BICLUSTER_ID : UPREG-130
PATHOGENS /4/ : yersinia enterocolitica,brucella ovis,mycobacterium tuberculosis,ehrlichia chaffeensis
TARGETS /9/ : NFKB1, CCL2, TNFRSF1B, IL6, CCL5, CD86, PIM1, PLAUR, TNF
Gene SetLeading Edge Genes
NETPATH KIT RECEPTOR PATHWAY UPIL6, JUNB, CCL5, CCL2, PIM1, TNF, IER3
NETPATH IL 2 PATHWAY UPNFKB1, IFIT1, TRIM21, TRAFD1, LCP2, IL6, IRF1, UPP1, PLAUR, CCL4, TNF
NCI IL23PATHWAYNFKB1, CCL2, TNF
NETPATH IL 1 PATHWAY UPNFKB1, IL6, CCL2, CXCL2, HBEGF, CCL4
SA MMP CYTOKINE CONNECTIONTNFRSF1B, TNF
NETPATH IL 7 PATHWAY UPCCL5, CD86, CXCL2, CCL4
NETPATH IL 3 PATHWAY UPCCL2, CD86, CCL4
NETPATH IL 6 PATHWAY UPGADD45B, JUNB, IRF1, PIM1, HBEGF, TNF
NETPATH IL 5 PATHWAY UPCCL2, PIM1, UPP1
NETPATH IL 4 PATHWAY DOWNGEM, GADD45B, CCL2, CXCL2, IRF1
NCI IL12 2PATHWAYNFKB1, GADD45B, CCL4
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
BIOCARTA IL10 PATHWAY
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
NETPATH IL 9 PATHWAY UP
BIOCARTA NFKB PATHWAY
MAHAJAN RESPONSE TO IL1A UP
WEINMANN ADAPTATION TO HYPOXIA DN
ZHANG INTERFERON RESPONSE
KEGG GRAFT VERSUS HOST DISEASE
DORN ADENOVIRUS INFECTION 32HR DN
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
CROONQUIST STROMAL STIMULATION UP
LINDSTEDT DENDRITIC CELL MATURATION B
BIOCARTA IL1R PATHWAY
LINDSTEDT DENDRITIC CELL MATURATION A
NETPATH IL 1 PATHWAY
RADAEVA RESPONSE TO IFNA1 UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP
BOWIE RESPONSE TO EXTRACELLULAR MATRIX
WOO LIVER CANCER RECURRENCE UP
MISHRA CARCINOMA ASSOCIATED FIBROBLAST UP
MAHADEVAN RESPONSE TO MP470 DN
UROSEVIC RESPONSE TO IMIQUIMOD
BROWNE INTERFERON RESPONSIVE GENES
LIN SILENCED BY TUMOR MICROENVIRONMENT
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
DIRMEIER LMP1 RESPONSE LATE UP
HINATA NFKB TARGETS KERATINOCYTE UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
XU HGF TARGETS INDUCED BY AKT1 48HR UP
OSADA ASCL1 TARGETS DN
VART KSHV INFECTION ANGIOGENIC MARKERS UP
MARZEC IL2 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
BOYLAN MULTIPLE MYELOMA C D DN
DIRMEIER LMP1 RESPONSE EARLY
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
AMIT EGF RESPONSE 120 HELA
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
KEGG LEISHMANIA INFECTION
MCLACHLAN DENTAL CARIES UP
DAZARD RESPONSE TO UV NHEK UP
JAATINEN HEMATOPOIETIC STEM CELL DN
BERENJENO TRANSFORMED BY RHOA FOREVER DN
DAZARD UV RESPONSE CLUSTER G2
MCLACHLAN DENTAL CARIES DN
FOSTER INFLAMMATORY RESPONSE LPS DN
KEGG ALLOGRAFT REJECTION
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
NETPATH EGFR1 PATHWAY UP
HELLER SILENCED BY METHYLATION UP
GRANDVAUX IFN RESPONSE NOT VIA IRF3
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BOWIE RESPONSE TO TAMOXIFEN
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
SMID BREAST CANCER LUMINAL B DN
ZHOU INFLAMMATORY RESPONSE LPS UP
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
MOSERLE IFNA RESPONSE
FOSTER INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 120 MCF10A
XU HGF TARGETS INDUCED BY AKT1 6HR
ONDER CDH1 TARGETS 2 DN
DORN ADENOVIRUS INFECTION 24HR DN
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KIM WT1 TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
LIAN LIPA TARGETS 3M
GEISS RESPONSE TO DSRNA UP
ONDER CDH1 TARGETS 1 DN
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1
ZHOU INFLAMMATORY RESPONSE FIMA UP
DASU IL6 SIGNALING UP
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
KEGG TYPE I DIABETES MELLITUS
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6yersinia enterocolitica p60 bl6ehrlichia chaffeensis wakullamycobacterium tuberculosisbrucella ovisGeneSet Name
0.00062 0.00015 0.00015 0.00019 0.17580NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.01769 0.00994 0.00006 0.00008 0.18663NETPATH_IL_2_PATHWAY_UP
0.00000 0.00000 0.00020 0.00126 0.05836NCI_IL23PATHWAY
0.00024 0.00000 0.00022 0.00602 0.01452NETPATH_IL_1_PATHWAY_UP
0.00406 0.01474 0.00000 0.00814 0.18285SA_MMP_CYTOKINE_CONNECTION
0.00623 0.00709 0.00004 0.00856 0.01316NETPATH_IL_7_PATHWAY_UP
0.00000 0.00000 0.00000 0.00171 0.00156NETPATH_IL_3_PATHWAY_UP
0.00000 0.00000 0.00000 0.00000 0.01065NETPATH_IL_6_PATHWAY_UP
0.02712 0.00711 0.00000 0.00000 0.03173NETPATH_IL_5_PATHWAY_UP
0.00145 0.00146 0.00000 0.00000 0.00062NETPATH_IL_4_PATHWAY_DOWN
0.00709 0.00272 0.00000 0.00051 0.14294NCI_IL12_2PATHWAY
0.00000 0.00000 0.00000 0.00225 0.03342KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00000 0.00000 0.00301 0.00000 0.01964OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00016 0.00108 0.00114 0.00336 0.16352BIOCARTA_IL10_PATHWAY
0.00000 0.00021 0.00547 0.00002 0.07308GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00016 0.00016 0.00000 0.08229 0.00706NETPATH_IL_9_PATHWAY_UP
0.11451 0.05121 0.00699 0.00073 0.12428BIOCARTA_NFKB_PATHWAY
0.00113 0.00010 0.00447 0.00132 0.08148MAHAJAN_RESPONSE_TO_IL1A_UP
0.00024 0.00006 0.04046 0.03354 0.07459WEINMANN_ADAPTATION_TO_HYPOXIA_DN
0.00001 0.00037 0.00000 0.00000 0.14676ZHANG_INTERFERON_RESPONSE
0.00424 0.00069 0.00000 0.02321 0.01234KEGG_GRAFT_VERSUS_HOST_DISEASE
0.13670 0.00369 0.17242 0.00008 0.03181DORN_ADENOVIRUS_INFECTION_32HR_DN
0.00000 0.00011 0.00000 0.00000 0.03248ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.04761 0.00954 0.00000 0.00025 0.01979CROONQUIST_STROMAL_STIMULATION_UP
0.04571 0.04591 0.00000 0.00000 0.02851LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00017 0.00114 0.01394 0.00118 0.03199BIOCARTA_IL1R_PATHWAY
0.00011 0.00029 0.00000 0.00000 0.00044LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.04934 0.02533 0.10950 0.03544 0.08064NETPATH_IL_1_PATHWAY
0.00075 0.00709 0.00000 0.00000 0.11979RADAEVA_RESPONSE_TO_IFNA1_UP
0.00023 0.00069 0.00000 0.00000 0.12412TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP
0.00289 0.00618 0.00166 0.00000 0.19318BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX
0.01536 0.00424 0.00000 0.00002 0.14802WOO_LIVER_CANCER_RECURRENCE_UP
0.05070 0.10787 0.00056 0.01530 0.15429MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP
0.00031 0.00072 0.08720 0.00000 0.06080MAHADEVAN_RESPONSE_TO_MP470_DN
0.00114 0.00167 0.00001 0.00000 0.06159UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.00000 0.00006 0.00000 0.00000 0.12548BROWNE_INTERFERON_RESPONSIVE_GENES
0.08419 0.05264 0.06953 0.00125 0.11922LIN_SILENCED_BY_TUMOR_MICROENVIRONMENT
0.00024 0.00184 0.00174 0.00000 0.06140THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00000 0.00000 0.00000 0.00000 0.04753TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.01109 0.00708 0.00001 0.00000 0.18029TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.15215 0.00164 0.00539 0.00003 0.03254DIRMEIER_LMP1_RESPONSE_LATE_UP
0.00000 0.00000 0.00001 0.00000 0.03817HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00045 0.00058 0.00000 0.00060 0.05857KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00018 0.00000 0.00000 0.08843BASSO_CD40_SIGNALING_UP
0.03329 0.01826 0.05349 0.00027 0.09865XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_UP
0.08327 0.08169 0.00002 0.00021 0.17587OSADA_ASCL1_TARGETS_DN
0.01528 0.00294 0.01577 0.01566 0.10314VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP
0.00016 0.00021 0.00004 0.00127 0.05261MARZEC_IL2_SIGNALING_UP
0.00000 0.00018 0.00027 0.02521 0.00716SOUCEK_MYC_TARGETS
0.00646 0.00201 0.00000 0.00002 0.01264DUTTA_APOPTOSIS_VIA_NFKB
0.00251 0.01871 0.00000 0.02453 0.18270BOYLAN_MULTIPLE_MYELOMA_C_D_DN
0.00000 0.00018 0.00000 0.00000 0.01330DIRMEIER_LMP1_RESPONSE_EARLY
0.00508 0.01472 0.00156 0.00018 0.08101FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00002 0.00012 0.00000 0.00176 0.05049REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00018 0.00069 0.00000 0.00000 0.03492SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
0.00001 0.00079 0.00000 0.00000 0.05898BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.00208 0.00000 0.00024 0.00000 0.06372BILD_HRAS_ONCOGENIC_SIGNATURE
0.00000 0.00000 0.00039 0.00002 0.00746ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00150 0.00026 0.00507 0.10086 0.00115ONDER_CDH1_TARGETS_3_DN
0.00077 0.00029 0.00037 0.00000 0.12378AMIT_EGF_RESPONSE_120_HELA
0.05660 0.06189 0.00307 0.00000 0.10980DAUER_STAT3_TARGETS_UP
0.00000 0.00000 0.00000 0.00000 0.03860LIANG_SILENCED_BY_METHYLATION_2
0.00675 0.07814 0.00000 0.00007 0.13650KEGG_LEISHMANIA_INFECTION
0.00049 0.00050 0.00000 0.00000 0.03202MCLACHLAN_DENTAL_CARIES_UP
0.08717 0.01128 0.05265 0.00196 0.12521DAZARD_RESPONSE_TO_UV_NHEK_UP
0.00110 0.00289 0.00000 0.00097 0.16593JAATINEN_HEMATOPOIETIC_STEM_CELL_DN
0.19546 0.00332 0.00358 0.08977 0.17996BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN
0.11521 0.01250 0.00111 0.01541 0.14937DAZARD_UV_RESPONSE_CLUSTER_G2
0.00078 0.00065 0.00000 0.00001 0.04417MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000 0.00000 0.01159FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00363 0.00288 0.00014 0.00549 0.13146KEGG_ALLOGRAFT_REJECTION
0.00000 0.00000 0.00005 0.00000 0.08142AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00000 0.00000 0.00076SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00000 0.00000 0.00581GAURNIER_PSMD4_TARGETS
0.04029 0.00038 0.03402 0.01945 0.19976NETPATH_EGFR1_PATHWAY_UP
0.00210 0.00251 0.00000 0.00000 0.11472HELLER_SILENCED_BY_METHYLATION_UP
0.00158 0.00375 0.00070 0.00000 0.10265GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3
0.00810 0.00398 0.00003 0.00000 0.05672GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00150 0.00593 0.00001 0.00000 0.09220BOWIE_RESPONSE_TO_TAMOXIFEN
0.00000 0.00000 0.00000 0.00000 0.00055ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00087 0.00018 0.00000 0.07952 0.19116SMID_BREAST_CANCER_LUMINAL_B_DN
0.00000 0.00000 0.00012 0.00000 0.04278ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00595 0.05068 0.00765BIOCARTA_INFLAM_PATHWAY
0.00017 0.00022 0.00000 0.00000 0.01931SANA_TNF_SIGNALING_UP
0.00044 0.00236 0.00000 0.00000 0.05076MOSERLE_IFNA_RESPONSE
0.00000 0.00004 0.00000 0.00000 0.08922FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00013 0.00007 0.00009 0.00013 0.01293AMIT_SERUM_RESPONSE_120_MCF10A
0.01150 0.02501 0.00223 0.00001 0.12444XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.00065 0.00022 0.00036 0.00500 0.13624ONDER_CDH1_TARGETS_2_DN
0.09507 0.00061 0.07444 0.00000 0.12363DORN_ADENOVIRUS_INFECTION_24HR_DN
0.00080 0.00030 0.00004 0.00000 0.00038HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00757 0.00078 0.01412 0.00000 0.12374SESTO_RESPONSE_TO_UV_C3
0.01612 0.00039 0.00017 0.00007 0.09311KIM_WT1_TARGETS_UP
0.00001 0.00000 0.00000 0.00000 0.08159VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.01061 0.00252 0.00000 0.00000 0.10503LIAN_LIPA_TARGETS_3M
0.00179 0.00109 0.00022 0.00000 0.08028GEISS_RESPONSE_TO_DSRNA_UP
0.07697 0.00405 0.13248 0.07350 0.11964ONDER_CDH1_TARGETS_1_DN
0.00145 0.00200 0.00252 0.00059 0.03178KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00000 0.00000 0.00336 0.00000 0.01384UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00093 0.00070 0.00050 0.00666 0.19115SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1
0.00018 0.00000 0.02576 0.00047 0.01646ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.01073 0.00177 0.03956 0.00006 0.14484DASU_IL6_SIGNALING_UP
0.02376 0.00086 0.03134 0.03451 0.12289AMIT_EGF_RESPONSE_120_MCF10A
0.00000 0.00016 0.00000 0.00000 0.02617TIAN_TNF_SIGNALING_VIA_NFKB
0.02045 0.03630 0.00083 0.00000 0.06104ZHU_CMV_ALL_UP
0.00027 0.01680 0.00000 0.00000 0.13418KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00024 0.00037 0.00009 0.00002 0.00040GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00000 0.00265 0.00000 0.01906OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00139 0.00058 0.00011 0.13990 0.15857LEE_LIVER_CANCER_HEPATOBLAST
0.08451 0.04370 0.00899 0.00039 0.10002ZUCCHI_METASTASIS_DN
0.00000 0.00000 0.00000 0.00000 0.19801NAGASHIMA_EGF_SIGNALING_UP
0.03824 0.01506 0.00184 0.06667 0.14828KEGG_TYPE_I_DIABETES_MELLITUS
0.03435 0.00034 0.00151 0.00000 0.16302HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00000 0.00070 0.00004 0.03197AMIT_EGF_RESPONSE_60_MCF10A
0.00032 0.00005 0.00050 0.00205 0.05093CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN