BICLUSTER_ID : UPREG-136
PATHOGENS /4/ : pseudomonas aeruginosa,streptococcus pneumoniae,yersinia enterocolitica,ehrlichia chaffeensis
TARGETS /4/ : NFKB1, LCN2, IL6, AMPD3
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPNFKB1, IL6, LCN2, AMPD3, CXCL1, CXCL2, PTX3
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
MAHAJAN RESPONSE TO IL1A UP
WEINMANN ADAPTATION TO HYPOXIA DN
LINDGREN BLADDER CANCER CLUSTER 2B
CHUANG OXIDATIVE STRESS RESPONSE UP
CHEN LVAD SUPPORT OF FAILING HEART UP
TENEDINI MEGAKARYOCYTE MARKERS
LINDSTEDT DENDRITIC CELL MATURATION B
MCBRYAN PUBERTAL BREAST 4 5WK UP
RASHI RESPONSE TO IONIZING RADIATION 2
NETPATH IL 1 PATHWAY
LINDSTEDT DENDRITIC CELL MATURATION A
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP
ELVIDGE HYPOXIA UP
IYENGAR RESPONSE TO ADIPOCYTE FACTORS
AMIT EGF RESPONSE 40 HELA
NETPATH IL 7 PATHWAY UP
MISHRA CARCINOMA ASSOCIATED FIBROBLAST UP
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
MORI EMU MYC LYMPHOMA BY ONSET TIME DN
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
BROWNE INTERFERON RESPONSIVE GENES
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP
HINATA NFKB TARGETS KERATINOCYTE UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
XU HGF TARGETS INDUCED BY AKT1 48HR UP
DUTTA APOPTOSIS VIA NFKB
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS MAGENTA UP
KRISHNAN FURIN TARGETS UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN
DIRMEIER LMP1 RESPONSE EARLY
NCI REG GR PATHWAY
KORKOLA TERATOMA
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
AMIT EGF RESPONSE 120 HELA
BIOCARTA RANKL PATHWAY
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
WINTER HYPOXIA METAGENE
GAJATE RESPONSE TO TRABECTEDIN UP
PODAR RESPONSE TO ADAPHOSTIN UP
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP
FOSTER INFLAMMATORY RESPONSE LPS DN
LU TUMOR VASCULATURE UP
HELLER SILENCED BY METHYLATION UP
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER
BIOCARTA CARDIACEGF PATHWAY
GESERICK TERT TARGETS DN
BROWNE HCMV INFECTION 2HR UP
NCI IL1PATHWAY
SESTO RESPONSE TO UV C3
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
NCI P53DOWNSTREAMPATHWAY
GERY CEBP TARGETS
ST TUMOR NECROSIS FACTOR PATHWAY
TIAN TNF SIGNALING VIA NFKB
CHASSOT SKIN WOUND
GENTILE UV LOW DOSE UP
LEE LIVER CANCER HEPATOBLAST
NAGASHIMA EGF SIGNALING UP
KRIGE AMINO ACID DEPRIVATION
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN
NOJIMA SFRP2 TARGETS UP
RHEIN ALL GLUCOCORTICOID THERAPY UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP
NCI ATF2 PATHWAY
LEONARD HYPOXIA
CROONQUIST STROMAL STIMULATION UP
HORIUCHI WTAP TARGETS UP
ONDER CDH1 SIGNALING VIA CTNNB1
WOO LIVER CANCER RECURRENCE UP
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
MAHADEVAN RESPONSE TO MP470 DN
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN
NCI LYSOPHOSPHOLIPID PATHWAY
HARRIS HYPOXIA
DIRMEIER LMP1 RESPONSE LATE UP
AMIT EGF RESPONSE 20 HELA
BASSO CD40 SIGNALING UP
KAN RESPONSE TO ARSENIC TRIOXIDE
TIAN TNF SIGNALING NOT VIA NFKB
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
ZERBINI RESPONSE TO SULINDAC UP
WANG ESOPHAGUS CANCER VS NORMAL UP
CROMER TUMORIGENESIS UP
GENTILE UV LOW DOSE DN
FERRARI RESPONSE TO FENRETINIDE UP
BILD HRAS ONCOGENIC SIGNATURE
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NETPATH IL 6 PATHWAY UPMAFF, CXCL1, IRF1, MAP3K8
BERENJENO TRANSFORMED BY RHOA FOREVER DN
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN
AMIT EGF RESPONSE 60 HELA
DAZARD UV RESPONSE CLUSTER G2
CHEN HOXA5 TARGETS 9HR UP
NETPATH IL 5 PATHWAY UP
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
NETPATH EGFR1 PATHWAY UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
CONCANNON APOPTOSIS BY EPOXOMICIN UP
HELLER SILENCED BY METHYLATION DN
BIERIE INFLAMMATORY RESPONSE TGFB1
SANA TNF SIGNALING UP
SENESE HDAC1 AND HDAC2 TARGETS UP
WANG METHYLATED IN BREAST CANCER
ONDER CDH1 TARGETS 2 DN
SENESE HDAC1 TARGETS UP
LIU TARGETS OF VMYB VS CMYB DN
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
CASTELLANO NRAS TARGETS UP
KIM WT1 TARGETS UP
REACTOME P75NTR SIGNALS VIA NFKB
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
LINDSTEDT DENDRITIC CELL MATURATION C
NCI NFKAPPABCANONICALPATHWAY
HESS TARGETS OF HOXA9 AND MEIS1 DN
ELVIDGE HYPOXIA BY DMOG UP
DASU IL6 SIGNALING UP
NETPATH IL 2 PATHWAY UP
HUPER BREAST BASAL VS LUMINAL UP
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
ZUCCHI METASTASIS DN
BIOCARTA ARENRF2 PATHWAY
PRAMOONJAGO SOX4 TARGETS UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6ehrlichia chaffeensis wakullastreptococcus pneumoniae g54pseudomonas aeruginosaGeneSet Name
0.00024 0.00022 0.02186 0.00004NETPATH_IL_1_PATHWAY_UP
0.00000 0.00547 0.03257 0.01558GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00113 0.00447 0.08911 0.00000MAHAJAN_RESPONSE_TO_IL1A_UP
0.00024 0.04046 0.00875 0.03347WEINMANN_ADAPTATION_TO_HYPOXIA_DN
0.02833 0.00000 0.08248 0.09315LINDGREN_BLADDER_CANCER_CLUSTER_2B
0.02433 0.12450 0.12323 0.17995CHUANG_OXIDATIVE_STRESS_RESPONSE_UP
0.02279 0.01382 0.01145 0.11056CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP
0.05734 0.00000 0.11247 0.09360TENEDINI_MEGAKARYOCYTE_MARKERS
0.04571 0.00000 0.00817 0.00005LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.08727 0.00085 0.03294 0.13408MCBRYAN_PUBERTAL_BREAST_4_5WK_UP
0.00427 0.00001 0.00271 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.04934 0.10950 0.03624 0.00603NETPATH_IL_1_PATHWAY
0.00011 0.00000 0.16372 0.00387LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.03142 0.02903 0.04813 0.02390LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP
0.00923 0.00027 0.00034 0.10177ELVIDGE_HYPOXIA_UP
0.05090 0.01247 0.03272 0.00802IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS
0.01474 0.00042 0.02615 0.00000AMIT_EGF_RESPONSE_40_HELA
0.00623 0.00004 0.11486 0.00151NETPATH_IL_7_PATHWAY_UP
0.05070 0.00056 0.17226 0.01601MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP
0.19093 0.02739 0.03309 0.00150YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.02652 0.01382 0.09386 0.11752MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_DN
0.00024 0.00174 0.09013 0.00381THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00000 0.00000 0.11107 0.10336BROWNE_INTERFERON_RESPONSIVE_GENES
0.01109 0.00001 0.13995 0.13363TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.00998 0.08132 0.14828 0.10385TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP
0.00000 0.00001 0.00568 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00200 0.00000 0.10730 0.02176MARKEY_RB1_ACUTE_LOF_UP
0.00045 0.00000 0.17463 0.00004KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.03329 0.05349 0.18837 0.06674XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_UP
0.00646 0.00000 0.05455 0.00086DUTTA_APOPTOSIS_VIA_NFKB
0.19398 0.04386 0.00558 0.00182GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_UP
0.03190 0.00348 0.11205 0.01934KRISHNAN_FURIN_TARGETS_UP
0.07127 0.00958 0.10702 0.19372TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN
0.00000 0.00000 0.08905 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.15957 0.14236 0.05556 0.03680NCI_REG_GR_PATHWAY
0.07706 0.15100 0.07871 0.06161KORKOLA_TERATOMA
0.00000 0.00039 0.11282 0.00000ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00150 0.00507 0.03102 0.00003ONDER_CDH1_TARGETS_3_DN
0.00077 0.00037 0.01466 0.00184AMIT_EGF_RESPONSE_120_HELA
0.05455 0.01515 0.11238 0.01532BIOCARTA_RANKL_PATHWAY
0.07010 0.06671 0.16628 0.00610HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS
0.10871 0.00276 0.13119 0.00593NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.06926 0.01067 0.01549 0.10229WINTER_HYPOXIA_METAGENE
0.09603 0.00261 0.00696 0.08239GAJATE_RESPONSE_TO_TRABECTEDIN_UP
0.00017 0.00028 0.00016 0.13378PODAR_RESPONSE_TO_ADAPHOSTIN_UP
0.00409 0.13273 0.01570 0.07679GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP
0.00000 0.00000 0.01680 0.00185FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.01825 0.13594 0.16618 0.06642LU_TUMOR_VASCULATURE_UP
0.00210 0.00000 0.17361 0.17408HELLER_SILENCED_BY_METHYLATION_UP
0.04808 0.04099 0.02405 0.01071SATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER
0.03501 0.07216 0.13908 0.08574BIOCARTA_CARDIACEGF_PATHWAY
0.00141 0.00032 0.00310 0.00178GESERICK_TERT_TARGETS_DN
0.06014 0.11885 0.04469 0.00000BROWNE_HCMV_INFECTION_2HR_UP
0.05191 0.06247 0.18632 0.07942NCI_IL1PATHWAY
0.00757 0.01412 0.01104 0.00703SESTO_RESPONSE_TO_UV_C3
0.00001 0.00000 0.12533 0.00267VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00179 0.00022 0.03258 0.00051GEISS_RESPONSE_TO_DSRNA_UP
0.00514 0.00030 0.03598 0.02559GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.08860 0.03452 0.06541 0.04260NCI_P53DOWNSTREAMPATHWAY
0.00277 0.00116 0.12493 0.00843GERY_CEBP_TARGETS
0.16103 0.00254 0.10551 0.00000ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.00000 0.00000 0.16057 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.13170 0.04468 0.03610 0.06576CHASSOT_SKIN_WOUND
0.05500 0.07239 0.16976 0.00359GENTILE_UV_LOW_DOSE_UP
0.00139 0.00011 0.06587 0.00093LEE_LIVER_CANCER_HEPATOBLAST
0.00000 0.00000 0.00045 0.00102NAGASHIMA_EGF_SIGNALING_UP
0.09096 0.04509 0.04467 0.00099KRIGE_AMINO_ACID_DEPRIVATION
0.03435 0.00151 0.02432 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00070 0.00090 0.00367AMIT_EGF_RESPONSE_60_MCF10A
0.00032 0.00050 0.06179 0.06344CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN
0.00172 0.00340 0.17017 0.06631NOJIMA_SFRP2_TARGETS_UP
0.07223 0.00170 0.05094 0.03016RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP
0.00468 0.00006 0.00810 0.00002MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.00301 0.01878 0.00003OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.05054 0.00000 0.01189 0.02594SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP
0.19595 0.00196 0.03036 0.00003NCI_ATF2_PATHWAY
0.08551 0.00008 0.00548 0.09020LEONARD_HYPOXIA
0.04761 0.00000 0.09861 0.01456CROONQUIST_STROMAL_STIMULATION_UP
0.00735 0.00059 0.00695 0.10214HORIUCHI_WTAP_TARGETS_UP
0.05101 0.02499 0.01436 0.00094ONDER_CDH1_SIGNALING_VIA_CTNNB1
0.01536 0.00000 0.02446 0.16140WOO_LIVER_CANCER_RECURRENCE_UP
0.01516 0.02715 0.04993 0.04274GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.00031 0.08720 0.15502 0.00187MAHADEVAN_RESPONSE_TO_MP470_DN
0.07134 0.00022 0.02167 0.06176CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN
0.12479 0.08711 0.17451 0.09661NCI_LYSOPHOSPHOLIPID_PATHWAY
0.00250 0.00025 0.10031 0.00391HARRIS_HYPOXIA
0.15215 0.00539 0.06964 0.12927DIRMEIER_LMP1_RESPONSE_LATE_UP
0.16753 0.00184 0.04591 0.00091AMIT_EGF_RESPONSE_20_HELA
0.00000 0.00000 0.03498 0.00006BASSO_CD40_SIGNALING_UP
0.04922 0.01034 0.04440 0.00906KAN_RESPONSE_TO_ARSENIC_TRIOXIDE
0.01664 0.00264 0.00388 0.05837TIAN_TNF_SIGNALING_NOT_VIA_NFKB
0.00002 0.00000 0.00022 0.00113NAGASHIMA_NRG1_SIGNALING_UP
0.00000 0.00027 0.08229 0.00251SOUCEK_MYC_TARGETS
0.13677 0.11589 0.09092 0.08983ZERBINI_RESPONSE_TO_SULINDAC_UP
0.11437 0.00010 0.10110 0.06142WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP
0.03004 0.08461 0.02045 0.00771CROMER_TUMORIGENESIS_UP
0.06577 0.07482 0.17440 0.00316GENTILE_UV_LOW_DOSE_DN
0.00508 0.00156 0.01205 0.00003FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00208 0.00024 0.00093 0.00110BILD_HRAS_ONCOGENIC_SIGNATURE
0.05660 0.00307 0.03237 0.00006DAUER_STAT3_TARGETS_UP
0.00000 0.00000 0.01216 0.00126LIANG_SILENCED_BY_METHYLATION_2
0.00000 0.00000 0.01842 0.01244NETPATH_IL_6_PATHWAY_UP
0.19546 0.00358 0.02282 0.00379BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN
0.16114 0.03269 0.09462 0.02053ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN
0.02663 0.00102 0.02905 0.17983AMIT_EGF_RESPONSE_60_HELA
0.11521 0.00111 0.03619 0.01158DAZARD_UV_RESPONSE_CLUSTER_G2
0.01506 0.00291 0.00050 0.00776CHEN_HOXA5_TARGETS_9HR_UP
0.02712 0.00000 0.07746 0.00238NETPATH_IL_5_PATHWAY_UP
0.00000 0.00005 0.00737 0.00028AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.02093 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.04029 0.03402 0.11210 0.02903NETPATH_EGFR1_PATHWAY_UP
0.00810 0.00003 0.11160 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00231 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00369 0.01806 0.01005 0.00121CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP
0.04866 0.06295 0.18318 0.02836HELLER_SILENCED_BY_METHYLATION_DN
0.07716 0.02732 0.05057 0.00508BIERIE_INFLAMMATORY_RESPONSE_TGFB1
0.00017 0.00000 0.15203 0.00000SANA_TNF_SIGNALING_UP
0.02769 0.01080 0.15156 0.03137SENESE_HDAC1_AND_HDAC2_TARGETS_UP
0.00217 0.05272 0.02474 0.17963WANG_METHYLATED_IN_BREAST_CANCER
0.00065 0.00036 0.00297 0.00503ONDER_CDH1_TARGETS_2_DN
0.08354 0.03717 0.05349 0.16126SENESE_HDAC1_TARGETS_UP
0.16617 0.00731 0.15815 0.03971LIU_TARGETS_OF_VMYB_VS_CMYB_DN
0.00080 0.00004 0.00067 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00165 0.00260 0.11522 0.13383CASTELLANO_NRAS_TARGETS_UP
0.01612 0.00017 0.00273 0.00318KIM_WT1_TARGETS_UP
0.19205 0.07392 0.13024 0.02915REACTOME_P75NTR_SIGNALS_VIA_NFKB
0.00000 0.00336 0.00000 0.00002UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.14282 0.11084 0.00761 0.08129LINDSTEDT_DENDRITIC_CELL_MATURATION_C
0.11497 0.02559 0.05639 0.10947NCI_NFKAPPABCANONICALPATHWAY
0.00000 0.00000 0.13868 0.15886HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.01114 0.00131 0.00018 0.03582ELVIDGE_HYPOXIA_BY_DMOG_UP
0.01073 0.03956 0.09369 0.00000DASU_IL6_SIGNALING_UP
0.01769 0.00006 0.16635 0.11013NETPATH_IL_2_PATHWAY_UP
0.06398 0.11431 0.03108 0.12933HUPER_BREAST_BASAL_VS_LUMINAL_UP
0.00024 0.00009 0.03864 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00265 0.01851 0.00003OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.08451 0.00899 0.01824 0.00002ZUCCHI_METASTASIS_DN
0.02952 0.06878 0.02407 0.06917BIOCARTA_ARENRF2_PATHWAY
0.02502 0.00099 0.00000 0.00151PRAMOONJAGO_SOX4_TARGETS_UP
0.00000 0.00107 0.00267 0.04258PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.07123 0.04364 0.07009 0.09212YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1