| Gene Set | Leading Edge Genes |
|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | TARS, PTPLA, POLR2B, MTIF2, EI24, AASDHPPT, TXNL1, ICT1, NDUFA8, POLD2, SLC37A4, ALDH4A1, FECH, ECHS1, CNBP, TERF1, PDHA1, DUSP12, SREBF1, IDE, ACYP1, COPS4, ETFA, COPB2, POLRMT, CAD, AGL, PPM1A, UBTF, TM9SF3, LMAN1, UBE2G1, SEPHS2, ALG3, ETNK1, PRKRA, ITGAE, FKBP3, NDUFB6, GLO1, WDR13, WDR61, PRDX3, ATP5B, HSD17B4, XPOT, PHB2, MRPS35, STK11, PRPSAP2, SREBF2, MEN1, C1QBP, ALAD, NCBP2, SS18, SMARCC2, ARCN1, TMEM59, CTNNBL1, POLR2E, UQCRC1, FNTA, RPS27L, DPAGT1, PPP2R5A, COX15, MPDU1, SSBP1, NIPSNAP1, UROD, NDUFAB1, AK2, ARL1, TLK1, ALDH1A1, DLD, PAICS, ACSL1, COPS2, PHYH, TOMM22, SCARB2, UBE2B, NIT2, MTCH2, CMAS, ATIC, MAP2K2, ACAA2, ACADM, DAG1, EIF2B1, CPOX, PRKD3, ACAD8, ADK, NUDT6, ACOT7, UBE2E3, PGRMC1, MRPS31, UROS, RRAGA, AUP1, PRDX6, MYCBP, BTBD2, NME1, RBBP4, ABCE1, COPS5, ILF2, CETN2, HSP90AB1, ACY1, ELAVL1, NGRN, CCT3, MRPL49, MRPS30, CANX, PSMA3, CYC1, FTSJ2, ATP5O, BLMH, MAP4K5, GSPT1, CPSF1, ECD, SORD, COPS3, SUCLA2, IDH3B, UBE4B, NDUFV2, HRSP12, ABCB6, VPS72, PAPSS1, TEK, SNRPD3, ALDH9A1, SHMT1, NFYB, NQO2, IMMT, HSD17B12, MAN2A2, ACAT1, HP1BP3, TCEA1, PCCB, PUS1, PECI, PEX1, HADHA, ALDH5A1, XRCC5, CBX1, CFDP1, RBM39, EIF5, TFG, PKP4, ERGIC3, SHMT2, SNX3, SEPHS1, NDUFA5, TM2D1, MCCC2, HADHB, STOML2, COMT, NDUFB5, MIF, ORC5L, PCTP, MDH1, LANCL1, SLC29A1, LSS, RAD23B, ST13, PDHX, SLC27A2, GRSF1, MLF2, UBE4A, ZNF22, APEH, HMBS, SOD1, MXI1, SLC25A15, UPF3B, GTF3C3, CCNH, LASS2, RANGAP1, ZFP36L1, ACO2, USP9X, RSC1A1, PSMD2, AQP3, PSMD12, SUCLG1, PMS1, CBARA1, ZMPSTE24, ANP32A, ATP5G3, H2AFV, MIPEP, HMGCS1, QDPR, MPST |
| MOOTHA PGC | GSTO1, MRPS18A, LRBA, VIPR1, HSPE1, CARHSP1, CYC1, ENO1, ICT1, TIMM13, NDUFA8, DBI, ATP5O, TFB2M, MKRN3, SUPV3L1, SKIV2L, GUK1, CDC34, PDHA1, COPS3, ACYP1, EIF4A2, DDT, SUCLA2, DHX16, NDUFC1, TIMM8B, NDUFV2, MRPL4, TIMM44, PSMB7, SHMT1, MRPL15, FDX1, SGTA, MRPL18, ETFB, PUS1, NFIX, NDUFB6, PRDX3, COX7C, IDH2, NDRG2, STARD7, NDUFA5, MRPS34, SDHA, HADHB, COMT, FAM18B, FASTK, UQCRC1, NDUFA6, AES, TUFM, UROD, NDUFAB1, MARS, GRSF1, MRPL34, HCCS, NDUFS3, MRPL13, NFS1, DLD, SDHB, MRPS12, PHYH, RANGAP1, IDH3G, MTCH2, COX5B, RPA3, ACADM, SEPX1, PDXK, MRPS2, NRP1, APBA3, CLPP, SLC25A5, SUCLG1, COX6A1, EEF1A2, ATP5L |
| TIEN INTESTINE PROBIOTICS 24HR UP | NME1, MRPL9, FARP1, POLDIP2, CSRP2, EI24, LMAN2L, HSPE1, FBXO3, AASDHPPT, RDH11, AHSA1, TIMM13, NDUFA8, DBI, EMG1, ECHS1, ENTPD4, ACYP1, SLC36A1, SUCLA2, LMNB2, NDUFC1, TIMM8B, NDUFV2, NDUFA13, POLR2L, ALDH7A1, SNRPD3, CUGBP1, GGA2, PSMB7, PDCD5, DNAJA1, ETNK1, NUDT1, ACAT2, SMYD2, TSN, FKBP3, NDUFB6, WDR61, SLC25A13, IDI1, UMPS, STARD7, DHCR7, SC5DL, SNX3, NDUFA5, C1QBP, UBL5, RAN, ALAD, GLRX5, NDUFA6, DCXR, CYB5B, PDHX, UROD, FBXO9, DDX46, NDUFB2, UBE4A, HCCS, EBP, EXOSC2, PXMP2, MRPL22, CMTM6, MMD, EXOSC7, TFAM, RPA3, ACAA2, PRDX2, CUL2, DERA, PSMD2, MRPS2, TBX3, H2AFV, POLR3K, HMGCS1, QDPR, ATP5L |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | NME1, CLPB, ACY1, CCT3, NTHL1, EI24, HSPE1, COX11, AHSA1, TIMM13, NDUFB7, RHOT2, TFB2M, SUPV3L1, SLC37A4, GSPT1, SORD, PUS7, PMPCA, ATG3, TIMM8B, HRSP12, GPR125, VKORC1, CECR5, SRM, GGA2, PRKACA, TMEM70, PDCD5, CYB5A, ASB13, RPP40, DNAJA1, ACAT1, ALG3, INSIG1, WDR77, PFDN6, ALDH5A1, NSBP1, WDR61, CFDP1, UMPS, TH1L, STK11, PKP4, MPP6, IFRD2, TUSC4, MRPS34, C1QBP, PRPS2, UBL5, NCBP2, LAS1L, FTSJ1, MIF, GLRX5, DCXR, MRP63, NDUFAB1, DDX46, GRSF1, CWF19L1, MRPL16, NDUFS3, TRMU, EBP, SLC19A2, PEMT, UAP1, ATP5D, EXOSC7, MRPS12, RANGAP1, RFK, MTCH2, TFAM, ARD1A, RSC1A1, SLC25A30, WDR74, SNRPN, ACOT7, GCAT, MIPEP, QDPR, STIP1, ENDOG |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | MMACHC, ACADSB, CHCHD7, CCT3, NTHL1, EI24, CBX5, HSPE1, COX11, AHSA1, TIMM13, NDUFB7, RHOT2, TFB2M, SLC37A4, GSPT1, SORD, PUS7, PMPCA, CD81, NDUFC1, ATG3, TIMM8B, HRSP12, VKORC1, MRPL4, CECR5, SRM, GGA2, PRKACA, TMEM70, PDCD5, CYB5A, ASB13, DNAJA1, ALG3, INSIG1, WDR77, PFDN6, ALDH5A1, SMYD2, CFDP1, UMPS, TH1L, STK11, MPP6, TUSC4, MRPS34, C1QBP, PRPS2, UBL5, NCBP2, LAS1L, MIF, GLRX5, DCXR, MRP63, GRSF1, CWF19L1, MRPL16, NDUFS3, TRMU, EBP, SLC19A2, PEMT, UAP1, EXOSC7, MRPS12, RANGAP1, RFK, MTCH2, TFAM, ARD1A, RSC1A1, SLC25A30, WDR74, ACOT7, SNRPN, GCAT, QDPR, STIP1, ENDOG |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | ARPC5L, TXNDC14, MRPS18A, ASPH, CCT3, TM7SF2, ATP5H, HSPE1, HIBADH, BRP44, EPM2AIP1, CYC1, C1GALT1C1, SMU1, NDUFS8, AHSA1, NDUFA8, DDX56, NDUFS6, GUK1, LRPAP1, COPS3, TIMM8B, NDUFV2, NDUFS7, SERF2, COPS6, MRPS11, MRPL15, SEPHS2, MRPS28, PDCD5, TMEM147, RPL36AL, ACAT2, IDH1, NFIX, SMYD2, FKBP3, PRDX3, CFDP1, FNDC4, ZNHIT1, UQCR, TUSC4, C1QBP, WHSC1, PRPS2, GLS2, POLR2J, MRPL28, UFC1, MKKS, HIGD2A, MRP63, SSR4, NIPSNAP1, BCCIP, NDUFAB1, CWF19L1, NDUFB2, UQCRC2, NDUFS3, BCAP31, ACSL1, COQ4, MRPS12, IDH3G, COX5B, MEA1, ABHD11, SLC25A5, PURA, MVD, STIP1, ATP5L |
| REACTOME METABOLISM OF AMINO ACIDS | DLD, AGMAT, ALDH7A1, CPS1, SRM, GLS2, OTC, ASS1, SHMT1, HIBADH, GAMT, ACAT1, GSTZ1, ACAD8, ALDH4A1, FAH, SLC36A1, QDPR |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | FKBP11, GSTO1, GPAA1, ILF2, CSTF2, CETN2, HSP90AB1, DYNLRB1, SDF2L1, EXOSC5, BRP44, EPM2AIP1, ZHX3, STT3A, ICT1, HSPA14, GPR98, NDUFA8, TFB2M, PSMB5, GMPS, GOLGA4, SSR2, DUSP12, DHX16, COPB2, ATG3, CTCF, PTTG1IP, PAPSS1, SAP30L, SCAMP3, COMMD3, GEMIN6, PPP1R2, PDCD5, SATB2, MRPL18, RPL36AL, TAF12, PSMD6, NUDT1, NUP37, SFRS2, PFDN6, IDH1, TUSC2, NDUFB6, TMCO3, WDR61, SEC61G, IDI1, HSD17B8, MRPL48, TFG, XRCC6, IFRD2, RSRC1, C1QBP, COPE, TM2D1, DHX29, CHMP5, MPV17, NCBP2, NDUFA7, SDF2, UFC1, APEX1, PIGC, TOM1L1, ACP1, PPA1, PSEN2, DDX46, CRY1, HAX1, ZFAND1, SURF1, VAMP5, DVL3, OXA1L, SLC35B1, SEC14L2, MAP2K2, RPA3, PIGB, NEDD8, UFM1, CUL2, MEA1, PSMD2, EIF2B1, DRG1, PURA, FADD, COX6A1, SPCS1, MRPS18C, CCDC51, IPO4, DARS2, APEX2, TBL2, CRKL |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | UQCR, MRPS18A, NDUFA3, NDUFA5, NDUFB8, UBL5, NCBP2, TMEM93, MRPL28, DBI, CUTA, ATP5O, PQBP1, CYB5B, GUK1, NDUFS2, NDUFAB1, UQCRC2, MRPL13, EBP, TIMM8B, NDUFC1, NDUFA13, ATP5D, PEX7, MRPL35, PARK7, CAT, COX5B, PDCD5, TSEN34, MRPL18, FKBP3, COX6A1, POLR3K, ECH1, PRPSAP2 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | MRPS34, CLPB, COPE, MTIF2, EI24, UFC1, ICT1, TIMM13, NDUFB7, MAP3K7, NDUFAB1, LRPAP1, DDT, MRPL34, MRPL16, LIAS, NDUFS3, HMBS, NDUFV2, SDHB, COPS6, MRPS7, MRPS12, ARL3, MRPS11, PSMB7, ALDH9A1, ARD1A, TCEA1, UQCRQ, NDUFB6, YIPF5, GSTP1, RAMP2, POLR3K, CSNK2B, HMGCS1, PHB2, HSD17B4, STARD7 |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | MMACHC, RBBP4, TOP2B, CLPB, TEX264, CCDC85B, PINK1, EI24, EPM2AIP1, NADK, AASDHPPT, STT3A, ZMYM4, SLC37A4, GPBP1L1, GOLGA4, UTP11L, ECHS1, WDR6, ECD, TKT, BMPR1A, QARS, AHDC1, TIMM8B, GPR125, MLH1, MRPS16, LAP3, TM9SF3, RBMS3, ASRGL1, PTS, ACAT1, HP1BP3, TAF12, RDX, TUSC2, PRDX3, WAPAL, MRPL48, PANK4, SC5DL, CPSF3L, DDX50, WHSC1, DHDDS, TM2D1, NUDC, NARS2, CTNNB1, COL16A1, ELOVL1, ARCN1, NEK4, ALG8, LETM1, TMEM135, UROD, PRKCZ, AK2, CWF19L1, UBE4A, APEH, TMEM39B, MFN2, HMBS, MED8, SDHB, CMTM6, HECTD3, ARL3, USP48, PARK7, PPME1, ZBTB48, PPCS, PRDM10, FBXL15, DNAJC16, RSC1A1, ACAD8, DYNC2H1, ACOT7, CBARA1, ATM, RNF4, WNT4 |
| RAMALHO STEMNESS UP | YAP1, FKBP11, RNF138, MRPL17, GFER, PSMD11, LAS1L, ARCN1, TXNL1, ZMYM4, ANKRD17, TOM1L1, RAD23B, PPA1, MPDU1, BYSL, MTERFD1, USP10, NDUFAB1, PAFAH2, MRPL34, RABGGTB, COPS4, RYK, LSM2, LIG3, COPS7A, CAD, HRSP12, PEX7, ALDH7A1, ACADM, PPP1R2, USP9X, MRPS2, NDUFAF1, ACAT2, PSMD12, GLO1, RNF4, XRCC5, GCAT, MRPS10, MRPS31, UMPS |
| SCHUHMACHER MYC TARGETS UP | POLD2, NME1, CAD, ABCE1, PAICS, ACSL1, PRPS2, EXOSC7, AHCY, SRM, SORD, GPD1L, GRSF1, HSPE1 |
| CORUM RESPIRATORY CHAIN COMPLEX I LAMBDA SUBUNIT MITOCHONDRIAL | NDUFS2, NDUFA13, NDUFS6, NDUFS7, NDUFS8, NDUFS3, NDUFA5 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 | FKBP11, NME1, CAD, HDLBP, SSR3, PDLIM3, CCT3, SNRPD3, YKT6, EIF2B5, MRPS28, MRPL20, GPS1, PSMB5, APEX1, PSMD6, WDR74, PPA1, GORASP2, SMYD2, SSR2, NSBP1, PDIA4, SEC61A1, PREP, LMAN2, SMARCA4, MRPS10, GALK1, PSMB3, NDE1 |
| REACTOME CHOLESTEROL BIOSYNTHESIS | SC5DL, LSS, DHCR24, TM7SF2, MVD, FDFT1, IDI1, HMGCS1, MVK, EBP, DHCR7, NSDHL |
| SCHLOSSER MYC TARGETS REPRESSED BY SERUM | ATP5C1, TARS, RAN, TRIAP1, UBE2G1, EI24, TFAM, HSPE1, AASDHPPT, COX11, ALG8, CNBP, SSBP1, NDUFB6, ZMPSTE24, USP10, FBXO9, RABGGTB, AFG3L2, U2AF1, XPOT |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | ERGIC3, PSMA5, COPE, PSMB1, PSMB7, PSMD4, COPZ1, SIL1, GOSR2, PSMD2, TRAPPC3, PSMD6, PSMD3, PDIA4, YIPF5, TRAPPC4, PSMB3, COPB2, BCAP31 |
| ROME INSULIN TARGETS IN MUSCLE UP | PRDX6, HRSP12, COPS6, COPE, OXA1L, MRPS16, SLC35B1, PSMA4, PPP2R5B, SEPHS2, TMEM70, ARCN1, USP9X, TMEM93, AHSA1, DAG1, HIGD1A, YWHAQ, COPS3, CUTC, PRDX1, CRKL, HCCS, MLLT1, QARS |
| WELCSH BRCA1 TARGETS 1 DN | NME3, HDLBP, MRPS12, PPM1F, SRM, CCDC85B, ATIC, PRKACA, EMG1, ALG3, SKIV2L, BYSL, DHCR24, DDT, PMPCA, U2AF1, LMNB2 |
| HONMA DOCETAXEL RESISTANCE | SLC25A3, PTPLB, MRPL17, SQRDL, MRPS6, COX7C, CTNNB1, NDUFS3, UFM1, ENO1, PDCD5 |
| RICKMAN METASTASIS UP | TFAM, RPE, LMAN2L, EPM2AIP1, SEPHS2, YIPF6, COX11, CDK5RAP3, E2F6, GLRX5, IDH1, SNRPN, ABCB7, PGRMC1, GCAT, MYST1, MRPS35, ZBTB33, PKP4 |
| SCHLOSSER MYC AND SERUM RESPONSE SYNERGY | KHSRP, COG2, MRPS12, SRM, SCAMP3, CCDC85B, ZNF22, SNRPA, ARMC6, SGTA |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10 | COX17, CHCHD7, POLR2L, LASS2, RANGAP1, TM9SF3, TMEM11, PSMA4, MRPL40, HSPE1, CANX, BRP44, UFM1, ARCN1, PEX13, SLC30A5, POLR2F, CDK2AP2, ADK, CACYBP, TIMM23, CCT7, SEC61A1, YIPF5, EDF1, BCKDHB, PRDX1 |
| REACTOME VITAMIN B5 (PANTOTHENATE) METABOLISM | COASY, PPCS, AASDHPPT, PPCDC, PANK4 |
| KIM MYC AMPLIFICATION TARGETS UP | |
| NCI RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE | |
| NCI RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE1 | |
| NCI TAT MEDIATED ELONGATION OF THE HIV 1 TRANSCRIPT | |
| REACTOME RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE | |
| ALONSO METASTASIS UP | |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | POLR2E, POLR2B, RDBP, NCBP2, POLR2F, POLR2J, TH1L |
| CORUM DDB2 COMPLEX | |
| REACTOME RNA POLYMERASE I III AND MITOCHONDRIAL TRANSCRIPTION | TFB2M, GTF2H3, POLRMT, POLR2F, POLR3B, GTF3C3, HIST1H2BC, MTERF, NFIX, TFAM, ERCC2, GTF3C1, MNAT1, TTF1 |
| NCI FORMATION OF THE HIV 1 EARLY ELONGATION COMPLEX | GTF2H3, POLR2E, RDBP, POLR2F, CCNH, POLR2B, NCBP2, ERCC2, POLR2J, TH1L |
| CORUM CSA COMPLEX | |
| NCI MRNA CAPPING | GTF2H3, NCBP2, POLR2F, ERCC2, POLR2J |
| NIKOLSKY BREAST CANCER 1Q21 AMPLICON | |
| KEGG TERPENOID BACKBONE BIOSYNTHESIS | |
| CORUM RESPIRATORY CHAIN COMPLEX I GAMMA SUBUNIT MITOCHONDRIAL | |
| NCI FORMATION OF THE EARLY ELONGATION COMPLEX | GTF2H3, POLR2E, RDBP, POLR2F, CCNH, POLR2B, NCBP2, ERCC2, POLR2J, TH1L |
| NCI RNA POLYMERASE II TRANSCRIPTION ELONGATION | GTF2H3, POLR2E, RDBP, TCEA1, POLR2F, TCEB2, CCNH, POLR2B, NCBP2, ERCC2, POLR2J, TH1L |
| NCI UREA SYNTHESIS | |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | |
| NCI HIV 1 TRANSCRIPTION ELONGATION | GTF2H3, POLR2E, RDBP, POLR2F, CCNH, POLR2B, NCBP2, ERCC2, POLR2J, TH1L |
| REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX | GTF2H3, POLR2E, RDBP, POLR2F, POLR2B, NCBP2, ERCC2, TH1L, POLR2J |
| NCI FORMATION OF HIV 1 ELONGATION COMPLEX CONTAINING HIV 1 TAT | GTF2H3, POLR2E, RDBP, TCEA1, POLR2F, TCEB2, CCNH, POLR2B, NCBP2, ERCC2, POLR2J, TH1L |
| MOOTHA TCA | |
| CORUM RESPIRATORY CHAIN COMPLEX I INCOMPLETE INTERMEDIATE MITOCHONDRIAL | |
| CORUM RESPIRATORY CHAIN COMPLEX I INTERMEDIATE VII/650KD MITOCHONDRIAL | |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 | |
| MORI PLASMA CELL UP | |
| REACTOME GENE EXPRESSION | |
| NCI FORMATION OF RNA POL II ELONGATION COMPLEX | GTF2H3, POLR2E, RDBP, TCEA1, POLR2F, TCEB2, CCNH, POLR2B, NCBP2, ERCC2, POLR2J, TH1L |
| SHEN SMARCA2 TARGETS UP | |
| REACTOME MICRORNA BIOGENESIS | |
| NCI ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT | POLR2E, POLR2B, RDBP, NCBP2, POLR2F, POLR2J, TH1L |
| CORUM CNS-P53 COMPLEX | |
| PENG RAPAMYCIN RESPONSE DN | |
| NCI MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS | |
| NCI VALINE CATABOLISM | |
| REACTOME HIV1 TRANSCRIPTION ELONGATION | GTF2H3, POLR2E, RDBP, TCEA1, POLR2F, TCEB2, CCNH, POLR2B, NCBP2, ERCC2, POLR2J, TH1L |
| BIOCARTA ETC PATHWAY | |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | |
| CORUM 28S RIBOSOMAL SUBUNIT MITOCHONDRIAL | MRPS18A, MRPS34, MRPS7, MRPS12, MRPS16, MRPS11, MRPS33, MRPS18C, DAP3, MRPS28, MRPS35 |
| NCI PHENYLALANINE AND TYROSINE CATABOLISM | |
| REACTOME TRANSCRIPTION | GTF2H3, POLRMT, RDBP, CSTF2, GTF3C3, UPF3B, TCEB2, HIST1H2BC, POLR2B, NCBP2, TFAM, MNAT1, POLR2J, TAF13, TTF1, TFB2M, POLR2E, POLR2F, TAF12, NFX1, PAPOLA, CPSF1, SFRS2, NFIX, MTERF, U2AF1, CSTF1, ERCC2, GTF3C1, TH1L |
| NIKOLSKY BREAST CANCER 16P13 AMPLICON | |
| CORUM CSA-POLIIA COMPLEX | |
| NCI MICRORNA MIRNA BIOGENESIS | |
| CORUM UBIQUITIN E3 LIGASE CSN1 CSN8 HRT1 SKP1 SKP2 CUL1 CUL2 CUL3 | |