| Gene Set | Leading Edge Genes |
|---|
| RHEIN ALL GLUCOCORTICOID THERAPY DN | PTGDR, SET, SCCPDH, CETN2, MLF1IP, PRDX4, PRPS2, STMN1, BZW2, SPARC, E2F8, ADSL, CANX, TUFM, ING2, MAGED1, RAB13, DPYSL2, ESD, BUB1B, LTA4H, PDLIM1, PPIA, CAT, CCNG1, TBC1D4, ACAA2, MEF2C, PSIP1, CCNB2, RACGAP1, TTK, GMNN, HADH, POLE2, ALDH5A1, GLO1, PRDX3, RPL31, RPA1, MRPS35, ATP5L, BIRC5 |
| HORIUCHI WTAP TARGETS DN | KIF20A, ESPL1, DDX11, SEPHS1, TMPO, NUCKS1, CCNB1, CENPA, CANX, PSRC1, LMNB2, ASPM, BUB1B, PGF, LMNB1, PPIA, ARSB, CNN2, SPAG5, CAT, H2AFX, POLD1, KIF4A, CCNB2, GMNN, RACGAP1, TTK, RPL7A, MBNL1, ACAT2, TPX2, GTSE1, SLC25A5, ST8SIA4, FDFT1, H2AFV, FASN, KIF2C, TROAP, BIRC5 |
| NUYTTEN EZH2 TARGETS DN | SET, LIMD2, TMPO, CENPA, GLT8D1, E2F8, CANX, TMEM19, AUH, INPP5F, RAP2A, ANTXR1, PEBP1, PMF1, ETV4, PTMA, PSRC1, CAD, GNPAT, CLSPN, GMNN, RACGAP1, HP1BP3, TPX2, MBTPS1, IDI1, MRPS35, KIF2C, BIRC5, KIF20A, PCK2, PRPS2, CCNB1, CENPF, METTL7A, RPS4X, CBX7, RPL5, RAB13, ASPM, HMBS, RPS15A, LMNB1, CDK5, CASP6, ABCC5, SPAG5, DDHD2, H2AFX, GALK2, POLD1, HMGB1, SYTL2, KIF4A, TTK, CCNB2, RPL7A, AP2B1, RAD54L, GTSE1, CDC25C, H2AFV, RPS6KA5, NDE1 |
| KEGG PROPANOATE METABOLISM | PCCB, ACAT2, ALDH3A2, ECHS1, HADHA, MUT, SUCLG1, ALDH9A1 |
| KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION | MCCC2, BCKDHA, AUH, ALDH9A1, ACAT2, ACAA2, IVD, HADH |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | DYNLT3, TMPO, PRPS2, PRDX4, CCNB1, STMN1, CENPA, E2F8, CENPF, DBI, TOM1L1, CDKN2C, PEBP1, PXMP4, TK1, GMCL1, DAB2, ANXA4, ARRB2, CKAP2, GNPAT, ALDH9A1, KIF4A, GMNN, RACGAP1, CCNB2, RAD54L, SUCLG1, GLO1, H2AFV, TACC3, KIF2C, BIRC5 |
| MOOTHA FFA OXYDATION | CPT2, CRAT, ACADL, ACAA2, CPT1A, ECHS1, HADH, DECR1 |
| WONG EMBRYONIC STEM CELL CORE | KIF20A, SET, RPS16, CTNNA1, ADSL, ECHS1, RPS8, DPP3, PABPC1, TIMM8B, BUB1B, LMNB1, SPAG5, SEPHS2, POLD1, RPS23, PSMA7, RPS19, KIF4A, GMNN, RACGAP1, TTK, CCNB2, HADH, GTSE1, CCT5, SLC25A5, POLE2, GLO1, NONO, DARS2, EIF4B, PROM1, BIRC5 |
| WILCOX PRESPONSE TO ROGESTERONE UP | KIF20A, CCNB1, IFT74, KLHL24, GALK2, SCD, CENPF, CCNB2, PPL, CDKN2C, ACAT2, METTL7A, IDH1, FDFT1, IDI1, DHCR7, ASPM |
| KEGG PARKINSONS DISEASE | NDUFB3, ATP5O, ATP5A1, GPR37, NDUFA3, UQCRH, COX6B1, ATP5J, ATP5E, PINK1, COX7C, COX6C, NDUFC1 |
| PRAMOONJAGO SOX4 TARGETS DN | KIF20A, PEBP1, CCNB1, MCCC2, PDCD4, CANX, POLD1, ANAPC5, ARRB2, BIRC5 |
| BLUM RESPONSE TO SALIRASIB DN | KIF20A, ESPL1, SEPT9, TMPO, GALNT1, CENPA, MCCC2, CENPF, RGS2, CDKN2C, IRS1, PXMP2, BUB1B, FZD2, CD37, SPAG5, POLD1, HMGB1, SMARCE1, NDUFB3, KIF4A, GMNN, TTK, CCNB2, MSH6, NR2F1, TPX2, CDC25C, POLE2, PRDX3, H2AFV, ACLY, RPA1, FASN, KIF2C |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | MCCC2, BCKDHA, AUH, IVD |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | RPL10, RACGAP1, TTK, PHF17, CDKN2C, CDC25C, CCNB1, NUCKS1, E2F8, TK1, H2AFX, KIF2C, RAMP1 |
| VANTVEER BREAST CANCER ESR1 UP | NPDC1, SCCPDH, CHRD, ABCA3, LRBA, MCCC2, SOX12, CAMLG, HEXIM1, WDR6, SREBF1, GPD1L, ERBB3, LZTFL1, COX6C, ELOVL5, PBX1 |
| REACTOME INFLUENZA LIFE CYCLE | RPL10, RPS11, RPL37A, RPS17, RPS3A, RPS16, CANX, RPL32, NUP85, RPL6, RPL14, RPS4X, RPS2, RPL39, RPL5, RPS8, RPL13A, RPL41, RPS15A, RPLP1, RPL23A, RPS10, RPS5, RPS21, RPS23, RPS19, RPL30, RPL7A, HSPA1B, RPL19, RPL15, RPL31, RPL35A, RPS24, RPL7 |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP | BUB1B, KIF20A, ESPL1, PDLIM1, PRDX4, CCNB1, STMN1, CENPA, E2F8, H2AFX, CENPF, CCNB2, TTK, RACGAP1, GMNN, MICAL2, TPX2, POLE2, TK1, KIF2C, BIRC5, ASPM |
| MITSIADES RESPONSE TO APLIDIN DN | BUB1B, SEPT9, CASP6, RSRC1, NUCKS1, CCNB1, CTNNA1, NF2, CENPF, SCD, MSH6, RAP2A, MBNL1, MAGED1, BIRC5, ASPM |
| LEE EARLY T LYMPHOCYTE UP | BUB1B, KIF20A, SYK, MLF1IP, CCNB1, CENPA, E2F8, HMMR, TFDP2, TTK, CCNB2, PRC1, NEIL3, KIF2C, ASPM, BIRC5 |
| NCI AURORA B PATHWAY | KIF20A, RACGAP1, PEBP1, TACC1, CENPA, STMN1, DES, KIF2C, BIRC5 |
| TANG SENESCENCE TP53 TARGETS DN | KIF4A, TTK, RACGAP1, CCNB2, LMNB1, PPL, CENPA, SPAG5, TK1, BIRC5 |
| CORUM NOP56P-ASSOCIATED PRE-RRNA COMPLEX | RPL10, RPS15A, RPS11, RPL37A, RPL23A, RPLP1, RPS17, RPS3A, RPS16, RPL32, RPS23, EEF1A1, RPL30, RPL7A, RPL19, TUFM, RPL6, SLC25A5, EBNA1BP2, RPL14, RPS2, RPL39, RPL5, RPL15, RPS8, RPL35A, RPL31, RPL13A, RPL7, RPS24 |
| CROONQUIST IL6 DEPRIVATION DN | BUB1B, CCNB2, MYBL2, SEPHS1, TPX2, KIFC1, SPP1, POLE2, CCNB1, SPAG5, CENPA, TK1, HMMR, POLD1, KIF2C |
| MORI LARGE PRE BII LYMPHOCYTE UP | RACGAP1, SMARCC1, TTK, LMNB1, CDKN2C, NUCKS1, CENPA, H2AFV, E2F8, PRC1, H2AFX, ANAPC5, CALM2 |
| ZHAN VARIABLE EARLY DIFFERENTIATION GENES UP | ANXA2 |
| REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | RAC1, PLXNA2, CFL1 |
| REACTOME CELL CYCLE MITOTIC | |
| NAKAYAMA SOFT TISSUE TUMORS PCA2 UP | |
| NCI CENTROSOME MATURATION | |
| MONTERO THYROID CANCER POOR SURVIVAL UP | CCNB2, NUSAP1, PRC1, ASPM, BIRC5, CENPA |
| WHITEFORD PEDIATRIC CANCER MARKERS | |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | KIFC1, CCNB1, CENPF, KIF2C, SPAG5 |
| ODONNELL TARGETS OF MYC AND TFRC DN | BUB1B, POLE2, CENPF, SCD, CCNB1, BIRC5 |
| ZHAN MULTIPLE MYELOMA PR UP | BUB1B, RACGAP1, CCNB2, TTK, TPX2, CCNB1, E2F8, BIRC5, ASPM |
| TIEN INTESTINE PROBIOTICS 6HR UP | |
| REACTOME PEROXISOMAL LIPID METABOLISM | |
| REACTOME CENTROSOME MATURATION | CETN2, CCNB1, PRKACA, ODF2, NUMA1, CEP164, CENPJ, NDE1 |
| CORUM F1F0-ATP SYNTHASE EC 3.6.3.14 MITOCHONDRIAL | |
| ODONNELL TFRC TARGETS DN | BUB1B, KIF20A, CCNB1, CENPA, HMMR, SCD, CENPF, KIF4A, TTK, GTSE1, APBB1, POLE2, PRC1, NRTN, FETUB, SURF1, BIRC5, ASPM |
| CORUM SWI-SNF CHROMATIN REMODELING-RELATED-BRCA1 COMPLEX | SMARCE1, SMARCC1, SMARCA4, SMARCD2 |
| MARKEY RB1 ACUTE LOF DN | |
| NCI LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME | |
| REACTOME G2 M TRANSITION | CCNB2, CETN2, CDC25C, CCNB1, PRKACA, ODF2, NUMA1, NDE1, CENPJ, CEP164 |
| REACTOME METABOLISM OF PROTEINS | RPL10, RPS11, ACTB, RPL37A, RPS17, RPS3A, RPS16, RPL32, FBXW2, EEF1A1, RPL6, RPL14, RPS4X, RPS2, RPL39, RPL5, RPS8, RPL13A, GAS6, RPL41, PABPC1, RPS15A, RPLP1, RPL23A, RPS10, TBCD, RPS21, RPS5, PIGH, RPS23, RPS19, RPL30, RPL7A, RPL19, CCT5, PFDN6, RPL15, EIF4B, RPL31, RPL35A, RPS24, RPL7 |
| CORUM BRG1-SIN3A-HDAC CONTAINING SWI/SNF REMODELING COMPLEX I | |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | |
| CROONQUIST NRAS SIGNALING DN | |
| REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | PRKACA, ODF2, CETN2, NDE1, CEP164, CENPJ |
| KEGG BUTANOATE METABOLISM | |
| CORUM 40S RIBOSOMAL SUBUNIT CYTOPLASMIC | RPS15A, RPS11, RPS17, RPS3A, RPS2, RPS4X, RPS10, RPS8, RPS5, RPS21, RPS16, RPS24, RPS23, RPS19 |
| REACTOME INSULIN SYNTHESIS AND SECRETION | RPL10, RPS11, RPL37A, RPS17, RPS3A, RPN2, RPS16, RPL32, RPL6, RPL14, RPS4X, RPS2, RPL39, RPL5, RPS8, RPL13A, RPL41, RPS15A, RPL23A, RPLP1, RPS10, RPS5, RPS21, RPS23, RPS19, RPL30, SRP9, RPL7A, RPL19, SPCS2, RPL15, RPL35A, RPL31, RPL7, RPS24 |
| CORUM SIN3-ING1B COMPLEX II | |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | BUB1B, KIF20A, ESPL1, LMNB1, CENPI, MLF1IP, TMPO, CCNB1, SPAG5, STMN1, CENPA, E2F8, HMMR, PSMA7, CENPF, KIF4A, CCNB2, TTK, RACGAP1, TPX2, GTSE1, PFDN6, CCT5, H2AFV, PRC1, TROAP, KIF2C, ASPM, BIRC5 |
| CORUM BRM-SIN3A COMPLEX | SMARCE1, SMARCC1, SMARCD2, SMARCD1 |
| SHEPARD CRUSH AND BURN MUTANT DN | |
| CORUM BRG1-ASSOCIATED COMPLEX I | SMARCE1, SMARCC1, SMARCA4, SMARCD2, SMARCD1 |
| JEON SMAD6 TARGETS DN | |
| REACTOME TRANSLATION INITIATION COMPLEX FORMATION | RPS15A, RPS11, RPS17, RPS3A, RPS10, RPS5, RPS21, RPS16, RPS23, RPS19, RPS4X, RPS2, RPS8, EIF4B, RPS24, PABPC1 |
| MOOTHA VOXPHOS | |
| CORUM TRBP CONTAINING COMPLEX DICER RPL7A EIF6 MOV10 AND SUBUNITS OF THE 60S RIBOSOMAL PARTICLE | RPL30, RPL7A, RPL37A, RPLP1, RPL19, RPL14, RPL15, RPL35A, RPL32, RPL7 |
| NCI TRANSLATION INITIATION COMPLEX FORMATION | RPS15A, RPS11, RPS17, RPS3A, RPS10, RPS5, RPS21, RPS16, RPS23, RPS19, RPS4X, RPS2, RPS8, EIF4B, RPS24, PABPC1 |
| BENPORATH CYCLING GENES | |
| FERRANDO T ALL WITH MLL ENL FUSION DN | CSE1L, LMNB1, TFDP2, PLCB2 |
| REACTOME ELECTRON TRANSPORT CHAIN | |
| MORI IMMATURE B LYMPHOCYTE DN | TTK, LMNB1, CDKN2C, CCNB1, CENPA, E2F8, H2AFV, H2AFX |
| MODY HIPPOCAMPUS PRENATAL | EEF1A1, RPS8, RPL30, H2AFV, H2AFX, RPL23A |
| MUELLER PLURINET | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| POMEROY MEDULLOBLASTOMA PROGNOSIS DN | |
| NCI FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | RPS15A, RPS11, RPS17, RPS3A, RPS2, RPS4X, RPS10, RPS8, RPS5, RPS21, RPS16, RPS24, RPS23, RPS19 |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | RPS15A, RPS11, RPS17, RPS3A, RPS2, RPS4X, RPS10, RPS8, RPS5, RPS21, RPS16, RPS24, RPS23, RPS19 |
| NCI LOSS OF NLP FROM MITOTIC CENTROSOMES | |
| CORUM BRM-SIN3A-HDAC COMPLEX | SMARCE1, SMARCC1, SMARCD2, SMARCD1 |
| NCI RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | |
| CORUM BRG1-SIN3A COMPLEX | SMARCE1, SMARCC1, SMARCA4, SMARCD2, SMARCD1 |
| YU MYC TARGETS UP | |
| NCI RIBOSOMAL SCANNING AND START CODON RECOGNITION | RPS15A, RPS11, RPS17, RPS3A, RPS2, RPS4X, RPS10, RPS8, RPS5, RPS21, RPS16, EIF4B, RPS24, RPS23, RPS19 |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | BUB1B, KIF20A, CCNB2, RACGAP1, TTK, LMNB1, CCNB1, GPD1L, ETV4, CKAP4, KIF2C, CENPF, BIRC5, ASPM |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN | BUB1B, ESPL1, E2F8, NEIL3, CDKN2C, TMPO |
| ROSTY CERVICAL CANCER PROLIFERATION CLUSTER | BUB1B, ESPL1, KIF20A, LMNB1, MLF1IP, TMPO, CCNB1, SPAG5, CENPA, E2F8, H2AFX, CENPF, KIF4A, GMNN, CCNB2, TTK, RACGAP1, TPX2, GTSE1, DPP3, KIF2C, BIRC5, ASPM |
| CHANG CYCLING GENES | GMNN, CCNB2, ARL4A, LMNB1, TACC3, PSRC1, CDC25C, CENPA |
| TOMLINS PROSTATE CANCER UP | |
| CHNG MULTIPLE MYELOMA HYPERPLOID UP | RPL7A, RPL4, RPLP1, RPS17, RPL14, RPL15, RPS16, RPL35A, RPL13A, RPL32, RPS15, RPS23, RPS19 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | RPL10, RPS11, RPL37A, RPS17, RPS3A, RPS16, RPL32, RPL6, RPL14, RPS4X, RPS2, RPL39, RPL5, RPS8, RPL13A, RPL41, RPS15A, RPL23A, RPLP1, RPS10, RPS5, RPS21, RPS23, RPS19, RPL30, RPL7A, RPL19, RPL15, RPL31, RPL35A, RPS24, RPL7 |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN | |
| REACTOME TRANSLATION | RPL10, RPS11, RPL37A, RPS17, RPS3A, RPS16, RPL32, EEF1A1, RPL6, RPL14, RPS4X, RPS2, RPL39, RPL5, RPS8, RPL13A, RPL41, PABPC1, RPS15A, RPLP1, RPL23A, RPS10, RPS5, RPS21, RPS23, RPS19, RPL30, RPL7A, RPL19, RPL15, EIF4B, RPL35A, RPL31, RPL7, RPS24 |
| CORUM BRM-ASSOCIATED COMPLEX | SMARCE1, SMARCC1, SMARCD2, SMARCD1 |