BICLUSTER_ID : UPREG-160
PATHOGENS /4/ : bifidobacterium bifidum,yersinia enterocolitica,helicobacter pylori,streptococcus pyogenes
TARGETS /6/ : IL6, GCH1, CCL5, CCL2, PIM1, TNFRSF1B
Gene SetLeading Edge Genes
NETPATH KIT RECEPTOR PATHWAY UPIL6, JUNB, CCL5, CCL2, PIM1, IER3
NETPATH IL 2 PATHWAY UPIL6, LIF, PIM1, IRF1, CSF2, TNFRSF1B, GADD45G, UPP1
NETPATH IL 4 PATHWAY DOWNIL6, GADD45B, CCL2, CXCL2, IRF1
NCI IL23PATHWAYIL6, CXCL1, CCL2
GERY CEBP TARGETSGADD45B, GCH1, TGTP, JUNB, PIM1, GADD45G
NETPATH IL 1 PATHWAY UPLIF, CXCL1, PLK2, CCL2, CCL7, IL6, ZFP36, CXCL2, CSF2
NETPATH IL 9 PATHWAY UPCCL7, CCL2, JUNB
NETPATH IL 7 PATHWAY UPCXCL1, CCL5, CXCL2
NETPATH IL 6 PATHWAY UPGADD45B, ZFP36, JUNB, IRF1, PIM1
NETPATH IL 5 PATHWAY UPPLSCR1, CCL2, UPP1, CASP4
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
MISSIAGLIA REGULATED BY METHYLATION UP
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP
BIOCARTA STEM PATHWAY
BIOCARTA NFKB PATHWAY
MAHAJAN RESPONSE TO IL1A UP
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
LINDSTEDT DENDRITIC CELL MATURATION B
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
RADAEVA RESPONSE TO IFNA1 UP
WALLACE PROSTATE CANCER RACE UP
SIMBULAN UV RESPONSE NORMAL UP
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
HARRIS HYPOXIA
ROETH TERT TARGETS UP
DER IFN BETA RESPONSE UP
SCHAVOLT TARGETS OF TP53 AND TP63
BIOCARTA LAIR PATHWAY
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
HINATA NFKB TARGETS KERATINOCYTE UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
MUELLER METHYLATED IN GLIOBLASTOMA
MARZEC IL2 SIGNALING UP
SOUCEK MYC TARGETS
NUYTTEN EZH2 TARGETS UP
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
MAHADEVAN RESPONSE TO MP470 UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NETPATH IL 3 PATHWAY UP
BIOCARTA RANKL PATHWAY
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
KEGG LEISHMANIA INFECTION
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
LIAN LIPA TARGETS 6M
MCLACHLAN DENTAL CARIES UP
LEE LIVER CANCER ACOX1 UP
WU HBX TARGETS 1 UP
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
HELLER SILENCED BY METHYLATION UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BROWNE HCMV INFECTION 4HR UP
WONG ENDOMETRIAL CANCER LATE
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
MARKEY RB1 CHRONIC LOF DN
SMID BREAST CANCER LUMINAL B DN
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
FOSTER INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 120 MCF10A
ONDER CDH1 TARGETS 2 DN
CORUM REL-MAP3K8-RELA-TNIP2-PAPOLA COMPLEX
NCI IL1PATHWAY
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2
VERHAAK AML WITH NPM1 MUTATED UP
BROCKE APOPTOSIS REVERSED BY IL6
LIAN LIPA TARGETS 3M
KEGG CHEMOKINE SIGNALING PATHWAY
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
BIOCARTA GRANULOCYTES PATHWAY
NCI IL12 2PATHWAY
HESS TARGETS OF HOXA9 AND MEIS1 DN
DASU IL6 SIGNALING UP
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
ZUCCHI METASTASIS DN
PRAMOONJAGO SOX4 TARGETS UP
HINATA NFKB TARGETS FIBROBLAST UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6yersinia enterocolitica wap bcbifidobacterium bifidumstreptococcus pyogeneshelicobacter pylori kx2 mgepGeneSet Name
0.00062 0.00004 0.08735 0.02708 0.00355NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.01769 0.00010 0.07512 0.01602 0.04909NETPATH_IL_2_PATHWAY_UP
0.00145 0.00024 0.00103 0.00471 0.00009NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.00001 0.00000 0.00014 0.01454NCI_IL23PATHWAY
0.00277 0.00013 0.00008 0.01652 0.00038GERY_CEBP_TARGETS
0.00024 0.00001 0.00007 0.03192 0.00000NETPATH_IL_1_PATHWAY_UP
0.00016 0.00001 0.00572 0.00011 0.00202NETPATH_IL_9_PATHWAY_UP
0.00623 0.00052 0.01764 0.04416 0.00019NETPATH_IL_7_PATHWAY_UP
0.00000 0.00000 0.00007 0.00001 0.01969NETPATH_IL_6_PATHWAY_UP
0.02712 0.00001 0.11144 0.03974 0.00002NETPATH_IL_5_PATHWAY_UP
0.00000 0.00001 0.00000 0.00010 0.00022KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00172 0.00224 0.00005 0.08281 0.00000NOJIMA_SFRP2_TARGETS_UP
0.00468 0.00107 0.00000 0.01557 0.00396MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.05054 0.00133 0.08510 0.01265 0.06739SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP
0.00467 0.04118 0.06747 0.03626 0.00925BIOCARTA_STEM_PATHWAY
0.11451 0.01359 0.00950 0.16684 0.00304BIOCARTA_NFKB_PATHWAY
0.00113 0.00000 0.00474 0.17839 0.00001MAHAJAN_RESPONSE_TO_IL1A_UP
0.01525 0.01777 0.00419 0.02059 0.01624AUJLA_IL22_AND_IL17A_SIGNALING
0.00000 0.00000 0.00000 0.00000 0.07361ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00006 0.00741 0.01762 0.00032 0.06781REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.04571 0.00004 0.00000 0.02304 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00427 0.00001 0.00098 0.00000 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00011 0.00000 0.00005 0.00032 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00075 0.00379 0.00000 0.00000 0.10408RADAEVA_RESPONSE_TO_IFNA1_UP
0.00001 0.00000 0.00167 0.00000 0.14952WALLACE_PROSTATE_CANCER_RACE_UP
0.11226 0.00821 0.02109 0.01756 0.04290SIMBULAN_UV_RESPONSE_NORMAL_UP
0.07134 0.00124 0.11419 0.01836 0.10649CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN
0.00024 0.00000 0.07330 0.11415 0.00010THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.01109 0.00012 0.00139 0.13253 0.09686TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.00250 0.00004 0.05400 0.15102 0.00009HARRIS_HYPOXIA
0.05386 0.03831 0.00294 0.00062 0.08283ROETH_TERT_TARGETS_UP
0.04202 0.00563 0.02261 0.00032 0.12957DER_IFN_BETA_RESPONSE_UP
0.17012 0.03696 0.03308 0.14369 0.11104SCHAVOLT_TARGETS_OF_TP53_AND_TP63
0.00578 0.00992 0.01086 0.00201 0.00141BIOCARTA_LAIR_PATHWAY
0.05961 0.00012 0.04303 0.19929 0.00012DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.00000 0.00000 0.00013 0.05930 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00200 0.00001 0.00000 0.00000 0.09595MARKEY_RB1_ACUTE_LOF_UP
0.00045 0.00000 0.00000 0.02604 0.00019KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.00006 0.00023 0.01278BASSO_CD40_SIGNALING_UP
0.11405 0.09968 0.00645 0.00116 0.13657MUELLER_METHYLATED_IN_GLIOBLASTOMA
0.00016 0.00006 0.02397 0.13526 0.01784MARZEC_IL2_SIGNALING_UP
0.00000 0.00001 0.00012 0.00021 0.00002SOUCEK_MYC_TARGETS
0.00615 0.00008 0.00779 0.10005 0.02487NUYTTEN_EZH2_TARGETS_UP
0.00646 0.00003 0.00215 0.02575 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.00000 0.00294 0.00616 0.00124DIRMEIER_LMP1_RESPONSE_EARLY
0.00025 0.00006 0.00318 0.01593 0.00001MAHADEVAN_RESPONSE_TO_MP470_UP
0.00002 0.00000 0.00006 0.00007 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.02548 0.03958 0.00015 0.01314 0.00254KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.19163 0.00121 0.08197 0.18510 0.13593RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP
0.05660 0.06147 0.00011 0.00038 0.00008DAUER_STAT3_TARGETS_UP
0.00000 0.00007 0.00000 0.00099 0.00002LIANG_SILENCED_BY_METHYLATION_2
0.00000 0.00000 0.01084 0.00095 0.13629NETPATH_IL_3_PATHWAY_UP
0.05455 0.02104 0.00140 0.08751 0.04291BIOCARTA_RANKL_PATHWAY
0.03866 0.10223 0.13644 0.00012 0.00467NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.00675 0.00695 0.00573 0.00061 0.01576KEGG_LEISHMANIA_INFECTION
0.10871 0.00012 0.04736 0.01028 0.00622NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.00491 0.00074 0.04912 0.00004 0.11920LIAN_LIPA_TARGETS_6M
0.00049 0.00000 0.00155 0.00000 0.00006MCLACHLAN_DENTAL_CARIES_UP
0.02761 0.01516 0.00208 0.17117 0.16748LEE_LIVER_CANCER_ACOX1_UP
0.00703 0.00334 0.02956 0.18465 0.03293WU_HBX_TARGETS_1_UP
0.00000 0.00000 0.00000 0.00568 0.00146FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00078 0.00001 0.00444 0.00000 0.00040MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00007 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00210 0.00040 0.02743 0.00113 0.08092HELLER_SILENCED_BY_METHYLATION_UP
0.00810 0.00008 0.00000 0.05533 0.00677GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00017 0.00028 0.10226 0.06323 0.04014BROWNE_HCMV_INFECTION_4HR_UP
0.04702 0.04580 0.05377 0.03561 0.10814WONG_ENDOMETRIAL_CANCER_LATE
0.00000 0.00000 0.00000 0.00019 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00025 0.00004 0.00006 0.00367 0.11599ZHU_CMV_8_HR_UP
0.00491 0.00565 0.07695 0.00039 0.05877MARKEY_RB1_CHRONIC_LOF_DN
0.00087 0.00824 0.13028 0.05508 0.18998SMID_BREAST_CANCER_LUMINAL_B_DN
0.00000 0.00000 0.00000 0.06782 0.00059ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00141 0.00000 0.05480 0.01538 0.00002GESERICK_TERT_TARGETS_DN
0.00000 0.00006 0.00002 0.19333 0.02042BIOCARTA_INFLAM_PATHWAY
0.00017 0.00000 0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.00000 0.00000 0.00000 0.00000 0.00313FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00013 0.00000 0.07807 0.09332 0.00109AMIT_SERUM_RESPONSE_120_MCF10A
0.00065 0.00111 0.09938 0.16233 0.01031ONDER_CDH1_TARGETS_2_DN
0.05454 0.17454 0.02230 0.04834 0.11696CORUM_REL-MAP3K8-RELA-TNIP2-PAPOLA_COMPLEX
0.05191 0.00841 0.00356 0.19947 0.02503NCI_IL1PATHWAY
0.00080 0.00000 0.02116 0.09492 0.00008HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00075 0.05211 0.00313 0.07017 0.05209SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2
0.00001 0.00000 0.02011 0.01128 0.00145VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.01123 0.00001 0.02793 0.00074 0.00158BROCKE_APOPTOSIS_REVERSED_BY_IL6
0.01061 0.00070 0.05374 0.00004 0.00925LIAN_LIPA_TARGETS_3M
0.04586 0.00276 0.10844 0.01866 0.12696KEGG_CHEMOKINE_SIGNALING_PATHWAY
0.00179 0.00000 0.00426 0.01876 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.00145 0.01094 0.00006 0.04007 0.01719KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.03005 0.00514 0.01849 0.01558 0.12825BIOCARTA_GRANULOCYTES_PATHWAY
0.00709 0.00156 0.00033 0.00000 0.10946NCI_IL12_2PATHWAY
0.00000 0.00000 0.09533 0.00000 0.11528HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.01073 0.00001 0.05109 0.04449 0.10056DASU_IL6_SIGNALING_UP
0.02376 0.00001 0.01036 0.12740 0.00229AMIT_EGF_RESPONSE_120_MCF10A
0.00000 0.00000 0.00000 0.00455 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.02045 0.00018 0.03180 0.06342 0.01057ZHU_CMV_ALL_UP
0.00027 0.00177 0.00000 0.00011 0.01658KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00024 0.00000 0.00000 0.05507 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.08451 0.00010 0.03751 0.01684 0.00076ZUCCHI_METASTASIS_DN
0.02502 0.00024 0.00000 0.19931 0.00000PRAMOONJAGO_SOX4_TARGETS_UP
0.03435 0.00001 0.05376 0.14412 0.00009HINATA_NFKB_TARGETS_FIBROBLAST_UP