BICLUSTER_ID : DNREG-60
PATHOGENS /4/ : pseudomonas aeruginosa,helicobacter pylori,aeromonas caviae,porphyromonas gingivalis
TARGETS /19/ : SQLE, HMGCR, PAPSS1, MGST3, VDAC1, PPP2CA, ALDH9A1, NSDHL, DUT, NDUFA6, PSMB2, PSMB5, GMPS, NDUFS4, HADHA, IDH1, SLC25A5, NDUFS2, HSD17B4
Gene SetLeading Edge Genes
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DNSQLE, HMGCR, ZWINT, CCNB1, CYC1, CTDSPL, NSDHL, PSMB5, NHP2L1, INSIG1, HEXIM1, HADHA, CCT5, GPSM2, TARDBP, HMGCS1, HSD17B4, RYK, EBP
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UPMAGOH, PAPSS1, MGST3, MRPL40, NCBP2, RFC4, RPA3, PSMB2, NHP2L1, PSMB5, RPL36AL, LSM3, GMPS, TAF12, TOM1L1, ACP1, CCT8, ETF1, IDH1, BTF3, SSR2, HAX1, NUP205, COPB2
REACTOME CELL CYCLE MITOTICPSMB2, PSMC5, PSMD7, PSMB5, ZWINT, DBF4, CCNB1, PPP2CA, PSMC1, PSMB7, DCTN2, RFC4, RPA3
HORIUCHI WTAP TARGETS DNSQLE, SC5DL, HMGCR, GSPT1, TMPO, UNG, SLC25A5, CCNB1, FDFT1
TARTE PLASMA CELL VS PLASMABLAST DNMYCBP, PSMC5, CASP6, TMPO, UQCRH, CCNB1, VDAC1, PAK2, HSPE1, RFC4, PSMB2, ATP5O, DUT, GSPT1, TCP1, EBNA1BP2, CCT5, ETF1, FDFT1, UQCRC2, EBP
KEGG PARKINSONS DISEASENDUFS2, ATP5O, NDUFA6, HTRA2, NDUFS4, CYC1
BIOCARTA PROTEASOME PATHWAYPSMB2, PSMB5, PSMB7, UBE3A
CORUM 26S PROTEASOMEPSMB2, PSMC5, PSMC1, PSMB5, PSMB7
CORUM PA700-20S-PA28 COMPLEXPSMB2, PSMC5, PSMB5, PSMC1, PSMB7
PAL PRMT5 TARGETS UPPSMB5, TMPO, SLBP, COPS3, CFDP1, NCBP2, TARDBP, LSM2
LINDGREN BLADDER CANCER CLUSTER 3 UPINSIG1, TOM1L1, TMPO, CCNB1, ZNF148, AK2, RFC4, ALDH9A1, RPA3, COPB2, EBP
REACTOME MITOTIC PROMETAPHASEZWINT, PPP2CA
REACTOME G1 S TRANSITIONPSMC5, PSMC1, PSMB5, PSMB7, RPA3, CCNB1
BENPORATH MYC MAX TARGETS
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP
PUJANA BRCA1 PCC NETWORK
DANG BOUND BY MYC
ROME INSULIN TARGETS IN MUSCLE UP
REACTOME CELL CYCLE CHECKPOINTS
RHODES UNDIFFERENTIATED CANCER
ALONSO METASTASIS UP
LEE EARLY T LYMPHOCYTE UP
ZHAN MULTIPLE MYELOMA SUBGROUPS
BASSO B LYMPHOCYTE NETWORK
ODONNELL TARGETS OF MYC AND TFRC DN
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN
ZHAN MULTIPLE MYELOMA PR UP
OUELLET OVARIAN CANCER INVASIVE VS LMP UP
SANA RESPONSE TO IFNG DN
NCI HOST INTERACTIONS OF HIV FACTORS
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN
NUYTTEN EZH2 TARGETS DN
NCI APC C CDC20 MEDIATED DEGRADATION OF SECURIN
MARKEY RB1 ACUTE LOF DN
NCI ORC1 REMOVAL FROM CHROMATIN
ZHAN VARIABLE EARLY DIFFERENTIATION GENES DN
CORUM CSA COMPLEX
NCI SCF SKP2 MEDIATED DEGRADATION OF P27 P21
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21
NCI MITOTIC PROMETAPHASE
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
CROONQUIST NRAS SIGNALING DN
KOBAYASHI EGFR SIGNALING 24HR DNGPSM2, PARP2, ZWINT, TMPO, UNG, ETV5, CCNB1
REACTOME CHOLESTEROL BIOSYNTHESIS
MANN RESPONSE TO AMIFOSTINE DN
CORUM PA28GAMMA-20S PROTEASOME
REACTOME HOST INTERACTIONS OF HIV FACTORS
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX
REACTOME SYNTHESIS OF DNA
SHEDDEN LUNG CANCER POOR SURVIVAL A6
REACTOME DNA REPLICATION PRE INITIATION
NCI VPU MEDIATED DEGRADATION OF CD4
MORI EMU MYC LYMPHOMA BY ONSET TIME UP
KEGG STEROID BIOSYNTHESIS
NCI AUTODEGRADATION OF CDH1 BY CDH1 APC C
REACTOME REGULATION OF APC ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE
REACTOME CDC20 PHOSPHO APC MEDIATED DEGRADATION OF CYCLIN A
RAMALHO STEMNESS UP
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G
NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6
DING LUNG CANCER EXPRESSION BY COPY NUMBER
MORI IMMATURE B LYMPHOCYTE DNCCNB1, CENPA
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13
CAFFAREL RESPONSE TO THC 24HR 5 UP
LEE LIVER CANCER SURVIVAL DN
MUELLER PLURINET
GARY CD5 TARGETS DN
NCI CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP
BLUM RESPONSE TO SALIRASIB DNMYCBP, PRDX3, GPSM2, TMPO, LSM5, EBP
RICKMAN METASTASIS UP
GRADE COLON AND RECTAL CANCER UP
NCI CDC20 PHOSPHO APC C MEDIATED DEGRADATION OF CYCLIN A
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN
CORUM 20S PROTEASOME
KAAB FAILED HEART ATRIUM DN
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS
WEST ADRENOCORTICAL TUMOR UP
YU MYC TARGETS UP
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DNCCT2, POLE3, RAN, UBE2E3, COPS3, XRCC5, RNASEH2A, RFC4, RPA3, NUP205, LSM2
CROONQUIST IL6 DEPRIVATION DNCCNB1
NCI MRNA SPLICING MAJOR PATHWAY
KINSEY TARGETS OF EWSR1 FLII FUSION UP
FOURNIER ACINAR DEVELOPMENT LATE 2
MOHANKUMAR TLX1 TARGETS UP
CAFFAREL RESPONSE TO THC 24HR 5 DN
REACTOME S PHASE
MORI LARGE PRE BII LYMPHOCYTE UP
KEGG CELL CYCLE
PUJANA BRCA CENTERED NETWORK
ROSTY CERVICAL CANCER PROLIFERATION CLUSTERRPA3, TMPO, ZWINT, CCNB1, EBP
CORUM SPLICEOSOME
MOREAUX MULTIPLE MYELOMA BY TACI DN
NUYTTEN NIPP1 TARGETS DN
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP
RHODES CANCER META SIGNATURE
NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION1
NCI VIF MEDIATED DEGRADATION OF APOBEC3G
CORUM CSA-POLIIA COMPLEX
ACEVEDO LIVER CANCER UP
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION
NCI DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX
NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A
MISSIAGLIA REGULATED BY METHYLATION DN
DODD NASOPHARYNGEAL CARCINOMA DN
KEGG NUCLEOTIDE EXCISION REPAIR
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION
BENPORATH PROLIFERATIONGPSM2, RFC4, SHFM1, DBF4
Color legend
q-value-1-0.2-0.05-0.01-0.001-0.0001
Color
TABLE OF Q-VALUES
pseudomonas aeruginosaporphyromonas gingivalisaeromonas caviahelicobacter pylori kx1 npgecGeneSet Name
-0.01995 -0.00446 -0.00007 -0.00349CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN
-0.01279 -0.00366 -0.00040 -0.00733ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP
-0.00096 -0.00002 -0.01738 -0.00054REACTOME_CELL_CYCLE_MITOTIC
-0.00235 -0.00150 -0.02805 -0.00232HORIUCHI_WTAP_TARGETS_DN
-0.00025 -0.00195 -0.00013 -0.00391TARTE_PLASMA_CELL_VS_PLASMABLAST_DN
-0.04469 -0.00196 -0.00031 -0.00043KEGG_PARKINSONS_DISEASE
-0.01812 -0.03291 -0.01760 -0.00229BIOCARTA_PROTEASOME_PATHWAY
-0.02911 -0.00246 -0.00087 -0.00041CORUM_26S_PROTEASOME
-0.08038 -0.00038 -0.00461 -0.00045CORUM_PA700-20S-PA28_COMPLEX
-0.00092 -0.00394 -0.00510 -0.00038PAL_PRMT5_TARGETS_UP
-0.01432 -0.02524 -0.00804 -0.00109LINDGREN_BLADDER_CANCER_CLUSTER_3_UP
-0.00072 -0.02038 -0.01572 -0.00233REACTOME_MITOTIC_PROMETAPHASE
-0.05329 -0.00005 -0.03437 -0.00298REACTOME_G1_S_TRANSITION
-0.08688 -0.02655 -0.02326 -0.01238BENPORATH_MYC_MAX_TARGETS
-0.18953 -0.19892 -0.00002 -0.00058GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP
-0.01546 -0.02359 -0.02210 -0.03725PUJANA_BRCA1_PCC_NETWORK
-0.17910 -0.09746 -0.04846 -0.02924DANG_BOUND_BY_MYC
-0.08090 -0.02002 -0.03612 -0.01595ROME_INSULIN_TARGETS_IN_MUSCLE_UP
-0.00423 -0.00004 -0.12741 -0.00086REACTOME_CELL_CYCLE_CHECKPOINTS
-0.02924 -0.00835 -0.08510 -0.00202RHODES_UNDIFFERENTIATED_CANCER
-0.01131 -0.14187 -0.01561 -0.00963ALONSO_METASTASIS_UP
-0.00995 -0.02965 -0.13798 -0.00370LEE_EARLY_T_LYMPHOCYTE_UP
-0.19470 -0.08383 -0.02796 -0.01414ZHAN_MULTIPLE_MYELOMA_SUBGROUPS
-0.16721 -0.03873 -0.00040 -0.05536BASSO_B_LYMPHOCYTE_NETWORK
-0.09189 -0.02032 -0.10956 -0.02871ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN
-0.06230 -0.13208 -0.04764 -0.00940BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN
-0.00283 -0.10560 -0.07638 -0.06738ZHAN_MULTIPLE_MYELOMA_PR_UP
-0.00029 -0.02711 -0.12665 -0.06498OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP
-0.01466 -0.05467 -0.05430 -0.00182SANA_RESPONSE_TO_IFNG_DN
-0.15917 -0.00011 -0.15534 -0.00332NCI_HOST_INTERACTIONS_OF_HIV_FACTORS
-0.07235 -0.00539 -0.02451 -0.03248MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN
-0.00115 -0.00360 -0.09241 -0.00564NUYTTEN_EZH2_TARGETS_DN
-0.02054 -0.00022 -0.15341 -0.00082NCI_APC_C_CDC20_MEDIATED_DEGRADATION_OF_SECURIN
-0.08917 -0.15592 -0.03439 -0.00100MARKEY_RB1_ACUTE_LOF_DN
-0.16693 -0.00011 -0.16795 -0.00240NCI_ORC1_REMOVAL_FROM_CHROMATIN
-0.07862 -0.08387 -0.02520 -0.00951ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_DN
-0.14494 -0.15805 -0.00746 -0.14727CORUM_CSA_COMPLEX
-0.04441 -0.00013 -0.16007 -0.00295NCI_SCF_SKP2__MEDIATED_DEGRADATION_OF_P27_P21
-0.18355 -0.00002 -0.14701 -0.00110REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21
-0.00094 -0.02882 -0.05777 -0.00299NCI_MITOTIC_PROMETAPHASE
-0.15393 -0.00003 -0.17884 -0.00197REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
-0.00118 -0.04603 -0.10708 -0.00331CROONQUIST_NRAS_SIGNALING_DN
-0.08946 -0.00406 -0.00012 -0.00610KOBAYASHI_EGFR_SIGNALING_24HR_DN
-0.18726 -0.01829 -0.00074 -0.00080REACTOME_CHOLESTEROL_BIOSYNTHESIS
-0.14582 -0.19511 -0.05970 -0.05983MANN_RESPONSE_TO_AMIFOSTINE_DN
-0.04070 -0.01817 -0.09441 -0.00082CORUM_PA28GAMMA-20S_PROTEASOME
-0.13662 -0.00012 -0.06036 -0.01709REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS
-0.17194 -0.00011 -0.16138 -0.00103REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX
-0.12476 -0.00002 -0.13465 -0.00059REACTOME_SYNTHESIS_OF_DNA
-0.01610 -0.00219 -0.00092 -0.03282SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6
-0.08852 -0.00014 -0.12621 -0.00239REACTOME_DNA_REPLICATION_PRE_INITIATION
-0.15682 -0.00019 -0.13870 -0.00423NCI_VPU_MEDIATED_DEGRADATION_OF_CD4
-0.04215 -0.19698 -0.03498 -0.09524MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_UP
-0.12908 -0.15823 -0.00868 -0.13314KEGG_STEROID_BIOSYNTHESIS
-0.02932 -0.00049 -0.12840 -0.00058NCI_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
-0.00892 -0.00004 -0.13836 -0.00031REACTOME_REGULATION_OF_APC_ACTIVATORS_BETWEEN_G1_S_AND_EARLY_ANAPHASE
-0.01770 -0.00008 -0.18920 -0.00031REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A
-0.00090 -0.03607 -0.00752 -0.01531RAMALHO_STEMNESS_UP
-0.14667 -0.00004 -0.09110 -0.00211REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
-0.11639 -0.00015 -0.19025 -0.00005NCI_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
-0.00113 -0.01809 -0.01153 -0.14078DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER
-0.07989 -0.02597 -0.01113 -0.00202MORI_IMMATURE_B_LYMPHOCYTE_DN
-0.15890 -0.00001 -0.00014 -0.00033YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13
-0.14486 -0.05885 -0.01437 -0.01918CAFFAREL_RESPONSE_TO_THC_24HR_5_UP
-0.00284 -0.12425 -0.00011 -0.00959LEE_LIVER_CANCER_SURVIVAL_DN
-0.07862 -0.00024 -0.01895 -0.10442MUELLER_PLURINET
-0.01258 -0.00029 -0.00012 -0.10908GARY_CD5_TARGETS_DN
-0.13320 -0.00011 -0.14799 -0.00233NCI_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX
-0.00868 -0.07138 -0.17884 -0.03512RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP
-0.00107 -0.01336 -0.01909 -0.00297BLUM_RESPONSE_TO_SALIRASIB_DN
-0.00225 -0.02769 -0.04631 -0.05493RICKMAN_METASTASIS_UP
-0.07257 -0.01065 -0.01034 -0.05976GRADE_COLON_AND_RECTAL_CANCER_UP
-0.01606 -0.00011 -0.14365 -0.00056NCI_CDC20_PHOSPHO_APC_C_MEDIATED_DEGRADATION_OF_CYCLIN_A
-0.00052 -0.05214 -0.13184 -0.01818SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN
-0.07750 -0.02065 -0.05586 -0.00236CORUM_20S_PROTEASOME
-0.02180 -0.14344 -0.07845 -0.00239KAAB_FAILED_HEART_ATRIUM_DN
-0.06489 -0.10564 -0.17521 -0.17124REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS
-0.01510 -0.04057 -0.00123 -0.00298WEST_ADRENOCORTICAL_TUMOR_UP
-0.12022 -0.03945 -0.00075 -0.00084YU_MYC_TARGETS_UP
-0.04093 -0.00019 -0.17256 -0.00035REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC
-0.05357 -0.06682 -0.15511 -0.01555FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP
-0.00006 -0.00284 -0.00408 -0.00179CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN
-0.03272 -0.00054 -0.02538 -0.00330CROONQUIST_IL6_DEPRIVATION_DN
-0.12422 -0.00002 -0.00363 -0.01681NCI_MRNA_SPLICING___MAJOR_PATHWAY
-0.00097 -0.01136 -0.00039 -0.00330KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
-0.11866 -0.00037 -0.00027 -0.00300FOURNIER_ACINAR_DEVELOPMENT_LATE_2
-0.02157 -0.19488 -0.01503 -0.00718MOHANKUMAR_TLX1_TARGETS_UP
-0.03826 -0.13906 -0.01792 -0.01708CAFFAREL_RESPONSE_TO_THC_24HR_5_DN
-0.10989 -0.00004 -0.05997 -0.00088REACTOME_S_PHASE
-0.02813 -0.03260 -0.08123 -0.01648MORI_LARGE_PRE_BII_LYMPHOCYTE_UP
-0.00226 -0.10582 -0.16594 -0.00463KEGG_CELL_CYCLE
-0.01365 -0.01278 -0.13176 -0.00614PUJANA_BRCA_CENTERED_NETWORK
-0.00901 -0.00111 -0.02207 -0.00180ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER
-0.13655 -0.00003 -0.12815 -0.15924CORUM_SPLICEOSOME
-0.01021 -0.00320 -0.00005 -0.04602MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN
-0.13346 -0.18750 -0.17645 -0.00278NUYTTEN_NIPP1_TARGETS_DN
-0.14610 -0.03580 -0.19744 -0.01296OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_UP
-0.02762 -0.06689 -0.00533 -0.03118RHODES_CANCER_META_SIGNATURE
-0.08212 -0.00012 -0.12440 -0.00333NCI_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
-0.09720 -0.00009 -0.13777 -0.00244NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION1
-0.14776 -0.00007 -0.06065 -0.00392NCI_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
-0.14479 -0.14882 -0.01507 -0.13273CORUM_CSA-POLIIA_COMPLEX
-0.00067 -0.06123 -0.06712 -0.01628ACEVEDO_LIVER_CANCER_UP
-0.15806 -0.00012 -0.16114 -0.00369NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION
-0.11690 -0.00010 -0.13493 -0.00307NCI_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX
-0.15650 -0.00008 -0.15849 -0.00436NCI_UBIQUITIN_MEDIATED_DEGRADATION_OF_PHOSPHORYLATED_CDC25A
-0.00099 -0.00095 -0.05423 -0.00244MISSIAGLIA_REGULATED_BY_METHYLATION_DN
-0.00288 -0.02277 -0.06032 -0.06590DODD_NASOPHARYNGEAL_CARCINOMA_DN
-0.03758 -0.00290 -0.02124 -0.04356KEGG_NUCLEOTIDE_EXCISION_REPAIR
-0.14317 -0.00004 -0.12841 -0.00251REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_
-0.00017 -0.02164 -0.01238 -0.00727BENPORATH_PROLIFERATION