BICLUSTER_ID : UPREG-126
PATHOGENS /6/ : pseudomonas aeruginosa,bacillus anthracis,escherichia coli,brucella ovis,helicobacter pylori,brucella melitensis
TARGETS /6/ : NFKB1, IL6, PTGS2, PDE4B, CCL2, PLAUR
Gene SetLeading Edge Genes
NETPATH IL 2 PATHWAY UPETS2, SRC, NFKB1, IL6, PDE4B, PLAUR, IER3
NETPATH IL 1 PATHWAY UPNFKB1, NFKBIA, IL6, BIRC3, PTGS2, CXCL2
NETPATH IL 4 PATHWAY DOWNNFKBIA, PTGS2, CCL2, CXCL2
NETPATH IL 5 PATHWAY UPNFKB1, BIRC3, NFKB2, CCL2, IER3
NETPATH IL 1 PATHWAYNFKB1, NFKBIA
NCI IL23PATHWAYNFKB1, NFKBIA
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
BIOCARTA NFKB PATHWAY
BIOCARTA EPONFKB PATHWAY
DORN ADENOVIRUS INFECTION 32HR DN
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
CROONQUIST STROMAL STIMULATION UP
LINDSTEDT DENDRITIC CELL MATURATION B
BIOCARTA IL1R PATHWAY
BIOCARTA RELA PATHWAY
LINDSTEDT DENDRITIC CELL MATURATION A
SIMBULAN UV RESPONSE NORMAL UP
NETPATH IL 7 PATHWAY UPCXCL2
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
NETPATH KIT RECEPTOR PATHWAY UP
DIRMEIER LMP1 RESPONSE LATE UP
HINATA NFKB TARGETS KERATINOCYTE UP
DORN ADENOVIRUS INFECTION 48HR DN
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
GILMORE CORE NFKB PATHWAY
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA TID PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
DAUER STAT3 TARGETS UP
NETPATH IL 3 PATHWAY UP
KEGG LEISHMANIA INFECTION
DAZARD RESPONSE TO UV NHEK UP
MCLACHLAN DENTAL CARIES UP
DAZARD UV RESPONSE CLUSTER G2
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
REACTOME HUMAN TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHOU INFLAMMATORY RESPONSE LPS UP
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
VERHAAK AML WITH NPM1 MUTATED UP
KIM WT1 TARGETS UP
GEISS RESPONSE TO DSRNA UP
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
KEGG CYTOSOLIC DNA SENSING PATHWAY
BIOCARTA TNFR2 PATHWAY
BIOCARTA GRANULOCYTES PATHWAY
ZHOU INFLAMMATORY RESPONSE FIMA UP
TIAN TNF SIGNALING VIA NFKB
AMIT EGF RESPONSE 120 MCF10A
ZHU CMV ALL UP
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
NAGASHIMA EGF SIGNALING UP
AMIT EGF RESPONSE 60 MCF10A
HINATA NFKB TARGETS FIBROBLAST UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
helicobacter pylori kx1 mgeppseudomonas aeruginosabrucella ovisbacillus anthracisbrucella melitensispseudomonas aeruginosa fdr440helicobacter pylori kx2 mgepescherichia coliGeneSet Name
0.02575 0.11013 0.18663 0.18345 0.03203 0.00843 0.04909 0.00000NETPATH_IL_2_PATHWAY_UP
0.00000 0.00004 0.01452 0.00738 0.00061 0.00000 0.00000 0.00000NETPATH_IL_1_PATHWAY_UP
0.00002 0.00000 0.00062 0.12825 0.00471 0.00000 0.00009 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00021 0.00238 0.03173 0.00652 0.01177 0.00726 0.00002 0.00001NETPATH_IL_5_PATHWAY_UP
0.00053 0.00603 0.08064 0.15756 0.02567 0.00311 0.00458 0.00003NETPATH_IL_1_PATHWAY
0.00589 0.00049 0.05836 0.00010 0.03782 0.01471 0.01454 0.00000NCI_IL23PATHWAY
0.02218 0.00066 0.03342 0.00020 0.10177 0.00195 0.00022 0.00000KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00008 0.00003 0.01964 0.01784 0.00628 0.00010 0.00000 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.03509 0.01558 0.07308 0.15911 0.03113 0.01700 0.00541 0.00000GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00155 0.04067 0.12428 0.09838 0.00822 0.00100 0.00304 0.00000BIOCARTA_NFKB_PATHWAY
0.00105 0.00600 0.11461 0.07439 0.06482 0.00002 0.00246 0.00507BIOCARTA_EPONFKB_PATHWAY
0.00013 0.00267 0.03181 0.05861 0.00667 0.00021 0.00009 0.00003DORN_ADENOVIRUS_INFECTION_32HR_DN
0.02414 0.00016 0.03248 0.00986 0.03772 0.00068 0.07361 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.09639 0.00095 0.12412 0.14368 0.03016 0.02145 0.06781 0.00015REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.03674 0.01456 0.01979 0.03531 0.07941 0.00017 0.05041 0.00003CROONQUIST_STROMAL_STIMULATION_UP
0.00000 0.00005 0.02851 0.00000 0.01411 0.00000 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00078 0.02041 0.03199 0.00016 0.01663 0.06380 0.00292 0.00000BIOCARTA_IL1R_PATHWAY
0.03110 0.08343 0.15619 0.08726 0.04753 0.00063 0.09700 0.00033BIOCARTA_RELA_PATHWAY
0.00015 0.00387 0.00044 0.00000 0.00644 0.00003 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.02203 0.00361 0.05634 0.13030 0.02965 0.01311 0.04290 0.01024SIMBULAN_UV_RESPONSE_NORMAL_UP
0.00294 0.00151 0.01316 0.04896 0.02550 0.00003 0.00019 0.00000NETPATH_IL_7_PATHWAY_UP
0.00000 0.00381 0.06140 0.00240 0.00944 0.00052 0.00010 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00065 0.05123 0.17580 0.01116 0.02966 0.18259 0.00355 0.00023NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00800 0.12927 0.03254 0.04511 0.04289 0.00027 0.04267 0.00000DIRMEIER_LMP1_RESPONSE_LATE_UP
0.00002 0.00000 0.03817 0.00000 0.05127 0.00000 0.00000 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00007 0.00817 0.09920 0.18980 0.02820 0.00037 0.00009 0.00089DORN_ADENOVIRUS_INFECTION_48HR_DN
0.00005 0.00004 0.05857 0.00215 0.03717 0.00034 0.00019 0.00000KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00077 0.00006 0.08843 0.00000 0.04270 0.00000 0.01278 0.00000BASSO_CD40_SIGNALING_UP
0.00011 0.00251 0.00716 0.00345 0.00824 0.02994 0.00002 0.00037SOUCEK_MYC_TARGETS
0.00003 0.00340 0.18747 0.00319 0.01568 0.00085 0.00000 0.00003GILMORE_CORE_NFKB_PATHWAY
0.00000 0.00086 0.01264 0.01600 0.00246 0.00513 0.00000 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.00157 0.00000 0.01330 0.00000 0.00015 0.00002 0.00124 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00018 0.00003 0.05049 0.00253 0.02236 0.00009 0.00000 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00325 0.01521 0.16728 0.01740 0.09531 0.00010 0.01576 0.00058BIOCARTA_TID_PATHWAY
0.00029 0.00110 0.06372 0.13675 0.15734 0.00028 0.00132 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.00000 0.00000 0.00746 0.00000 0.00487 0.00010 0.00000 0.00000ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00085 0.00003 0.00115 0.00403 0.00670 0.00194 0.00020 0.00000ONDER_CDH1_TARGETS_3_DN
0.00067 0.00006 0.10980 0.00062 0.00563 0.00085 0.00008 0.00003DAUER_STAT3_TARGETS_UP
0.03326 0.01596 0.00156 0.19023 0.00052 0.15088 0.13629 0.00000NETPATH_IL_3_PATHWAY_UP
0.00031 0.00366 0.13650 0.01847 0.01414 0.00027 0.01576 0.00028KEGG_LEISHMANIA_INFECTION
0.00624 0.00080 0.12521 0.15309 0.10000 0.10778 0.01957 0.00002DAZARD_RESPONSE_TO_UV_NHEK_UP
0.00018 0.00000 0.03202 0.11704 0.01108 0.00001 0.00006 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.00079 0.01158 0.14937 0.15429 0.06885 0.00228 0.00000 0.00004DAZARD_UV_RESPONSE_CLUSTER_G2
0.00006 0.00185 0.01159 0.09653 0.00031 0.00037 0.00146 0.00000FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00030 0.00005 0.04417 0.12968 0.01946 0.00017 0.00040 0.00002MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00076 0.00000 0.00010 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00002 0.00036 0.00581 0.00000 0.00642 0.00002 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.06009 0.00110 0.15402 0.06097 0.09916 0.00194 0.07448 0.00016REACTOME_HUMAN_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX
0.00937 0.00000 0.05672 0.00009 0.02218 0.00002 0.00677 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00055 0.00000 0.00017 0.00000 0.00000 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00307 0.00043 0.04278 0.00000 0.02743 0.00027 0.00059 0.00000ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.05381 0.08424 0.00765 0.00049 0.03484 0.00030 0.02042 0.00000BIOCARTA_INFLAM_PATHWAY
0.00000 0.00000 0.01931 0.00096 0.00362 0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.00215 0.00000 0.00038 0.00029 0.00468 0.00011 0.00008 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00438 0.00703 0.12374 0.00327 0.04719 0.02538 0.00018 0.00001SESTO_RESPONSE_TO_UV_C3
0.00063 0.00267 0.08159 0.00551 0.01897 0.00218 0.00145 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00000 0.00318 0.09311 0.11950 0.10192 0.00002 0.00000 0.00002KIM_WT1_TARGETS_UP
0.00000 0.00051 0.08028 0.03512 0.09792 0.00007 0.00000 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.00000 0.00002 0.01384 0.00003 0.05866 0.02749 0.00000 0.00044UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.03185 0.00006 0.03178 0.02609 0.05929 0.01678 0.01719 0.00000KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00067 0.00125 0.12499 0.00304 0.18375 0.02358 0.00009 0.00004BIOCARTA_TNFR2_PATHWAY
0.01647 0.04859 0.05900 0.03044 0.00520 0.02115 0.12825 0.15379BIOCARTA_GRANULOCYTES_PATHWAY
0.00157 0.00000 0.01646 0.00000 0.00643 0.00013 0.00011 0.00000ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.00000 0.00000 0.02617 0.00000 0.00659 0.00000 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.02386 0.00069 0.12289 0.14343 0.03700 0.00020 0.00229 0.00004AMIT_EGF_RESPONSE_120_MCF10A
0.01293 0.13854 0.06104 0.14821 0.10116 0.02420 0.01057 0.00000ZHU_CMV_ALL_UP
0.00000 0.00000 0.00040 0.00000 0.00050 0.00000 0.00000 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00010 0.00003 0.01906 0.01781 0.00613 0.00011 0.00000 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.07700 0.00093 0.15857 0.00308 0.04602 0.00243 0.10358 0.00010LEE_LIVER_CANCER_HEPATOBLAST
0.00000 0.00102 0.19801 0.00009 0.04193 0.00002 0.00000 0.00003NAGASHIMA_EGF_SIGNALING_UP
0.00002 0.00367 0.03197 0.00559 0.02006 0.00027 0.00000 0.00000AMIT_EGF_RESPONSE_60_MCF10A
0.00000 0.00000 0.16302 0.00000 0.15037 0.00000 0.00009 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP