BICLUSTER_ID : <a href="#qvalue">DNREG-764</a><BR>PATHOGENS /4/ : <a href="http://www.ebi.ac.uk/2can/genomes/bacteria/pseudomonas aeruginosa.html">pseudomonas aeruginosa</a>,<a href="http://www.ebi.ac.uk/2can/genomes/bacteria/streptococcus pneumoniae.html">streptococcus pneumoniae</a>,<a href="http://www.ebi.ac.uk/2can/genomes/bacteria/yersinia enterocolitica.html">yersinia enterocolitica</a>,<a href="http://www.ebi.ac.uk/2can/genomes/bacteria/porphyromonas gingivalis.html">porphyromonas gingivalis</a><BR>TARGETS /7/ : <a href=drug-id-and-target-info.html#PSMB2>PSMB2</a>, <a href=drug-id-and-target-info.html#HDAC1>HDAC1</a>, <a href=drug-id-and-target-info.html#ADSL>ADSL</a>, <a href=drug-id-and-target-info.html#PAPSS1>PAPSS1</a>, <a href=drug-id-and-target-info.html#ME2>ME2</a>, <a href=drug-id-and-target-info.html#HADH>HADH</a>, <a href=drug-id-and-target-info.html#GART>GART</a><BR>
<table border="1">
<tbody>
<tr><th width="300">Gene Set</th><th width="900">Leading Edge Genes</th></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/WONG_EMBRYONIC_STEM_CELL_CORE">WONG EMBRYONIC STEM CELL CORE</a></td><td><a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=4852">HDAC1</a>, ATP5O, <a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=4799">HADH</a>, DBF4, <a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=4163">GART</a>, DHX9, ABCB7, CKS2, NCBP2, <a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=291">ADSL</a>, RPA3, XPO1, ZNF22, LSM5</td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP">ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP</a></td><td>CTCF, MAGOH, CETN2, <a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=8603">PAPSS1</a>, TMED10, ANKMY2, MRPL40, NCBP2, NUP133, RPA3, IGBP1, TAF12, TOM1L1, ACP1, RPL36AL, CKS2, XPO1</td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/REACTOME_CELL_CYCLE_MITOTIC">REACTOME CELL CYCLE MITOTIC</a></td><td><a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=9539">PSMB2</a>, NUP133, CETN2, RPA3, POLD3, ORC2L, DBF4</td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/NUYTTEN_EZH2_TARGETS_DN">NUYTTEN EZH2 TARGETS DN</a></td><td>CASC3, CASP6, ZWINT, TMPO, FANCG, <a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=4163">GART</a>, PAK2, SYPL1, TFAM, TOPBP1, KIF3A, SP3, EXOSC8, C1D, PAPOLA, MKRN1, PBXIP1, CYB5B, BRD8, ABCB7, ENTPD4, ANP32A, NUP88, SSRP1, BAZ1B, LSM5</td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/GARY_CD5_TARGETS_DN">GARY CD5 TARGETS DN</a></td><td>ATR, POLE3, NUP133, <a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=291">ADSL</a>, CYB5B, DHX9</td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN">CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN</a></td><td>POLE3, TM9SF2, MSH2, <a href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=6984">ME2</a>, PSMA2, UBE2E3, XRCC5, SYPL1, SLC39A6, RPA3, HBXIP</td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/CORUM_SPLICEOSOME">CORUM SPLICEOSOME</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN">MOREAUX MULTIPLE MYELOMA BY TACI DN</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/BENPORATH_MYC_MAX_TARGETS">BENPORATH MYC MAX TARGETS</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS">REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN">LASTOWSKA NEUROBLASTOMA COPY NUMBER DN</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/REACTOME_CELL_CYCLE_CHECKPOINTS">REACTOME CELL CYCLE CHECKPOINTS</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN">STARK PREFRONTAL CORTEX 22Q11 DELETION DN</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/NCI_MRNA_SPLICING___MAJOR_PATHWAY">NCI MRNA SPLICING   MAJOR PATHWAY</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN">ZHONG RESPONSE TO AZACITIDINE AND TSA DN</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA">REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA</a></td><td></td></tr>
<tr><td><a href="http://www.broad.mit.edu/gsea/msigdb/cards/REACTOME_G2_M_CHECKPOINTS">REACTOME G2 M CHECKPOINTS</a></td><td></td></tr>
</tbody>
</table>
<table border="1"rules="all" VSPACE=10>
<tr><th colspan="12"<a name="qvalue">Color legend </a></th></tr>
<tr><th>q-value</th><th>-1</th><th>-0.2</th><th>-0.05</th><th>-0.01</th><th>-0.001</th><th>-0.0001</th></tr>
<tr><th>Color</th><td bgcolor="#ffffff" title="-1"></td><td bgcolor="#d9ef8b" title="-0.2"></td><td bgcolor="#a6d96a"
title="-0.05"></td><td bgcolor="#66bd63" title="-0.01"></td><td bgcolor="#1a9850" title="-0.001"></td><td title="-0.0001"
bgcolor="#006837"></td></tr>
</table>
<table border="1" VSPACE=0>
<table border="1" rules="all">
<caption align="top">TABLE OF Q-VALUES</caption>
<tbody>
<tr><th width="150">yersinia enterocolitica p60 bc</th><th width="150">pseudomonas aeruginosa</th><th width="150">porphyromonas gingivalis</th><th width="150">streptococcus pneumoniae d39</th><th>GeneSet Name</th></tr>
<tr><td align="center" width="150" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.04038</span></font></td><td align="center" width="150" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00224</span></font></td><td align="center" width="150" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00002</span></font></td><td align="center" width="150" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.09472</span></font></td><td>WONG_EMBRYONIC_STEM_CELL_CORE</td></tr>
<tr><td align="center" width="150" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.08472</span></font></td><td align="center" width="150" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.01279</span></font></td><td align="center" width="150" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00366</span></font></td><td align="center" width="150" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.03975</span></font></td><td>ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP</td></tr>
<tr><td align="center" width="150" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.19845</span></font></td><td align="center" width="150" bgcolor="#1a9850"><font size=1> <span style="background-color:white">-0.00096</span></font></td><td align="center" width="150" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00002</span></font></td><td align="center" width="150" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.03832</span></font></td><td>REACTOME_CELL_CYCLE_MITOTIC</td></tr>
<tr><td align="center" width="150" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.11233</span></font></td><td align="center" width="150" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00115</span></font></td><td align="center" width="150" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00360</span></font></td><td align="center" width="150" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.01919</span></font></td><td>NUYTTEN_EZH2_TARGETS_DN</td></tr>
<tr><td align="center" width="150" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.16036</span></font></td><td align="center" width="150" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.01258</span></font></td><td align="center" width="150" bgcolor="#1a9850"><font size=1> <span style="background-color:white">-0.00029</span></font></td><td align="center" width="150" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00609</span></font></td><td>GARY_CD5_TARGETS_DN</td></tr>
<tr><td align="center" width="150" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.09455</span></font></td><td align="center" width="150" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00006</span></font></td><td align="center" width="150" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00284</span></font></td><td align="center" width="150" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.02845</span></font></td><td>CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN</td></tr>
<tr><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00310</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.13655</span></font></td><td align="center" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00003</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.07735</span></font></td><td>CORUM_SPLICEOSOME</td></tr>
<tr><td align="center" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.01804</span></font></td><td align="center" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.01021</span></font></td><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00320</span></font></td><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00101</span></font></td><td>MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN</td></tr>
<tr><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.11972</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.08688</span></font></td><td align="center" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.02655</span></font></td><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00995</span></font></td><td>BENPORATH_MYC_MAX_TARGETS</td></tr>
<tr><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.06137</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.06489</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.10564</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.06131</span></font></td><td>REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS</td></tr>
<tr><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.05026</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.11040</span></font></td><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00531</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.08443</span></font></td><td>LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN</td></tr>
<tr><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.07433</span></font></td><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00423</span></font></td><td align="center" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00004</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.18352</span></font></td><td>REACTOME_CELL_CYCLE_CHECKPOINTS</td></tr>
<tr><td align="center" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00010</span></font></td><td align="center" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.02880</span></font></td><td align="center" bgcolor="#1a9850"><font size=1> <span style="background-color:white">-0.00014</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.08271</span></font></td><td>STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN</td></tr>
<tr><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00116</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.12422</span></font></td><td align="center" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00002</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.15699</span></font></td><td>NCI_MRNA_SPLICING___MAJOR_PATHWAY</td></tr>
<tr><td align="center" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.03477</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.10608</span></font></td><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00819</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.16660</span></font></td><td>ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN</td></tr>
<tr><td align="center" bgcolor="#66bd63"><font size=1> <span style="background-color:white">-0.00404</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.17386</span></font></td><td align="center" bgcolor="#006837"><font size=1> <span style="background-color:white">-0.00007</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.05927</span></font></td><td>REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA</td></tr>
<tr><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.14437</span></font></td><td align="center" bgcolor="#a6d96a"><font size=1> <span style="background-color:white">-0.01177</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.05896</span></font></td><td align="center" bgcolor="#d9ef8b"><font size=1> <span style="background-color:white">-0.09478</span></font></td><td>REACTOME_G2_M_CHECKPOINTS</td></tr>
</tbody>
</table>