| Gene Set | Leading Edge Genes |
|---|
| RHEIN ALL GLUCOCORTICOID THERAPY DN | PRDX6, SET, PCNA, INTS8, CETN2, MLF1IP, PRPS2, STMN1, CDK4, BZW2, ADSL, CANX, TOP2A, GMPS, CCT8, TUFM, GDI2, TMEM135, RAD51, RAB13, DPYSL2, LTA4H, MYH10, RRM1, CCNG1, HMMR, ACAA2, PCCB, NUDT1, HADH, POLE2, GLO1, PRDX3, PRC1, MRPS35, ATP5L, BIRC5 |
| WONG EMBRYONIC STEM CELL CORE | KIF20A, SQLE, YAP1, PCNA, ALDH7A1, EXOSC7, CDK4, CTNNA1, IPO9, ADSL, PPM1G, PSMA7, RPS19, KIF4A, MCM3, ECHS1, HADH, SLC25A5, CCT5, EBNA1BP2, GLO1, NDUFS2, DARS2, DPP3, BIRC5, TIMM8B |
| PUJANA CHEK2 PCC NETWORK | ESPL1, PCNA, POLE3, HMGCR, GTF3A, TMPO, YBX1, CCNB1, ADSL, RFC5, TFDP2, CENPF, CNOT1, TOE1, MCM3, EXOSC8, ATP5S, GMPS, CCT8, CPT1A, NUP88, LIG1, COPS3, DDX46, LMNB2, NUP205, CENPC1, CAD, KIFC1, CDC45L, PSMD9, HMMR, TTF1, ACAT2, CCNE2, SLC25A5, PFDN6, MRE11A, PRDX3, H2AFV, IDI1, IFT20, KIF2C |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | PCNA, CSTF2, KIFC1, TMPO, PRPS2, CCNB1, POLDIP2, STMN1, ALDH9A1, CENPF, DBI, KIF4A, TOM1L1, PTPLB, SUCLG1, GLO1, RAD51, LIG1, PRC1, TACC3, ARRB2, BIRC5 |
| REACTOME CELL CYCLE MITOTIC | KIF20A, PSMC5, PCNA, CENPC1, CDK5RAP2, CETN2, CCNB1, AZI1, CDK4, PSMB1, PRKACA, PSMD9, PSMD4, TSGA14, RFC5, CENPF, NUP85, PSMA7, MCM3, CDC25C, CCNE2, LIG1, POLE, ODF2, KIF2C, NDE1, BIRC5 |
| MISSIAGLIA REGULATED BY METHYLATION DN | ESPL1, LIG1, CAD, GMPS, KIFC1, CDC25C, HMGB1 |
| NUYTTEN EZH2 TARGETS DN | KIF20A, TMPO, PRPS2, CCNB1, PBK, TSGA14, RFC5, TOPBP1, CENPF, CNOT1, SP3, EXOSC8, PYCRL, ANTXR1, MRP63, NUP88, YWHAQ, RAD51, ETV4, RAB13, HMBS, CDK5RAP2, CAD, CASP6, MUTYH, KIFC1, FCHO1, ABCC5, FANCG, PRR11, AZI1, MDFIC, H2AFX, HMMR, HMGB1, KIF4A, HP1BP3, AP2B1, CDC25C, CCNE2, WIPI2, H2AFV, PRC1, IDI1, MRPS35, KIF2C, NDE1, BIRC5, SRPRB |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | SQLE, CAD, POLE3, GNB1, TMPO, CDC45L, ITGA3, GLT25D1, PRPS1, PARP2, KIF4A, MCM3, EXOSC8, MBNL1, PRDX3, H2AFV, PRC1, IDI1, ETV4, NUP205, KIF2C, HMBS, BIRC5 |
| WHITEFORD PEDIATRIC CANCER MARKERS | TWIST1, ESPL1, PCNA, NUDT1, TMPO, CCNB1, CDK4, STMN1, PRC1, H2AFX, LMNB2, MFN2, CENPF, BIRC5 |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | KIF20A, ESPL1, KIFC1, CDC45L, CCNB1, STMN1, HMMR, PSMA7, KIF4A, MCM3, GMPS, NUDT1, CCNE2, PFDN6, CCT5, RAD51, PRC1, BIRC5 |
| BLUM RESPONSE TO SALIRASIB DN | PXMP2, KIF20A, ESPL1, PCNA, TOP2B, TMPO, CDC45L, PBK, HMMR, RFC5, CENPF, KIF4A, MCM3, CCNE2, RAD51, PRDX3, LIG1, MRE11A, CHST12, PRC1 |
| REACTOME LAGGING STRAND SYNTHESIS | |
| NAKAYAMA SOFT TISSUE TUMORS PCA2 UP | |
| NCI CENTROSOME MATURATION | |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP | |
| LI WILMS TUMOR VS FETAL KIDNEY 1 DN | |
| MITSIADES RESPONSE TO APLIDIN DN | |
| PUJANA BRCA2 PCC NETWORK | |
| REACTOME CELL CYCLE CHECKPOINTS | PSMC5, MCM3, PSMD9, CDC25C, CCNE2, PSMA7, CCNB1 |
| KUMAMOTO RESPONSE TO NUTLIN 3A DN | |
| REACTOME REPAIR SYNTHESIS OF PATCH 27 30 BASES LONG BY DNA POLYMERASE | |
| LEE EARLY T LYMPHOCYTE UP | KIF20A, PRC1, HMMR, MLF1IP, TFDP2, KIF2C, CCNB1, BIRC5 |
| HORIUCHI WTAP TARGETS DN | |
| ODONNELL TARGETS OF MYC AND TFRC DN | |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | |
| REACTOME NUCLEOTIDE EXCISION REPAIR | |
| ZHAN MULTIPLE MYELOMA PR UP | |
| NCI PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | |
| REACTOME CENTROSOME MATURATION | CDK5RAP2, CETN2, CCNB1, AZI1, PRKACA, TSGA14, ODF2, NDE1 |
| ODONNELL TFRC TARGETS DN | |
| REACTOME GLOBAL GENOMIC NER | |
| NCI REPAIR SYNTHESIS FOR GAP FILLING BY DNA POLYMERASE IN TC NER | |
| FRASOR RESPONSE TO SERM OR FULVESTRANT DN | |
| MARKEY RB1 ACUTE LOF DN | |
| NCI LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME | |
| REACTOME METABOLISM OF PROTEINS | |
| REACTOME G2 M TRANSITION | PRKACA, ODF2, CDC25C, CCNB1, NDE1, AZI1 |
| KAUFFMANN MELANOMA RELAPSE UP | |
| KEGG DNA REPLICATION | |
| REACTOME DOUBLE STRAND BREAK REPAIR | |
| REACTOME TRANSCRIPTION COUPLED NER | |
| REN BOUND BY E2F | |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | |
| NCI MITOTIC PROMETAPHASE | CENPC1, MLF1IP, ZWINT, KIF2C, NDE1, BIRC5 |
| KOBAYASHI EGFR SIGNALING 24HR DN | |
| CROONQUIST NRAS SIGNALING DN | |
| REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | |
| MANN RESPONSE TO AMIFOSTINE DN | |
| CORUM DNA SYNTHESOME COMPLEX 13 SUBUNITS | |
| REACTOME DNA REPAIR | |
| KANG DOXORUBICIN RESISTANCE UP | KIF4A, FOXM1, PBK, PRC1, HMMR, ZWINT, BIRC5 |
| TANG SENESCENCE TP53 TARGETS DN | |
| REACTOME SYNTHESIS OF DNA | |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | |
| KAUFFMANN DNA REPAIR GENES | |
| NCI BARD1PATHWAY | |
| MOOTHA VOXPHOS | |
| CORUM DNA SYNTHESOME COMPLEX 15 SUBUNITS | |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | |
| PUJANA XPRSS INT NETWORK | |
| BENPORATH CYCLING GENES | |
| REACTOME ELECTRON TRANSPORT CHAIN | |
| MORI IMMATURE B LYMPHOCYTE DN | |
| KAUFFMANN DNA REPLICATION GENES | |
| CORUM DNA SYNTHESOME COMPLEX 17 SUBUNITS | |
| PRAMOONJAGO SOX4 TARGETS DN | |
| KEGG PARKINSONS DISEASE | |
| REACTOME MITOTIC PROMETAPHASE | |
| WINNEPENNINCKX MELANOMA METASTASIS UP | |
| MUELLER PLURINET | |
| TOYOTA TARGETS OF MIR34B AND MIR34C | |
| MANALO HYPOXIA DN | |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | |
| ZHANG BREAST CANCER PROGENITORS UP | |
| MOOTHA FFA OXYDATION | |
| REACTOME EXTENSION OF TELOMERES | |
| NCI LOSS OF NLP FROM MITOTIC CENTROSOMES | |
| NCI RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | PRKACA, CDK5RAP2, TSGA14, CETN2, TUBGCP3, NDE1, AZI1 |
| MORI MATURE B LYMPHOCYTE DN | |
| BIDUS METASTASIS UP | |
| YU MYC TARGETS UP | |
| CROONQUIST IL6 DEPRIVATION DN | |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | |
| EGUCHI CELL CYCLE RB1 TARGETS | |
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | KIF4A, KIF20A, PBK, PRC1, CCNB1, BIRC5 |
| REACTOME G1 S TRANSITION | |
| NCI TELOMERE C STRAND LAGGING STRAND SYNTHESIS | |
| NCI REPAIR SYNTHESIS OF PATCH 27 30 BASES LONG BY DNA POLYMERASE | |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN | |
| REACTOME S PHASE | |
| MORI LARGE PRE BII LYMPHOCYTE UP | |
| KEGG CELL CYCLE | |
| PUJANA BRCA CENTERED NETWORK | |
| KEGG BASE EXCISION REPAIR | |
| CHANG CYCLING GENES | FOXM1, TACC3, CDC25C |
| ROSTY CERVICAL CANCER PROLIFERATION CLUSTER | KIF20A, ESPL1, PCNA, KIFC1, TMPO, CCNB1, PBK, H2AFX, HMMR, CENPF, KIF4A, CCNE2, DPP3, PRC1, KIF2C, BIRC5 |
| FAELT B CLL WITH VH REARRANGEMENTS DN | |
| PUJANA BREAST CANCER WITH BRCA1 MUTATED UP | |
| AMUNDSON GAMMA RADIATION RESPONSE | ESPL1, TACC3, LBR, H2AFX, KIFC1, CDC25C, CCNB1 |
| SONG TARGETS OF IE86 CMV PROTEIN | |
| FUJII YBX1 TARGETS DN | |
| KEGG NUCLEOTIDE EXCISION REPAIR | |