| Gene Set | Leading Edge Genes |
|---|
| KAUFFMANN DNA REPLICATION GENES | CHAF1B, RFC1, POLQ, RRM1, ORC6L, HTATSF1, RFC4, TFAM, RPA3, POLD1, TOPBP1, RFC5, ORC5L, CENPF, MCM4, DUT, RPA2, MCM3, FEN1, MSH2, MCM5, CDC6, POLE2, MCM7, POLG2, MCM6, POLH, RPA1, SUV39H1, CTBP2, BLM |
| KAUFFMANN DNA REPAIR GENES | CHAF1B, MPG, XRCC1, TOP2B, CETN3, EXO1, TOP2A, TOPBP1, RFC5, OGG1, CIB1, RPA2, APEX1, RECQL4, MSH2, TERF1, POLG2, TERF2, NEIL3, BLM, GTF2H5, MAD2L1, RFC1, MUTYH, MLH1, TDP1, DCLRE1B, RRM1, RFC4, H2AFX, NUDT3, RPA3, PRKDC, POLD1, DUT, MSH6, UNG, POLE2, PMS1, RAD51AP1, MRE11A, POLE, POLH, RPA1 |
| BENPORATH CYCLING GENES | PKNOX1, CHAF1B, BUB1, PLK1, CCNB1, NUCKS1, CENPA, AURKA, PBK, ASF1B, MCAM, E2F8, EXO1, SHCBP1, TOP2A, TOPBP1, CENPF, CDCA3, C6, RPA2, NUSAP1, RECQL4, MSH2, MCM5, UBE2C, CDC6, MCM6, KIF22, CAPN7, ACYP1, BUB1B, ATAD2, KIF11, MAD2L1, CKAP2, CEP55, PASK, ARHGAP11A, RFC4, H2AFX, HMMR, CCNA2, MCM4, TRIP13, DTL, CCNB2, ECT2, TTK, CDC20, KIF23, UNG, NUP37, CCNE2, CDC25C, ARMC1, NEK2, PRC1, SMC4, CDCA8, SMTN, KIF2C, BIRC5 |
| BOYAULT LIVER CANCER SUBCLASS G23 UP | BUB1B, TUBG1, MCM3, ECT2, CCNE2, CENPA, SMC2, MCM6, NEK2, RRM1 |
| NCI UNWINDING OF DNA | MCM6, MCM7, MCM3, MCM5, MCM4 |
| STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN | DTL, ATAD2, SKP2, MCM5, MLF1IP, CDC6, CCNE2, POLE2, MCM6, RRM1, SMC4, WDHD1 |
| REACTOME MITOTIC M M G1 PHASES | BUB1B, KIF20A, CENPC1, MAD2L1, BUB1, PLK1, CENPA, E2F1, ZWILCH, ORC6L, SMC3, ORC5L, CENPF, MCM4, FBXO5, KIF18A, MCM3, CDC20, MCM5, KIF23, NUP37, CDC6, MCM7, MCM6, CDCA8, KNTC1, KIF2C, BIRC5, NDE1 |
| CORUM MCM COMPLEX | MCM6, MCM7, MCM3, MCM5, MCM4 |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | BUB1B, KIF20A, ATAD2, BUB1, NUP210, CCNB1, AURKA, ASF1B, TOP2A, CENPF, MCM4, CCNB2, TTK, NUSAP1, EIF4EBP1, UBE2C, CDC6, TK1, RNASEH2A, PRC1, SMC4, XPOT, BIRC5, ASPM |
| BIDUS METASTASIS UP | PREPL, KIF11, MAD2L1, WHSC1, BUB1, CCNB1, CENPA, MPHOSPH9, AURKA, ASF1B, PBK, RFC4, PRKDC, CCNA2, RFC5, CENPF, KIF4A, CCNB2, ECT2, NUSAP1, RACGAP1, WRB, MNS1, RMND5A, UBE2C, CDC6, SFRS1, SMC4, WDHD1, BIRC5 |
| KEGG CELL CYCLE | BUB1B, MAD2L1, SKP2, BUB1, PLK1, CCNB1, E2F1, SMC3, CCNA2, PRKDC, MCM4, CCNB2, MCM3, TTK, CDC20, MCM5, CCNE2, CDC25C, CDC6, MCM7, MCM6 |
| LOPEZ MESOTELIOMA SURVIVAL TIME UP | AURKA, DCLRE1B, CDC25C, BIRC5, TRIP13 |
| NCI PLK1 PATHWAY | FBXO5, BUB1B, KIF20A, ECT2, TUBG1, CDC20, BUB1, CDC25C, PLK1, CCNB1, AURKA, PRC1, PAK1 |
| NCI M G1 TRANSITION | MCM6, MCM3, ORC6L, MCM5, ORC5L, CDC6, MCM4 |
| NCI ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | MCM6, MCM3, ORC6L, MCM5, ORC5L, CDC6, MCM4 |
| NCI DNA REPLICATION PRE INITIATION | MCM6, MCM3, ORC6L, MCM5, ORC5L, CDC6, MCM4 |
| BIOCARTA MCM PATHWAY | MCM6, MCM3, ORC6L, MCM5, ORC5L, CDC6, MCM4 |
| WU APOPTOSIS BY CDKN1A VIA TP53 | RACGAP1, MCM3, ATAD2, BUB1, CCNB1, AURKA, PBK, PRC1, KNTC1, ASPM, MCM4 |
| WAKASUGI HAVE ZNF143 BINDING SITES | TDP1, MUS81, EXO1, PRKDC, POLD1, APEX1, RECQL4, FEN1, MSH6, MSH2, PMS1, CHEK1, MRE11A, POLE, FANCL, RAD1, GTF2H5 |
| FINETTI BREAST CANCER BASAL VS LUMINAL | BUB1B, TTK, BUB1, PLK1, AURKB, CDC7, AURKA, PBK, NEK2, SRPK1 |
| LY AGING MIDDLE DN | CDC20, KIF11, KIF23, PLK1, UBE2C, CCNB1, CCNF, CENPA, H2AFX, CCNA2, CENPF |
| KEGG BASE EXCISION REPAIR | OGG1, APEX1, MPG, XRCC1, MUTYH, UNG, POLE2, POLE, NEIL3, POLD1 |
| NAKAYAMA SOFT TISSUE TUMORS PCA2 UP | ESPL1, KIF20A, KIF11, BUB1, CEP55, CCNB1, CENPA, PBK, HMMR, CCNA2, TOP2A, CENPF, MCM4, NUSAP1, CCNB2, CDC20, MICAL2, UBE2C, NEK2, CDCA8, KIF2C, ASPM, BIRC5 |
| RHODES UNDIFFERENTIATED CANCER | MAD2L1, CCNB1, CENPA, RFC4, H2AFX, TOP2A, CCNA2, TRIP13, MCM3, CDC20, UBE2C, CDC6, KIF23, MCM6, KIF2C, BIRC5 |
| NCI G1 S TRANSITION | MCM6, MCM3, ORC6L, MCM5, ORC5L, CDC6, MCM4 |
| SU TESTIS | NCAPH, BUB1B, CCNB2, TTK, PRKAR2A, BUB1, CCNB1, AURKA, NEK2, RFC4, HMMR, TOPBP1, KIF2C |
| NCI CELL CYCLE MITOTIC | MCM6, MCM3, ORC6L, MCM5, ORC5L, CDC6, MCM4 |
| FINETTI BREAST CANCER KINOME RED | BUB1B, TTK, BUB1, PLK1, AURKB, CDC7, AURKA, PBK, NEK2, SRPK1 |
| KALMA E2F1 TARGETS | MCM6, RPA2, RFC4, POLD1, TOP2A |
| NCI RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | |
| REACTOME LAGGING STRAND SYNTHESIS | RPA2, FEN1, RFC1, RPA1, RFC4, RPA3, RFC5, POLD1, PRIM1 |
| FERRANDO HOX11 NEIGHBORS | |
| BOYAULT LIVER CANCER SUBCLASS G123 UP | |
| MONTERO THYROID CANCER POOR SURVIVAL UP | CCNB2, NUSAP1, UBE2C, CENPA, PRC1, DIAPH3, ASPM, BIRC5 |
| CORUM BRAFT COMPLEX | |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| REACTOME REPAIR SYNTHESIS OF PATCH 27 30 BASES LONG BY DNA POLYMERASE | RPA2, POLE, RFC4, RPA1, RFC1, RPA3, RFC5, POLE2 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | |
| REACTOME NUCLEOTIDE EXCISION REPAIR | RPA2, RFC1, POLE2, POLE, RFC4, RPA1, RPA3, RFC5, ERCC5, POLD1 |
| SLEBOS HEAD AND NECK CANCER WITH HPV UP | |
| CORUM C COMPLEX SPLICEOSOME | |
| REACTOME CENTROSOME MATURATION | |
| NCI VIRAL MESSENGER RNA SYNTHESIS | |
| NCI REPAIR SYNTHESIS FOR GAP FILLING BY DNA POLYMERASE IN TC NER | RPA2, POLE, RFC4, RPA1, RFC1, RPA3, RFC5, POLE2 |
| NCI DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 | |
| REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | |
| REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | |
| REACTOME E2F TRANSCRIPTIONAL TARGETS AT G1 S | |
| CORUM GCN5-TRRAP HISTONE ACETYLTRANSFERASE COMPLEX | |
| KEGG MISMATCH REPAIR | RPA2, MSH6, MSH2, RFC1, MLH1, RPA1, RFC4, EXO1, RPA3, POLD1, RFC5 |
| CORUM DNA SYNTHESOME COMPLEX 13 SUBUNITS | RPA1, RFC1, TOP2B, TOP2A, PRIM1 |
| CORUM CENP-A NAC-CAD COMPLEX | |
| PYEON HPV POSITIVE TUMORS UP | |
| REACTOME SYNTHESIS OF DNA | |
| NCI SYNTHESIS OF DNA | |
| CORUM DNA SYNTHESOME CORE COMPLEX | |
| CORUM BASC AB 80 COMPLEX BRCA1-ASSOCIATED GENOME SURVEILLANCE COMPLEX | |
| CORUM BASC COMPLEX BRCA1-ASSOCIATED GENOME SURVEILLANCE COMPLEX | |
| MORI EMU MYC LYMPHOMA BY ONSET TIME UP | |
| CORUM NUCLEAR PORE COMPLEX | |
| CORUM RC COMPLEX REPLICATION COMPETENT COMPLEX | |
| NCI SNRNP ASSEMBLY | |
| NCI TRANSCRIPTION COUPLED NER TC NER | |
| NCI REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | |
| NCI FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | |
| REACTOME POLYMERASE SWITCHING | |
| RIZ ERYTHROID DIFFERENTIATION | |
| NCI DNA STRAND ELONGATION | |
| NCI RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | |
| NCI PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | |
| REACTOME BASE EXCISION REPAIR | |
| REACTOME REMOVAL OF THE FLAP INTERMEDIATE | |
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | |
| REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | |
| NCI E2F PATHWAY | |
| NCI REPAIR SYNTHESIS OF PATCH 27 30 BASES LONG BY DNA POLYMERASE | RPA2, POLE, RFC4, RPA1, RFC1, RPA3, RFC5, POLE2 |
| CORUM CONDENSIN I COMPLEX | |
| NCI PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE | |
| CORUM CONDENSIN I-PARP-1-XRCC1 COMPLEX | |
| CORUM 13S CONDENSIN COMPLEX | |
| STEIN ESR1 TARGETS | |
| KEGG NUCLEOTIDE EXCISION REPAIR | RPA2, RFC1, POLE2, POLE, RFC4, RPA1, RPA3, RFC5 |
| CORUM CONDENSIN II | |
| KEGG HOMOLOGOUS RECOMBINATION | |
| CORUM PCNA-MUTS-ALPHA-DNA INITIAL COMPLEX | |
| NCI REMOVAL OF THE FLAP INTERMEDIATE | RPA2, FEN1, RPA1, DNA2L, RPA3, POLD1, PRIM1 |
| SHEPARD BMYB TARGETS | |
| NCI GLOBAL GENOMIC NER GG NER | |
| NCI PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | |
| CORUM MSH2-MSH6-PMS2-MLH1 COMPLEX | |
| REACTOME GLOBAL GENOMIC NER | RPA2, RFC1, POLE2, POLE, RFC4, RPA1, RPA3, RFC5 |
| REACTOME G2 M TRANSITION | |
| REACTOME TRANSCRIPTION COUPLED NER | RPA2, RFC1, POLE2, POLE, RFC4, RPA1, RPA3, RFC5, POLD1 |
| ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN | |
| REACTOME CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX | |
| SEMBA FHIT TARGETS DN | ECT2, MNS1, CENPF, ASPM, BIRC5 |
| NCI MITOTIC PROMETAPHASE | BUB1B, CENPC1, MAD2L1, BUB1, MLF1IP, PLK1, AURKB, CENPA, SMC3, KIF18A, CDC20, NUP37, CDCA8, KNTC1, KIF2C, NDE1, BIRC5 |
| NCI CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX | |
| KEGG BUTANOATE METABOLISM | |
| SHEPARD CRUSH AND BURN MUTANT DN | |
| KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION | |
| TANG SENESCENCE TP53 TARGETS DN | |
| NCI LAGGING STRAND SYNTHESIS | |
| CORUM PCAF COMPLEX | |
| REACTOME REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE | |
| NCI DUAL INCISION REACTION IN TC NER | |
| REACTOME UNWINDING OF DNA | |
| CORUM DNA SYNTHESOME COMPLEX 15 SUBUNITS | POLE, RFC1, POLE2, PRIM1 |
| CORUM BRCA1-BARD1-BACH1-DNA DAMAGE COMPLEX I | |
| NCI POLYMERASE SWITCHING | |
| BIOCARTA RANMS PATHWAY | |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | FBXO5, ORC6L, ORC5L, CDC6, CCNB1 |
| CORUM DNA SYNTHESOME COMPLEX 17 SUBUNITS | POLE, RPA1, RFC1, TOP2B, TOP2A, POLE2, PRIM1 |
| CORUM RC COMPLEX DURING G2/M-PHASE OF CELL CYCLE | |
| PRAMOONJAGO SOX4 TARGETS DN | |
| REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | |
| CORUM MSH2-MLH1-PMS2-PCNA DNA-REPAIR INITIATION COMPLEX | |
| REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | |
| NCI DNA REPLICATION | |
| NCI E2F TRANSCRIPTIONAL TARGETS AT G1 S | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| NCI E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | |
| REACTOME EXTENSION OF TELOMERES | RPA2, RFC1, POLE2, POLE, RUVBL1, RFC4, RPA1, RPA3, RFC5, PRIM1 |
| CORUM BLM COMPLEX II | |
| NCI CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | |
| NCI DEPURINATION | |
| ALCALAY AML BY NPM1 LOCALIZATION DN | |
| OZEN MIR125B1 TARGETS | |
| NCI LEADING STRAND SYNTHESIS | |
| CORUM PCNA-MUTS-ALPHA-MUTL-ALPHA-DNA COMPLEX | |
| NCI POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE | |
| NCI DUAL INCISION REACTION IN GG NER | |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | ATAD2, CKAP2, CEP55, CCNB1, ARHGAP11A, SMC2, TMEM48, RPA3, CCNA2, TOP2A, CENPF, KIF18A, NUSAP1, KIF23, CDC6, POLE2, CHEK1, ODF2, WDHD1, KNTC1, KIF2C, BLM |
| NCI PHOSPHORYLATION OF EMI1 | |
| NCI TELOMERE C STRAND LAGGING STRAND SYNTHESIS | |
| REACTOME S PHASE | |
| NCI FORMATION OF INCISION COMPLEX IN GG NER | |
| REACTOME DUAL INCISION REACTION IN TC NER | |
| CORUM SRCAP-ASSOCIATED CHROMATIN REMODELING COMPLEX | |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | |
| VANTVEER BREAST CANCER METASTASIS DN | |
| REACTOME DUAL INCISION REACTION IN GG NER | |
| CORUM RC COMPLEX DURING S-PHASE OF CELL CYCLE | RPA2, POLE, RPA1, RFC1, RPA3, POLD1, CCNA2 |