| Gene Set | Leading Edge Genes |
|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | ERCC8, POLE3, HMGCR, PPP1CC, SLBP, RRAS2, UBE2V2, CREG1, ABCD3, EFHA1, ATP6AP2, AZIN1, GMCL1, RBM3, NBN, COPB2, BNIP3, SDCCAG1, RALA, GNAQ, AGL, UBAP2, TCEB1, MED6, LMAN1, FEM1B, ETNK1, ARF4, CSNK1G3, SSB, KHDRBS1, PPP6C, LIN7C, XPOT, NMT2, MRPS35, ZMYND11, DEGS1, ARFIP1, NUP98, NMD3, BCAT1, TIMM17A, SMC2, MED4, NCBP2, ARCN1, TOPBP1, AMMECR1, TFRC, TCP1, SNX4, EHD1, RAB4A, IPO7, PDHB, EXOC5, CASP6, COPS2, TXNRD1, WSB2, PTGES3, CPOX, EIF2B1, DDX23, UBE2E3, DNAJA2, GTF2H1, HDAC2, IMPA1, EIF1B, SRP19, ABCE1, PPP2CB, ARHGEF3, NOLC1, PRKAR1A, ALG5, BRCA1, YES1, LSM1, MRPS30, CSNK2A1, CHERP, FTSJ2, ACTL6A, GSPT1, GTF2B, PLAA, IFRD1, SUCLA2, CNIH, MAPK1, KIF2A, CLIC4, CUL5, CCT6A, AMD1, SLC16A1, FOXK2, RANBP9, DHX15, GMNN, GCLC, PUS1, KHSRP, PEX1, CYP51A1, CLPX, SDHD, EIF5, DDX21, ANAPC10, SFRS3, NDUFA5, FXN, DBF4, TM2D1, EIF2S2, SEC31A, UCHL5, GAS2, ATP6V1A, RREB1, STAU2, PDCD2, GARS, ETF1, TMEM165, BCKDHB, UBE4A, GBE1, PGRMC2, CRY1, GTPBP4, PSTPIP2, MTR, SNX5, MTMR2, MAD2L1, ORC4L, FSCN1, USP14, NFE2L2, SNRPB2, RSC1A1, MSH6, TSNAX, DCUN1D1, AQP3, PSMD12, TOP1, SLC25A32, PFDN4, CDK8 |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | PRPF40A, POLE3, HSPD1, SLC1A4, TMPO, PVRL3, SLBP, GCH1, STAG1, EIF2C2, AASDHPPT, APBB2, SLC30A5, CHEK1, GMCL1, CUL3, NBN, ISOC1, ARG2, KIF11, NOL7, SKP2, CTPS, TCEB1, MED6, COX4NB, TMEM48, FEM1B, PPP1R2, KIF5B, DTL, ETNK1, TMED2, PPP6C, DNAJC9, CHORDC1, RAP1GAP, NIP7, DCK, GART, ELAC2, SMC2, BAG5, AMMECR1, DDX18, PPIF, TCP1, DDX39, USP10, BRCC3, IPO7, ACN9, EXOC5, UAP1, PHF20L1, HELLS, PPFIA1, THAP1, PTPLAD1, BAG2, ANP32E, EIF2B1, JOSD1, CCNE2, SUV39H2, NUP62, STIP1, METTL8, PLEKHF2, PCNA, MTDH, SFPQ, BRCA1, CSNK2A1, FTSJ2, KRR1, PLAA, IFRD1, GRPEL1, SUCLA2, KIF2A, ATAD2, SLC16A1, BXDC2, RANBP9, TMEM70, SEPT10, SNRPA1, E2F6, DHX15, MCM4, GMNN, KIF18A, MPP5, PUS1, GTF2A2, DDX21, SFRS3, DBF4, NUPL1, PAK2, EIF2S2, MCM10, YRDC, CBS, UCHL5, NAP1L4, CLDN1, NEDD4, NOC3L, MRPL19, STAU2, CAV2, DICER1, ETF1, NR2F2, PTP4A1, CDR2, KNTC1, ZDHHC6, ASF1A, CAPZA2, MAD2L1, IDH3A, ITGB3BP, NFE2L2, MSH6, NUP160, SLC25A32, NET1, ARMC1, UBE3A, POLR3F |
| PUJANA CHEK2 PCC NETWORK | PCNA, MTDH, ABCE1, HMGCR, POLE3, SFPQ, HSPD1, NOLC1, SLC1A4, TMPO, BRCA1, PPP1CC, LSM1, SLBP, HSPE1, CSNK2A1, GCH1, CHERP, ACTL6A, CEBPZ, GTF2B, GSPT1, CHUK, CHEK1, CNIH, NBN, KIF11, AGL, SKP2, CTPS, TCEB1, MED6, SLC16A1, RANBP9, DHX15, SNRPA1, VRK1, SSB, KHSRP, KHDRBS1, DNAJC9, CLPX, RCN2, IARS, DDX21, ANAPC10, RB1, SFRS3, FXN, RBM14, DCK, DBF4, TIMM17A, BCAT1, EIF2S2, SMC2, ELAC2, RBM34, NCBP2, SEC31A, TOPBP1, OGG1, SYNCRIP, LARP5, MRPL19, METAP1, DDX18, TFRC, POLG, TCP1, SNX4, DDX39, KNTC1, ASF1A, MAD2L1, ITGB3BP, TRIM24, ANP32E, SNRPB2, PRMT3, CAPZA1, MSH6, POLR3G, NUP160, PLAGL2, CCNE2, TOP1, GTF2E1, PFDN4, HDAC2, SRP19, NUP62, CDV3 |
| WEI MYCN TARGETS WITH E BOX | DYNLT3, CA2, PRPF40A, VDR, PKNOX1, MTDH, ABCE1, POLE3, SFPQ, NOLC1, RIOK2, CSRP2, MRPS30, EGLN1, LASS6, CHEK1, RABGGTB, GRPEL1, ISOC1, SPCS3, ATAD2, SKP2, CTPS, GOLT1B, ARL5A, CCT6A, AMD1, SLC16A1, TMEM70, MRPS28, PTS, MCM4, GMNN, VRK1, DUSP5, PUS1, MANEA, TIMM50, EIF5, MRPS35, DDX21, RB1, GLIPR1, PHLDA2, NUPL1, TIMM17A, SMC2, ATP2B1, MCM10, NEDD4, SYNCRIP, MRPL19, PMM2, DDX18, PPIF, TFRC, ETF1, SPATA5L1, ZBTB38, CCNE1, CD3EAP, LACTB2, SLC39A2, MAD2L1, UAP1, LPGAT1, CHML, ERGIC2, ATP6V1C1, HELLS, DUSP14, OGFOD1, PTPLAD1, USP14, BAG2, ANP32E, NOL11, PRMT3, POLR3B, PSMD12, CCNE2, SLC25A32, TOP1, ERO1L, POP7, DAPK3, SRP19, STIP1, OPA1 |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | BACE1, ABCE1, MTDH, EREG, SFPQ, ELOVL6, RBM14, ASPH, NOLC1, BCAT1, ATP2B1, VPS33A, EIF2C2, ABLIM1, GNG12, SYNCRIP, NARG1L, PMM2, NIPBL, PPIF, TFRC, ETF1, DUSP9, SCIN, MTR, SDCCAG1, TPM1, IAPP, TXNRD1, CDK6, LRRC59, GCLC, SLC25A32, CDK8, GTF2H1, NARG1, IL1RL1, CCDC93, TAOK1, NMT2 |
| UDAYAKUMAR MED1 TARGETS UP | MTDH, ASPH, TMPO, COX4NB, SLC16A1, FEM1B, GCH1, CBS, EML4, RDH11, DHX15, ANP32E, OGG1, AMMECR1, GARS, POLR3G, CAV2, DICER1, TMED7, TLE6, IPO7, ZMYND11 |
| ELVIDGE HYPOXIA DN | DNAJA1, PUS1, CTPS, PPIF, NUP98, NIP7, IDH3A, ETF1, CHUK, NCLN, TMEM33, AMD1, DHX29, GCH1, CDV3, MAPK1 |
| RAMALHO STEMNESS UP | SEC23A, SFRS3, YES1, SFRS6, PPP1R2, GAS2, ARCN1, BLZF1, TXNRD1, PDCD2, GARS, CHD1, PSMD12, DICER1, USP10, RNF4, XPOT, IARS, ZZZ3 |
| KOBAYASHI EGFR SIGNALING 24HR DN | ABCE1, EREG, NOLC1, TMPO, PHLDA2, DBF4, BRCA1, SMC2, MCM10, SHCBP1, NOC3L, PPIF, DDX39, MAFF, MET, TUBB2A, DUSP4, ATAD2, KIF11, CTPS, MAD2L1, HELLS, SNRPA1, MCM4, IER3, DTL, GMNN, DUSP5, MSH6, PHLDA1, CCNE2, DNAJC9, NARG1 |
| ZHANG BREAST CANCER PROGENITORS UP | SFRS3, MTDH, SFPQ, TMPO, DBF4, BRCA1, TIMM17A, TMEM33, LPHN3, SMC2, TSPAN13, SHCBP1, RNF128, TOPBP1, SYNCRIP, ACTL6A, CAV2, TFRC, TRIM37, UGDH, AZIN1, DSG2, CHEK1, MET, SUCLA2, CPSF6, SNX5, CAPZA2, SLC38A1, ATAD2, SKP2, IDH3A, HELLS, MED6, USP34, ANP32E, SNRPB2, GMNN, DNAJA1, APPBP2, SSB, HISPPD1, DNAJC9, PCYOX1 |
| BORCZUK MALIGNANT MESOTHELIOMA UP | DYNLT3, RALA, SFRS3, KIF11, MAD2L1, LPGAT1, FSCN1, PAK2, NCBP2, RHOBTB3, PPP1R2, KIF5B, WSB2, ACTL6A, DNAJA1, MSH6, DDX18, GARS, CCNE2, MFN1, TMED7, AZIN1, UBE2E3, XPOT, STIP1, IPO7, ZMYND11, RCN2 |
| DORN ADENOVIRUS INFECTION 48HR DN | EPHA2, SERPINB5, TXNRD1, IER3, NFE2L2 |
| TOOKER GEMCITABINE RESISTANCE DN | ANXA3, GPRC5A, LPGAT1, TFRC, TOP1, ATP6V1C1, SH3BP4, CLIC4, AZIN1, TIAM1, XPOT, SMURF2, FHL1 |
| ELVIDGE HIF1A TARGETS UP | DNAJA1, GCH1, CTPS, CHUK, IDH3A, TMEM33 |
| BIDUS METASTASIS UP | DDX21, SEC23A, NFIB, KIF11, MTDH, MAD2L1, SFPQ, DBF4, PAK2, TMEM33, AMD1, NCBP2, MCM10, GMNN, PTGES3, TFRC, KHDRBS1, AZIN1, PTP4A1, ATP6V0A2, CHEK1, RABGGTB, CRY1, CBLL1, MAPK1 |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | ASF1A, TTRAP, PAK1IP1, DBF4, NCLN, SLC33A1, DHX29, FEM1B, DNAJB14, ACTL6A, RSF1, MRPL19, DDX18, PEX1, NADSYN1, TMEM165, HISPPD1, TMEM135, SPATA5L1, PFDN4, MINA, MET, IARS |
| WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP | ABCD3, SEC24A, CA2, SAR1B, RALA, DDAH1, ETNK1, PHLDA2, CYP51A1, SEC22B, SFXN1, RNF128 |
| TOOKER RESPONSE TO BEXAROTENE UP | ANXA3, GPRC5A, LPGAT1, TFRC, TOP1, ATP6V1C1, SH3BP4, CLIC4, AZIN1, TIAM1, XPOT, SMURF2, FHL1 |
| MMS MOUSE LYMPH HIGH 4HRS UP | DCK, PRKAR1A, RCN2, TXNRD1, ATP6V1A |
| ELVIDGE HIF1A AND HIF2A TARGETS UP | GCH1, CHUK, IDH3A |
| DING LUNG CANCER EXPRESSION BY COPY NUMBER | PDCD6, NIPBL, RAE1, TOMM70A, KBTBD11, PPFIA1, MFN1, PAK2, LSM1, CDK8, ARMC1, MRPS28, CBLL1, FBXW11, MAPK8 |
| STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN | DTL, RAI14, PCNA, RAB31, PAPSS2, ATAD2, SKP2, ASPH, TMPO, MANEA, CCNE2, ZWILCH, MCM10 |
| REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | |
| NCI NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | |
| NCI TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON CONTAINING TRANSCRIPT | NXF1, SFRS3, TPR, NUP98, NUP160, NUPL1, SFRS6, SFRS7, RNPS1, NCBP2, RBM8A, NUP62, SFRS11 |
| BOYAULT LIVER CANCER SUBCLASS G123 UP | PEG10, TUFT1, ATAD2, RBM3, ENAH, TMPO, CPSF6 |
| REACTOME NUCLEAR IMPORT OF REV PROTEIN | |
| NCI TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | |
| DORN ADENOVIRUS INFECTION 32HR DN | |
| NCI ERBB NETWORK PATHWAY | |
| DAZARD RESPONSE TO UV SCC UP | |
| NCI VPR MEDIATED NUCLEAR IMPORT OF PICS | |
| LUND SILENCED BY METHYLATION | |
| CHOI ATL CHRONIC VS ACUTE DN | |
| KIM WT1 TARGETS 12HR DN | |
| REACTOME REV MEDIATED NUCLEAR EXPORT OF HIV1 RNA | |
| KEGG GLYCOSYLPHOSPHATIDYLINOSITOL GPI ANCHOR BIOSYNTHESIS | |
| NCI LATE PHASE OF HIV LIFE CYCLE | |
| REACTOME TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA | |
| NCI TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS | |
| TIEN INTESTINE PROBIOTICS 2HR DN | |
| WANG LMO4 TARGETS DN | |
| REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON CONTAINING TRANSCRIPT | NXF1, SFRS3, TPR, NUP98, NUP160, NUPL1, SFRS6, SFRS7, RNPS1, NCBP2, RBM8A, NUP62, SFRS11 |
| GUTIERREZ MULTIPLE MYELOMA DN | |
| NCI TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA | |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | |
| SCHLOSSER SERUM RESPONSE DN | |
| REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | |
| FARMER BREAST CANCER APOCRINE VS BASAL | |
| NCI NUCLEAR IMPORT OF REV PROTEIN | |
| REACTOME MRNA 3 END PROCESSING | |
| GEORGES CELL CYCLE MIR192 TARGETS | |
| NCI TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA | |
| WANG SMARCE1 TARGETS DN | |
| WANG LMO4 TARGETS UP | |
| BROWNE HCMV INFECTION 14HR UP | |
| SIMBULAN UV RESPONSE IMMORTALIZED DN | |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | |
| REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | |
| PUIFFE INVASION INHIBITED BY ASCITES DN | |
| NCI TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | |
| NCI REV MEDIATED NUCLEAR EXPORT OF HIV 1 RNA | |
| BIOCARTA RARRXR PATHWAY | |
| NCI CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | |
| NCI TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | |
| CORUM SPLICEOSOME | |
| NUYTTEN NIPP1 TARGETS DN | |
| AMIT EGF RESPONSE 120 MCF10A | |
| GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN | |
| BIOCARTA CARM1 PATHWAY | |
| SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN | |
| NCI MRNA 3 END PROCESSING | |
| DODD NASOPHARYNGEAL CARCINOMA DN | |
| NCI INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS | |