| Gene Set | Leading Edge Genes |
|---|
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | RFC3, ESPL1, PCNA, POLE3, RBBP4, SLC1A4, TMPO, BRCA1, CENPA, PSAT1, E2F8, OXCT1, CDCA3, BOLA1, TYMS, FTSJ2, MCM3, EIF4EBP1, MCM5, COPS3, CHEK1, ACYP1, GMCL1, RNASEH2A, TK1, LIAS, KIF2A, TMEM97, KIF11, ATAD2, SKP2, MCM2, ZWILCH, ASRGL1, TMEM48, RUVBL1, NFYB, MCM4, DTL, MAZ, KIF18A, XPO7, SFRS1, GTF2A2, DNAJC9, GPSM2, RPA1, KIF15, MRPL48, BIRC5, PKP4, PHF17, ZWINT, DCK, PLK1, CCNB1, NARS2, CCDC99, SMC2, ASF1B, HTATSF1, MCM10, ORC5L, NAP1L4, SIP1, STAU2, CEP152, ACN9, KNTC1, BUB1B, MAD2L1, TPRKB, PHF20L1, PLK4, ITGB3BP, RFC4, HMMR, PRKDC, SNRPA, TTK, TUBG1, CCNB2, MSH6, CCNE2, CACYBP, POLE2, NET1, ARMC1, ADSS, PRIM1, POLR3F |
| PUJANA CHEK2 PCC NETWORK | RFC3, ESPL1, PCNA, POLE3, RBBP4, FXN, ZWINT, SLC1A4, TMPO, PLK1, DCK, BRCA1, CCNB1, CENPA, IARS2, MRPL3, SMC2, SLBP, FTSJ1, ORC5L, COX11, TOPBP1, ICT1, POLR2G, TYMS, OGG1, ACTL6A, MCM3, METAP1, RECQL4, GMPS, MTX2, COPS3, CHEK1, RNASEH2A, KNTC1, KIF11, CAD, AGL, CENPI, MAD2L1, SKP2, TAF5L, PLK4, CSE1L, ITGB3BP, MPHOSPH6, RFC4, RUVBL1, RPA3, CCNA2, DUT, TTK, PCMT1, CCNB2, MSH6, POLR3G, UNG, CCNE2, SFRS1, POLE2, DNAJC9, RCN2 |
| BLUM RESPONSE TO SALIRASIB DN | RFC3, ESPL1, PCNA, NME4, ZWINT, TMPO, PLK1, DCK, BRCA1, CENPA, SMC2, SFRS6, PBK, TOPBP1, HSPA14, TYMS, ABCD3, GAMT, MCM3, ADCY9, RECQL4, MCM5, CHEK1, RAB4A, TK1, RNASEH2A, SLC25A10, BUB1B, KIF11, MAD2L1, SKP2, MCM2, VDAC3, RAB40B, RBBP7, PLK4, ITGB3BP, NFYB, RFC4, RPA3, HMMR, PRKDC, CCNA2, DUT, CCNB2, TUBG1, TTK, MSH6, SFRS1, CCNE2, POLE2, UBE2E3, MRE11A, GPSM2, RPA1, KIF15, FASN, PRIM1 |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | PCNA, ZWINT, DCK, CCNB1, CENPA, SMC2, PBK, PSAT1, MCM10, E2F8, SHCBP1, CDCA3, TYMS, EIF4EBP1, RECQL4, MCM5, CHEK1, TK1, WDR62, KNTC1, SLC25A10, KIF2A, CENPI, ATAD2, KIF11, CAD, MAD2L1, TPRKB, PLK4, RFC4, HMMR, PRKDC, CCNA2, MCM4, DTL, PCMT1, CCNB2, KIF18A, TUBG1, TTK, MSH6, CCNE2, POLE2, DNAJC9, GPSM2, KIF15, XRCC3, BIRC5 |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | PCNA, MLF1IP, ZWINT, MRPS33, IARS2, SMC2, E2F8, OXCT1, COX11, TYMS, EPRS, APEX1, PDCD2, GMPS, MCM5, TMEM14A, RAD51, CHEK1, BUB1B, TMEM97, KIF11, MAD2L1, MCM2, ITGB3BP, RFC4, HMMR, PRKDC, MCM4, DUT, DTL, CCNB2, TTK, UNG, POLE2, RPA1, KIF15, PRIM1, BIRC5 |
| HORIUCHI WTAP TARGETS DN | KIF20A, ESPL1, BUB1, TMPO, PLK1, CCNB1, CENPA, ASF1B, PBK, CDCA3, TYMS, ABCD3, DCXR, LSM4, TK1, DRG2, BUB1B, TMEM97, KIF11, MAD2L1, CNN2, H2AFX, OIP5, HMMR, POLD1, CCNA2, TRIP13, TTK, CCNB2, TSNAX, POLR3G, UNG, FASN, CDCA8, BIRC5 |
| KOBAYASHI EGFR SIGNALING 24HR DN | RFC3, ESPL1, PCNA, ZWINT, TMPO, PLK1, BRCA1, CCNB1, CENPA, CCDC99, SMC2, PBK, ASF1B, PSAT1, MCM10, E2F8, SHCBP1, CDCA3, HSPA14, TYMS, MCM3, MCM5, TK1, RNASEH2A, BUB1B, ATAD2, KIF11, MAD2L1, MCM2, CSE1L, PLK4, ZWILCH, RFC4, HMMR, CCNA2, MCM4, DUT, DTL, TUBG1, TTK, MSH6, UNG, CCNE2, POLE2, DNAJC9, GPSM2, POLR3K, KIF15, BIRC5, PRIM1 |
| WINNEPENNINCKX MELANOMA METASTASIS UP | PCNA, KIF11, ZWINT, CCNB1, CENPA, SMC2, RFC4, SHCBP1, RPA3, TYMS, OGG1, CCNB2, MSH6, GMPS, CHEK1, TK1, KNTC1, BIRC5 |
| ZHANG BREAST CANCER PROGENITORS UP | PHF17, ACTR6, TMPO, DCK, CETN3, BRCA1, MRPS33, LPHN3, SMC2, PBK, PSAT1, SHCBP1, OXCT1, ORC5L, TOPBP1, ACTL6A, ACYP1, CHEK1, NVL, ATAD2, SKP2, MCM2, VDAC3, RPA3, CCNA2, GMNN, UNG, DNAJC9, HISPPD1, GPSM2, POLR3K, RPA1, PCYOX1, PKP4 |
| MARKEY RB1 ACUTE LOF DN | KIF2A, PCNA, KIF11, MAD2L1, TMPO, PLK1, CCNB1, BRCA1, CENPA, SMC2, ALAD, E2F8, RFC4, CCNA2, CDCA3, DTL, CCNB2, DNAJC9, TK1, ZMYND11, BIRC5 |
| BASAKI YBX1 TARGETS UP | ESPL1, ZWINT, PLK1, CCNB1, CENPA, SMC2, PBK, MCM10, SHCBP1, COTL1, CDCA3, TYMS, MCM3, CDK2AP2, PDLIM7, MCM5, CHEK1, TK1, CAD, CENPI, TPRKB, MAD2L1, MCM2, ZWILCH, PRKDC, CCNA2, SAC3D1, MCM4, DTL, CCNB2, UNG, DNAJC9, BIRC5 |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | TMEM97, PCNA, ATAD2, KIF11, MAD2L1, ZWINT, TMPO, PLK1, CCNB1, BRCA1, RBM38, CENPA, PLK4, RBBP7, E2F8, RFC4, ALDH9A1, RPA3, MCM4, SAC3D1, TYMS, CCNB2, MCM5, RNASEH2A, GMCL1, XPOT, BIRC5 |
| MUELLER PLURINET | PCNA, TMPO, STXBP2, CCNB1, MCM10, HSPA14, SIP1, MCM3, APEX1, GMPS, MCM5, COPS3, CHEK1, TK1, BUB1B, CASP6, MCM2, ITGB3BP, RFC4, RUVBL1, HMMR, RPA3, CCNA2, POLD1, MCM4, TRIP13, GMNN, CCNB2, MSH6, UNG, MRE11A, RPA1, BIRC5 |
| LI WILMS TUMOR VS FETAL KIDNEY 1 DN | ESPL1, PCNA, KIF11, POLE3, MAD2L1, BRCA1, PLK4, CACNB3, TOPBP1, CCNB2, TTK, MSH6, UNG, DNAJC9, RNASEH2A, XPOT |
| REACTOME CELL CYCLE MITOTIC | RFC3, PCNA, ZWINT, PLK1, CCNB1, CENPA, MCM10, NUP133, TYMS, MCM3, MCM5, CEP152, KNTC1, BUB1B, KIF2A, CENPI, SKP2, MAD2L1, MCM2, PLK4, ITGB3BP, RFC4, RPA3, CCNA2, MCM4, KIF18A, TUBG1, CCNB2, CCNE2, POLE2, RPA1, BIRC5, PRIM1 |
| BOYAULT LIVER CANCER SUBCLASS G23 UP | SMC2, MCM3, TUBG1, CCNE2, TYMS, CENPA |
| REACTOME DNA REPAIR | OGG1, RFC3, APEX1, PCNA, POLE2, BRCA1, MRE11A, RPA1, RFC4, RPA3, PRKDC, POLR2G |
| BIDUS METASTASIS UP | KIF11, RBBP4, MAD2L1, CCNB1, CENPA, PLK4, PBK, ASF1B, MCM10, RFC4, CCNA2, PRKDC, CCNB2, SFRS1, CHEK1, ZNF318, BIRC5 |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | ACTL6A, DDX18, ACTR6, PEX1, TMEM135, HISPPD1, DHX29, CHEK1, ORC5L, LSM5, TYMS |
| BENPORATH PROLIFERATION | DTL, CCNB2, TTK, MCM3, PCNA, MAD2L1, TMEM14A, CENPA, GPSM2, RFC4, BIRC5, TYMS |
| FERRANDO HOX11 NEIGHBORS | |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | |
| BOYAULT LIVER CANCER SUBCLASS G123 UP | CCNB2, ATAD2, RFC4, TMPO, PRKDC, NT5DC2, SAC3D1 |
| RHODES UNDIFFERENTIATED CANCER | |
| PAL PRMT5 TARGETS UP | |
| ODONNELL TARGETS OF MYC AND TFRC DN | |
| REACTOME NUCLEOTIDE EXCISION REPAIR | ERCC8, PCNA, RPA1, RFC4, RPA3, POLE2, POLR2G |
| NCI VIRAL MESSENGER RNA SYNTHESIS | |
| REACTOME GLOBAL GENOMIC NER | |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | |
| REACTOME TRANSCRIPTION COUPLED NER | PCNA, RPA1, RFC4, RPA3, POLD1, POLE2, POLR2G |
| NCI MITOTIC PROMETAPHASE | |
| LE EGR2 TARGETS UP | |
| KEGG BUTANOATE METABOLISM | |
| NCI UNWINDING OF DNA | |
| CORUM BRG1-ASSOCIATED COMPLEX I | |
| REACTOME SYNTHESIS OF DNA | |
| NCI SYNTHESIS OF DNA | |
| NCI DUAL INCISION REACTION IN TC NER | |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | |
| MORI EMU MYC LYMPHOMA BY ONSET TIME UP | |
| GARCIA TARGETS OF FLI1 AND DAX1 DN | |
| FURUKAWA DUSP6 TARGETS PCI35 DN | |
| BIOCARTA RANMS PATHWAY | |
| NCI SNRNP ASSEMBLY | |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | |
| NCI TRANSCRIPTION COUPLED NER TC NER | |
| REACTOME MITOTIC PROMETAPHASE | BUB1B, KIF18A, KIF2A, CENPI, MAD2L1, ZWINT, PLK1, CENPA, CCDC99, ITGB3BP, ZWILCH, NUP133, KNTC1, NDE1, BIRC5 |
| NCI FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | |
| TOYOTA TARGETS OF MIR34B AND MIR34C | |
| NCI DNA REPLICATION | |
| NCI E2F TRANSCRIPTIONAL TARGETS AT G1 S | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| NCI ACTIVATION OF THE PRE REPLICATIVE COMPLEX | |
| NCI E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | |
| STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN | DTL, PCNA, ATAD2, SKP2, MCM5, MLF1IP, TMPO, MANEA, CCNE2, MCM2, POLE2, MCM10 |
| CORUM BRG1-SIN3A COMPLEX | |
| NCI PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | |
| YU MYC TARGETS UP | DTL, CCNB2, PCNA, E2F8, PLK1, CCNB1, BIRC5 |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | |
| REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | |
| REACTOME S PHASE | |
| REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | |
| KEGG CELL CYCLE | |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| REACTOME DUAL INCISION REACTION IN TC NER | |
| CORUM SRCAP-ASSOCIATED CHROMATIN REMODELING COMPLEX | |
| VANTVEER BREAST CANCER METASTASIS DN | |
| GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN | |
| CORUM BRM-ASSOCIATED COMPLEX | |
| REACTOME MITOTIC M M G1 PHASES | BUB1B, KIF2A, CENPI, MAD2L1, ZWINT, MCM2, PLK1, CENPA, CCDC99, ITGB3BP, ZWILCH, NUP133, ORC5L, MCM4, KIF18A, MCM3, MCM5, KNTC1, BIRC5, NDE1 |
| NCI MRNA SPLICING MINOR PATHWAY | |
| STEIN ESR1 TARGETS | |
| KEGG NUCLEOTIDE EXCISION REPAIR | PCNA, POLE3, RFC4, RPA1, RPA3, POLE2 |