BICLUSTER_ID : UPREG-114
PATHOGENS /6/ : pseudomonas aeruginosa,bifidobacterium bifidum,lactobacillus acidophilus,helicobacter pylori,mycobacterium tuberculosis,ehrlichia chaffeensis
TARGETS /4/ : NFKB1, IL6, CCL20, CCL2
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPIL6, BIRC3, CCL20, CXCL1, CCL2, CXCL2
NETPATH IL 4 PATHWAY DOWNCCL20, CCL2, IRF1, CXCL2
NCI IL23PATHWAYIL6, CXCL1, CCL2
ST TUMOR NECROSIS FACTOR PATHWAYNFKB1, BIRC3, TNFAIP3, NFKB2
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
LEONARD HYPOXIA
NETPATH IL 9 PATHWAY UP
MAHAJAN RESPONSE TO IL1A UP
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
LINDSTEDT DENDRITIC CELL MATURATION B
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
WALLACE PROSTATE CANCER RACE UP
ELVIDGE HYPOXIA UP
IYENGAR RESPONSE TO ADIPOCYTE FACTORS
AMIT EGF RESPONSE 40 HELA
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
MAHADEVAN RESPONSE TO MP470 DN
HARRIS HYPOXIA
HINATA NFKB TARGETS KERATINOCYTE UP
MARKEY RB1 ACUTE LOF UP
GALI TP53 TARGETS APOPTOTIC UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
GILMORE CORE NFKB PATHWAY
DUTTA APOPTOSIS VIA NFKB
ZERBINI RESPONSE TO SULINDAC UP
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
MAHADEVAN RESPONSE TO MP470 UP
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA CD40 PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
ONDER CDH1 TARGETS 3 DN
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NETPATH IL 3 PATHWAY UP
BIOCARTA RANKL PATHWAY
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
NETPATH IL 6 PATHWAY UPCXCL1, IRF1
LIAN LIPA TARGETS 6M
MCLACHLAN DENTAL CARIES UP
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2
DAZARD UV RESPONSE CLUSTER G2
CHEN HOXA5 TARGETS 9HR UP
NCI CD40 PATHWAYBIRC3, TNFAIP3
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
BROWNE HCMV INFECTION 4HR UP
ZHU CMV 8 HR UP
ZHOU INFLAMMATORY RESPONSE LPS UP
SANA TNF SIGNALING UP
BIOCARTA INFLAM PATHWAY
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
LIAN LIPA TARGETS 3M
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
GERY CEBP TARGETSATF3, CXCL1, EREG, GADD45G, CD47
BIOCARTA TNFR2 PATHWAY
ELVIDGE HYPOXIA BY DMOG UP
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
CORUM NFKB1-NFKB2-REL-RELA-RELB COMPLEX
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
PRAMOONJAGO SOX4 TARGETS UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis wakullalactobacillus acidophilusbifidobacterium bifidumpseudomonas aeruginosamycobacterium tuberculosishelicobacter pylori kx2 mgephelicobacter pylori kx1 npgecGeneSet Name
0.00022 0.00114 0.00007 0.00004 0.00602 0.00000 0.00201NETPATH_IL_1_PATHWAY_UP
0.00000 0.00012 0.00103 0.00000 0.00000 0.00009 0.00644NETPATH_IL_4_PATHWAY_DOWN
0.00020 0.00000 0.00000 0.00049 0.00126 0.01454 0.14576NCI_IL23PATHWAY
0.00254 0.00006 0.00028 0.00000 0.00010 0.00008 0.01817ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.00000 0.00000 0.00000 0.00066 0.00225 0.00022 0.06985KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00340 0.00685 0.00005 0.06631 0.00000 0.00000 0.01127NOJIMA_SFRP2_TARGETS_UP
0.00006 0.00001 0.00000 0.00002 0.00000 0.00396 0.00255MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00301 0.00598 0.01391 0.00003 0.00000 0.00000 0.09695OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00547 0.00008 0.00214 0.01558 0.00002 0.00541 0.18497GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00008 0.05078 0.00822 0.09020 0.01105 0.00000 0.00008LEONARD_HYPOXIA
0.00000 0.01316 0.00572 0.06627 0.08229 0.00202 0.00667NETPATH_IL_9_PATHWAY_UP
0.00447 0.00430 0.00474 0.00000 0.00132 0.00001 0.00083MAHAJAN_RESPONSE_TO_IL1A_UP
0.00000 0.00000 0.00000 0.00016 0.00000 0.07361 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00000 0.00000 0.00000 0.00005 0.00000 0.00000 0.00011LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00001 0.00034 0.00098 0.00000 0.00000 0.00000 0.10813RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00000 0.00005 0.00387 0.00000 0.00000 0.00003LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00000 0.00000 0.00167 0.03564 0.00000 0.14952 0.03695WALLACE_PROSTATE_CANCER_RACE_UP
0.00027 0.10353 0.02232 0.10177 0.00052 0.00095 0.11617ELVIDGE_HYPOXIA_UP
0.01247 0.00648 0.01539 0.00802 0.00217 0.01339 0.00098IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS
0.00042 0.00081 0.00190 0.00000 0.00000 0.00053 0.12195AMIT_EGF_RESPONSE_40_HELA
0.02715 0.02475 0.02725 0.04274 0.01382 0.01011 0.09623GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.08720 0.00321 0.00016 0.00187 0.00000 0.00005 0.09518MAHADEVAN_RESPONSE_TO_MP470_DN
0.00025 0.18721 0.05400 0.00391 0.00067 0.00009 0.08612HARRIS_HYPOXIA
0.00001 0.00000 0.00013 0.00000 0.00000 0.00000 0.00256HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00000 0.00000 0.00000 0.02176 0.00000 0.09595 0.00008MARKEY_RB1_ACUTE_LOF_UP
0.01408 0.00830 0.03207 0.06810 0.17731 0.00280 0.06541GALI_TP53_TARGETS_APOPTOTIC_UP
0.00000 0.00000 0.00000 0.00004 0.00060 0.00019 0.06948KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.00006 0.00006 0.00000 0.01278 0.12757BASSO_CD40_SIGNALING_UP
0.00027 0.00010 0.00012 0.00251 0.02521 0.00002 0.00009SOUCEK_MYC_TARGETS
0.02155 0.00978 0.06213 0.00340 0.00092 0.00000 0.00208GILMORE_CORE_NFKB_PATHWAY
0.00000 0.00233 0.00215 0.00086 0.00002 0.00000 0.05736DUTTA_APOPTOSIS_VIA_NFKB
0.11589 0.18728 0.11328 0.08983 0.04554 0.00100 0.06538ZERBINI_RESPONSE_TO_SULINDAC_UP
0.00000 0.00007 0.00294 0.00000 0.00000 0.00124 0.06932DIRMEIER_LMP1_RESPONSE_EARLY
0.00650 0.00091 0.00551 0.01592 0.00000 0.03368 0.00454DER_IFN_GAMMA_RESPONSE_UP
0.00001 0.00272 0.00318 0.00009 0.00004 0.00001 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.00156 0.15133 0.05329 0.00003 0.00018 0.00002 0.11271FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00000 0.00017 0.00006 0.00003 0.00176 0.00000 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.04824 0.03092 0.00439 0.00168 0.01971 0.00076 0.13504BIOCARTA_CD40_PATHWAY
0.00024 0.00628 0.00118 0.00110 0.00000 0.00132 0.16783BILD_HRAS_ONCOGENIC_SIGNATURE
0.00507 0.00174 0.01033 0.00003 0.10086 0.00020 0.06938ONDER_CDH1_TARGETS_3_DN
0.00307 0.00259 0.00011 0.00006 0.00000 0.00008 0.01934DAUER_STAT3_TARGETS_UP
0.00000 0.00000 0.00000 0.00126 0.00000 0.00002 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.00000 0.00372 0.01084 0.01596 0.00171 0.13629 0.05322NETPATH_IL_3_PATHWAY_UP
0.01515 0.00384 0.00140 0.01532 0.03099 0.04291 0.04517BIOCARTA_RANKL_PATHWAY
0.00000 0.01636 0.13644 0.01171 0.00000 0.00467 0.10968NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.00000 0.00006 0.00007 0.01244 0.00000 0.01969 0.02074NETPATH_IL_6_PATHWAY_UP
0.00000 0.01844 0.04912 0.14139 0.00002 0.11920 0.05227LIAN_LIPA_TARGETS_6M
0.00000 0.00667 0.00155 0.00000 0.00000 0.00006 0.02102MCLACHLAN_DENTAL_CARIES_UP
0.03294 0.00206 0.00667 0.00066 0.00136 0.00012 0.10289CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_CHUK_KPNA3_NFKB2_NFKBIB_REL_IKBKG__NFKB1_NFKBIE_RELB__NFKBIA_RELA_TNIP2
0.00111 0.06213 0.03296 0.01158 0.01541 0.00000 0.15355DAZARD_UV_RESPONSE_CLUSTER_G2
0.00291 0.04051 0.07447 0.00776 0.00006 0.00000 0.00899CHEN_HOXA5_TARGETS_9HR_UP
0.00163 0.02747 0.01529 0.00075 0.01575 0.00002 0.14335NCI_CD40_PATHWAY
0.00000 0.01242 0.00444 0.00005 0.00001 0.00040 0.06509MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00005 0.00031 0.01845 0.00028 0.00000 0.00219 0.13910AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00007 0.00036 0.00000 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00003 0.00000 0.00000 0.00000 0.00000 0.00677 0.00796GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00002ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.01785 0.03781 0.10226 0.06023 0.00024 0.04014 0.06493BROWNE_HCMV_INFECTION_4HR_UP
0.00000 0.00000 0.00006 0.02114 0.00000 0.11599 0.00000ZHU_CMV_8_HR_UP
0.00012 0.00000 0.00000 0.00043 0.00000 0.00059 0.00001ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.00595 0.00000 0.00002 0.08424 0.05068 0.02042 0.04107BIOCARTA_INFLAM_PATHWAY
0.00004 0.11701 0.02116 0.00000 0.00000 0.00008 0.06147HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.03043 0.02011 0.00267 0.00000 0.00145 0.06454VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00000 0.02013 0.05374 0.12753 0.00000 0.00925 0.09060LIAN_LIPA_TARGETS_3M
0.00022 0.00027 0.00426 0.00051 0.00000 0.00000 0.00002GEISS_RESPONSE_TO_DSRNA_UP
0.00252 0.00033 0.00006 0.00006 0.00059 0.01719 0.00515KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00336 0.03748 0.08234 0.00002 0.00000 0.00000 0.00603UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00116 0.00427 0.00008 0.00843 0.00000 0.00038 0.04422GERY_CEBP_TARGETS
0.05996 0.00403 0.00048 0.00125 0.00388 0.00009 0.02476BIOCARTA_TNFR2_PATHWAY
0.00131 0.12346 0.00784 0.03582 0.00043 0.00024 0.06336ELVIDGE_HYPOXIA_BY_DMOG_UP
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.00083 0.00466 0.03180 0.13854 0.00000 0.01057 0.00201ZHU_CMV_ALL_UP
0.00000 0.00000 0.00000 0.00027 0.00000 0.01658 0.14588KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00009 0.00000 0.00000 0.00000 0.00002 0.00000 0.00039GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00265 0.00475 0.01525 0.00003 0.00000 0.00000 0.10013OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00011 0.04137 0.02142 0.00093 0.13990 0.10358 0.18870LEE_LIVER_CANCER_HEPATOBLAST
0.02218 0.05429 0.17640 0.06462 0.05523 0.00445 0.03228CORUM_NFKB1-NFKB2-REL-RELA-RELB_COMPLEX
0.00899 0.04132 0.03751 0.00002 0.00039 0.00076 0.02425ZUCCHI_METASTASIS_DN
0.00000 0.05878 0.09324 0.00102 0.00000 0.00000 0.01564NAGASHIMA_EGF_SIGNALING_UP
0.00001 0.01593 0.11780 0.00340 0.00002 0.10547 0.09552BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP
0.00099 0.00031 0.00000 0.00151 0.00000 0.00000 0.00004PRAMOONJAGO_SOX4_TARGETS_UP
0.00107 0.00034 0.00605 0.04258 0.00000 0.00000 0.15432PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.00151 0.01167 0.05376 0.00000 0.00000 0.00009 0.05134HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00070 0.00978 0.00467 0.00367 0.00004 0.00000 0.04711AMIT_EGF_RESPONSE_60_MCF10A