| Gene Set | Leading Edge Genes |
|---|
| MOOTHA MITOCHONDRIA | NNT, ATP5I, UQCR, NDUFA3, ACADL, ACADSB, GNAS, NDUFB8, CROT, DAP3, MRPL49, TST, IVD, MRPL28, ATP5O, UQCRC1, MRPL44, MBD3, TUFM, MUT, ECHS1, COX15, BCKDHA, COX6C, MRPL46, ACADVL, DECR1, SLC25A3, CAD, ATP5C1, SARDH, DLAT, ATP5D, OXA1L, DHODH, FARS2, CAT, FPGS, FDX1, ACAA2, GLUD1, MRPS15, TP53, SLC25A1, SLC9A6, NDUFB3, NFKBIL2, ACAT1, SLC25A17, HADH, ALDH2, LARS2, SUCLG1, FDXR, BCKDK, CS, ATP5G3, ACADS, PRDX3, SLC25A13, SLC25A23, COX7C, TOMM34, MPST |
| MOOTHA HUMAN MITODB 6 2002 | NNT, ATP5I, UQCR, NDUFA3, ACADL, ACADSB, NDUFB8, CPT2, DAP3, MRPL49, TST, IVD, GALR3, ATP5O, UQCRC1, MRPL44, MBD3, TUFM, MUT, ECHS1, COX15, ACSL3, BCKDHA, COX6C, MRPL46, ACADVL, DECR1, SLC25A3, ATP5C1, SARDH, DLAT, ATP5D, OXA1L, DHODH, FARS2, SCP2, FPGS, FDX1, ACAA2, GLUD1, MRPS15, SLC25A1, SLC9A6, NDUFB3, NFKBIL2, ACAT1, SLC25A17, ACSL5, HADH, ALDH2, LARS2, SUCLG1, FDXR, BCKDK, CS, ATP5G3, ACADS, PRDX3, SLC25A13, TRAP1, TOMM34, MPST |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | SET, SCCPDH, SMS, CETN2, HSP90AB1, PRDX4, SPARC, E2F8, CANX, CKS1B, TUBB, TKT, PKD2, HSPB1, ISOC1, MPP1, ESD, GPR125, COPS6, VDAC1, PPIA, SCP2, CCNG1, CTBP1, CCND3, RACGAP1, ACAT1, PXDN, PTTG1, HADH, ALDH5A1, GLO1, PRDX3, CSNK2B, RPA1, MRPS35, PFKM, WHSC1, PRPS2, STMN1, ADSL, HMGB3, APEX1, MDH1, PDIA6, TUFM, TMEM14A, ATP5J, BCAP31, MAGED1, BUB1B, RSU1, ATP5C1, MAD2L1, PHYH, CAT, SEPT11, ACAA2, ACADM, PSIP1, TTK, POLE2, ATP5G3, PRDX1, RPL31, KDELR2 |
| TIEN INTESTINE PROBIOTICS 24HR UP | TMEM109, TTF2, ATOX1, CENPA, FBXO3, RDH11, NUP85, DBI, NTAN1, ECHS1, LRPAP1, GM2A, ISOC1, LMNB2, NDUFC1, TPCN1, NDUFA13, TMEM50A, POLR2L, HSBP1, PSMD1, PHB, NUDT15, DNAJA1, HSDL2, RACGAP1, ACAT2, PTTG1, LARS2, TSN, NUP93, ARF3, PLEKHB2, SLC25A13, TARDBP, HIBCH, RPA1, IDI1, DHCR7, KIF20A, FAIM, SNX3, GALNT1, ALAD, FKBP4, ADSL, UTS2, CENPF, GLRX5, ERCC3, MAP3K4, TMEM14A, ATP5J, DDX46, DPP3, TUBB2A, DAB2, MRPL46, EBP, BUB1B, MAD2L1, UBE2D1, CMTM6, MMD, CCND1, LRRC47, ACAA2, PRDX2, CAST, SLC25A1, SLC9A6, NDUFB3, DERA, PSMD2, TUBG1, MSH6, POLE2, ATP5G3, H2AFV, ACLY, HMGCS1 |
| REACTOME ELECTRON TRANSPORT CHAIN | NDUFA13, SDHB, NDUFA3, NDUFB8, NDUFV1, ETFDH, COX5B, NDUFB5, UQCRFS1, NDUFS8, SDHC, NDUFB3, ETFB, UQCRC1, NDUFA9, NDUFS6, UQCRB, COX6B1, COX6A1, NDUFA4, COX7C, COX6C, SDHD, NDUFS3, NDUFB11, NDUFC1, NDUFB10 |
| MOOTHA VOXPHOS | ATP5I, NDUFA3, UQCR, ATP5G2, NDUFB8, NDUFB5, UQCRFS1, NDUFS8, SDHC, UQCRC1, ATP5O, NDUFS6, MBD3, ATP5J2, COX15, COX6B1, ATP5J, ATP5E, COX6C, NDUFS3, NDUFC1, NDUFA13, SDHB, ATP5C1, ATP5D, COX5B, CYB5A, NDUFB3, NFKBIL2, NDUFA9, COX7A2, NDUFA4, ATP5G3, COX7C |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | SET, ILF2, CETN2, HSP90AB1, CHPT1, METRN, DYNLRB1, SH3D19, SPARC, TFIP11, SDF2L1, CANX, GPR98, CKS1B, RAP2A, XRCC6BP1, NANS, COPB2, TSPAN14, UBE4B, NUDT2, ARL2BP, PAPSS1, ZMAT2, SEC24D, FARS2, GNPAT, COL1A1, WDR8, RNF26, CDC20, PSMD6, TEAD2, IDH1, PFDN6, SPCS2, ARF3, TMCO3, SEC61G, PHPT1, RPA1, IDI1, HIST2H2BE, TFG, SEC61B, ELOVL6, COPE, KATNB1, NRAS, EPHX1, PEA15, NCBP2, NUP133, APEX1, PDIA6, TMEM14A, STXBP6, ALG14, DDX46, GNG11, SURF1, TDRD7, CDK5, BBX, OXA1L, MIF4GD, PIGM, CKAP4, MAPRE1, DNAJB11, NDUFB3, SLC9A6, PSMD2, MSH6, PARP1, PURA, ZMPSTE24, MRPS21, TUBB2C, DARS2, ACLY, DIRC2 |
| REACTOME INTEGRATION OF ENERGY METABOLISM | NNT, ATP5I, PFKM, NDUFA3, NDUFB8, GNAS, CPT2, SLC2A2, UQCRC1, ATP5O, ATP5A1, ATP5J, COX6B1, TKT, GNG8, GNG11, COX6C, PDK2, NDUFC1, NDUFB10, PPP2R5D, ADCY5, NDUFA13, ATP5C1, DLAT, ATP5D, RAPGEF3, PRKACA, NDUFB3, SLC25A5, SUCLG1, CS, NDUFA4, ACLY, COX7C, FASN, STK11 |
| KEGG ALZHEIMERS DISEASE | CDK5, ATP5C1, CALM3, NDUFA3, ATP5D, ATP5G2, NDUFB8, CASP3, CAPN2, MAPK3, ADAM10, PLCB3, UQCRFS1, NDUFS8, LRP1, NDUFB3, ATP5O, ATP5A1, APH1A, COX6B1, CASP9, ATP5J, NDUFA4, ATP5E, ATP5G3, IDE, COX7C, COX6C, NDUFC1, NDUFB10 |
| WONG EMBRYONIC STEM CELL CORE | KIF20A, SET, CBX3, ELOVL6, NLN, NDUFB8, NTHL1, DAP3, NCBP2, SS18, CDCA3, CKS1B, ATP5O, APEX1, PSMB5, UGDH, ECHS1, PDIA4, NIPSNAP1, DPP3, ZNF22, LSM2, NDUFB10, CHEK2, LMNB1, MAD2L1, CKAP2, DLAT, PSMA5, PSMB6, CCND1, CCNF, PHB, TP53, LYPLA1, KIF4A, RACGAP1, PARP1, TEAD2, HADH, POLE2, GLO1, NEK2, DARS2, NT5DC2 |
| KEGG PARKINSONS DISEASE | ATP5C1, NDUFA3, ATP5D, ATP5G2, NDUFB8, VDAC1, CASP3, UBE2G1, NDUFS8, UQCRFS1, NDUFB3, ATP5O, ATP5A1, ATP5J, CASP9, COX6B1, ATP5E, NDUFA4, ATP5G3, COX7C, COX6C, NDUFB10, NDUFC1 |
| KEGG PROPANOATE METABOLISM | ACAT1, MCEE, PCCB, ACAT2, ACSS2, ALDH3A2, ECHS1, HADHA, MUT, ALDH2, ALDH9A1 |
| BORCZUK MALIGNANT MESOTHELIOMA UP | DYNLT3, CBX3, SCCPDH, ILF2, HSP90AB1, PRPS2, PRDX4, SRD5A1, NCBP2, FKBP4, SS18, MRPL28, DBI, CKS1B, ATP5A1, CAPN7, MAGED1, BET1, BUB1B, SLC25A3, MAD2L1, UBE2D1, SEC24D, MAPKAP1, PSMB6, CSNK1D, FSCN1, CCNF, CCNG1, UBE2G1, RAC1, MAPRE1, LYPLA1, SLC25A1, PSMD2, DNAJA1, MSH6, PARP1, CNOT8, TPX2, FADS1, GLO1, H2AFV, SEC61G, DDOST, RPA1, MORF4L2 |
| MITSIADES RESPONSE TO APLIDIN DN | SEPT9, CALM3, MMD, CKAP2, MUM1, TTC3, TEX2, CENPA, LYPLA1, SCD, CENPF, NSDHL, PSMD2, RACGAP1, MSH6, PARP1, TUBB, RAP2A, HADH, PTTG1, NEK2, TACC3, TARDBP, MAGED1 |
| WOO LIVER CANCER RECURRENCE DN | PEMT, SARDH, LDLR, ACADSB, ALDH3A2, ACSL5, ECHS1, CAT, EPHX1, SLC2A9, PAOX, HSD17B4, CSAD, SUOX |
| WILCOX PRESPONSE TO ROGESTERONE UP | TTF2, ELOVL6, SCD, MVK, NSDHL, INSIG1, ACAT2, IDH1, FADS1, DLX4, FDFT1, FADS2, IDI1, HMGCS1, DHCR7, EBP |
| WANG ESOPHAGUS CANCER VS NORMAL DN | NRP1, GJB2, TIAM1, STK38, ARF3, CS, EPHX1, GM2A, IMPA1, RAC1, MOSPD3, SLC9A3R1, CAST, NSDHL |
| MOOTHA FFA OXYDATION | ACADS, CPT2, ACAT1, ACAA2, ACADSB, ACADVL, HADH, DECR1 |
| CAIRO HEPATOBLASTOMA UP | GSTA4, CETN2, ILF2, PFKM, PAPSS1, HSP90AB1, TSPYL4, NUP133, TP53, SCD, NSDHL, RACGAP1, RAP2A, MAP3K4, TSN, BRD3, CS, HSPB1, FDFT1, SMARCA4, ACLY, RPA1, HMGCS1, FASN, CLMN |
| LEE LIVER CANCER E2F1 DN | ALDH1A1, AQP8, IL1RAP, IGF1, DCT, PPCS, KYNU, RARRES1, ELOVL5, DBI, EGFR, ABCG2, ADIPOR2 |
| VANTVEER BREAST CANCER ESR1 UP | FAAH, NPDC1, SCCPDH, CHRD, PCSK6, ABCA3, ACADSB, LRBA, MCCC2, CXXC5, STARD10, CCNG2, GLI3, WDR6, FOXA1, LZTFL1, ERBB3, SREBF1, ESR1, COX6C, HSD17B4, SLC9A3R1, ELOVL5 |
| REACTOME REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA | TBL1XR1, CPT1A, FADS1, SCP2, SREBF1, CPT2, FADS2, FASN, SCD |
| KEGG PEROXISOME | SLC25A17, HACL1, DECR2, ACSL5, ACOX3, IDH1, ACSL3, PXMP4, SCP2, CAT, CROT, PAOX, HSD17B4, ECH1, MVK |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | SET, TMEM109, ACTB, COPE, RPN2, 1500032L24RIK, ADSL, ERCC3, CKS1B, PSMB5, LRPAP1, DDT, DPP3, PCX, 4931406C07RIK, HMBS, GCLM, ARL2BP, 2310003F16RIK, COPS6, PSMB6, CAPN2, ALDH9A1, MRPL36, MRPS15, LYPLA1, TRAM1, BPGM, RNF7, PIAS3, DDOST, CSNK2B, HMGCS1, TRAPPC4, HSD17B4 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | MCCC2, ACAT1, BCKDHA, ACADSB, IVD |
| REACTOME PEROXISOMAL LIPID METABOLISM | HACL1, SLC25A17, ACOX3, IDH1, PHYH, SCP2, CROT, GNPAT, ABCD1, HSD17B4, AGPS |
| SENESE HDAC1 TARGETS DN | BCAM, BTBD2, SET, HCFC1R1, CXXC5, RAC1, GSTM4, TRIM2, CCNG2, LAMB2, EPS8L2, CDC25C, FADS1, SIAE, PKD2, FDFT1, ZNF260, IRS1, EFEMP2, NRBP1, DAB2, MAGED1, GSTM2, MYLK |
| JI RESPONSE TO FSH UP | CLU, FADS1, BRD3, XPC, FDFT1, MVD, FADS2, IDI1, CTNNB1, FASN, CCNG2, EBP |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | ACADS, ACADL, ACADVL, ECHS1, HADH, HADHA, DECR1 |
| RAMASWAMY METASTASIS UP | RAB5C, RMND5B, CAND1, LMNB1, MAD2L1, TRIM37, PTTG1, PFDN6, COX6B1, P4HB, CANX, FASN, COL1A1, RALGPS1 |
| NCI MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS | ACADS, ACADL, ACADM, ECHS1, HADH, HADHA |
| CAFFAREL RESPONSE TO THC DN | SESN1, TMEM109, CALM3, TUBB, DHCR7, EBP |
| KEGG PPAR SIGNALING PATHWAY | ACADL, ACSL5, ACOX3, SORBS1, ACSL3, SCP2, CPT2, FADS2, SCD, DBI |
| REACTOME TRANSFORMATION OF LANOSTEROL TO CHOLESTEROL | HSD17B7, DHCR7, EBP, NSDHL |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 | COL6A1, SPARC, PCOLCE, IDI1, SARDH, DAB2, FADS1, WDR6 |
| KEGG BIOSYNTHESIS OF UNSATURATED FATTY ACIDS | FADS2, ELOVL6, ACOX3, SCD, ELOVL5, FADS1 |
| SENESE HDAC1 AND HDAC2 TARGETS DN | CAV1, SET, ACADL, SPP1, PPP2R2B, SCARA3, SCD, CLU, INSIG1, PCOLCE, SESN3, LRP11, FDFT1, FADS2, IDI1, NEXN, DHCR7, MYLK |
| MORI IMMATURE B LYMPHOCYTE DN | CKS1B, TTK, ENPEP, LMNB1, CENPA, TUBB2C, CKAP5, H2AFV, E2F8, HMGB3, CDCA3 |
| BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR DN | EPHX1, AQP8, IRS1, INSIG1, ADRA1B |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | ATP5O, ATP5A1, ATP5I, ATP5C1, ATP5D, ATP5J2, ATP5J, ATP5E |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | BUB1B, KIF20A, ORMDL2, LMNB1, CENPI, MAD2L1, CENPA, STMN1, C16ORF61, E2F8, MRPL15, HMMR, HMGB3, CENPF, CDCA3, KIF4A, RACGAP1, TTK, CDC20, TPX2, PTTG1, PFDN6, NUP93, NEK2, H2AFV, PRC1, TACC3, CDK2, KIF2C |
| HEIDENBLAD AMPLICON 8Q24 UP | MTA3, ALAD, MYO6, TRAP1, MGAT1, CDC25C, UBE2R2, AHSA1 |
| NCI REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE | CDC20, UBE2D1, CDC23, UBE2C, ANAPC1, CCNB1, ANAPC4, CDK2, ANAPC2, ANAPC5, FZR1 |
| MORI PLASMA CELL UP | BPGM, RRBP1, SPCS3, LMAN1, RPN1, CRELD2, DDOST, GMPPB, NANS, EBP, BET1 |
| NCI FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | ATP5O, ATP5A1, ATP5I, ATP5C1, ATP5D, ATP5J2, ATP5J, ATP5E |
| REACTOME CELL CYCLE MITOTIC | |
| KEGG CITRATE CYCLE TCA CYCLE | |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | |
| WHITEFORD PEDIATRIC CANCER MARKERS | |
| BOYAULT LIVER CANCER SUBCLASS G3 DN | |
| CORUM LARC COMPLEX LCR-ASSOCIATED REMODELING COMPLEX | |
| ZHAN MULTIPLE MYELOMA PR UP | BUB1B, NEK2, RACGAP1, TTK, E2F8, TPX2 |
| ODONNELL TFRC TARGETS DN | BUB1B, CDKN3, KIF20A, FBXL20, WHSC1, KBTBD8, PLK1, CCNB1, CENPA, FANCD2, HMMR, CCNA2, CENPF, SCD, GALT, KIF4A, CKS1B, TTK, CDC20, SGOL2, POLE2, APBB1, ANUBL1, MND1, PRC1, TACC3, CKAP2L, SURF1, FBXL21, BIRC5, ASPM |
| NCI APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | BUB1B, CDC20, MAD2L1, UBE2D1, ANAPC2, CDC23, ANAPC5, ANAPC1 |
| WONG MITOCHONDRIA GENE MODULE | |
| REACTOME GLUCOSE REGULATION OF INSULIN SECRETION | |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | |
| CROONQUIST NRAS SIGNALING DN | |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | |
| REACTOME INACTIVATION OF APC VIA DIRECT INHIBITION OF THE APCOMPLEX | |
| LANDIS ERBB2 BREAST TUMORS 65 DN | |
| JEON SMAD6 TARGETS DN | |
| LE EGR2 TARGETS DN | |
| SCIBETTA KDM5B TARGETS DN | |
| LEE LIVER CANCER SURVIVAL UP | |
| NCI TRANSFORMATION OF LANOSTEROL TO CHOLESTEROL | |
| KEGG HUNTINGTONS DISEASE | |
| NCI APC CDC20 MEDIATED DEGRADATION OF NEK2A | BUB1B, CDC20, MAD2L1, UBE2D1, CDC23, ANAPC1, NEK2, ANAPC2, ANAPC5 |
| DAIRKEE TERT TARGETS UP | |
| NCI GALACTOSE CATABOLISM | |
| NCI CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | |
| TOMLINS PROSTATE CANCER UP | |
| NCI INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX | |
| VANHARANTA UTERINE FIBROID UP | |
| KEGG PYRUVATE METABOLISM | |
| LANDIS ERBB2 BREAST PRENEOPLASTIC DN | |