BICLUSTER_ID : UPREG-152
PATHOGENS /4/ : bacillus anthracis,escherichia coli,lactobacillus acidophilus,yersinia enterocolitica
TARGETS /11/ : NFKB1, IL12B, CCL20, CCL2, IL6, GCH1, PTGS2, CCL5, SAT1, PIM1, TNF
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPNFKB1, CCL20, LIF, CXCL1, CCL2, IL1A, TNFAIP6, CCL7, IL6, PTGS2, PBEF1, INHBA, CXCL2, CCL4
NETPATH IL 4 PATHWAY DOWNCCL20, GADD45B, CCL2, GBP2, IL6, PTGS2, CXCL2, IRF1, TNF
NCI IL23PATHWAYNFKB1, IL6, IL12B, CXCL1, IL23A, CXCL9, TNF
NETPATH IL 2 PATHWAY UPNFKB1, B4GALT5, KLF6, LIF, GADD45G, TRIM21, IL6, SOCS1, PBEF1, IRF1, PIM1, CCL4, CFLAR, TNF
GERY CEBP TARGETSGADD45B, CXCL1, JUNB, GADD45G, TNFAIP6, GCH1, SAT1, PIM1, DUSP1, PTX3
NETPATH IL 3 PATHWAY UPCCL7, SOCS1, CCL2, PIM1, CCL4, TNF
NETPATH IL 5 PATHWAY UPNFKB1, PLSCR1, REL, CCL2, PIM1, IL1A, CASP4
NCI IL27PATHWAYIL12B, IL6, TNF
NCI IL12 2PATHWAYNFKB1, GADD45B, IL12B, SOCS1, RIPK2, GADD45G, CCL4
NCI NFKAPPABCANONICALPATHWAYNFKB1, TNFAIP3, RIPK2, TNF
NETPATH IL 7 PATHWAY UPCXCL1, CCL5, CXCL2, CCL4
SA MMP CYTOKINE CONNECTIONTNF
BIOCARTA IL10 PATHWAY
BIOCARTA PML PATHWAY
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
BIOCARTA STEM PATHWAY
BIOCARTA NFKB PATHWAY
MAHAJAN RESPONSE TO IL1A UP
KEGG GRAFT VERSUS HOST DISEASE
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
LINDSTEDT DENDRITIC CELL MATURATION B
BIOCARTA IL1R PATHWAY
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
NETPATH IL 1 PATHWAYIL1A
AMIT EGF RESPONSE 40 HELA
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
BROWNE INTERFERON RESPONSIVE GENES
BIOCARTA LAIR PATHWAY
HINATA NFKB TARGETS KERATINOCYTE UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
VART KSHV INFECTION ANGIOGENIC MARKERS UP
AMIT SERUM RESPONSE 60 MCF10A
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP
AMIT EGF RESPONSE 120 HELA
BIOCARTA ERYTH PATHWAY
BIOCARTA RANKL PATHWAY
WINTER HYPOXIA METAGENE
MCLACHLAN DENTAL CARIES UP
WHITESIDE CISPLATIN RESISTANCE UP
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2
TAVOR CEBPA TARGETS UP
FOSTER INFLAMMATORY RESPONSE LPS DN
GAURNIER PSMD4 TARGETS
ZHOU INFLAMMATORY RESPONSE LPS UP
SMID BREAST CANCER LUMINAL B DN
NCI AMB2 NEUTROPHILS PATHWAY
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
WONG ENDMETRIUM CANCER UP
BROWNE HCMV INFECTION 2HR UP
SESTO RESPONSE TO UV C3
VERHAAK AML WITH NPM1 MUTATED UP
BROCKE APOPTOSIS REVERSED BY IL6
GEISS RESPONSE TO DSRNA UP
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX RPL6 RPL30 RPS13 CHUK DDX3X NFKB2 NFKBIB REL IKBKG NFKB1 MAP3K8 RELB GLG1 NFKBIA RELA TNIP2 GTF2I
ZHOU INFLAMMATORY RESPONSE FIMA UP
REACTOME GPCR LIGAND BINDING
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
LEE LIVER CANCER HEPATOBLAST
NAGASHIMA EGF SIGNALING UP
KEGG TYPE I DIABETES MELLITUS
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
BIOCARTA EPONFKB PATHWAY
KEGG ASTHMA
AUJLA IL22 AND IL17A SIGNALING
CROONQUIST STROMAL STIMULATION UP
SIMBULAN UV RESPONSE NORMAL UP
KHETCHOUMIAN TRIM24 TARGETS UP
KIM LRRC3B TARGETS
DACOSTA ERCC3 ALLELE XPCS VS TTD UP
MAHADEVAN RESPONSE TO MP470 DN
BUDHU LIVER CANCER METASTASIS DN
KEGG JAK STAT SIGNALING PATHWAY
KEGG PRION DISEASES
HARRIS HYPOXIA
DIRMEIER LMP1 RESPONSE LATE UP
BIOCARTA CYTOKINE PATHWAY
SEIKE LUNG CANCER POOR SURVIVAL
BASSO CD40 SIGNALING UP
TIAN TNF SIGNALING NOT VIA NFKB
MARZEC IL2 SIGNALING UP
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
MAHADEVAN RESPONSE TO MP470 UP
KEGG AUTOIMMUNE THYROID DISEASE
FERRARI RESPONSE TO FENRETINIDE UP
BILD HRAS ONCOGENIC SIGNATURE
SANA RESPONSE TO IFNG UP
DAUER STAT3 TARGETS UP
KEGG LEISHMANIA INFECTION
BOYLAN MULTIPLE MYELOMA PCA1 UP
DAZARD UV RESPONSE CLUSTER G2
MCLACHLAN DENTAL CARIES DN
KEGG ALLOGRAFT REJECTION
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
BIOCARTA HSP27 PATHWAY
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP
FOSTER INFLAMMATORY RESPONSE LPS UP
BIOCARTA ASBCELL PATHWAY
ONDER CDH1 TARGETS 2 DN
LIU TARGETS OF VMYB VS CMYB DN
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
BIOCARTA GRANULOCYTES PATHWAY
HESS TARGETS OF HOXA9 AND MEIS1 DN
HUPER BREAST BASAL VS LUMINAL UP
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
ZUCCHI METASTASIS DN
WATTEL AUTONOMOUS THYROID ADENOMA DN
PRAMOONJAGO SOX4 TARGETS UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica p60 bl6lactobacillus acidophilusbacillus anthracisescherichia coliGeneSet Name
0.00000 0.00114 0.00738 0.00000NETPATH_IL_1_PATHWAY_UP
0.00146 0.00012 0.12825 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.00000 0.00010 0.00000NCI_IL23PATHWAY
0.00994 0.01173 0.18345 0.00000NETPATH_IL_2_PATHWAY_UP
0.00040 0.00427 0.01488 0.01389GERY_CEBP_TARGETS
0.00000 0.00372 0.19023 0.00000NETPATH_IL_3_PATHWAY_UP
0.00711 0.01533 0.00652 0.00001NETPATH_IL_5_PATHWAY_UP
0.02901 0.00000 0.00412 0.00000NCI_IL27PATHWAY
0.00272 0.00000 0.00781 0.00000NCI_IL12_2PATHWAY
0.04764 0.00905 0.05634 0.00009NCI_NFKAPPABCANONICALPATHWAY
0.00709 0.06237 0.04896 0.00000NETPATH_IL_7_PATHWAY_UP
0.01474 0.11732 0.15130 0.00133SA_MMP_CYTOKINE_CONNECTION
0.00108 0.00000 0.08594 0.00002BIOCARTA_IL10_PATHWAY
0.19301 0.01418 0.18545 0.01149BIOCARTA_PML_PATHWAY
0.00021 0.00008 0.15911 0.00000GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.03650 0.01289 0.18850 0.00008BIOCARTA_STEM_PATHWAY
0.05121 0.01221 0.09838 0.00000BIOCARTA_NFKB_PATHWAY
0.00010 0.00430 0.01475 0.00000MAHAJAN_RESPONSE_TO_IL1A_UP
0.00069 0.00180 0.03120 0.00002KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00794 0.07905 0.06042 0.00121REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.00011 0.00000 0.00986 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00054 0.01634 0.14368 0.00015REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.04591 0.00000 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00114 0.02532 0.00016 0.00000BIOCARTA_IL1R_PATHWAY
0.00297 0.00034 0.00554 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00029 0.00000 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.02533 0.10592 0.15756 0.00003NETPATH_IL_1_PATHWAY
0.00021 0.00081 0.00021 0.00000AMIT_EGF_RESPONSE_40_HELA
0.00184 0.09352 0.00240 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00006 0.00000 0.15574 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00330 0.00383 0.00839 0.05748BIOCARTA_LAIR_PATHWAY
0.00000 0.00000 0.00000 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00058 0.00000 0.00215 0.00000KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00294 0.00138 0.00675 0.00000VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP
0.00000 0.17039 0.17556 0.00109AMIT_SERUM_RESPONSE_60_MCF10A
0.00201 0.00233 0.01600 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.00018 0.00007 0.00000 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00012 0.00017 0.00253 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00000 0.00000 0.00000 0.00000ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00026 0.00174 0.00403 0.00000ONDER_CDH1_TARGETS_3_DN
0.00032 0.01803 0.02051 0.00155GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP
0.00029 0.09453 0.08697 0.00046AMIT_EGF_RESPONSE_120_HELA
0.00019 0.00077 0.00047 0.00332BIOCARTA_ERYTH_PATHWAY
0.07528 0.00384 0.02228 0.05932BIOCARTA_RANKL_PATHWAY
0.01519 0.11168 0.14321 0.02164WINTER_HYPOXIA_METAGENE
0.00050 0.00667 0.11704 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.19296 0.08149 0.13093 0.02432WHITESIDE_CISPLATIN_RESISTANCE_UP
0.07034 0.00206 0.01201 0.00012CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_CHUK_KPNA3_NFKB2_NFKBIB_REL_IKBKG__NFKB1_NFKBIE_RELB__NFKBIA_RELA_TNIP2
0.06979 0.10298 0.17277 0.00020TAVOR_CEBPA_TARGETS_UP
0.00000 0.00000 0.09653 0.00000FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.00000 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00000 0.00000 0.00000 0.00000ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00018 0.07352 0.02727 0.00006SMID_BREAST_CANCER_LUMINAL_B_DN
0.17478 0.18674 0.18280 0.00044NCI_AMB2_NEUTROPHILS_PATHWAY
0.00015 0.00084 0.11881 0.00769ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.05178 0.02529 0.04519 0.12623WONG_ENDMETRIUM_CANCER_UP
0.00222 0.06476 0.00022 0.00014BROWNE_HCMV_INFECTION_2HR_UP
0.00078 0.02540 0.00327 0.00001SESTO_RESPONSE_TO_UV_C3
0.00000 0.03043 0.00551 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.04624 0.03083 0.17260 0.00002BROCKE_APOPTOSIS_REVERSED_BY_IL6
0.00109 0.00027 0.03512 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.09809 0.03188 0.00097 0.00003CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_RPL6_RPL30_RPS13_CHUK_DDX3X_NFKB2_NFKBIB_REL_IKBKG_NFKB1_MAP3K8_RELB_GLG1_NFKBIA_RELA_TNIP2__GTF2I
0.00000 0.00018 0.00000 0.00000ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.01873 0.07560 0.08594 0.00318REACTOME_GPCR_LIGAND_BINDING
0.00016 0.00000 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.03630 0.00466 0.14821 0.00000ZHU_CMV_ALL_UP
0.01680 0.00000 0.15813 0.00000KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00058 0.04137 0.00308 0.00010LEE_LIVER_CANCER_HEPATOBLAST
0.00000 0.05878 0.00009 0.00003NAGASHIMA_EGF_SIGNALING_UP
0.01506 0.00022 0.00422 0.00002KEGG_TYPE_I_DIABETES_MELLITUS
0.00034 0.01167 0.00000 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00978 0.00559 0.00000AMIT_EGF_RESPONSE_60_MCF10A
0.00005 0.03196 0.14385 0.00492CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN
0.00000 0.00000 0.00020 0.00000KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00037 0.00685 0.00004 0.00018NOJIMA_SFRP2_TARGETS_UP
0.00038 0.00001 0.06111 0.00000MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.00598 0.01784 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.15613 0.08632 0.07439 0.00507BIOCARTA_EPONFKB_PATHWAY
0.02752 0.00095 0.11139 0.01109KEGG_ASTHMA
0.00953 0.00386 0.19473 0.00129AUJLA_IL22_AND_IL17A_SIGNALING
0.00954 0.04711 0.03531 0.00003CROONQUIST_STROMAL_STIMULATION_UP
0.13433 0.01522 0.13030 0.01024SIMBULAN_UV_RESPONSE_NORMAL_UP
0.05355 0.11812 0.17189 0.02879KHETCHOUMIAN_TRIM24_TARGETS_UP
0.03216 0.00009 0.15773 0.00004KIM_LRRC3B_TARGETS
0.06442 0.10069 0.06390 0.00108DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_UP
0.00072 0.00321 0.19442 0.00317MAHADEVAN_RESPONSE_TO_MP470_DN
0.02833 0.00234 0.00779 0.00126BUDHU_LIVER_CANCER_METASTASIS_DN
0.00111 0.00000 0.18321 0.00009KEGG_JAK_STAT_SIGNALING_PATHWAY
0.01379 0.02646 0.13100 0.10959KEGG_PRION_DISEASES
0.00029 0.18721 0.07884 0.00034HARRIS_HYPOXIA
0.00164 0.09243 0.04511 0.00000DIRMEIER_LMP1_RESPONSE_LATE_UP
0.00009 0.00000 0.00101 0.00002BIOCARTA_CYTOKINE_PATHWAY
0.00934 0.00139 0.00417 0.00018SEIKE_LUNG_CANCER_POOR_SURVIVAL
0.00018 0.00000 0.00000 0.00000BASSO_CD40_SIGNALING_UP
0.00683 0.14176 0.08646 0.00702TIAN_TNF_SIGNALING_NOT_VIA_NFKB
0.00021 0.15147 0.05995 0.00002MARZEC_IL2_SIGNALING_UP
0.00000 0.02256 0.00590 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.00018 0.00010 0.00345 0.00037SOUCEK_MYC_TARGETS
0.00018 0.00272 0.00593 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.01127 0.00927 0.12994 0.00009KEGG_AUTOIMMUNE_THYROID_DISEASE
0.01472 0.15133 0.01068 0.00016FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00000 0.00628 0.13675 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.01462 0.00000 0.09919 0.00000SANA_RESPONSE_TO_IFNG_UP
0.06189 0.00259 0.00062 0.00003DAUER_STAT3_TARGETS_UP
0.07814 0.00174 0.01847 0.00028KEGG_LEISHMANIA_INFECTION
0.00219 0.03024 0.06128 0.05581BOYLAN_MULTIPLE_MYELOMA_PCA1_UP
0.01250 0.06213 0.15429 0.00004DAZARD_UV_RESPONSE_CLUSTER_G2
0.00065 0.01242 0.12968 0.00002MCLACHLAN_DENTAL_CARIES_DN
0.00288 0.00026 0.03072 0.00000KEGG_ALLOGRAFT_REJECTION
0.00000 0.00031 0.00325 0.00142AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00398 0.00000 0.00009 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00000 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00061 0.00000 0.07377 0.00000ZHU_CMV_8_HR_UP
0.01131 0.07152 0.04456 0.05549BIOCARTA_HSP27_PATHWAY
0.00000 0.00000 0.00049 0.00000BIOCARTA_INFLAM_PATHWAY
0.00022 0.00000 0.00096 0.00000SANA_TNF_SIGNALING_UP
0.00043 0.00000 0.16722 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP
0.00004 0.00000 0.19461 0.00011FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.12689 0.01240 0.09695 0.00194BIOCARTA_ASBCELL_PATHWAY
0.00022 0.02211 0.14327 0.00002ONDER_CDH1_TARGETS_2_DN
0.04786 0.05963 0.12992 0.01565LIU_TARGETS_OF_VMYB_VS_CMYB_DN
0.00030 0.11701 0.00029 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00200 0.00033 0.02609 0.00000KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00000 0.03748 0.00003 0.00044UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.01449 0.01385 0.03044 0.15379BIOCARTA_GRANULOCYTES_PATHWAY
0.00006 0.04650 0.13442 0.08966HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.00812 0.18179 0.05486 0.00000HUPER_BREAST_BASAL_VS_LUMINAL_UP
0.00037 0.00000 0.00000 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00475 0.01781 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.04370 0.04132 0.00000 0.00000ZUCCHI_METASTASIS_DN
0.01530 0.08640 0.03664 0.02507WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN
0.02844 0.00031 0.08362 0.00005PRAMOONJAGO_SOX4_TARGETS_UP