BICLUSTER_ID : UPREG-166
PATHOGENS /3/ : yersinia enterocolitica,helicobacter pylori,ehrlichia chaffeensis
TARGETS /6/ : LCN2, JUN, HMOX1, CCL5, CCL2, TAP1
Gene SetLeading Edge Genes
NETPATH KIT RECEPTOR PATHWAY UPHMOX1, CCL5, CCL2, TAP1, IER3
NETPATH IL 9 PATHWAY UPLCN2, CCL2
GERY CEBP TARGETSGADD45B, LCN2, HMOX1, CXCL1, SLFN2, GADD45G, IFI203 /// IFI204 //, IFRD1, TGTP
NETPATH IL 1 PATHWAY UPLCN2, CXCL1, PBEF1, CCL2, CXCL2, CCL4
NETPATH IL 4 PATHWAY DOWNGADD45B, CCL2, CXCL2, MX1, GBP2
NETPATH IL 3 PATHWAY UPCSF1, CCL2, CCL4
NETPATH IL 6 PATHWAY UPGADD45B, CXCL1, JUN, JUNB, HBEGF, MAP3K8, MAFF, IRF1, MX1
NCI IL23PATHWAYCXCL1, CCL2, CXCL9
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
CHEN HOXA5 TARGETS 6HR UP
NCI VWF INTERACTION WITH COLLAGEN
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
LEONARD HYPOXIA
ZHANG INTERFERON RESPONSE
KEGG GRAFT VERSUS HOST DISEASE
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
KRASNOSELSKAYA ILF3 TARGETS UP
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
RADAEVA RESPONSE TO IFNA1 UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP
WALLACE PROSTATE CANCER RACE UP
KIM LRRC3B TARGETS
WIELAND UP BY HBV INFECTION
AMIT EGF RESPONSE 40 HELA
BOWIE RESPONSE TO EXTRACELLULAR MATRIX
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
ST INTERFERON GAMMA PATHWAY
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN
UROSEVIC RESPONSE TO IMIQUIMOD
BROWNE INTERFERON RESPONSIVE GENES
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
HARRIS HYPOXIA
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN
ROETH TERT TARGETS UP
DER IFN BETA RESPONSE UP
BIOCARTA LAIR PATHWAY
TSAI DNAJB4 TARGETS UP
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
HINATA NFKB TARGETS KERATINOCYTE UP
BIOCARTA CYTOKINE PATHWAY
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
XU AKT1 TARGETS 6HR
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
ZERBINI RESPONSE TO SULINDAC UP
DIRMEIER LMP1 RESPONSE EARLY
WOTTON RUNX TARGETS UP
MAHADEVAN RESPONSE TO MP470 UP
ZHAN MULTIPLE MYELOMA LB DN
SEMENZA HIF1 TARGETS
LIU VAV3 PROSTATE CARCINOGENESIS UP
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS
DAUER STAT3 TARGETS DN
BILD HRAS ONCOGENIC SIGNATURE
ONDER CDH1 TARGETS 3 DN
SANA RESPONSE TO IFNG UP
LIANG SILENCED BY METHYLATION 2
DAUER STAT3 TARGETS UP
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
LIAN LIPA TARGETS 6M
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
DER IFN ALPHA RESPONSE UP
MCLACHLAN DENTAL CARIES UP
EINAV INTERFERON SIGNATURE IN CANCER
DAZARD UV RESPONSE CLUSTER G2
CHEN HOXA5 TARGETS 9HR UP
MCLACHLAN DENTAL CARIES DN
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRANDVAUX IFN RESPONSE NOT VIA IRF3
FARMER BREAST CANCER CLUSTER 1
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BOWIE RESPONSE TO TAMOXIFEN
BROWNE HCMV INFECTION 4HR UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP
MOSERLE IFNA RESPONSE
WONG ENDMETRIUM CANCER UP
FOSTER INFLAMMATORY RESPONSE LPS UP
XU HGF TARGETS INDUCED BY AKT1 6HR
LEE LIVER CANCER MYC E2F1 UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME G ALPHA I SIGNALLING EVENTS
LIAN LIPA TARGETS 3M
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
BIOCARTA GRANULOCYTES PATHWAY
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
PRAMOONJAGO SOX4 TARGETS UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6ehrlichia chaffeensis wakullahelicobacter pylori kx1 npgecehrlichia chaffeensis libertyGeneSet Name
0.00062 0.00015 0.09166 0.05936NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00016 0.00000 0.00667 0.00207NETPATH_IL_9_PATHWAY_UP
0.00277 0.00116 0.04422 0.05794GERY_CEBP_TARGETS
0.00024 0.00022 0.00201 0.04640NETPATH_IL_1_PATHWAY_UP
0.00145 0.00000 0.00644 0.00340NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.00000 0.05322 0.00030NETPATH_IL_3_PATHWAY_UP
0.00000 0.00000 0.02074 0.00150NETPATH_IL_6_PATHWAY_UP
0.00000 0.00020 0.14576 0.00440NCI_IL23PATHWAY
0.00000 0.00000 0.06985 0.00077KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.03187 0.01388 0.08749 0.13502CHEN_HOXA5_TARGETS_6HR_UP
0.15144 0.01285 0.00540 0.01500NCI_VWF_INTERACTION_WITH_COLLAGEN
0.00000 0.00301 0.09695 0.09755OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00000 0.00547 0.18497 0.01105GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.08551 0.00008 0.00008 0.02395LEONARD_HYPOXIA
0.00001 0.00000 0.00002 0.00000ZHANG_INTERFERON_RESPONSE
0.00424 0.00000 0.07771 0.00002KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00000 0.00000 0.10299 0.00011TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP
0.00026 0.00004 0.01155 0.10026REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.01525 0.01045 0.04599 0.12142AUJLA_IL22_AND_IL17A_SIGNALING
0.00000 0.00000 0.00000 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.04571 0.00000 0.00011 0.02223LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00406 0.00000 0.13965 0.00029SA_MMP_CYTOKINE_CONNECTION
0.00249 0.00014 0.02655 0.00644KRASNOSELSKAYA_ILF3_TARGETS_UP
0.00427 0.00001 0.10813 0.09956RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00011 0.00000 0.00003 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00075 0.00000 0.00052 0.00009RADAEVA_RESPONSE_TO_IFNA1_UP
0.00023 0.00000 0.00740 0.00209TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP
0.00001 0.00000 0.03695 0.00000WALLACE_PROSTATE_CANCER_RACE_UP
0.01705 0.00017 0.00152 0.00144KIM_LRRC3B_TARGETS
0.18523 0.00000 0.03896 0.00000WIELAND_UP_BY_HBV_INFECTION
0.01474 0.00042 0.12195 0.15480AMIT_EGF_RESPONSE_40_HELA
0.00289 0.00166 0.00059 0.00412BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX
0.01516 0.02715 0.09623 0.03335GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.19093 0.02739 0.02657 0.03802YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.16553 0.02959 0.13122 0.03205ST_INTERFERON_GAMMA_PATHWAY
0.15456 0.10426 0.03559 0.09096SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN
0.00114 0.00001 0.00000 0.00027UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.00000 0.00000 0.00000 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00000 0.00000 0.00007 0.00004TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.00250 0.00025 0.08612 0.03906HARRIS_HYPOXIA
0.00700 0.00000 0.07405 0.00000FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN
0.05386 0.00022 0.00396 0.00140ROETH_TERT_TARGETS_UP
0.04202 0.00214 0.00085 0.08872DER_IFN_BETA_RESPONSE_UP
0.00578 0.00063 0.11387 0.00723BIOCARTA_LAIR_PATHWAY
0.03172 0.00356 0.08948 0.00743TSAI_DNAJB4_TARGETS_UP
0.05961 0.00056 0.02451 0.00766DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.00000 0.00001 0.00256 0.00058HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00000 0.04300 0.15912 0.02223BIOCARTA_CYTOKINE_PATHWAY
0.00200 0.00000 0.00008 0.00000MARKEY_RB1_ACUTE_LOF_UP
0.00045 0.00000 0.06948 0.00966KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.12757 0.00000BASSO_CD40_SIGNALING_UP
0.00299 0.00053 0.01016 0.00156XU_AKT1_TARGETS_6HR
0.00000 0.00027 0.00009 0.00038SOUCEK_MYC_TARGETS
0.00646 0.00000 0.05736 0.00023DUTTA_APOPTOSIS_VIA_NFKB
0.13677 0.11589 0.06538 0.13115ZERBINI_RESPONSE_TO_SULINDAC_UP
0.00000 0.00000 0.06932 0.00342DIRMEIER_LMP1_RESPONSE_EARLY
0.00495 0.18217 0.19024 0.12764WOTTON_RUNX_TARGETS_UP
0.00025 0.00001 0.00000 0.00131MAHADEVAN_RESPONSE_TO_MP470_UP
0.00434 0.00000 0.00155 0.00081ZHAN_MULTIPLE_MYELOMA_LB_DN
0.01510 0.02278 0.01227 0.10625SEMENZA_HIF1_TARGETS
0.02669 0.00000 0.13833 0.00000LIU_VAV3_PROSTATE_CARCINOGENESIS_UP
0.00508 0.00156 0.11271 0.18558FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00002 0.00000 0.00000 0.00023REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00018 0.00000 0.00051 0.00181SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
0.00001 0.00000 0.00000 0.00011BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.00300 0.00001 0.00003 0.00295DAUER_STAT3_TARGETS_DN
0.00208 0.00024 0.16783 0.05938BILD_HRAS_ONCOGENIC_SIGNATURE
0.00150 0.00507 0.06938 0.16184ONDER_CDH1_TARGETS_3_DN
0.00068 0.00000 0.00000 0.00245SANA_RESPONSE_TO_IFNG_UP
0.00000 0.00000 0.00000 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.05660 0.00307 0.01934 0.06350DAUER_STAT3_TARGETS_UP
0.03866 0.00000 0.10968 0.00000NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.00491 0.00000 0.05227 0.00000LIAN_LIPA_TARGETS_6M
0.10871 0.00276 0.14559 0.04791NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.06470 0.00122 0.00025 0.09673DER_IFN_ALPHA_RESPONSE_UP
0.00049 0.00000 0.02102 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.09928 0.00004 0.00000 0.00290EINAV_INTERFERON_SIGNATURE_IN_CANCER
0.11521 0.00111 0.15355 0.05324DAZARD_UV_RESPONSE_CLUSTER_G2
0.01506 0.00291 0.00899 0.02231CHEN_HOXA5_TARGETS_9HR_UP
0.00078 0.00000 0.06509 0.00000MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00005 0.13910 0.03677AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00158 0.00070 0.00007 0.00730GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3
0.00492 0.00000 0.00000 0.00000FARMER_BREAST_CANCER_CLUSTER_1
0.00810 0.00003 0.00796 0.00022GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00150 0.00001 0.00007 0.00007BOWIE_RESPONSE_TO_TAMOXIFEN
0.00017 0.01785 0.06493 0.07524BROWNE_HCMV_INFECTION_4HR_UP
0.00000 0.00000 0.00002 0.00059ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00025 0.00000 0.00000 0.00029ZHU_CMV_8_HR_UP
0.00000 0.00000 0.15656 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.00000 0.00012 0.00001 0.03822ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00141 0.00032 0.01048 0.00164GESERICK_TERT_TARGETS_DN
0.00000 0.00595 0.04107 0.02390BIOCARTA_INFLAM_PATHWAY
0.00017 0.00000 0.00000 0.00008SANA_TNF_SIGNALING_UP
0.00116 0.00084 0.02651 0.00351TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP
0.00044 0.00000 0.00000 0.00000MOSERLE_IFNA_RESPONSE
0.02941 0.03169 0.09571 0.13528WONG_ENDMETRIUM_CANCER_UP
0.00000 0.00000 0.03879 0.00000FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.01150 0.00223 0.01849 0.02953XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.00469 0.00000 0.16806 0.00544LEE_LIVER_CANCER_MYC_E2F1_UP
0.00080 0.00004 0.06147 0.02652HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00001 0.00000 0.06454 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.02054 0.00052 0.16706 0.00648REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.01061 0.00000 0.09060 0.00000LIAN_LIPA_TARGETS_3M
0.00179 0.00022 0.00002 0.01274GEISS_RESPONSE_TO_DSRNA_UP
0.00145 0.00252 0.00515 0.05665KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00000 0.00336 0.00603 0.10221UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.03005 0.00012 0.00519 0.00128BIOCARTA_GRANULOCYTES_PATHWAY
0.00000 0.00000 0.00000 0.02222TIAN_TNF_SIGNALING_VIA_NFKB
0.02045 0.00083 0.00201 0.06440ZHU_CMV_ALL_UP
0.00027 0.00000 0.14588 0.00866KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00024 0.00009 0.00039 0.00033GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00265 0.10013 0.10357OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00139 0.00011 0.18870 0.02333LEE_LIVER_CANCER_HEPATOBLAST
0.08451 0.00899 0.02425 0.05374ZUCCHI_METASTASIS_DN
0.00000 0.00000 0.01564 0.01422NAGASHIMA_EGF_SIGNALING_UP
0.02502 0.00099 0.00004 0.12936PRAMOONJAGO_SOX4_TARGETS_UP
0.00000 0.00107 0.15432 0.01248PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.03435 0.00151 0.05134 0.00960HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00070 0.04711 0.06686AMIT_EGF_RESPONSE_60_MCF10A