| Gene Set | Leading Edge Genes |
|---|
| PUJANA CHEK2 PCC NETWORK | RFC3, PCNA, SYK, HMGCR, POLE3, DLEU1, MYBPH, TMPO, BRCA1, MRPL3, EXO1, PARP2, RFC5, PPP2R5E, GINS1, MCM3, ATP5S, GMPS, CDKN2C, CDT1, MCM6, NUP88, PPP2R5C, WDHD1, WDR68, CENPI, CAD, SKP2, BARD1, SMC1A, CSE1L, RANBP9, DNMT1, CD1E, PPIG, UNG, DNAJC9, MRE11A, ARID1A, SMC4, USP1, KIF2C, HMGB2, RAD1, SEPHS1, CEP110, RAD51C, CCNB1, ARHGAP19, TOPBP1, TOP2A, CENPF, CNOT1, FEN1, PVALB, CDC23, WEE1, KIF14, CASP2, DDX46, BUB1B, KIAA0196, CENPC1, TIMELESS, LMNB1, C12ORF24, NUP210, SPAG5, MPHOSPH9, PLK4, RRM1, RFC4, OIP5, HMMR, PSIP1, TTK, MSH6, POLE2, POT1, ACLY |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | PCNA, INTS8, MLF1IP, STMN1, TCF12, SLC35E3, MRPL3, E2F8, NCAPG, SHCBP1, TOP2A, EPRS, NUSAP1, GMPS, TMEM135, MCM6, BLNK, RAD51, GBE1, BUB1B, TMEM97, GGH, LTA4H, FXR1, SMC1A, CAT, BARD1, RRM1, RFC4, TBC1D4, HMMR, PSIP1, DTL, PCMT1, GMNN, RACGAP1, TTK, PIN4, UNG, HADH, NUP37, POLE2, ANP32A, C18ORF10, WDR61, FANCL, PRC1, C14ORF147, KIF15, ANP32B, RBMX, BIRC5, PRIM1 |
| ZHANG BREAST CANCER PROGENITORS UP | PHF17, ACTR6, CRYZ, TMPO, DCK, BMI1, CETN3, CDC40, BRCA1, MRPS33, STMN1, LPHN3, PSAT1, PBK, SHCBP1, NCAPG, UCHL5, TOP2A, TOPBP1, CENPF, ADH5, ACTL6A, RBBP8, TRIM37, NCAPD3, WEE1, ING3, BUB1B, PCM1, NVL, ATAD2, SKP2, POLD3, HELLS, VDAC3, NUP155, PATZ1, SHMT1, SEPHS2, PCMTD2, GMNN, TCEA1, APPBP2, UNG, ADK, DNAJC9, USP1, SMC4, KIF2C, PRIM1, PKP4, HMGB2 |
| CAIRO HEPATOBLASTOMA CLASSES UP | TMPO, CENPA, PBK, NCAPG, FASTKD1, GINS1, EPRS, MCM3, KIAA1797, CDT1, MCM6, CREB3L2, HDHD1A, TMEM97, CENPI, CAD, SKP2, MKI67, DNMT1, DTL, MAZ, TPX2, C18ORF10, DNAJC9, MRE11A, PDCD4, C14ORF166, ODF2, KIF15, SMC4, KIF2C, CENPQ, HMGB2, BIRC5, KIF20A, CCNB1, MCM10, TOP2A, CENPF, NUSAP1, KIF14, ASPM, PCM1, BUB1B, TIMELESS, FXR1, LTA4H, C12ORF24, SSR3, TDP1, NUP210, SPAG5, RFC4, HMMR, OIP5, KIF4A, TTK, CCNB2, PTDSS1, MSH6, CDC25C, PMS1, TBL2, PRC1 |
| BLUM RESPONSE TO SALIRASIB DN | KIF20A, RFC3, PCNA, TOP2B, TMPO, BRCA1, CENPA, PBK, EXO1, NCAPG, TOP2A, TOPBP1, RFC5, CENPF, NUSAP1, MCM3, FEN1, ADCY9, CDKN2C, MCM6, VAV3, BUB1B, PXMP2, ACACA, TIMELESS, H2AFZ, RAB40B, VDAC3, SPAG5, CD37, PLK4, RBBP7, SMC1A, BARD1, CSE1L, RRM1, RFC4, SHMT1, HMMR, DNMT1, KIF4A, SMARCE1, ANKH, TTK, GMNN, MSH6, NUP50, CDC25C, POLE2, UBE2E3, DGCR2, MRE11A, ACLY, PRC1, USP1, SMC4, KIF15, PRIM1 |
| KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION | BCKDHA, EHHADH, IVD, MCCC1, HADH, ABAT |
| WILCOX PRESPONSE TO ROGESTERONE UP | KIF20A, TMEM97, CEP76, HMGCR, CCNB1, TBCCD1, PBK, SHMT1, SHCBP1, NCAPG, HMMR, TOP2A, CENPF, KIF4A, SC4MOL, NUSAP1, CDKN2C, IDH1, METTL7A, BBS10, PRC1, WDHD1, CENPQ, HMGB2, ASPM |
| MITSIADES RESPONSE TO APLIDIN DN | TMEM97, SYK, CASP6, RSRC1, NUP210, NUCKS1, CCNB1, POLQ, CSE1L, RRM1, MCAM, RFC4, SHCBP1, NF2, ARHGAP19, TOP2A, TOPBP1, CENPF, KIF4A, GINS1, EPRS, NUSAP1, MSH6, NUP50, CDT1, PIK3CB, WEE1, KIF14, ASPM |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | PCNA, IGF2BP3, SEPHS1, PSAT1, MCM10, MTIF2, E2F8, SHCBP1, NCAPG, EXO1, TOP2A, CENPF, GINS1, NUSAP1, CDKN2C, CDT1, NCAPD3, KIF14, MCM6, NEIL3, WDHD1, ASPM, BUB1B, ATAD2, CAD, GGH, LMNB1, C12ORF24, GPR19, NUP210, SPAG5, MPHOSPH9, RFC4, HMMR, OIP5, KIF4A, DTL, C12ORF48, MSH6, CDC25C, DEPDC1, POLE2, KIF15, PRIM1, HMGB2 |
| WONG EMBRYONIC STEM CELL CORE | BUB1B, KIF20A, PCNA, LMNB1, SPAG5, PLK4, IPO9, EXO1, SEPHS2, TOP2A, ADH5, DNMT1, KIF4A, NCAPH, DTL, CCNB2, TTK, NUSAP1, MCM3, RACGAP1, GMNN, HADH, POLE2, WEE1, SMC4, WDHD1, PRIM1, BIRC5, HMGB2 |
| VANTVEER BREAST CANCER METASTASIS DN | GGH, ATAD2, INTS7, CENPA, STMN1, ORC6L, RFC4, DTL, NUSAP1, PTDSS1, GMPS, DEPDC1, KIF14, MCM6, PRC1, GBE1, SMC4, ASPM |
| MISSIAGLIA REGULATED BY METHYLATION DN | BUB1B, LMNB1, CAD, TMPO, CSE1L, RRM1, RFC4, SHMT1, DNMT1, CENPF, PSIP1, GMNN, NUSAP1, MSH6, LANCL1, CDKN2C, CDT1, CDC25C, MDC1, KIF14, PRIM1, HMGB2 |
| HORIUCHI WTAP TARGETS DN | KIF20A, SEPHS1, HMGCR, CASC5, TMPO, NUCKS1, CCNB1, CENPA, PBK, NCAPG, TOP2A, RFC5, NUSAP1, SMAD5, KIF14, ING3, ASPM, BUB1B, TMEM97, LMNB1, SPAG5, RRM1, SHMT1, HMMR, OIP5, KIF4A, GMNN, RACGAP1, TTK, UNG, DEPDC1, PRC1, HMGB2 |
| SLEBOS HEAD AND NECK CANCER WITH HPV UP | GTPBP8, CDKN2C, MLH1, WEE1, NUP210, TBCCD1, MCM6, DNAJC13, RMI1, EHHADH, RFC4, USP1, KIF15, TOPBP1, SYCP2 |
| KOBAYASHI EGFR SIGNALING 24HR DN | RFC3, PCNA, TMPO, CCNB1, BRCA1, CENPA, RMI1, PSAT1, PBK, MCM10, E2F8, SHCBP1, EXO1, PARP2, NCAPG, TOP2A, RFC5, NCAPH, GINS1, NUSAP1, MCM3, FEN1, CDT1, NCAPD3, KIF14, MCM6, ASPM, BUB1B, LMNB1, TIMELESS, ATAD2, C12ORF24, SPAG5, PLK4, BARD1, CSE1L, RRM1, RFC4, HMMR, KIF4A, DTL, TTK, RACGAP1, GMNN, MSH6, TPX2, DEPDC1, UNG, POLE2, DNAJC9, PRC1, USP1, SMC4, KIF15, PRIM1, HMGB2 |
| MANALO HYPOXIA DN | RFC3, CAD, NVL, FANCG, BRCA1, MPHOSPH9, CSE1L, BARD1, RRM1, MCM10, SHCBP1, PARP2, EXO1, OIP5, RFC5, GINS1, NUSAP1, MCM3, C12ORF48, GMNN, FEN1, RPL39L, POLE2, NCAPD3, DNAJC9, MCM6, GPD1L, C1ORF112, USP1, NIF3L1 |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | RFC3, KIAA0406, POLE3, TMPO, CENPA, POLQ, MRPL3, PHTF2, PARP2, FASTKD1, GINS1, NUSAP1, MCM3, FEN1, MCM6, NIF3L1, ASPM, ACACA, CAD, TIMELESS, H2AFZ, BARD1, CSE1L, HPS1, DTL, KIF4A, RACGAP1, TTK, MSH6, DEPDC1, PMS1, CDCP1, DNAJC9, PRC1, USP1, SMC4 |
| PUJANA BRCA CENTERED NETWORK | RFC3, PCNA, LMNB1, TIMELESS, TMPO, BRCA1, RRM1, RFC4, HMMR, TOPBP1, TOP2A, DNMT1, UNG, MCM6, MRE11A, PPP2R5C, HMGB2 |
| PUJANA BREAST CANCER WITH BRCA1 MUTATED UP | RFC3, CAD, CDKN2C, CDC7, CENPA, STMN1, MCM6, MRE11A, RFC4, SMC4, USP1, HMMR, TOPBP1, DNMT1 |
| REACTOME CELL CYCLE MITOTIC | KIF20A, RFC3, CEP76, PCNA, CEP110, CASC5, CCNB1, CDC7, CENPA, MCM10, ORC6L, TSGA14, RFC5, CENPF, NUP85, GINS1, MCM3, FEN1, CDC23, CDT1, WEE1, ANAPC1, MCM6, ZW10, PPP2R5C, BUB1B, PCM1, CDK5RAP2, CENPC1, CENPI, SKP2, POLD3, TUBGCP5, AZI1, PLK4, SMC1A, RFC4, SMC3, GMNN, CDC25C, NUP37, POLE2, RPA1, ODF2, TUBGCP3, KIF2C, CENPQ, NDE1, PRIM1, BIRC5 |
| LEE EARLY T LYMPHOCYTE UP | BUB1B, KIF20A, SYK, GGH, MKI67, CCNB1, CENPA, PBK, E2F8, NCAPG, OIP5, HMMR, TOP2A, CD1E, DTL, GINS1, CCNB2, TTK, NUSAP1, PRC1, KIF15, NEIL3, KIF2C, BIRC5, ASPM |
| ODONNELL TARGETS OF MYC AND TFRC DN | ACACA, BUB1B, DEPDC1, POLE2, CCNB1, HELLS, PLK4, FOXM1, AURKA, MYNN, TOP2A, CENPF, RAD1 |
| BOYAULT LIVER CANCER SUBCLASS G23 UP | KIF4A, BUB1B, MCM3, FEN1, IGF2BP3, H2AFZ, CENPA, MCM6, XK, RRM1, USP1, OIP5 |
| WINNEPENNINCKX MELANOMA METASTASIS UP | ZNF587, PCNA, ATAD2, TIMELESS, RSRC1, C12ORF24, SSR3, CCNB1, SPAG5, CENPA, RFC4, SHCBP1, NCAPG, EXO1, TOP2A, RFC5, CENPF, NCAPH, C12ORF48, GMNN, RACGAP1, MSH6, GMPS, MCM6, PRC1, NEIL3, KIF2C, RBMX, BIRC5, ASPM |
| TOYOTA TARGETS OF MIR34B AND MIR34C | RFC3, PHF17, CCNB1, SACM1L, SHCBP1, PHTF2, LMAN2L, ARHGAP19, C14ORF106, CENPF, NUSAP1, MCM3, C19ORF42, FEN1, WEE1, KIF14, MOSC1, TMEM97, LMNB1, GPR19, NUP210, ZNF551, PASK, MPHOSPH9, SHMT1, MYST2, CLSPN, KIF4A, PSIP1, DTL, C12ORF48, CSPP1, UNG, ARID1A, MRE11A, SETD2, KIF15 |
| REACTOME MITOTIC M M G1 PHASES | BUB1B, KIF20A, CENPI, CENPC1, CASC5, PPP1CC, CENPA, ORC6L, SMC3, CENPF, MCM3, GMNN, MCM5, CDT1, NUP37, MCM6, ZW10, NUP43, PPP2R5C, CENPQ, KIF2C, NDE1, BIRC5, CENPM |
| SONG TARGETS OF IE86 CMV PROTEIN | RFC3, MCM3, PCNA, DLEU1, CDT1, UNG, POLD3, RAD51C, MCM6, BARD1, RRM1, TOPBP1, HMGB2 |
| LI WILMS TUMOR VS FETAL KIDNEY 1 DN | BUB1B, PCNA, LMNB1, TIMELESS, POLE3, C12ORF24, BRCA1, SPAG5, MPHOSPH9, PLK4, TOPBP1, TOP2A, RFC5, CENPF, TTK, MSH6, CDC25C, UNG, DNAJC9, KIF14, MCM6, CIT, SMC4, KIF2C, PRIM1 |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | KIF4A, DTL, NCAPH, KIF20A, MYBL1, CDKN2C, TPX2, CASC5, POLD3, AURKA, RFC5, KIF2C, CENPF |
| ZHAN MULTIPLE MYELOMA PR UP | RACGAP1, NUSAP1, TTK, CCNB1, KIF14, AURKA, FOXM1, MCM10, E2F8, PRC1, RFC4, TOP2A, ASPM |
| ODONNELL TFRC TARGETS DN | ACACA, KIF20A, CCNB1, CENPA, PLK4, SHCBP1, HMMR, TOP2A, CENPF, NCAPH, KIF4A, TTK, DEPDC1, POLE2, KIF14, PRC1, ASPM |
| REACTOME G2 M TRANSITION | PCM1, CEP76, CDK5RAP2, CEP110, TUBGCP5, CCNB1, CEP250, AZI1, PLK4, TSGA14, CCNB2, CEP57, CDC25C, WEE1, PCNT, ODF2, CEP152, TUBGCP3, NDE1 |
| KAUFFMANN MELANOMA RELAPSE UP | MCM3, GMNN, PCNA, MSH6, BRCA1, FANCG, POLQ, MCM6, ORC6L, RFC4, EXO1, NEIL3, TOP2A, CENPF |
| PYEON HPV POSITIVE TUMORS UP | SYK, ATAD2, INTS7, HELLS, CDC7, MPHOSPH9, BARD1, C3ORF63, CENPF, PSIP1, DTL, MCM3, CDKN2C, NOTCH1, CCHCR1, USP1, KIF15, SYCP2 |
| NCI ACTIVATION OF THE PRE REPLICATIVE COMPLEX | MCM6, MCM3, MCM10, ORC6L, CDT1, POLE2, PRIM1 |
| YU MYC TARGETS UP | DTL, CDKN3, KIF20A, GMNN, RACGAP1, PCNA, CCNB1, CKS2, AURKA, E2F8, UCHL5, TOP2A, ASPM |
| REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | MCM6, MCM3, MCM10, CDT1, POLE2, PRIM1 |
| CHANG CYCLING GENES | KIAA0101, GMNN, LMNB1, CDC25C, CENPA, CKS2, FOXM1, AURKA, PBK, TACC3, USP1, TOP2A, CENPQ |
| FUJII YBX1 TARGETS DN | RFC3, LMNB1, ATAD2, BRCA1, MCM10, RFC4, SHCBP1, BAG2, KIF4A, DTL, NUSAP1, MCM3, FEN1, CDC23, CDT1, CDC25C, UNG, POLE2, MCM6, CASP2, NEIL3, PRIM1, ASPM |
| REACTOME CELL CYCLE CHECKPOINTS | |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | CASC5, CCNB1, CENPF, SPAG5 |
| NCI AURORA B PATHWAY | |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | |
| REACTOME CENTROSOME MATURATION | |
| REACTOME PEROXISOMAL LIPID METABOLISM | |
| CORUM SWI-SNF CHROMATIN REMODELING-RELATED-BRCA1 COMPLEX | SMARCE1, ACTL6A, ARID1A, BRCA1 |
| MARKEY RB1 ACUTE LOF DN | |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | |
| KEGG DNA REPLICATION | |
| ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN | |
| NCI MITOTIC PROMETAPHASE | CENPC1, CASC5, ZWINT, NUP37, CENPA, SMC1A, STAG1, SMC3, XPO1 |
| KEGG MISMATCH REPAIR | |
| CORUM BRM-SIN3A COMPLEX | SMARCE1, ACTL6A, ARID1A |
| CORUM BRCA1-IRIS-PRE-REPLICATION COMPLEX | |
| REACTOME DNA REPAIR | |
| CORUM BRG1-ASSOCIATED COMPLEX I | SMARCE1, ACTL6A, ARID1A |
| TANG SENESCENCE TP53 TARGETS DN | KIF4A, TTK, RACGAP1, LMNB1, CENPA, SPAG5, MRE11A, PRC1, TOP2A |
| KAUFFMANN DNA REPAIR GENES | |
| PYEON CANCER HEAD AND NECK VS CERVICAL UP | ENOSF1, LMNB1, ATAD2, CASC5, TMPO, INTS7, NUP210, RMI1, E2F8, TOPBP1, OSBPL11, CENPF, DTL, GINS1, PSIP1, MCM3, ZNF236, XK, KIF15, SMC4, WDHD1, KLHL2 |
| GEORGES TARGETS OF MIR192 AND MIR215 | |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | |
| WU APOPTOSIS BY CDKN1A VIA TP53 | MCM3, RACGAP1, ATAD2, TPX2, NCAPD3, CCNB1, PBK, PRC1, PARP2, NCAPG, EXO1, C14ORF106, ASPM, HMGB2 |
| BENPORATH CYCLING GENES | |
| MORI IMMATURE B LYMPHOCYTE DN | |
| KAUFFMANN DNA REPLICATION GENES | |
| WAKASUGI HAVE ZNF143 BINDING SITES | |
| REACTOME MITOTIC PROMETAPHASE | CENPC1, CASC5, ZWINT, NUP37, CENPA, SMC3, PPP2R5C, CENPF |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| CORUM BRM-SIN3A-HDAC COMPLEX | SMARCE1, ACTL6A, ARID1A |
| NCI RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | |
| CORUM BRG1-SIN3A COMPLEX | SMARCE1, ACTL6A, ARID1A |
| MORI MATURE B LYMPHOCYTE DN | |
| BIDUS METASTASIS UP | |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | PSIP1, C12ORF48, GMNN, NUSAP1, LMNB1, ATAD2, TMPO, POLE2, BRCA1, GIT2, NCAPG, KIF15, TOP2A, WDHD1, CENPF, HMGB2 |
| EGUCHI CELL CYCLE RB1 TARGETS | |
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | KIF20A, LMNB1, CCNB1, PBK, E2F8, RFC4, SHCBP1, OIP5, TOP2A, CENPF, KIF4A, DTL, RACGAP1, TTK, NUSAP1, DEPDC1, GALNT7, KIF14, GPD1L, PRC1, HMGB2, ASPM |
| REACTOME G1 S TRANSITION | |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| KALMA E2F1 TARGETS | |
| CORUM BRM-ASSOCIATED COMPLEX | SMARCE1, ACTL6A, ARID1A |