| Gene Set | Leading Edge Genes |
|---|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | CDC16, GMPR2, POLE3, CHPT1, CETN3, PSMA2, YY1, SLC30A9, SLBP, EI24, ADH5, NDUFA8, POLD2, BTBD1, ANAPC1, CRIP1, DHCR24, KIF22, EIF2AK1, PDCD6, MDM1, ENSA, NFATC3, MAT2B, FEZ2, VTI1B, CDC5L, VDAC3, UBE2G1, SEPHS2, SUMO1, DDB1, SC4MOL, NDUFS4, MKRN1, HMG20A, ATF2, FKBP3, NDUFB6, ARL6IP5, WDR61, HSD17B4, MDH2, RAD1, TM9SF1, MEN1, C1QBP, MED4, SPTLC1, TOPBP1, FNTA, SMAD2, SLA, ITGB1BP1, EBAG9, MTX2, PPA2, ATP5J, SSBP1, OXSR1, NDUFAB1, ANXA4, NIF3L1, BAG4, PDHB, DLD, BIRC2, NIT2, CMAS, EIF4ENIF1, PUM2, ACADM, COIL, CRBN, PRKD3, FADS1, ADK, CTNND1, UBE2E3, BNIP2, HDAC2, ATXN10, AUP1, ZFR, RFC3, MYCBP, LMO2, MAGOH, CETN2, GBAS, PRDX4, NGRN, ALG5, TCF12, RAD50, B3GALNT1, CUL4A, CHERP, FTSJ2, ACTL6A, C1D, UGP2, PMPCB, RALBP1, CNIH, DNAJA3, IDH3B, STAG2, CHD1L, CTCF, LSM8, NDUFV2, KLHDC2, HRSP12, ARL5A, PHKB, AMD1, SNRPD3, PHF20, XPNPEP1, EPS15, SMC3, NUDT21, ACAT1, GMNN, PECI, GNS, PBX3, XRCC5, IKBKAP, USP1, SMC4, CASP8AP2, NNT, RTCD1, DBF4, RAD21, PTPRA, PTPN6, HADHB, STOML2, POLR2K, NDUFB5, ICMT, UCHL5, ORC5L, SFRS4, CAB39, LANCL1, TM9SF2, ZNF22, LSM5, UBP1, SFRS2IP, ACO1, SNRPB2, PSIP1, MSH6, RAD17, DHX9, PCNP, ZMPSTE24, ANP32A, KIFAP3, ACLY |
| NUYTTEN EZH2 TARGETS DN | ORMDL2, GMPR2, TBL1XR1, TMPO, CETN3, CENPA, MRPS33, PRPSAP1, GIT2, SYPL1, HEATR1, PTPN18, TOPBP1, BCLAF1, KIF3A, SP3, EXOSC8, SLC30A5, FIBP, C1D, EIF4EBP2, POP5, KIF22, NUP88, PUS7, SSRP1, DHRS7B, METTL5, EIF2AK1, BAZ1B, CERK, NDUFB11, LSM5, NEK9, ZFAND1, ASPM, NDUFV2, GOLT1B, ERGIC2, FANCG, MRPS16, DDHD2, NUP155, CMAS, SNAPC5, SMC3, EZH2, CLASP2, GMNN, PIGP, PSPH, NUP37, MKRN1, FADS1, POT1, TSN, MRPL24, ANP32A, HDAC2, NXT1, SMC4 |
| CORUM SNF2H-COHESIN-NURD COMPLEX | SMC1A, HDAC2, SMC3, RAD21, STAG2 |
| KEGG SPLICEOSOME | |
| NCI CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | |
| LINDGREN BLADDER CANCER CLUSTER 1 UP | |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | RDBP, POLR2F, NUP37, POLR2I, TAF10, POLR2H, NUP155, SSRP1, POLR2K, NUP133 |
| MORI PLASMA CELL UP | |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | |
| KEGG MISMATCH REPAIR | |
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | |
| REACTOME RNA POLYMERASE II TRANSCRIPTION | SFRS4, RDBP, MAGOH, POLR2F, POLR2I, TAF10, POLR2H, SSRP1, POLR2K, CSTF1, NUDT21 |
| NCI SNRNP ASSEMBLY | SNRPD3, SNRPE, NUP88, NUP133, NUP37 |
| NCI PHOSPHORYLATION OF THE APC C | |
| GENTILE UV RESPONSE CLUSTER D8 | |
| REACTOME DNA REPAIR | |
| CORUM POLYCOMB REPRESSIVE COMPLEX 2 PRC 2 | |
| CORUM SPLICEOSOME | SFRS4, SNRPE, MAGOH, CDC5L, DHX9, THOC7, SNRPD3, WTAP, PRPF4B, AQR, DDX17, NUDT21, THOC1, SNRPA1, SNRPB2 |
| KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION | |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | |
| REACTOME APCDC20 MEDIATED DEGRADATION OF CYCLIN B | |
| REACTOME TRANSCRIPTION | |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS | |
| REACTOME MICRORNA BIOGENESIS | |
| NCI APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS | |
| REACTOME HIV INFECTION | |
| REACTOME HIV LIFE CYCLE | |
| CORUM POLYCOMB REPRESSIVE COMPLEX 2 PRC2 | |
| NCI REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE | CDC16, ANAPC1 |
| LINDGREN BLADDER CANCER WITH LOH IN CHR9Q | |
| REACTOME FORMATION AND MATURATION OF MRNA TRANSCRIPT | |
| REACTOME PHOSPHORYLATION OF THE APC |
| Color legend | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| q-value | -1 | -0.2 | -0.05 | -0.01 | -0.001 | -0.0001 | |||||
| Color | |||||||||||
| burkholderia pseudomallei | yersinia enterocolitica p60 bl6 | streptococcus pneumoniae d39 | GeneSet Name |
|---|---|---|---|
| -0.00020 | -0.08381 | -0.01910 | DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP |
| -0.00050 | -0.19870 | -0.01919 | NUYTTEN_EZH2_TARGETS_DN |
| -0.00350 | -0.16476 | -0.08186 | CORUM_SNF2H-COHESIN-NURD_COMPLEX |
| -0.00035 | -0.05069 | -0.19380 | KEGG_SPLICEOSOME |
| -0.09825 | -0.09946 | -0.19334 | NCI_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE |
| -0.00178 | -0.14945 | -0.06131 | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS |
| -0.06043 | -0.11028 | -0.07800 | LINDGREN_BLADDER_CANCER_CLUSTER_1_UP |
| -0.01716 | -0.01025 | -0.05478 | REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE |
| -0.03365 | -0.14489 | -0.13714 | MORI_PLASMA_CELL_UP |
| -0.00725 | -0.00198 | -0.08271 | STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN |
| -0.00688 | -0.13198 | -0.16509 | KEGG_MISMATCH_REPAIR |
| -0.00012 | -0.02965 | -0.16660 | ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN |
| -0.01090 | -0.00114 | -0.14207 | REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION |
| -0.00157 | -0.16739 | -0.00366 | NCI_SNRNP_ASSEMBLY |
| -0.01882 | -0.01848 | -0.18366 | NCI_PHOSPHORYLATION_OF_THE_APC_C |
| -0.07617 | -0.08646 | -0.06410 | GENTILE_UV_RESPONSE_CLUSTER_D8 |
| -0.00513 | -0.02229 | -0.18550 | REACTOME_DNA_REPAIR |
| -0.12794 | -0.18139 | -0.12724 | CORUM_POLYCOMB_REPRESSIVE_COMPLEX_2_PRC_2 |
| -0.00004 | -0.07821 | -0.07735 | CORUM_SPLICEOSOME |
| -0.12647 | -0.14542 | -0.12459 | KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION |
| -0.00204 | -0.07429 | -0.00101 | MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN |
| -0.02193 | -0.10362 | -0.14210 | REACTOME_APCDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B |
| -0.12603 | -0.00229 | -0.07512 | REACTOME_TRANSCRIPTION |
| -0.07684 | -0.07135 | -0.19602 | BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS |
| -0.04408 | -0.00532 | -0.08168 | REACTOME_MICRORNA_BIOGENESIS |
| -0.17314 | -0.02182 | -0.18352 | NCI_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS |
| -0.01885 | -0.00675 | -0.19436 | REACTOME_HIV_INFECTION |
| -0.00484 | -0.01423 | -0.06724 | REACTOME_HIV_LIFE_CYCLE |
| -0.10770 | -0.18413 | -0.13497 | CORUM_POLYCOMB_REPRESSIVE_COMPLEX_2_PRC2 |
| -0.01297 | -0.12152 | -0.12200 | NCI_REGULATION_OF_APC_C_ACTIVATORS_BETWEEN_G1_S_AND_EARLY_ANAPHASE |
| -0.08712 | -0.02524 | -0.01258 | LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q |
| -0.00012 | -0.00112 | -0.18454 | REACTOME_FORMATION_AND_MATURATION_OF_MRNA_TRANSCRIPT |
| -0.03217 | -0.02517 | -0.15183 | REACTOME_PHOSPHORYLATION_OF_THE_APC |