| Gene Set | Leading Edge Genes |
|---|
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | MYCBP, VANGL1, GMPR2, AK1, CDCA3, FZD1, OSBPL3, CDKN2C, ANTXR1, VCL, PXMP4, COL4A1, NEIL3, ISOC1, LMNB2, MPPE1, TIMM8B, POLA2, GEMIN4, ARL5A, MAPK14, MRPL40, CYB5A, M6PR, MAT2A, HADH, ANAPC13, NEK2, CD302, RABIF, KIF20A, TGFBR2, PHF17, SEPHS1, PCSK6, ELOVL6, SSX2IP, POLR2I, AP1S1, PEX11B, MCCC2, ADAM10, ICMT, IVD, THAP11, FBXO5, CAV2, FHOD1, IRS1, TRAM2, ZNF22, INTS5, OSTF1, PXMP2, CCNE1, LMNB1, ZMYM3, PSMB9, CCND1, TSEN2, B3GNT1, NF2, CCNA2, DERA, DAG1, PTDSS1, UBQLN2, POLE2, PTCD2, MRPS14 |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | SET, EMP1, CETN2, PFKM, MLF1IP, PRDX4, PRPS2, STMN1, MRPS33, ADSL, SH3BGRL, TBCA, NDUFA8, PDIA6, PPA1, CPNE3, UGP2, ATP5J, WASF1, MELK, ISOC1, MAGED1, ZFAND1, MPP1, BUB1B, RSU1, RTN3, MAD2L1, LTA4H, ATP5C1, PDLIM1, GPR125, PAICS, NUCB2, PSMB9, PHYH, SCP2, CYFIP1, SEPT11, ACADM, CYB5A, FBXL14, PSIP1, GMNN, ACAT1, UBE2L6, RACGAP1, TTK, PIGP, PECI, ME2, ALDH6A1, HADH, PXDN, POLE2, CACYBP, ATP5G3, PRDX3, KDELR2, BIRC5, ATP5L |
| NUYTTEN NIPP1 TARGETS DN | SEC23A, ORMDL2, ASPH, CHPT1, TMPO, PLCE1, SLMAP, RGS10, SFXN1, TRIM2, ABCA1, FIBP, CDKN2C, NOTCH1, CPT1A, ANTXR1, UGDH, VCL, MAN2A1, DHCR24, CRIP1, ACSL3, PKD2, RALBP1, ROCK2, TSPAN5, NFATC3, PARVA, KLHL5, BTBD3, GLUD1, LYPLA1, CLSPN, SEC14L1, FBXO21, TACC1, RCN1, PRDX3, GALNT4, RBM12, DEPDC1B, TRIM8, KIF20A, AP3M1, NNT, TBL1XR1, SSX2IP, PRPS2, NUCKS1, MTMR9, RB1CC1, LMBR1, FBXO5, CAV2, TMED7, REEP4, MAGED1, F2R, CAV1, LMNB1, CMTM6, SMARCA2, CCND1, PHF15, PIR, NF2, GOLGA1, PCDH18, CAST, KIF4A, SLC9A6, CAPZA1, NSF, SSPN, ZFP106, RAB3D, IMPA1, SURF4 |
| TIEN INTESTINE PROBIOTICS 24HR UP | TTF2, TMPO, SNN, CENPA, EI24, FBXO3, NDUFA8, NTAN1, DHCR24, NPTN, ISOC1, LMNB2, NDUFC1, TIMM8B, NDUFV2, GEMIN4, HSBP1, RACGAP1, GMNN, ACAT2, TSN, PLEKHB2, NXT2, NUP93, SLC25A13, HIBCH, RBM12, ERH, KIF20A, ATP2C1, FAIM, CCNB1, GALNT1, UBL5, CHMP5, ADSL, RECQL, ICMT, CENPF, FBXO5, WRB, CBFB, MAP3K4, ATP5J, NR2F2, DDX46, DAB2, MRPL46, BUB1B, PXMP2, MAD2L1, TEAD4, UBE2D1, CMTM6, CCND1, SPAG5, LRRC47, CCNA2, CAST, SLC9A6, DERA, DAG1, NSF, MSH6, KIF23, POLE2, CACYBP, ATP5L |
| WONG EMBRYONIC STEM CELL CORE | HDAC1, KIF20A, SET, HN1, ELOVL6, UQCRH, NDUFB8, DAP3, CTNNA1, NCBP2, SS18, ADSL, CDCA3, ATP5O, MSH2, UGDH, ECHS1, ATP5J, PDIA4, NIPSNAP1, ZNF22, TIMM8B, NDUFB10, BUB1B, LMNB1, MAD2L1, DLAT, CKAP2, PSMA5, PSMB6, CCND1, SPAG5, CCNA2, LYPLA1, PHC1, KIF4A, CCNB2, RACGAP1, TTK, GMNN, PARP1, KIF23, HADH, POLE2, NEK2, CCNC, BIRC5 |
| NUYTTEN EZH2 TARGETS DN | FKBP5, SET, ORMDL2, GMPR2, TTF2, LRRCC1, TMPO, GLT8D1, CENPA, TMEM19, CDCA3, FANCE, FIBP, INPP5F, ANTXR1, USP12, RABGGTB, ISOC1, ROCK2, CMTM8, NDUFB10, NDUFV2, CAD, IL1RAP, CDAN1, GNPAT, TMEM48, LYSMD2, PCMTD2, CLSPN, CENPJ, RACGAP1, GMNN, FBXO21, PIGP, HP1BP3, TPX2, EDEM1, TSN, NEK2, HIBCH, TACC3, ODF2, DEPDC1B, RBM12, IMPAD1, ATP2C1, YIPF4, KIF20A, TBL1XR1, SSX2IP, PRPS2, CCNB1, MRPS33, SYPL1, SS18, PQLC3, CENPF, KIF3A, RPL5, REEP4, F2R, ASPM, CCNE1, LMNB1, CASP6, ITGA6, SPAG5, MIF4GD, CCND1, DDHD2, CMAS, SEC22C, FANCD2, OMA1, PCDH18, CCNA2, KLHDC5, TCF7L2, KIF4A, PHC1, ADD1, TTK, CCDC23, KIF23, CDC25C, FADS1 |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | FKBP5, SET, RPS25, CETN2, ILF2, CHPT1, SH3D19, CASK, NDUFA8, IGBP1, WIPI1, PPL, CREB3L2, XRCC6BP1, COL4A1, TAX1BP1, CNN3, NANS, ROD1, COPB2, TSPAN14, UBE4B, ROCK2, NUDT2, ARL2BP, PAPSS1, SEC24D, NUCB2, FARS2, CAP2, SNX27, GNPAT, MRPL40, DNAJC14, COL1A1, TOR1AIP1, GMNN, MAN1A2, IDH1, SPCS2, SUV39H1, SLC29A3, HIST2H2BE, TFG, IMPAD1, ELOVL6, AP1S1, NRAS, ANKMY2, CHMP5, NCBP2, BIVM, GALNTL4, BLVRA, THAP11, WRB, PDIA6, TOM1L1, TMED7, STXBP6, ALG14, DDX46, GOLPH3L, STT3B, SURF1, ASPM, TDRD7, BBX, MIF4GD, PIR, CKAP4, YIPF1, MAPRE1, CCNA2, DNAJB11, SLC9A6, MSH6, PARP1, ZFP106, ZMPSTE24 |
| KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION | MCCC2, ACAT1, BCKDHA, ACAT2, ACADM, IVD, HADH, AOX1 |
| BLUM RESPONSE TO SALIRASIB DN | KIF20A, MYCBP, TMPO, GALNT1, STMN1, CENPA, MCCC2, CENPF, FBXO5, GAMT, B4GALT5, MSH2, CBFB, CDKN2C, DHCR24, IRS1, CNN3, PXMP2, BUB1B, MAPRE2, B3GNT1, COL1A1, CCNA2, CYB5A, PLS3, KIF4A, TTK, GMNN, MSH6, SRP9, PARP1, KIF23, CDC25C, POLE2, PRDX3, NEK2, GPSM2, TACC3, SUV39H1, TWSG1 |
| REACTOME PEROXISOMAL LIPID METABOLISM | SCP2, CROT, GNPAT, HACL1, SLC25A17, HSD17B4, IDH1, PHYH |
| MITSIADES RESPONSE TO APLIDIN DN | CCNE1, CASP6, CKAP2, TEX2, CCNB1, NUCKS1, FUT8, CENPA, CTNNA1, NF2, CCNA2, IQGAP1, CENPF, LYPLA1, RACGAP1, MSH6, MSH2, MBNL1, PARP1, HADH, DHCR24, NEK2, MELK, TRAM2, TACC3, MAGED1, ASPM |
| ROSTY CERVICAL CANCER PROLIFERATION CLUSTER | KIF20A, POLA2, SLC25A15, LMNB1, MAD2L1, TMPO, CCNB1, CENPA, CCNA2, CENPF, CDCA3, KIF4A, FBXO5, TTK, RACGAP1, GMNN, KIF23, NETO2, NEK2, MELK, TACC3, CENPE, ASPM |
| CAIRO HEPATOBLASTOMA UP | NCOA3, GSTA4, SEPHS1, PFKM, ANKRD27, CETN2, ILF2, ITGA6, PAPSS1, DDHD2, TSPYL4, CAP2, GNPAT, CKAP4, RACGAP1, GMNN, RCOR3, MAGED2, TSN, TACC1, CREB3L2, DLG5, SEPT2, RNF38, MAGED1, RBM12, CLMN, ROCK2 |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP | CCNE1, KIF20A, PDLIM1, ELOVL6, PRDX4, CCNB1, STMN1, CENPA, SFXN1, CCNA2, CENPF, TTK, RACGAP1, GMNN, POLE2, SLC25A13, NEK2, MELK, ASPM |
| RHODES UNDIFFERENTIATED CANCER | GCLM, SEC61B, KIF23, PRDX4, CCNB1, CENPA, MELK, CCNA2, KIF2C, BIRC5 |
| REACTOME CELL CYCLE MITOTIC | |
| WILCOX PRESPONSE TO ROGESTERONE UP | |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | |
| BORCZUK MALIGNANT MESOTHELIOMA UP | |
| WHITEFORD PEDIATRIC CANCER MARKERS | |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| LEE EARLY T LYMPHOCYTE UP | BUB1B, CDKN3, KIF20A, FAIM, MLF1IP, CCNB1, CENPA, HMMR, TTK, CCNB2, MELK, PRC1, NEIL3, KIF2C, MPP1, ASPM, BIRC5 |
| HORIUCHI WTAP TARGETS DN | |
| NCI AURORA B PATHWAY | |
| SHEPARD BMYB TARGETS | |
| NCI PHOSPHORYLATION OF THE APC C | |
| ODONNELL TARGETS OF MYC AND TFRC DN | |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | |
| NCI PLK1 PATHWAY | |
| ZHAN MULTIPLE MYELOMA PR UP | |
| REACTOME CENTROSOME MATURATION | |
| ODONNELL TFRC TARGETS DN | |
| MARKEY RB1 ACUTE LOF DN | |
| REACTOME G2 M TRANSITION | CCNB2, TUBG1, SSNA1, CDC25C, CCNB1, CKAP5, ODF2, MAPRE1, CCNA2, NDE1, CENPJ |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | |
| KEGG BIOSYNTHESIS OF UNSATURATED FATTY ACIDS | |
| CROONQUIST NRAS SIGNALING DN | |
| LEE LIVER CANCER MYC UP | |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | KIF20A, CDKN3, ORMDL2, HN1, MLF1IP, TMPO, CCNB1, STMN1, CENPA, CENPF, CDCA3, FBXO5, MELK, CENPE, ASPM, BUB1B, CENPI, LMNB1, MAD2L1, MRPL15, HMMR, CCNA2, KIF4A, RACGAP1, TTK, TPX2, NUP93, NEK2, TACC3, PRC1, KIF2C, BIRC5 |
| CORUM BRM-SIN3A COMPLEX | |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | |
| REACTOME INACTIVATION OF APC VIA DIRECT INHIBITION OF THE APCOMPLEX | |
| CORUM EMERIN COMPLEX 32 | |
| REACTOME APCDC20 MEDIATED DEGRADATION OF CYCLIN B | |
| TANG SENESCENCE TP53 TARGETS DN | KIF4A, FBXO5, RACGAP1, TTK, LMNB1, PPL, CENPA, SPAG5, NEK2, CCNA2 |
| OUELLET OVARIAN CANCER INVASIVE VS LMP DN | |
| CORUM RNA POLYMERASE II COMPLEX CHROMATIN STRUCTURE MODIFYING | |
| SCIBETTA KDM5B TARGETS DN | |
| NCI REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE | |
| FARMER BREAST CANCER APOCRINE VS BASAL | |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | |
| KEGG PEROXISOME | |
| BENPORATH CYCLING GENES | |
| MORI PLASMA CELL UP | |
| REACTOME ELECTRON TRANSPORT CHAIN | |
| MORI IMMATURE B LYMPHOCYTE DN | |
| GRABARCZYK BCL11B TARGETS UP | |
| STEIN ESRRA TARGETS DN | |
| KEGG OOCYTE MEIOSIS | |
| LEE LIVER CANCER SURVIVAL DN | SET, TTK, NSF, MSH6, CD164, UBE2D1, ARHGAP18, KHDRBS1, VCL, CCNB1, NCBP2, CTBP2, CCNA2, ROD1, CENPF |
| NCI APC CDC20 MEDIATED DEGRADATION OF NEK2A | BUB1B, ANAPC4, MAD2L1, UBE2D1, CDC23, ANAPC1 |
| REACTOME APOPTOTIC EXECUTION PHASE | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| KEGG ADHERENS JUNCTION | |
| FINETTI BREAST CANCER BASAL VS LUMINAL | |
| NCI RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | |
| KAAB FAILED HEART ATRIUM DN | |
| NCI CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | |
| NCI CDC42 PATHWAY | |
| YU MYC TARGETS UP | |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | |
| CROONQUIST IL6 DEPRIVATION DN | |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | CCNE1, KIF20A, LMNB1, TTF2, NCK2, TMEM65, CCNB1, SELM, CCNA2, CENPF, SLC39A10, TTK, RACGAP1, B4GALT5, SGOL2, KIF23, ARHGAP18, WASF1, GPD1L, NEK2, DEPDC1B, ASPM |
| RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY UP | |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN | BUB1B, SGOL2, CDKN2C, ELOVL6, TMPO, TACC3, NEIL3, CCNA2, PPIL2 |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| FINETTI BREAST CANCER KINOME RED | |
| REACTOME RNA POLYMERASE I PROMOTER OPENING | |
| CHANG CYCLING GENES | GMNN, LMNB1, ILF2, KIF23, CDC25C, TSN, CENPA, MELK, TACC3, MBOAT1 |
| REACTOME GENES INVOLVED IN APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | ADD1, STK24, TJP2, LMNB1, CASP6, CLSPN |
| NCI INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX | |
| FARMER BREAST CANCER CLUSTER 2 | |
| NCI ARF6 TRAFFICKINGPATHWAY | |
| NCI LEUCINE CATABOLISM | |
| REACTOME PHOSPHORYLATION OF THE APC | UBE2D1, ANAPC1, CCNB1 |
| BENPORATH PROLIFERATION | |
| KANG CISPLATIN RESISTANCE DN | |