| Gene Set | Leading Edge Genes |
|---|
| STEIN ESRRA TARGETS | SLC31A1, MMACHC, ACADSB, ACY1, C16ORF61, BRP44, TRIM2, NDUFS8, TUBD1, NDUFA8, ATP5O, SLC37A4, GSTM1, MUT, UGP2, PDHA1, PXMP4, NDUFS2, ACYP1, GMCL1, GRPEL1, SUCLA2, IDH3B, DECR1, SLC25A3, EPAS1, FZD2, DLAT, MOSC2, MRPS11, MRPL4, SLC16A1, EHHADH, MRPL15, NQO2, IMMT, DCI, OPLAH, DGUOK, OGDH, ILVBL, NDUFA9, ACAT1, ASPSCR1, CXCL12, PEX26, CHCHD3, TIMM50, SDHD, PDCL, NNT, PFKM, MRPL2, ALDH3A2, TEX2, PRPS2, ETFDH, SDHA, WDR45, NDUFB5, UQCRFS1, NDUFS1, ABLIM1, UQCRC1, MDH1, AHCYL1, ATP5G1, CAV2, METTL7A, ATP5J, BRD3, LETMD1, YIPF2, MRPL34, NDUFS3, MFN2, EBP, NUCB1, ATP5C1, SDHB, SNX24, OXA1L, MRPS12, ACO2, IQSEC1, GATAD1, MYO6, B3GNT1, ACAA2, ACADM, FBXL15, MSH6, HEXIM1, SUCLG1, CS, ATP5G3, IMPA1, RNF5, MIPEP, ENDOG, ATP5L |
| STEIN ESRRA TARGETS UP | SLC31A1, MMACHC, ACADSB, ACY1, C16ORF61, BRP44, TRIM2, NDUFS8, NDUFA8, ATP5O, GSTM1, MUT, UGP2, PDHA1, PXMP4, NDUFS2, ACYP1, GMCL1, GRPEL1, SUCLA2, IDH3B, DECR1, SLC25A3, EPAS1, DLAT, MOSC2, MRPS11, MRPL4, SLC16A1, EHHADH, MRPL15, NQO2, IMMT, DCI, OPLAH, OGDH, ILVBL, NDUFA9, ACAT1, PEX26, CHCHD3, TIMM50, SDHD, NNT, SEC23B, PFKM, MRPL2, ALDH3A2, TEX2, ETFDH, SDHA, WDR45, NDUFB5, UQCRFS1, NDUFS1, ABLIM1, UQCRC1, MDH1, AHCYL1, ATP5G1, METTL7A, ATP5J, LETMD1, UQCRC2, YIPF2, MRPL34, NDUFS3, MFN2, EBP, NUCB1, ATP5C1, SDHB, OXA1L, MRPS12, MRPL35, ACO2, IQSEC1, ACAA2, ACADM, FBXL15, SUCLG1, CS, ATP5G3, IMPA1, RNF5, MIPEP, ENDOG, ATP5L |
| TIEN INTESTINE PROBIOTICS 24HR UP | TMEM109, POLDIP2, FARP1, IARS2, CSRP2, AURKAIP1, EI24, HSPE1, FBXO3, LMAN2L, AASDHPPT, RDH11, SDHC, NDUFA8, DBI, AHSA1, ABCD3, EMG1, ECHS1, FDPS, ACYP1, SUCLA2, ISOC1, LMNB2, NDUFC1, TIMM8B, NDUFV2, TPCN1, ALDH7A1, POLR2L, SNRPD3, GGA2, PSMD1, PSMB7, PEX3, DNAJA1, NDUFA9, ACAT2, NUDT1, SMYD2, TSN, FKBP3, TBL1X, NXT2, NDUFB6, SLC25A13, PSME3, IDI1, HIBCH, UMPS, DHCR7, SC5DL, SNX3, UBL5, RAN, ALAD, TRIAP1, FKBP4, GLRX5, NDUFA6, DCXR, ATP5J2, CYB5B, ATP5J, POP5, UROD, SPAST, CYB5R3, DDX46, NDUFB2, TUBB2A, DAB2, ABAT, EBP, PXMP2, PDHB, CMTM6, MMD, EXOSC7, TFAM, RPA3, ACAA2, PRDX2, CUL2, SLC25A1, NDUFB3, DERA, MRPS2, TUBG1, PSMD2, MSH6, OAT, CXADR, DGCR2, ATP5G3, H2AFV, POLR3K, QDPR, ATP5L |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | SLCO2A1, GPAA1, CHPT1, NUDCD2, SH3D19, SDF2L1, BRP44, ICT1, HSPA14, SDHC, NDUFA8, BOLA1, MCTS1, GMPS, YIF1B, RAP2A, DUSP12, COPB2, COPA, NUDT2, NOL7, IRAK1, SEC24D, SAP30L, PPP1R2, MRPL36, UBLCP1, MRPL18, MRPS17, PSMD6, TAF12, TEAD2, SFRS2, PFDN6, NDUFB6, PHPT1, PSME3, IDI1, XRCC6, IFRD2, SEC61B, SREBF2, SEC23B, ELOVL6, SLC33A1, EPHX1, NCBP2, TMEM9, MID1IP1, PIGC, APEX1, CDK2AP2, TOM1L1, PDIA6, ACP1, TINF2, PSEN2, ALG14, DDX46, REXO2, ZFAND1, ARL1, PGCP, VAMP5, CDK5, HPRT1, PIR, MAP2K2, CUL2, EIF2B1, SDC2, CCDC91, GABARAPL2, SPCS1, PSMB4, FKBP11, ILF2, CETN2, CSTF2, DAD1, HSP90AB1, IARS2, DYNLRB1, STRA13, CANX, EXOSC5, EPM2AIP1, TMEM85, PPOX, PSMB5, VPS25, SSR2, PIGY, XRCC6BP1, CNN3, CNIH, UBE4B, ATG3, CTCF, PAPSS1, TMED4, FARS2, GNPAT, COMMD3, MCFD2, TMEM147, RNF26, RPL36AL, NUDT1, IDH1, SPCS2, PEX19, MKRN2, HIST2H2BE, TFG, TRIP4, C12ORF57, COPE, AHCY, TM2D1, TMTC4, DHX29, BIVM, NDUFB5, UFC1, METAP1, CHCHD1, NAT9, STXBP6, HAX1, SSR1, STT3B, SURF1, OXA1L, MIF4GD, SLC35B1, NEDD8, RPA3, UFM1, DNAJB11, NDUFB3, MEA1, PSMD2, MSH6, DNAJC19, TSNAX, RDH14, PARP1, PURA, COX6A1, ZMPSTE24, MRPL24, TUBB2C, DARS2, KIFAP3, KDELR2 |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | TXNDC14, MRPL55, MRPS18A, ASPH, 1110008P14RIK, 1110031I02RIK, ATP5H, HSPE1, BRP44, SMU1, EPM2AIP1, NDUFS8, CYC1, C1GALT1C1, ADH5, NDUFA8, AHSA1, DDX56, MCTS1, NME2, NDUFS6, YAF2, GUK1, UGP2, FDPS, COPS3, LRPAP1, TSPAN31, PPP2R5C, TIMM8B, NDUFB10, CYBASC3, NDUFV2, APOA1BP, 2410015M20RIK, COPS6, MRPL41, 3110001D03RIK, KPNA1, MRPS11, MRPL15, SEC63, MRPS28, TMEM147, 1810027O10RIK, FKBP2, NDUFA9, SRP9, MRPS17, RPL36AL, ACAT2, IDH1, SMYD2, FKBP3, PRDX3, 5730494M16RIK, CFDP1, HIBCH, FNDC4, 0610037L13RIK, 2810405K02RIK, 2900010M23RIK, TPD52L1, SAR1B, HCFC1R1, IMMP1L, SIRT2, 1110020P15RIK, SEC61B, UQCR, TUSC4, PRPS2, WDR45, 2310016M24RIK, SEC22B, CARM1, TST, UQCRFS1, NDUFS1, TMEM42, UFC1, POLR2J, MRPL28, 0610011F06RIK, SLC27A4, 2700060E02RIK, CHCHD1, BOK, ATP5J2, AKR1A4, CHN2, ATP5J, SSR4, MRP63, ST13, MRPL51, NIPSNAP1, ATP5E, UQCRC2, SRA1, PGRMC2, NDUFB2, NDUFS3, BCAP31, CDK5, ATP5C1, ACSL1, B230118H07RIK, MRPS12, 9130011J15RIK, IDH3G, B3GNT1, GRLF1, ZFP560, PRDX2, DGCR6, SLC25A1, LSMD1, MEA1, TUBG1, ABHD11, SLC25A5, PURA, OAT, DGCR2, D10ERTD322E, STIP1, ATP5L |
| SHEN SMARCA2 TARGETS UP | HERC2, ZFAND6, IDS, FBXO3, AASDHPPT, ATP5O, MAP4K5, ITFG1, IDE, METTL5, SUCLA2, COPS4, RYK, PPP2R5C, SUCLG2, UBE2A, NBR1, ATG3, PREPL, CTCF, SCFD1, NOL7, MLH1, PHKB, DPM1, CSE1L, SEC63, PPP1R2, PCMTD2, CUL4B, TMEM126B, PEX3, AGGF1, SRP9, SERINC1, RDX, PRKRA, FTO, TSN, PJA2, NDUFB6, XRCC5, PEX19, HIBCH, SDHD, TWSG1, TRIP4, FEM1C, NNT, SEPHS1, INSIG2, RAF1, PEX11B, MTO1, DHX29, ARHGAP29, CHMP5, SS18, SPTLC1, BRWD2, FBXW2, RAB14, LANCL1, RMND5A, NSFL1C, ST13, TMEM135, CAPN7, DDX46, TNPO1, UQCRC2, ACVR1, ZDHHC6, TLK1, RAB23, PDHB, UPF3B, MOCS2, COPS2, SMARCA2, USP9X, CUL2, DERA, TSNAX, RDH14, PRKD3, PSMD12, PURA, PCNP, SUCLG1, ANP32A, ADSS, H2AFV, NCKAP1, KIFAP3, RHOT1, MRPS14, LAPTM4A, PKN2 |
| GOLDRATH HOMEOSTATIC PROLIFERATION | HDGF, ALDH3A2, PRPS2, NUDCD2, GPX1, UBL5, SFXN1, HSPE1, CANX, BRP44, SDHC, ZHX1, ITFG1, RNF141, MUT, ATP5J, SRPR, RNF11, NDUFB2, GALK1, PDAP1, NDUFC1, MRPS25, RAB18, PARK7, TM9SF3, DUSP19, CMAS, MYO6, NDUFB3, SNX9, PCCB, PCBD2, LIN7C, YIPF5, QDPR |
| REACTOME CITRIC ACID CYCLE | DLST, NNT, SDHB, SUCLG1, SDHA, CS, IDH3G, ACO2, SUCLA2, SDHD, IDH2, SUCLG2, IDH3B, SDHC, OGDH |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | 2010107E04RIK, UQCR, MRPS18A, NDUFA3, NDUFB8, UBL5, MTMR9, CSRP2, NCBP2, PIGX, USMG5, DBI, CUTA, ATP5O, PQBP1, CYB5B, ATP5J, GUK1, ATP5E, NDUFS2, 1810046J19RIK, PPIB, PMPCB, UQCRC2, PCX, PPP2R5C, EBP, NDUFC1, TIMM8B, 2410015M20RIK, 1810020G14RIK, PEX7, MRPL35, PARK7, GSTM5, PRDX2, DGCR6, TSEN34, MRPL18, ILVBL, NDUFA9, PCCB, SUMO3, ANAPC13, FKBP3, COX6A1, ECH1, 0610007P14RIK, PRPSAP2 |
| NCI CITRIC ACID CYCLE TCA CYCLE | SDHB, SDHA, SUCLG1, CS, IDH3G, ACO2, SUCLA2, SDHD, SUCLG2, SDHC, IDH3B |
| MOOTHA TCA | SDHB, SDHA, SUCLG1, CS, IDH3G, ACO2, IDH2, SUCLA2, SDHD, SDHC, OGDH, IDH3B |
| KEGG GLUTATHIONE METABOLISM | GSTA4, GSTZ1, MGST1, GSTM1, IDH1, GPX1, LAP3, GSTP1, IDH2, GSTM5 |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | SAR1B, COPE, PSMB1, SEC22A, SEC22B, PSMD4, COPZ1, HSP90B1, GOSR2, TRAPPC3, TMED7, PDIA4, COPB2, BCAP31, COPA, TXNDC12, SAR1A, PSMD1, PSMB7, TRAPPC1, PSMC4, PDIA3, PSMD2, CALR, PSMD6, TMED9, COPB1, YIPF5, TRAPPC4, PSMB3, COPG2, KDELR2, COPG, PSMB4 |
| BIOCARTA ETC PATHWAY | UQCRC1, GPD2, ATP5A1, NDUFA1, SDHB, SDHD, SDHC, SDHA |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 | FKBP11, SEC61B, YKT6, EIF2B5, MRPL12, 1110008P14RIK, CARM1, D17WSU104E, MRPL20, APEX1, PSMB5, VCL, SSR2, PDIA4, PREP, CAD, IRAK1, SSR3, SNRPD3, PSMD1, MRPS28, TMEM147, PDIA3, PTOV1, PSMD6, COL18A1, 1810009A15RIK, GORASP2, SMYD2, CS, NSBP1, SEC61A1, LMAN2, PSMB3, 2900010M23RIK, SLC39A7, NDE1 |
| PENG RAPAMYCIN RESPONSE DN | PSMD5, TMEM109, PFKM, TGDS, MRPS11, CSE1L, STRA13, MRPL12, HSPE1, AHSA1, ATF5, NDUFA9, SLC29A1, JTB, ALDH4A1, ATP5G1, ATP5G3, RABGGTB, FASN, COPB2 |
| REACTOME CHOLESTEROL BIOSYNTHESIS | SC5DL, DHCR24, CYP51A1, FDFT1, PMVK, IDI1, HMGCS1, MVK, DHCR7, EBP, NSDHL |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 | CAD, ABCE1, BOP1, GM98, IGF1, SLC35B1, GMPPB, DNAJB11, HSP90B1, 1110067D22RIK, PDIA6, GSTM1, GSPT1, ARMET, RDX, H47, ACOT7, STRAP, PSME3, CRELD2, RRAGA, TUBB2A, STIP1, UBQLN1 |
| ELLWOOD MYC TARGETS DN | FKBP2, PDIA6, MOSC2, ALDH2, GANAB, HIST1H2BC, IDE, MCFD2, 1110003E01RIK, TRP53INP2, 4931406C07RIK |
| KEGG N GLYCAN BIOSYNTHESIS | MAN1B1, B4GALT2, DPAGT1, MGAT1, DAD1, DOLPP1, GANAB, RPN2, DPM1, ALG14, STT3B |
| MORI PLASMA CELL UP | SPCS3, TMED2, TMEM39A, HDLBP, SSR2, LMAN1, RPN1, GMPPB, CRELD2, SURF4, BET1, EBP |
| NCI INSULIN SYNTHESIS AND SECRETION | KIF5B, TRAM1, SPCS3, SRP9, SEC61B, SSR3, RPN2, SSR4, SSR2, SPCS2, SRPR, SPCS1, SRP72, STT3B, SRPRB |
| JAERVINEN AMPLIFIED IN LARYNGEAL CANCER | |
| KAPOSI LIVER CANCER POOR SURVIVAL DN | |
| NCI MITOCHONDRIAL FATTY ACID BETA OXIDATION OF UNSATURATED FATTY ACIDS | |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | |
| BIOCARTA KREB PATHWAY | |
| ROME INSULIN TARGETS IN MUSCLE UP | |
| ALONSO METASTASIS UP | |
| LANDIS ERBB2 BREAST TUMORS 324 DN | |
| MCBRYAN PUBERTAL BREAST 4 5WK DN | |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | |
| REACTOME PEROXISOMAL LIPID METABOLISM | |
| CORUM F1F0-ATP SYNTHASE EC 3.6.3.14 MITOCHONDRIAL | ATP5O, ATP5A1, ATP5I, ATP5C1, ATP5G1, ATP5J2, ATP5J, ATP5E, ATP5H, ATP5B |
| REACTOME RNA POLYMERASE I III AND MITOCHONDRIAL TRANSCRIPTION | |
| BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR DN | |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10 | |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | |
| KEGG LIMONENE AND PINENE DEGRADATION | |
| NCI GLUCOSE REGULATION OF INSULIN SECRETION | |
| KEGG PPAR SIGNALING PATHWAY | |
| CORUM CSA COMPLEX | |
| NCI MRNA CAPPING | |
| KEGG TERPENOID BACKBONE BIOSYNTHESIS | |
| CORUM RESPIRATORY CHAIN COMPLEX I GAMMA SUBUNIT MITOCHONDRIAL | |
| KEGG BIOSYNTHESIS OF UNSATURATED FATTY ACIDS | |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | |
| RODWELL AGING KIDNEY NO BLOOD DN | |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | ATP5O, ATP5A1, ATP5I, ATP5C1, ATP5G1, ATP5J2, ATP5J, ATP5E, ATP5H, ATP5B |
| KEGG GLYOXYLATE AND DICARBOXYLATE METABOLISM | |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | |
| REACTOME PYRUVATE METABOLISM AND TCA CYCLE | |
| WELCSH BRCA1 TARGETS 1 DN | |
| SCHLOSSER MYC TARGETS REPRESSED BY SERUM | |
| NCI HIV 1 TRANSCRIPTION ELONGATION | |
| KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS | |
| REACTOME COPI MEDIATED TRANSPORT | |
| REACTOME GLUTATHIONE CONJUGATION | |
| REACTOME REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA | |
| VANTVEER BREAST CANCER ESR1 UP | |
| NCI BETA OXIDATION OF DECANOYL COA TO OCTANOYL COA COA | |
| NCI REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA PPARALPHA | |
| CORUM RESPIRATORY CHAIN COMPLEX I INCOMPLETE INTERMEDIATE MITOCHONDRIAL | |
| NCI BETA OXIDATION OF PRISTANOYL COA | |
| FARMER BREAST CANCER CLUSTER 7 | |
| CORUM RESPIRATORY CHAIN COMPLEX I INTERMEDIATE VII/650KD MITOCHONDRIAL | |
| RAMALHO STEMNESS UP | |
| HONMA DOCETAXEL RESISTANCE | |
| UEDA PERIFERAL CLOCK | |
| CORUM WRN-KU70-KU80-PARP1 COMPLEX | |
| NCI COPI MEDIATED TRANSPORT | |
| WANG RESPONSE TO ANDROGEN UP | |
| BOYAULT LIVER CANCER SUBCLASS G12 UP | |
| SMITH LIVER CANCER | |
| MCBRYAN PUBERTAL BREAST 6 7WK UP | |
| LUCAS HNF4A TARGETS UP | |
| BIOCARTA CDK5 PATHWAY | |
| SCHUHMACHER MYC TARGETS UP | |
| KEGG PROTEIN EXPORT | |
| CORUM RESPIRATORY CHAIN COMPLEX I BETA SUBUNIT MITOCHONDRIAL | |
| NCI PYRUVATE METABOLISM AND TCA CYCLE | |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | |
| NCI BETA OXIDATION OF OCTANOYL COA TO HEXANOYL COA | |
| REACTOME DIABETES PATHWAYS | |
| LANDIS ERBB2 BREAST TUMORS 65 UP | |
| CORUM RAP1 COMPLEX | |
| CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP | |
| NCI ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT | |
| HU ANGIOGENESIS DN | |
| CORUM CNS-P53 COMPLEX | |
| HOSHIDA LIVER CANCER SUBCLASS S2 | |
| NCI BETA OXIDATION OF HEXANOYL COA TO BUTANOYL COA | |
| KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM | |
| RICKMAN METASTASIS UP | |
| WANG RESPONSE TO FORSKOLIN UP | |
| NCI MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS | |
| CORUM RESPIRATORY CHAIN COMPLEX I LAMBDA SUBUNIT MITOCHONDRIAL | |
| SCHLOSSER MYC AND SERUM RESPONSE SYNERGY | |
| PETRETTO HEART MASS QTL CIS UP | |
| CORUM COP9 SIGNALOSOME COMPLEX | |
| BIOCARTA EIF4 PATHWAY | |
| BLALOCK ALZHEIMERS DISEASE DN | |
| GRUETZMANN PANCREATIC CANCER DN | |
| NCI VALINE CATABOLISM | |
| NCI BETA OXIDATION OF LAUROYL COA TO DECANOYL COA COA | |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | |
| CORUM 28S RIBOSOMAL SUBUNIT MITOCHONDRIAL | |
| PARENT MTOR SIGNALING UP | |
| KEGG LYSINE DEGRADATION | |
| REACTOME TRANSCRIPTION | |
| NCI FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | |
| LANDIS ERBB2 BREAST PRENEOPLASTIC DN | |
| KEGG PYRUVATE METABOLISM | |
| CORUM CSA-POLIIA COMPLEX | |
| KAAB HEART ATRIUM VS VENTRICLE DN | |
| NIKOLSKY BREAST CANCER 16P13 AMPLICON | |
| NCI LEUCINE CATABOLISM | |
| SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN | |
| REACTOME PHASE II CONJUGATION | |
| MOOTHA PGC | |
| REACTOME ACTIVATION OF CHAPERONES BY IRE1 ALPHA | DNAJC3, XBP1, PDIA6, DNAJB11, EDEM1 |
| REACTOME METABOLISM OF AMINO ACIDS | |