| Gene Set | Leading Edge Genes |
|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | MYCBP, GMPR2, POLE3, COPS5, MAGOH, RBBP4, CETN3, ALG5, LSM1, MRPL49, SLBP, MRPS30, ITPA, CYC1, POLR1D, ICT1, NDUFA8, CHERP, PEF1, ATP5O, POLD2, ACTR1A, DFFB, PLAA, COPS3, IDH3B, BNIP3, LSM8, CHD1L, PDCD6, NDUFV2, NFATC3, ABCB6, PAPSS1, MAT2B, VTI1B, NT5C, AMD1, WBSCR22, LMAN1, RUVBL1, GSS, PUS1, NDUFS4, NDUFB6, GLO1, DCTN6, FDFT1, PHB2, MRPS35, STK11, ZMYND11, SQLE, RTCD1, NDUFA5, C1QBP, DBF4, STOML2, ALAD, COMT, NCBP2, NDUFB5, GALNT2, UCHL5, ORC5L, TOPBP1, ARCN1, CTNNBL1, POLR2E, SLC29A1, ACP1, DPAGT1, SSBP1, NDUFAB1, ING2, DRG2, LSM5, HMBS, DRAP1, HTRA2, CASP6, DDX10, COPS2, PSMC3, TOMM22, NIT2, MAP2K2, ADORA2B, NFE2L2, SNRPB2, DDX41, DRG1, SRP19, MRPS31, HMGCS1 |
| KEGG PARKINSONS DISEASE | HTRA2, NDUFS7, SDHB, ATP5D, NDUFA5, UQCRH, SDHA, CYC1, NDUFA2, NDUFA8, UQCRC1, NDUFB7, NDUFA6, ATP5O, NDUFS6, NDUFS4, UQCRQ, NDUFB6, NDUFAB1, COX7C, NDUFS3, NDUFC1 |
| KEGG HUNTINGTONS DISEASE | SDHB, NDUFS7, ATP5D, NDUFA5, UQCRH, SDHA, CYC1, NDUFA2, NDUFA8, NDUFA6, NDUFB7, ATP5O, UQCRC1, NDUFS6, NDUFS4, BAX, UQCRQ, POLR2H, NDUFB6, NDUFAB1, DCTN2, COX7C, NDUFS3, NDUFC1 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | PIN1, C1QBP, GIPC1, GPX4, NSDHL, NDUFB7, UQCRC1, NDUFS6, CDK2AP2, DCXR, MBD3, DPAGT1, CYB5B, CHUK, BAX, DDT, BANF1, DUS1L, HMBS, EBP, NDUFV2, SCAND1, ATP5D, TCEB2, TAF10, MAP2K2, NDUFA2, PDCD5, PGLS, TESK1, MEA1, GSS, DNAJB5, APBA3, HEXIM1, PSMD13, UQCRQ, NUBP2, CFDP1, SRP19, PSMB3, HMGCS1 |
| CORUM RESPIRATORY CHAIN COMPLEX I LAMBDA SUBUNIT MITOCHONDRIAL | NDUFS6, NDUFS4, NDUFS7, NDUFS3, NDUFA5, NDUFA2 |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | PSMD2, TRAPPC3, PSMD6, PSMD13, COPE, HERPUD1, PDIA4, PSMB3, COPZ1 |
| CORUM PA700-20S-PA28 COMPLEX | PSMB2, PSMC5, PSMD2, PSMD6, PSMB3, PSMD13, PSMC3 |
| NCI HIV 1 TRANSCRIPTION INITIATION | POLR2H, POLR2E, ERCC3, MNAT1 |
| NCI RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE | POLR2H, ERCC3, MNAT1 |
| NCI RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE1 | POLR2H, ERCC3, MNAT1 |
| NCI TAT MEDIATED ELONGATION OF THE HIV 1 TRANSCRIPT | POLR2H, POLR2E, ERCC3, MNAT1 |
| NCI PAUSING AND RECOVERY OF ELONGATION | |
| REACTOME RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE | POLR2H, ERCC3, MNAT1 |
| NCI RNA POLYMERASE II TRANSCRIPTION PRE INITIATION | POLR2H, POLR2E, ERCC3, MNAT1 |
| CORUM BRCA1-RNA POLYMERASE II COMPLEX | POLR2H, ERCC3, POLR2E, POLR2B, GTF2E2, POLR2F, POLR2J |
| REACTOME NUCLEOTIDE EXCISION REPAIR | POLR2H, POLR2E, ERCC3, RFC2, RPA3, MNAT1 |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | POLR2H, POLR2E, NCBP2 |
| NCI HIV 1 ELONGATION ARREST AND RECOVERY | |
| REACTOME RNA POLYMERASE I III AND MITOCHONDRIAL TRANSCRIPTION | |
| NCI VIRAL MESSENGER RNA SYNTHESIS | POLR2E, POLR2F, CD2BP2, SFRS2, POLR2H, SNRP70, SNRPB, NCBP2, POLR2C, POLR2J |
| NUYTTEN EZH2 TARGETS DN | |
| NCI APC C CDC20 MEDIATED DEGRADATION OF SECURIN | |
| NCI FORMATION OF THE HIV 1 EARLY ELONGATION COMPLEX | POLR2H, POLR2E, ERCC3, NCBP2, MNAT1 |
| CORUM RNA POLYMERASE II RNAPII | |
| REACTOME TRANSCRIPTION COUPLED NER | POLR2E, ERCC3, POLR2F, RFC2, POLR2H, RPA3, POLR2J, MNAT1 |
| CORUM CSA COMPLEX | |
| KEGG RNA POLYMERASE | |
| NCI MRNA CAPPING | POLR2H, ERCC3, NCBP2, MNAT1 |
| KEGG SPLICEOSOME | PRPF31, MAGOH, SFRS2, SF3B5, SNRPB, NCBP2, BUD31, SNRPD2, CTNNBL1, LSM5, SNRPB2 |
| NCI SCF SKP2 MEDIATED DEGRADATION OF P27 P21 | |
| NCI RNA POLYMERASE II TRANSCRIPTION | POLR2H, POLR2E, ERCC3, MNAT1 |
| REACTOME MRNA PROCESSING | |
| NCI FORMATION OF THE EARLY ELONGATION COMPLEX | POLR2H, POLR2E, ERCC3, NCBP2, MNAT1 |
| CORUM PA700 COMPLEX | |
| REACTOME VIRAL MESSENGER RNA SYNTHESIS | |
| ZHANG RESPONSE TO CANTHARIDIN DN | |
| REACTOME DNA REPAIR | POLR2H, POLD2, ERCC3, POLR2E, RFC2, RPA3, MNAT1 |
| NCI HIV 1 TRANSCRIPTION ELONGATION | POLR2H, POLR2E, ERCC3, NCBP2, MNAT1 |
| REACTOME TAT MEDIATED HIV1 ELONGATION ARREST AND RECOVERY | |
| REACTOME HIV INFECTION | PSMC5, TCEB2, AP1S1, PSMC3, TAF10, NCBP2, NUP133, MNAT1, ERCC3, POLR2E, RBX1, PSMD6, POLR2H, PSMB3, BANF1, NUP62, AP1B1 |
| NCI DUAL INCISION REACTION IN TC NER | POLR2E, ERCC3 |
| NCI PAUSING AND RECOVERY OF TAT MEDIATED HIV 1 ELONGATION | |
| REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX | POLR2H, POLR2E, ERCC3, NCBP2, MNAT1 |
| NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | MAGOH, POLR2L, SLBP, POLR2B, NCBP2, NUP133, NUDT21, POLR2J, SNRPB2, POLR2E, CD2BP2, POLR2F, SFRS2, NUP37, SF3B5, POLR2H, SNRPD2, CSTF1 |
| NCI AUTODEGRADATION OF CDH1 BY CDH1 APC C | |
| NCI FORMATION OF HIV 1 ELONGATION COMPLEX CONTAINING HIV 1 TAT | POLR2H, POLR2E, ERCC3, NCBP2, MNAT1 |
| REACTOME REGULATION OF APC ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE | |
| CORUM RESPIRATORY CHAIN COMPLEX I INCOMPLETE INTERMEDIATE MITOCHONDRIAL | |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | POLR2H, ERCC3, POLR2E, NCBP2, NUP133, NUP62, TCEB2, MNAT1, TAF10 |
| REACTOME CDC20 PHOSPHO APC MEDIATED DEGRADATION OF CYCLIN A | |
| NCI ELONGATION ARREST AND RECOVERY | |
| CORUM RESPIRATORY CHAIN COMPLEX I INTERMEDIATE VII/650KD MITOCHONDRIAL | |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | |
| MORI PLASMA CELL UP | |
| REACTOME GENE EXPRESSION | MAGOH, TCEB2, POLR2L, TAF10, MED6, EIF2B5, SNRPB, SLBP, NCBP2, POLR2K, NUP133, EIF2S1, MNAT1, SNRPB2, ERCC3, POLR2E, CD2BP2, SF3B5, POLR2H, NUP62, POLR2C, CSTF1, LSM2, MED8, EEF1D |
| NCI TRANSCRIPTION COUPLED NER TC NER | POLR2E, ERCC3 |
| NCI ELONGATION OF INTRON CONTAINING TRANSCRIPTS AND CO TRANSCRIPTIONAL MRNA SPLICING | POLR2H, POLR2E, ERCC3, NCBP2, POLR2F, MNAT1, POLR2J |
| NCI FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | POLR2E, ERCC3 |
| REACTOME MICRORNA BIOGENESIS | |
| REACTOME HIV1 TRANSCRIPTION INITIATION | POLR2H, POLR2E, ERCC3, MNAT1 |
| CORUM BRCA1-CORE RNA POLYMERASE II COMPLEX | |
| DAIRKEE TERT TARGETS UP | |
| NCI RNA POLYMERASE II PROMOTER ESCAPE | POLR2H, POLR2E, ERCC3, MNAT1 |
| NCI ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT | POLR2E, NCBP2 |
| CORUM CNS-P53 COMPLEX | |
| NCI RNA POLYMERASE II TRANSCRIPTION INITIATION | POLR2H, POLR2E, ERCC3, MNAT1 |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL CIS | |
| PENG RAPAMYCIN RESPONSE DN | |
| NCI CDC20 PHOSPHO APC C MEDIATED DEGRADATION OF CYCLIN A | |
| NCI RNA POLYMERASE II HIV 1 PROMOTER ESCAPE | POLR2H, POLR2E, ERCC3, MNAT1 |
| REACTOME REGULATION OF INSULIN SECRETION | |
| REACTOME MRNA SPLICING MINOR PATHWAY | POLR2H, POLR2E, NCBP2, POLR2K, SF3B5 |
| NCI PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | POLR2E, POLR2B, NCBP2, POLR2F, POLR2J |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | |
| CORUM RNASE/MRP COMPLEX | |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC | |
| CORUM RNA POLYMERASE II HOLOENZYME COMPLEX | POLR2H, ERCC3, POLR2E, POLR2B, GTF2E2, POLR2F, POLR2J |
| REACTOME HIV1 TRANSCRIPTION ELONGATION | POLR2H, POLR2E, ERCC3, NCBP2, MNAT1 |
| REACTOME DUAL INCISION REACTION IN TC NER | POLR2E, ERCC3 |
| CORUM SPLICEOSOME | |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | PDCD6, TTRAP, C1QBP, MRPS12, DBF4, SSBP1, ORC5L, LSM5 |
| NCI FORMATION AND MATURATION OF MRNA TRANSCRIPT | POLR2H, POLR2E, ERCC3, MNAT1 |
| NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | |
| REACTOME TRANSCRIPTION | MAGOH, GTF2E2, TCEB2, TAF10, POLR2B, NCBP2, TFAM, POLR1D, MNAT1, POLR2J, POLR2E, ERCC3, POLR2F, SFRS2, POLR2H, CSTF1 |
| NCI RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE | POLR2H, POLR2E, ERCC3, MNAT1 |
| NCI TAT MEDIATED HIV 1 ELONGATION ARREST AND RECOVERY | |
| NCI PAUSING AND RECOVERY OF HIV 1 ELONGATION | |
| NCI VIF MEDIATED DEGRADATION OF APOBEC3G | |
| NCI HIV 1 TRANSCRIPTION PRE INITIATION | POLR2H, POLR2E, ERCC3, MNAT1 |
| CORUM CSA-POLIIA COMPLEX | |
| REACTOME HIV LIFE CYCLE | ERCC3, POLR2E, TCEB2, TAF10, POLR2H, NCBP2, NUP133, BANF1, NUP62, MNAT1 |
| NCI DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX | |
| NCI MICRORNA MIRNA BIOGENESIS | |
| NCI TRANSCRIPTION OF THE HIV GENOME | POLR2H, POLR2E, ERCC3, MNAT1 |
| NCI MRNA SPLICING MINOR PATHWAY | POLR2E, POLR2F, SFRS2, POLR2L, SF3B5, POLR2H, WDR57, POLR2B, POLR2K, NCBP2, SNRPD2, POLR2J |
| KEGG NUCLEOTIDE EXCISION REPAIR | RBX1, ERCC3, POLE3, RFC2, RPA3, MNAT1 |