| Gene Set | Leading Edge Genes |
|---|
| WONG EMBRYONIC STEM CELL CORE | HDAC1, BUB1, AURKA, NCBP2, ADSL, TOP2A, SDHC, ATP5O, MSH2, BANF1, ZNF22, BUB1B, KIF11, LMNB1, MAD2L1, DLAT, SPAG5, CSE1L, RRM1, SUMO1, RPA3, LYPLA1, TRIP13, TTK, CCNB2, HADH, KIF23, CCT5, POLE2, DHX9, VBP1, XRCC5, RCN2 |
| REACTOME ELECTRON TRANSPORT CHAIN | NDUFA6, NDUFS5, COX4I1, UQCRH, NDUFS2, NDUFB5, UQCRC2, SDHD, NDUFS1, CYC1, SDHC |
| BLUM RESPONSE TO SALIRASIB DN | HDAC1, MYCBP, UPK1B, TOP2B, BUB1, ZWINT, TMPO, GALNT1, STMN1, CENPA, AURKA, RFC5, TOP2A, TOPBP1, CENPF, ABCD3, MSH2, MCM6, IRS1, BUB1B, KIF11, MAD2L1, VDAC3, RRM1, RPA3, PRKDC, TRIP13, CCNB2, TTK, MSH6, TPX2, KIF23, CDC25C, POLE2, UBE2E3, H2AFV, GPSM2, KIF2C |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | KIF11, MAD2L1, BUB1, ZWINT, TMPO, PRPS2, CCNB1, STMN1, CENPA, AURKA, ALDH9A1, RPA3, TOP2A, CENPF, TRIP13, CCNB2, MSH2, PTPLB, KIF23, TMEM106C, CPD, MCM6, H2AFV, AK2, PPAT, KIFAP3, WDHD1, KIF2C |
| PAL PRMT5 TARGETS UP | NNT, KIF11, TMPO, CETN3, STMN1, RRM1, FKBP4, TOPBP1, RFC5, TRIP13, PSIP1, TTK, CCNB2, CDC25C, KIF23, POLE2, UBE2E3, HAT1, COPS3, NUP88, H2AFV, EHMT2, RCN2 |
| MARKEY RB1 ACUTE LOF DN | CAV1, KIF2A, KIF11, MAD2L1, BUB1, TMPO, CCNB1, RAD21, STMN1, CENPA, AURKA, ADSL, SMC3, TOPBP1, RFC5, TRIP13, PSIP1, CCNB2, DSTN, CDC25C, KIF23, TMEM106C, H2AFV, HDAC2 |
| MORI LARGE PRE BII LYMPHOCYTE UP | MCM6, AURKA, TTK, RRM1, H2AFV, LMNB1, CENPA |
| KEGG CELL CYCLE | BUB1B, HDAC1, TTK, CCNB2, MAD2L1, BUB1, CDC25C, CCNB1, MCM6, HDAC2, SMC3, PRKDC |
| REACTOME CELL CYCLE MITOTIC | BUB1B, KIF2A, MAD2L1, BUB1, ZWINT, RAD21, CCNB1, AZI1, CENPA, AURKA, CKAP5, RPA3, SMC3, RFC5, CENPF, CCNB2, KIF23, CDC25C, POLE2, MCM6, KIF2C |
| REN BOUND BY E2F | RFC3, TTK, MSH2, MAD2L1, MLH1, CENPA, MCM6, RRM1, CENPE, RPA3, TOP2A, PRKDC |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | BUB1B, LMNB1, KIF11, MAD2L1, ZWINT, CCNB1, FOXM1, OIP5, TOP2A, CD24, CENPF, TRIP13, CCNB2, TTK, TPX2, KIF23, WASF1, GPD1L, HDAC2, KIF2C |
| BENPORATH PROLIFERATION | CCNB2, TTK, MAD2L1, MSH2, ILF2, BUB1, SPAG5, STMN1, CENPA, AURKA, HDAC2, H2AFV, GPSM2, TOP2A |
| RHODES UNDIFFERENTIATED CANCER | MAD2L1, ILF2, KIF23, CCNB1, RAD21, CENPA, MCM6, FOXM1, RPA3, TOP2A, KIF2C, TRIP13 |
| NCI AURORA B PATHWAY | BUB1, KIF23, EVI5, CENPA, STMN1, AURKA, SMC4, CUL3, KIF2C |
| NCI PLK1 PATHWAY | AURKA, BUB1B, KIF2A, TPX2, BUB1, CDC25C, CCNB1 |
| CHANG CYCLING GENES | CCNB2, LMNB1, ILF2, KIF23, CDC25C, CENPA, FOXM1, AURKA |
| AMUNDSON GAMMA RADIATION RESPONSE | CCNB2, TTK, MAD2L1, CDKN2C, BUB1, KIF23, CDC25C, CCNB1, CENPA, AURKA, CENPF |
| CORUM ANTI-HDAC2 COMPLEX | |
| REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | |
| NCI NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | |
| PUJANA BRCA1 PCC NETWORK | |
| SCIAN CELL CYCLE TARGETS OF TP53 AND TP73 DN | |
| BOYAULT LIVER CANCER SUBCLASS G123 UP | |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| HORIUCHI WTAP TARGETS DN | |
| ZHAN MULTIPLE MYELOMA SUBGROUPS | |
| ODONNELL TARGETS OF MYC AND TFRC DN | |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | |
| CORUM F1F0-ATP SYNTHASE EC 3.6.3.14 MITOCHONDRIAL | |
| MOREAUX B LYMPHOCYTE MATURATION BY TACI DN | |
| NCI REPAIR SYNTHESIS FOR GAP FILLING BY DNA POLYMERASE IN TC NER | |
| FRASOR RESPONSE TO SERM OR FULVESTRANT DN | |
| CORUM CTBP CORE COMPLEX | |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | |
| NCI MITOTIC PROMETAPHASE | BUB1B, KIF2A, BUB1, ZWINT, CENPA, SMC1A, CKAP5, STAG1, SMC3, KIF2C |
| KOBAYASHI EGFR SIGNALING 24HR DN | |
| NCI CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX | |
| BOYAULT LIVER CANCER SUBCLASS G23 UP | |
| PUJANA BREAST CANCER LIT INT NETWORK | |
| KEGG MISMATCH REPAIR | |
| HUMMEL BURKITTS LYMPHOMA UP | |
| CORUM DNA SYNTHESOME COMPLEX 13 SUBUNITS | |
| CORUM BRM-SIN3A COMPLEX | |
| CAIRO HEPATOBLASTOMA CLASSES UP | |
| REACTOME INACTIVATION OF APC VIA DIRECT INHIBITION OF THE APCOMPLEX | |
| NCI MITOTIC METAPHASE ANAPHASE TRANSITION | |
| REACTOME SYNTHESIS OF DNA | |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | |
| SCIBETTA KDM5B TARGETS DN | |
| KAUFFMANN DNA REPAIR GENES | |
| NCI REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE | |
| CORUM BASC AB 80 COMPLEX BRCA1-ASSOCIATED GENOME SURVEILLANCE COMPLEX | |
| CORUM BASC COMPLEX BRCA1-ASSOCIATED GENOME SURVEILLANCE COMPLEX | |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | |
| CORUM RAD17-RFC COMPLEX | |
| MORI EMU MYC LYMPHOMA BY ONSET TIME UP | |
| MOOTHA VOXPHOS | |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | |
| BENPORATH CYCLING GENES | |
| NCI SNRNP ASSEMBLY | |
| CORUM DNA SYNTHESOME COMPLEX 17 SUBUNITS | |
| WAKASUGI HAVE ZNF143 BINDING SITES | |
| REACTOME MITOTIC PROMETAPHASE | |
| NCI APC CDC20 MEDIATED DEGRADATION OF NEK2A | |
| MUELLER PLURINET | |
| MANALO HYPOXIA DN | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| FINETTI BREAST CANCER BASAL VS LUMINAL | |
| CORUM ANAPHASE-PROMOTING COMPLEX | |
| YU MYC TARGETS UP | |
| CORUM PCNA-MUTS-ALPHA-MUTL-ALPHA-DNA COMPLEX | |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | PSIP1, LMNB1, TPX2, TMPO, ZWINT, KIF23, POLE2, CCNB1, ARHGAP11A, CENPE, RPA3, TOP2A, KIF2C, CENPF |
| NCI MRNA SPLICING MAJOR PATHWAY | |
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | |
| CAFFAREL RESPONSE TO THC 24HR 5 DN | |
| REACTOME S PHASE | |
| NCI MITOCHONDRIAL TRNA AMINOACYLATION | |
| FINETTI BREAST CANCER KINOME RED | |
| NCI INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX | |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | |
| CORUM SNF2H-COHESIN-NURD COMPLEX | |
| RHODES CANCER META SIGNATURE | |
| VANTVEER BREAST CANCER METASTASIS DN | |
| REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | |
| SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN | |
| DODD NASOPHARYNGEAL CARCINOMA DN | |
| KEGG NUCLEOTIDE EXCISION REPAIR | |