPONSE TO SALIRASIB DN | HDAC1, KIF20A, CDKN3, PCNA, HN1, RRM2, BUB1, TMPO, PLK1, STMN1, GINS2, TUBB3, AURKB, PBK, CDC2, NCAPG, CARHSP1, CENPF, HSPA14, FBXO5, GAMT, RECQL4, UBE2C, DHCR24, CKS2, RNASEH2A, RAB4A, ZBTB33, PXMP2, MKI67, HIRIP3, RAB40B, SPAG5, CCNF, ITGB3BP, SHMT1, HMMR, CCNA2, KIF4A, RAGE, CDC20, CCNE2, PTTG1, ANP32A, POLE, PRC1, CDC25A, MIPEP |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | ARPC5L, PCNA, RRM2, MLF1IP, ZWINT, PAK2, GINS2, STMN1, MRPS33, SLC35E3, CDC2, NDUFB5, NCAPG, COX11, TOP2A, APEX1, TUBB, CPNE3, CKS2, RAD51, ING2, C21ORF45, ITGB3BP, HMMR, ACAA2, ACADM, ANP32E, PIN4, PIGP, NUP37, UNG, PTTG1, POLE2, ANP32A, RAD51AP1, CFDP1, PRC1, CDC25A, IDH2, RBMX, BIRC5 |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | PCNA, HN1, RSRC1, ZWINT, TMPO, DBF4, CCNB1, NMD3, GINS2, STMN1, CCDC99, PBK, CDC2, NCAPG, UCHL5, TFDP2, CENPF, AP2S1, HSPA14, FBXO5, GINS1, OSBPL3, ACP1, GUF1, UBE2C, GSR, CKS2, C21ORF45, RNASEH2A, PSRC1, RASAL2, C1ORF103, HIST3H2A, SERPINH1, EXOC5, MKI67, INTS7, CEBPG, ITGB3BP, TFAM, CCNA2, PPP1R14B, NUDT21, CKLF, KIF18A, CCNE2, YIPF5, PRKAA1, XRCC4, PRC1, KIF2C, NDE1 |
| LEE EARLY T LYMPHOCYTE UP | CDKN3, KIF20A, SYK, MKI67, BUB1, CCNB1, PBK, CDC2, NCAPG, OIP5, HMMR, TFDP2, GINS1, UBE2C, CKS2, RAD51AP1, TUBB2C, CDC25A, KIF2C, BIRC5 |
| MUELLER PLURINET | HDAC1, PCNA, CASP6, TMPO, CCNB1, SPAG5, AURKB, ITGB3BP, PAK1, RPA3, HMMR, PIAS2, CCNA2, HSPA14, APEX1, CDC25C, NPPB, DHCR24, ANP32A, CKS2, COPS3, VAMP8, CTBP2, CENPE, BIRC5, C1ORF103 |
| WONG EMBRYONIC STEM CELL CORE | HDAC1, KIF20A, CDKN3, PCNA, SERPINH1, NCAPD2, HN1, BUB1, PLK1, DBF4, CCNF, SPAG5, AURKB, IPO9, RPA3, CCNA2, CDCA3, HSPA14, KIF4A, APEX1, CDC20, ACAD8, CKS2, KIF22, POLR3K, CDCA8, NT5DC2, BIRC5 |
| ZHANG BREAST CANCER PROGENITORS UP | HRSP12, NVL, NCAPD2, SAP30, BUB1, TMPO, DBF4, TULP3, MRPS33, STMN1, PBK, SHMT1, NCAPG, RPA3, CCNA2, CENPF, NUP85, RNF7, IK, CDC25A, CDCA8, ING3 |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | CDKN3, PCNA, POLE3, H2AFZ, PBK, CMAS, RPA3, GLUD2, NUDT21, TYMS, CAB39, ATP6V0D1, MSH2, C14ORF109, TPX2, RNF141, NUP37, UBE2E3, RAD51AP1, COPS3, RNASEH2A, MRPL39 |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | PDCD6, MBD4, DBF4, ZNF131, CDC2, PRKDC, TYMS, FIBP, C17ORF42, NASP, ANKRD49, SF3B2, COMMD4, IK, BUB3, LRRC40, LSM5 |
| REACTOME CELL CYCLE MITOTIC | KIF20A, PCNA, CEP76, RRM2, BUB1, ZWINT, PLK1, DBF4, CCNB1, GINS2, AURKB, CCDC99, CENPF, NUP85, FBXO5, GINS1, UBE2C, CENPE, TUBGCP2, CDK5RAP2, ITGB3BP, RPA3, CCNA2, CLASP2, KIF18A, PSMD2, CDC20, CCNE2, CDC25C, NUP37, POLE, ODF2, CDC25A, CDCA8, KIF2C, NDE1, BIRC5 |
| ODONNELL TARGETS OF MYC AND TFRC DN | CDC20, DEPDC1, CCNB1, DBF4, AURKB, FOXM1, CDC2, CCNA2, CENPF, BIRC5 |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | KIF4A, AURKA, KIF20A, TPX2, CDCA8, KIF2C, CENPF |
| BASAKI YBX1 TARGETS UP | KIF20A, ARPC5L, CDKN3, HN1, NCAPD2, BUB1, PLK1, CCNB1, GINS2, AURKB, CCDC99, PBK, CDC2, DR1, C3ORF14, PEX13, CDCA3, GINS1, UBE2C, FOXE1, C21ORF45, MKI67, TPRKB, C13ORF34, H2AFX, OIP5, CCNA2, KIF4A, CDC20, KRT10, DEPDC1, SNAI2, PRC1, CDCA8, BIRC5 |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | KIF20A, CDKN3, PCNA, VANGL1, NCAPD2, HN1, QSER1, BUB1, ZWINT, DBF4, CCNB1, GINS2, STMN1, AURKB, PBK, SLBP, CDC2, NCAPG, CARHSP1, DR1, CENPF, CDCA3, AP2S1, FBXO5, GINS1, RECQL4, UBE2C, CKS2, PSRC1, CENPE, NEIL3, RASAL2, ZNF248, FIP1L1, C1ORF103, TPRKB, SAP30, MKI67, SPAG5, FOXM1, CMAS, TNNT1, H2AFX, OIP5, HMMR, CCNA2, KIF4A, KIF18A, CDC20, SETD8, TFPT, DEPDC1, NUP37, CCNE2, CDC25C, NCAPG2, PRC1, CDC25A, CDCA8, KIF2C, BIRC5 |
| MORI IMMATURE B LYMPHOCYTE DN | CDKN3, RRM2, UBE2C, CCNB1, CENPA, TUBB2C, SLBP, H2AFV, PRC1, H2AFX, TOP2A, CDCA3 |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | KIF20A, HN1, CCNB1, AURKB, FOXM1, ASRGL1, PBK, OIP5, CCNA2, CENPF, FBXO5, KIF4A, CDC20, DEPDC1, UBE2C, PTTG1, PRC1, SC65, CTBP2, CENPE, BIRC5 |
| NAKAYAMA SOFT TISSUE TUMORS PCA2 UP | |
| BORCZUK MALIGNANT MESOTHELIOMA UP | |
| LI WILMS TUMOR VS FETAL KIDNEY 1 DN | |
| MITSIADES RESPONSE TO APLIDIN DN | |
| REACTOME CELL CYCLE CHECKPOINTS | CDC20, CDC25A, RPA3, CDC25C, UBE2C, CCNB1, DBF4 |
| RHODES UNDIFFERENTIATED CANCER | CDKN3, PCNA, CDC20, UBE2C, CEBPG, CCNB1, CKS2, FOXM1, H2AFX, RPA3, CCNA2, BIRC5 |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| LIANG SILENCED BY METHYLATION DN | |
| PAL PRMT5 TARGETS UP | |
| REACTOME REPAIR SYNTHESIS OF PATCH 27 30 BASES LONG BY DNA POLYMERASE | |
| TARTE PLASMA CELL VS PLASMABLAST DN | |
| NCI PLK1 PATHWAY | |
| ZHAN MULTIPLE MYELOMA PR UP | |
| REACTOME NUCLEOTIDE EXCISION REPAIR | PCNA, POLE, RPA3, POLR2G |
| CORUM C COMPLEX SPLICEOSOME | |
| NCI VIRAL MESSENGER RNA SYNTHESIS | |
| ODONNELL TFRC TARGETS DN | |
| REACTOME GLOBAL GENOMIC NER | |
| NCI REPAIR SYNTHESIS FOR GAP FILLING BY DNA POLYMERASE IN TC NER | |
| MARKEY RB1 ACUTE LOF DN | |
| REACTOME TRANSCRIPTION COUPLED NER | PCNA, POLE, RPA3, POLR2G |
| SMID BREAST CANCER LUMINAL A DN | |
| NCI MITOTIC PROMETAPHASE | |
| LE EGR2 TARGETS UP | |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | |
| TANG SENESCENCE TP53 TARGETS DN | KIF4A, FBXO5, CDC20, PTTG1, UBE2C, SPAG5, PRC1, CENPE, CDC25A, CCNA2, BIRC5 |
| REACTOME SYNTHESIS OF DNA | |
| REACTOME DNA REPLICATION PRE INITIATION | |
| NCI DUAL INCISION REACTION IN TC NER | |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | |
| FURUKAWA DUSP6 TARGETS PCI35 DN | NCAPD2, TPX2, CCNB1, AURKB, CENPA, PBK, NCAPG, CCNA2, CENPF, PDLIM2 |
| RIZ ERYTHROID DIFFERENTIATION CCNE1 | |
| BENPORATH CYCLING GENES | |
| CORUM RC COMPLEX REPLICATION COMPETENT COMPLEX | |
| DING LUNG CANCER EXPRESSION BY COPY NUMBER | |
| NCI TRANSCRIPTION COUPLED NER TC NER | |
| CORUM RC COMPLEX DURING G2/M-PHASE OF CELL CYCLE | |
| REACTOME MITOTIC PROMETAPHASE | |
| SHEN SMARCA2 TARGETS UP | |
| WINNEPENNINCKX MELANOMA METASTASIS UP | CDKN3, PCNA, RSRC1, BUB1, CCNB1, SPAG5, GINS2, NCAPG, RPA3, CENPF, PTTG1, NCAPG2, CKS2, PRC1, NEIL3, CDCA8, RBMX, BIRC5 |
| NCI FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | |
| MANALO HYPOXIA DN | |
| NCI P53REGULATIONPATHWAY | |
| STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN | |
| FINETTI BREAST CANCER BASAL VS LUMINAL | |
| NCI PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | |
| MORI MATURE B LYMPHOCYTE DN | |
| WEST ADRENOCORTICAL TUMOR UP | |
| YU MYC TARGETS UP | |
| CORUM RNASE/MRP COMPLEX | |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | |
| EGUCHI CELL CYCLE RB1 TARGETS | KIF20A, KIF18A, BUB1, CCNE2, CDC25C, CENPE, CCNA2, CDCA8 |
| REACTOME G1 S TRANSITION | |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | |
| NCI REPAIR SYNTHESIS OF PATCH 27 30 BASES LONG BY DNA POLYMERASE | |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | |
| REACTOME S PHASE | |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| KEGG CELL CYCLE | |
| CORUM CONDENSIN I COMPLEX | |
| FINETTI BREAST CANCER KINOME RED | |
| REACTOME DUAL INCISION REACTION IN TC NER | |
| CHANG CYCLING GENES | CDKN3, CDC25C, UBE2C, CCNF, GINS2, CKS2, FOXM1, PBK, ASF1B, TACC3, PSRC1 |
| BOYAULT LIVER CANCER SUBCLASS G3 UP | C17ORF71, HN1, TBL1XR1, NCAPD2, TPRKB, BUB1, STMN1, ZWILCH, NCAPG, HMMR, CCNA2, EML4, CKLF, NUP37, RAD51AP1, TACC3, KIF2C |
| VECCHI GASTRIC CANCER EARLY UP | |
| PUJANA BREAST CANCER WITH BRCA1 MUTATED UP | |
| CORUM 13S CONDENSIN COMPLEX | |
| REACTOME MITOTIC M M G1 PHASES | KIF20A, ZWINT, BUB1, PLK1, AURKB, CCDC99, ITGB3BP, CENPF, NUP85, FBXO5, CLASP2, KIF18A, CDC20, NUP37, CENPE, CDCA8, KIF2C, BIRC5, NDE1 |
| CORUM RC COMPLEX DURING S-PHASE OF CELL CYCLE | |
| MISSIAGLIA REGULATED BY METHYLATION DN | |
| NCI MRNA SPLICING MINOR PATHWAY | |
| FUJII YBX1 TARGETS DN | |
| BENPORATH PROLIFERATION | CDKN3, PCNA, RRM2, BUB1, CEBPG, DBF4, SPAG5, STMN1, PBK, NCAPG, CENPF, HSPA14, PTTG1, CKS2, PRC1, IDH2, CENPE, BIRC5 |
| KEGG NUCLEOTIDE EXCISION REPAIR | PCNA, POLE, POLE3, RPA3 |