BICLUSTER_ID : UPREG-164
PATHOGENS /4/ : yersinia enterocolitica,mycobacterium tuberculosis,burkholderia pseudomallei,ehrlichia chaffeensis
TARGETS /3/ : PTGS2, JUN, CCL2
Gene SetLeading Edge Genes
NETPATH IL 4 PATHWAY DOWNGEM, PTGS2, CCL2, CXCL2
NETPATH IL 7 PATHWAY UPCXCL1, JUN, CXCL2, CCL4
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
CHEN HOXA5 TARGETS 6HR UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
MAHAJAN RESPONSE TO IL1A UP
CROONQUIST STROMAL STIMULATION UP
SA MMP CYTOKINE CONNECTION
RASHI RESPONSE TO IONIZING RADIATION 2
HALMOS CEBPA TARGETS UP
LINDSTEDT DENDRITIC CELL MATURATION A
BOYLAN MULTIPLE MYELOMA C DN
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP
ELVIDGE HYPOXIA UP
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT DN
HORIUCHI WTAP TARGETS UP
AMIT EGF RESPONSE 40 HELA
MISHRA CARCINOMA ASSOCIATED FIBROBLAST UP
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
MAHADEVAN RESPONSE TO MP470 DN
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
HARRIS HYPOXIA
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP
BOYAULT LIVER CANCER SUBCLASS G56 DN
HINATA NFKB TARGETS KERATINOCYTE UP
AMIT EGF RESPONSE 20 HELA
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN
OSADA ASCL1 TARGETS DN
TIAN TNF SIGNALING NOT VIA NFKB
VART KSHV INFECTION ANGIOGENIC MARKERS UP
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN
ZERBINI RESPONSE TO SULINDAC UP
CROMER TUMORIGENESIS UP
DIRMEIER LMP1 RESPONSE EARLY
MAHADEVAN RESPONSE TO MP470 UP
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
AMIT EGF RESPONSE 120 HELA
DAUER STAT3 TARGETS UP
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS
LIAN LIPA TARGETS 6M
NEWMAN ERCC6 TARGETS UP
PODAR RESPONSE TO ADAPHOSTIN UP
AMIT EGF RESPONSE 60 HELA
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN
BERENJENO TRANSFORMED BY RHOA FOREVER DN
JAATINEN HEMATOPOIETIC STEM CELL DN
CHEN HOXA5 TARGETS 9HR UP
DAZARD UV RESPONSE CLUSTER G2
TAVOR CEBPA TARGETS UP
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GRAHAM CML QUIESCENT VS CML DIVIDING UP
CONCANNON APOPTOSIS BY EPOXOMICIN UP
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
GESERICK TERT TARGETS DN
SENESE HDAC1 AND HDAC2 TARGETS UP
AMIT SERUM RESPONSE 120 MCF10A
BROWNE HCMV INFECTION 2HR UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KIM WT1 TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
LIAN LIPA TARGETS 3M
BUDHU LIVER CANCER METASTASIS UP
GEISS RESPONSE TO DSRNA UP
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
GERY CEBP TARGETSATF3, IFRD1, CXCL1, GADD45G
BOYLAN MULTIPLE MYELOMA C CLUSTER DN
ZHOU INFLAMMATORY RESPONSE FIMA UP
HESS TARGETS OF HOXA9 AND MEIS1 DN
DASU IL6 SIGNALING UP
ELVIDGE HYPOXIA BY DMOG UP
CHASSOT SKIN WOUND
TIAN TNF SIGNALING VIA NFKB
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
NAGASHIMA EGF SIGNALING UP
PRAMOONJAGO SOX4 TARGETS UP
WATTEL AUTONOMOUS THYROID ADENOMA DN
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
LU TUMOR ENDOTHELIAL MARKERS UP
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6yersinia enterocolitica wap bcehrlichia chaffeensis arkansaburkholderia pseudomalleimycobacterium tuberculosisGeneSet Name
0.00145 0.00024 0.00001 0.16712 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00623 0.00052 0.00034 0.16021 0.00856NETPATH_IL_7_PATHWAY_UP
0.00000 0.00001 0.00000 0.02392 0.00225KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00172 0.00224 0.01772 0.00000 0.00000NOJIMA_SFRP2_TARGETS_UP
0.03187 0.01068 0.01170 0.01125 0.00079CHEN_HOXA5_TARGETS_6HR_UP
0.00468 0.00107 0.00123 0.00964 0.00000MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.00000 0.00488 0.01050 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.05054 0.00133 0.00021 0.13459 0.00000SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP
0.00000 0.00000 0.00021 0.00002 0.00002GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00113 0.00000 0.01198 0.01913 0.00132MAHAJAN_RESPONSE_TO_IL1A_UP
0.04761 0.00829 0.00000 0.02367 0.00025CROONQUIST_STROMAL_STIMULATION_UP
0.00406 0.00860 0.00037 0.13793 0.00814SA_MMP_CYTOKINE_CONNECTION
0.00427 0.00001 0.00307 0.16626 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00185 0.00154 0.03101 0.11122 0.01212HALMOS_CEBPA_TARGETS_UP
0.00011 0.00000 0.00000 0.00750 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.01814 0.02924 0.18326 0.09928 0.00171BOYLAN_MULTIPLE_MYELOMA_C_DN
0.03142 0.01065 0.03933 0.09910 0.00196LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP
0.00923 0.00006 0.01170 0.02727 0.00052ELVIDGE_HYPOXIA_UP
0.06527 0.01664 0.01123 0.02554 0.15708GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_DN
0.00735 0.00023 0.00147 0.03425 0.00000HORIUCHI_WTAP_TARGETS_UP
0.01474 0.00018 0.03874 0.00290 0.00000AMIT_EGF_RESPONSE_40_HELA
0.05070 0.00162 0.00076 0.00869 0.01530MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP
0.19093 0.01552 0.00697 0.03172 0.05325YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.00031 0.00006 0.18500 0.00025 0.00000MAHADEVAN_RESPONSE_TO_MP470_DN
0.00024 0.00000 0.01384 0.12979 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00250 0.00004 0.00160 0.16949 0.00067HARRIS_HYPOXIA
0.00998 0.02964 0.04656 0.16014 0.00199TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP
0.13082 0.06378 0.00017 0.00734 0.07983BOYAULT_LIVER_CANCER_SUBCLASS_G56_DN
0.00000 0.00000 0.00055 0.00143 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.16753 0.06004 0.00013 0.02388 0.00486AMIT_EGF_RESPONSE_20_HELA
0.00195 0.00004 0.00053 0.01777 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN
0.08327 0.08630 0.00001 0.01311 0.00021OSADA_ASCL1_TARGETS_DN
0.01664 0.00034 0.09628 0.00280 0.00011TIAN_TNF_SIGNALING_NOT_VIA_NFKB
0.01528 0.00218 0.02454 0.07425 0.01566VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP
0.00002 0.00000 0.00648 0.00002 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.00000 0.00001 0.00003 0.03675 0.02521SOUCEK_MYC_TARGETS
0.00646 0.00003 0.00000 0.07914 0.00002DUTTA_APOPTOSIS_VIA_NFKB
0.00017 0.00000 0.17707 0.05436 0.00228TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN
0.13677 0.16203 0.07345 0.11717 0.04554ZERBINI_RESPONSE_TO_SULINDAC_UP
0.03004 0.01752 0.12793 0.04511 0.01999CROMER_TUMORIGENESIS_UP
0.00000 0.00000 0.00000 0.04849 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00025 0.00006 0.00029 0.14983 0.00004MAHADEVAN_RESPONSE_TO_MP470_UP
0.00508 0.00007 0.00947 0.05896 0.00018FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00002 0.00000 0.00000 0.10469 0.00176REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00208 0.00000 0.00696 0.01123 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.00000 0.00000 0.01092 0.00909 0.00002ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00150 0.01083 0.02809 0.05647 0.10086ONDER_CDH1_TARGETS_3_DN
0.00077 0.00000 0.07404 0.00027 0.00000AMIT_EGF_RESPONSE_120_HELA
0.05660 0.06147 0.01097 0.00256 0.00000DAUER_STAT3_TARGETS_UP
0.00018 0.00001 0.06898 0.02735 0.00534ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN
0.07010 0.00401 0.13021 0.09145 0.00036HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS
0.00491 0.00074 0.00000 0.04822 0.00002LIAN_LIPA_TARGETS_6M
0.00882 0.01325 0.00936 0.10910 0.00177NEWMAN_ERCC6_TARGETS_UP
0.00017 0.00000 0.00428 0.00000 0.00000PODAR_RESPONSE_TO_ADAPHOSTIN_UP
0.02663 0.00000 0.05909 0.02574 0.00000AMIT_EGF_RESPONSE_60_HELA
0.16114 0.00197 0.02809 0.17112 0.00008ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN
0.19546 0.00000 0.00705 0.00758 0.08977BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN
0.00110 0.00069 0.00000 0.06589 0.00097JAATINEN_HEMATOPOIETIC_STEM_CELL_DN
0.01506 0.00001 0.01709 0.03571 0.00006CHEN_HOXA5_TARGETS_9HR_UP
0.11521 0.00772 0.03944 0.02586 0.01541DAZARD_UV_RESPONSE_CLUSTER_G2
0.15470 0.01106 0.00572 0.08082 0.00011TAVOR_CEBPA_TARGETS_UP
0.00000 0.00000 0.00000 0.01261 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00705 0.06818 0.00000AMIT_SERUM_RESPONSE_40_MCF10A
0.00810 0.00008 0.00007 0.00000 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00369 0.00014 0.06066 0.00000 0.00028CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP
0.04808 0.03490 0.02810 0.00209 0.00117SATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER
0.00000 0.00000 0.00000 0.00139 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00141 0.00000 0.00047 0.00623 0.00002GESERICK_TERT_TARGETS_DN
0.02769 0.00001 0.15854 0.10073 0.01303SENESE_HDAC1_AND_HDAC2_TARGETS_UP
0.00013 0.00000 0.04018 0.02599 0.00013AMIT_SERUM_RESPONSE_120_MCF10A
0.06014 0.02213 0.15614 0.05164 0.00000BROWNE_HCMV_INFECTION_2HR_UP
0.00080 0.00000 0.00262 0.00000 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00757 0.00406 0.17152 0.00000 0.00000SESTO_RESPONSE_TO_UV_C3
0.01612 0.00000 0.13365 0.05021 0.00007KIM_WT1_TARGETS_UP
0.00001 0.00000 0.00000 0.13600 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.01061 0.00070 0.00000 0.03580 0.00000LIAN_LIPA_TARGETS_3M
0.15654 0.04554 0.14460 0.05630 0.05729BUDHU_LIVER_CANCER_METASTASIS_UP
0.00179 0.00000 0.00175 0.11502 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.00514 0.00011 0.00015 0.00009 0.00000GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.00000 0.00000 0.02814 0.00019 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00277 0.00013 0.01308 0.00015 0.00000GERY_CEBP_TARGETS
0.01366 0.00565 0.07185 0.06803 0.04451BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_DN
0.00018 0.00001 0.09979 0.00000 0.00047ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.00000 0.00000 0.00000 0.08705 0.00000HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.01073 0.00001 0.14492 0.03694 0.00006DASU_IL6_SIGNALING_UP
0.01114 0.00045 0.04510 0.03396 0.00043ELVIDGE_HYPOXIA_BY_DMOG_UP
0.13170 0.00188 0.15171 0.16088 0.00066CHASSOT_SKIN_WOUND
0.00000 0.00000 0.00003 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.00024 0.00000 0.00001 0.00000 0.00002GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00000 0.00511 0.02880 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00000 0.00000 0.00040 0.00000 0.00000NAGASHIMA_EGF_SIGNALING_UP
0.02502 0.00024 0.07569 0.01688 0.00000PRAMOONJAGO_SOX4_TARGETS_UP
0.01754 0.02654 0.00144 0.19540 0.04327WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN
0.00000 0.00000 0.05114 0.09787 0.00000PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.00476 0.09440 0.19587 0.01030 0.15152LU_TUMOR_ENDOTHELIAL_MARKERS_UP
0.03435 0.00001 0.00358 0.03538 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00000 0.02646 0.00375 0.00004AMIT_EGF_RESPONSE_60_MCF10A