| Gene Set | Leading Edge Genes |
|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | CDC16, POLE3, HMGCR, TRAK2, PPP1CC, POLR2B, SLBP, MTIF2, ZNF302, EI24, AASDHPPT, UBE2V2, BECN1, ALDH4A1, FECH, TERF1, C21ORF45, SEPT2, COPB2, CPSF6, BNIP3, CCDC6, ZNF146, AGL, CDC27, UBAP2, TCEB1, CSNK1D, MED6, TM9SF3, LMAN1, SEPHS2, CUL4B, ETNK1, CSNK1G3, KHDRBS1, PRKRA, PPP6C, FCGR2A, POLR1C, WDR61, XPOT, TUBGCP3, MRPS35, MATR3, ZMYND11, TCERG1, PRKRIR, APBA2, NMD3, GART, NCBP2, SS18, SMARCC2, ARCN1, TOPBP1, SEC23IP, SMARCA5, RBBP8, SLC2A10, CBFB, EBAG9, TCP1, SLC5A3, EHD1, SEMA4D, RAB4A, WDR3, TLK1, RANBP2, EXOC5, PAICS, CASP6, COPS2, ILF3, ABL1, SCARB2, UBE2B, EIF4ENIF1, LARP1, ACADM, COIL, WSB2, PNN, EIF2B1, CPOX, CASP8, PRKD3, NCBP1, DDX23, UBE2E3, DNAJA2, GTF2H1, CRKL, SRP19, ABCE1, PPP2CB, PTPN22, NOLC1, ALG5, TCF12, LSM1, MRPS30, B3GALNT1, CHERP, FTSJ2, SERPINE2, MAP4K5, RBM7, C1D, GTF2B, GSPT1, HIRA, PLAA, IFRD1, SUCLA2, VPS26A, UBE4B, CTCF, ZNF267, MBD4, CCT6A, AMD1, SQSTM1, NDEL1, PHF20, FOXK2, EPS15, C11ORF58, DHX15, RAP2C, API5, PUS1, KHSRP, PEX1, GNS, GTF2A2, MRE11A, KPNA3, CBX1, SLC7A5, EIF5, UPF1, CASP8AP2, SNW1, NDUFA5, BRD1, WBP11, ATG12, BMI1, DYNC1LI1, DBF4, TM2D1, PWP1, EIF2S2, UCHL5, SEC24B, METAP2, CAB39, MSH2, RAD23B, ETF1, GRSF1, BCKDHB, UBE4A, CRY1, ZNF167, GTPBP4, SNX5, GNL2, MXI1, SLC25A15, UPF3B, ORC4L, FSCN1, ZFP36L1, UBP1, ODC1, SRRM1, ACTR2, NFE2L2, SNRPB2, RSC1A1, BAZ1A, LBR, TSNAX, AQP3, PSMD12, SLC25A32, PMS1, C17ORF48, ZMPSTE24, TBPL1, NSMAF, MIPEP |
| DODD NASOPHARYNGEAL CARCINOMA DN | PRPF40A, PRF1, TMPO, ARHGAP8 /// LOC55315, POLR2B, SLBP, KCNMA1, C2ORF3, FASTKD1, RBM4, ZNF532, MTF2, ISG20L2, PLXNA1, SFRS7, PUS7, C21ORF45, RABGGTB, COL4A1, CPSF6, ZNF146, CDC27, SCNN1G, SKP2, CKAP2, LMAN1, FASTKD2, RBM15, ZNF84, ETNK1, C12ORF11, NUP37, MAP2K4, HIC2, TM7SF3, UMPS, RBMX, PAIP1, ZNF195, NMD3, GART, RSL1D1, FASTKD3, NCBP2, ZNF131, RBM34, TOPBP1, SCYL2, HOMER3, RBBP8, TAF1A, C1ORF109, TRAM2, CENPE, WDR3, DPYSL2, RAI14, FRMD4A, ATR, CASP6, PAICS, RIF1, COPS2, ILF3, PROSC, PMS2 /// PMS2CL, IPO9, ZNF557, EIF2B1, CPOX, NCBP1, CCNE2, GJA1, XRCC4, NUP62, LRRC40, PCNA, ABCE1, TMEM168, QSER1, NOLC1, TCF12, E2F3, C1ORF163, SMG1, HSPE1, ADIPOR2, TFB2M, GINS1, FTSJ2, PAPSS2, INTS12, KDELC1, NOL8, TMF1, MYNN, BAZ1B, SH2B3, ZNF267, GOLT1B, BXDC2, TMEM70, DHX15, E2F6, KIF18A, SOCS5, PUS1, MAT2A, NT5M, KHSRP, RCHY1, PPP3R1, SLC7A5, EIF5A2, CASP8AP2, WBP11, NUPL1, DBF4, EIF2S2, POP1, JMJD4, NOC3L, FBXO5, POLR2D, MTRR, KLHL23, GRSF1, KNTC1, GTPBP4, CLASP1, SNX5, TOR1A, UPF3B, PGAP1, PHF14, EZH2, NOL11, CUL1, USP18, SLC25A32, PMS1, RNF4, PELO, SLC39A6, UBE3A |
| TIEN INTESTINE PROBIOTICS 24HR UP | HMGCR, TGOLN2, TAF11, TMPO, ARHGAP8 /// LOC55315, ZC3HAV1, CSRP2, SLBP, EI24, HSPE1, FBXO3, AASDHPPT, RDH11, LGALS2, FASTKD1, GINS1, C1D, ENTPD4, SFRS7, SUCLA2, CPSF6, SKP2, AMD1, BRD9, MRPS28, PTS, DNAJA1, ETNK1, GNS, KIAA1598, TSN, WDR61, FAM35A, TM7SF3, UMPS, C17ORF62, CEP76, SC5DL, PHACTR2, WBP11, NDUFA5, TRIM14, FASTKD5, DBF4, FASTKD3, DHX29, RBM34, TOPBP1, METAP2, SMARCA5, FBXO5, C6ORF62, FAM98A, MTRR, ETF1, SPATA5L1, TCEAL4, UBE4A, SLC25A44, KLHL21, CMTM6, CCND1, MORC2, PNN, ZFYVE16, PTPLB, LYRM2, LARP4, RBM8A |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | PRPF40A, PCNA, POLE3, TMPO, RNF138, DCP2, SLBP, ZNF232, C2ORF3, ARL4C, AASDHPPT, FTSJ2, GINS1, SLC30A5, C17ORF42, ISG20L2, PLAA, MTERF, PUS7, COL4A1, SUCLA2, VAMP3, SH2B3, SKP2, SCNN1G, MBD4, TCEB1, MED6, HSPA8, TM9SF3, COX4NB, BXDC2, TMEM70, PPP1R2, DHX15, WWP1, SPRED2, E2F6, PER2, KIF18A, PUS1, MAT2A, ETNK1, APIP, GTF2A2, PPP6C, MATR3, TUBGCP3, UMPS, CHORDC1, CASP8AP2, WBP11, PRPS2, NUPL1, DBF4, GART, POGK, PAK2, FASTKD3, EIF2S2, ELAC2, SS18, UCHL5, POP1, SLC20A1, METAP2, CNOT1, FBXO5, SLC17A7, POLR2D, NEK4, RAB14, TAF1A, PAQR3, ETF1, TCP1, NETO2, C1ORF109, GRSF1, SERBP1, KNTC1, TLK1, GNL2, RAB23, ATR, EXOC5, UAP1, PAICS, PHF20L1, RIF1, ILF3, ITGB3BP, THAP1, SRRM1, ACTR2, COIL, TTF1, ITPR3, EIF2B1, CUL1, PRKD3, NCBP1, CCNE2, SLC25A32, LARP4, CRKL, NUP62, STIP1, UBE3A |
| PUJANA CHEK2 PCC NETWORK | PCNA, ABCE1, HMGCR, POLE3, NOLC1, TAF11, TMPO, PPP1CC, DCP2, LSM1, SLBP, POLR2B, HSPE1, DNTTIP2, C2ORF3, GINS1, EXOSC8, C1D, GTF2B, GSPT1, MTF2, ISG20L2, CHUK, MTERF, BAZ1B, CTR9, CPSF6, MPHOSPH10, CTCF, AGL, SKP2, TCEB1, MED6, HSPA8, ZNF250, TMEM123, DHX15, VRK1, MAT2A, KHSRP, PRKRA, GTF2A2, TAF4, MRE11A, SMG7, SLC7A5, TUBGCP3, RBMX, CHRNA5, TCERG1, PRKRIR, ATG12, PFAS, ZNF195, DBF4, EIF2S2, ELAC2, ZNF131, RBM34, NCBP2, TOPBP1, METAP2, CNOT1, OGG1, TOE1, SMARCA5, LARP5, RBBP8, ZNF337, KLHL23, TCP1, DDX46, WTAP, CENPE, KNTC1, GNL2, KIAA0196, ATR, PAICS, RIF1, ILF3, ITGB3BP, ODC1, EZH2, SNRPB2, TTF1, LBR, NCBP1, CCNE2, LARP4, ATM, GTF2E1, SRP19, NUP62 |
| WEI MYCN TARGETS WITH E BOX | PRPF40A, VDR, PKNOX1, ABCE1, POLE3, QSER1, NOLC1, RNF138, HOMER1, RIOK2, E2F3, CSRP2, MRPS30, DNTTIP2, AASDHPPT, ASCC3, LSG1, UPF2, SFRS7, PUS7, C21ORF45, RABGGTB, MPHOSPH10, ZNF267, SKP2, GOLT1B, HSPA8, AMD1, GPR77, FASTKD2, TMEM70, MRPS28, PTS, RPP40, VRK1, PUS1, NUP37, TSN, OAS2, KIAA0556, EIF5, UMPS, MRPS35, IMPAD1, DYNC1LI1, NUPL1, PHLDA2, SBNO1, ATP2B1, POP1, SLC20A1, CD58, DCBLD2, PMM2, TAF1A, CBFB, PAPOLA, ETF1, NETO2, SPATA5L1, C1ORF109, DDX46, GEM, ZBTB38, SERBP1, GNL2, CCNE1, UAP1, PAICS, CHML, ZNF468, RIF1, PHF15, ODC1, HPS1, NOL11, ADPGK, POLR3B, CASP8, PSMD12, CCNE2, LARP4, SLC25A32, POP7, ZMPSTE24, XRCC4, SRP19, MIPEP, SLC39A6, TTC27, STIP1 |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | PRPF40A, PCNA, ABCE1, NOLC1, TMPO, DBF4, PHLDA2, GART, NMD3, FRYL, EIF2S2, SLC7A11, ZC3H7A, C1ORF163, RHOBTB3, NCBP2, SS18, USP16, MTIF2, DNTTIP2, TOPBP1, CD58, FBXO5, GINS1, BRWD1, SLC30A5, RBBP8, GUF1, GSPT1, PAPOLA, PAQR3, NETO2, C21ORF45, RABGGTB, KNTC1, GTPBP4, RASAL2, WDR3, MPHOSPH10, TLK1, C1ORF103, GNL2, CCNE1, RAI14, ZNF146, ATR, EXOC5, PAICS, CKAP2, SSR3, RIF1, RARS, MED6, PHF14, BXDC2, TMEM30A, ACTR2, CUL4B, KIF18A, MBNL1, CCNE2, SLC25A32, PMS1, XRCC4, WAPAL, MATR3 |
| ELVIDGE HYPOXIA DN | IDH3A, FASTKD5, AMD1, DHX29, ODC1, POLR3E, SEC23IP, C14ORF169, SCYL2, DNAJA1, PUS1, ALDH4A1, SPAG1, CHUK, ETF1, LARP4, NETO2, ZMPSTE24, PRPF4B, SLC25A44 |
| PUJANA XPRSS INT NETWORK | PCNA, TCERG1, TAF11, TMPO, PPP1CC, DCP2, POLR2B, ZNF131, TOPBP1, TOP2A, GINS1, EXOSC8, RBBP8, MSH2, MTF2, DDX46, KNTC1, CTCF, SKP2, PAICS, RIF1, ILF3, KIAA0922, SNRPA1, ANP32E, EZH2, PNN, LBR, MAT2A, ATM, RAD51AP1, MRE11A |
| RAMALHO STEMNESS UP | GNL2, YAP1, RNF138, FASTKD5, CCND1, RSL1D1, PPP1R2, ACADM, ARCN1, SEC23IP, ZCCHC10, LSG1, MSH2, CHD1, RAD23B, PSMD12, USP10, PKD2, RNF4, PCF11, UMPS, INTS5, MPHOSPH10 |
| BIDUS METASTASIS UP | NFIB, YTHDF1, PNMA1, WBP11, RABGAP1L, RNF138, DBF4, PAK2, AMD1, NCBP2, ODC1, FBXO3, SEC24B, C14ORF104, CAND1, CBFB, KHDRBS1, LARP4, KLHL23, AZIN1, CRKL, RABGGTB, CRY1, CBLL1, NF1, CCDC47 |
| KOBAYASHI EGFR SIGNALING 24HR DN | ABCE1, NOLC1, TMPO, DKK1, PHLDA2, DBF4, CCND1, ZC3HAV1, ODC1, SLC20A1, SPRED2, EZH2, GINS1, DTL, NOC3L, PNN, EXOSC8, DCBLD2, PHLDA1, MSH2, CCNE2, HMGA2, NETO2, SFRS7, RAD51AP1, IL11, PUS7, NARG1 |
| ZHANG BREAST CANCER PROGENITORS UP | CASP8AP2, TTC3, LRBA, TMPO, PRPS2, BMI1, DBF4, SBNO1, TSPAN13, POLR2B, TOPBP1, SMARCA5, METTL9, C1D, SERBP1, SUCLA2, WDR3, CPSF6, SNX5, CTCF, ATR, SKP2, RIF1, ILF3, MED6, PHF14, SEPHS2, EZH2, HBXIP, DNAJA1, EMID1, NCBP1, POLR1C, IK, LRRC40, MATR3 |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | TTRAP, MBD4, PAK1IP1, ILF3, DBF4, MCM3AP, DHX29, AASDHPPT, EZH2, DNAJB14, ZCCHC10, PAPOLA, C17ORF42, PEX1, RNF111, NADSYN1, TMEM135, SPATA5L1, WDR61, NOL8, MINA, IK, MATR3, LRRC40 |
| SCHLOSSER MYC TARGETS REPRESSED BY SERUM | GNL2, TCERG1, POLE3, NOLC1, COPS2, IDH3A, NUPL1, PWP1, FASTKD2, CSNK1E, EI24, HSPE1, SFRS2B, AASDHPPT, CHERP, API5, EXOSC8, ZC3H14, HIRA, ETF1, ZMPSTE24, USP10, SERBP1, RABGGTB, SLC39A6, XPOT, ZZZ3 |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | |
| NCI TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON CONTAINING TRANSCRIPT | UPF3B, NCBP1, NUPL1, SFRS7, NCBP2, SRRM1, NUP62, RBM8A |
| REACTOME MRNA 3 END PROCESSING | PAPOLA, UPF3B, NCBP1, SFRS7, NCBP2, SRRM1, PCF11, RBM8A |
| BORCZUK MALIGNANT MESOTHELIOMA UP | CDC27, TAF11, RIF1, PRPS2, FSCN1, PAK2, HSPA8, NCBP2, RHOBTB3, PPP1R2, SEC23IP, HBXIP, GINS1, DNAJA1, HIPK1, NEK4, PAPOLA, PTPLB, CGRRF1, CCNE2, ISG20L2, C1ORF156, UBE2E3, WTAP, SERBP1, STIP1, ZMYND11 |
| BENPORATH CYCLING GENES | |
| GOVONI GH1 TARGETS 24HR DN | |
| MITSIADES RESPONSE TO APLIDIN DN | CCNE1, CSNK2A1 /// CSNK2A1P, CASP6, SKP2, TTC3, ANKRD10, DCP2, ZC3HAV1, POLR2B, NF2, TOPBP1, GINS1, FBXO5, LBR, MBNL1, SLC5A3, DDX46, TRAM2, SERBP1 |
| DING LUNG CANCER EXPRESSION BY COPY NUMBER | PDCD6, BRWD1, NIPBL, RAE1, ANKRD10, PAK2, LSM1, E2F3, ZNF302, MYNN, MIPEP, MRPS28, CBLL1, FBXW11, MAPK8 |
| NCI TRAFFICKING OF AMPA RECEPTORS | |
| HAHTOLA MYCOSIS FUNGOIDES CD4 DN | |
| BROWNE HCMV INFECTION 14HR UP | |
| REACTOME REV MEDIATED NUCLEAR EXPORT OF HIV1 RNA | |
| STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN | |
| ELVIDGE HIF1A TARGETS UP | |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | |
| CORUM EXON JUNCTION COMPLEX | UPF2, RBM8A, SRRM1, UPF3B |
| NCI TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | |
| NCI REV MEDIATED NUCLEAR EXPORT OF HIV 1 RNA | |
| CORUM CF IIAM COMPLEX CLEAVAGE FACTOR IIAM COMPLEX | |
| CORUM BETA1-AR RECEPTOSOME ADRB1-SAP97-AKAP79-PRKAR2A | |
| BIOCARTA RARRXR PATHWAY | |
| NCI CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | PAPOLA, UPF3B, NCBP1, SFRS7, NCBP2, SRRM1, PCF11, RBM8A |
| UDAYAKUMAR MED1 TARGETS UP | |
| REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON CONTAINING TRANSCRIPT | UPF3B, NCBP1, NUPL1, SFRS7, NCBP2, SRRM1, NUP62, RBM8A |
| NCI TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA | |
| GUTIERREZ MULTIPLE MYELOMA DN | |
| CORUM POSTSPLICING COMPLEX | |
| CORUM SPLICEOSOME | PRPF40A, TCERG1, WBP11, PRPF3, NCBP2, RBM15, SRRM1, RBM22, SNRPB2, PPWD1, NCBP1, SFRS7, PRPF4B, WTAP, RBM8A, IK, CPSF6 |
| NUYTTEN NIPP1 TARGETS DN | |
| BROWNE HCMV INFECTION 16HR UP | |
| PUJANA BREAST CANCER WITH BRCA1 MUTATED UP | |
| NCI MRNA 3 END PROCESSING | PAPOLA, UPF3B, NCBP1, SFRS7, NCBP2, SRRM1, PCF11, RBM8A |
| RODRIGUES NTN1 TARGETS UP | |