BICLUSTER_ID : UPREG-176
PATHOGENS /4/ : bifidobacterium bifidum,mycobacterium tuberculosis,helicobacter pylori,brucella melitensis
TARGETS /11/ : NFKB1, PDE4B, CCL2, CD40, TNFRSF1B, CD80, IL6, PTGS2, CCL5, PIM1, TNF
Gene SetLeading Edge Genes
NETPATH KIT RECEPTOR PATHWAY UPGDF15, JUNB, CCL2, IL6, CCL5, PIM1, IER3, TNF
NETPATH IL 2 PATHWAY UPNR4A2, NFIL3, IL6, PDE4B, PIM1, TNFRSF1B, TNF, IER3
NETPATH IL 1 PATHWAY UPNFKB1, BIRC3, CCL2, FOSL1, IL6, PTGS2, ZFP36, INHBA, CXCL2, SOD2
NCI TNFPATHWAYNFKB1, SQSTM1, TRAF1, BIRC3, TNFRSF1B, TNF
ST TUMOR NECROSIS FACTOR PATHWAYNFKB1, BIRC3, NFKB2, TNFRSF1B, TNF
NETPATH IL 4 PATHWAY DOWNGEM, GADD45B, PTGS2, CCL2, CXCL2, GBP2
NETPATH IL 6 PATHWAY UPGADD45B, ZFP36, JUNB, BCL3, PIM1, TNF
NCI CD40 PATHWAYTRAF1, NFKB1, BIRC3, TNFAIP3, TRAF2, TRAF3, CD40
NETPATH IL 5 PATHWAY UPNFIL3, PLSCR1, BIRC3, PDE4B, CCL2, IER3, HIF1A
NCI IL23PATHWAYCCL2, TNF
NETPATH IL 7 PATHWAY UPFAS, TRAF3, CXCL2, CD80
CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 COMPLEXNFKB1, TNIP1, NFKB2
NETPATH IL 3 PATHWAY UPCCL2
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
NETPATH IL 9 PATHWAY UP
BIOCARTA NFKB PATHWAY
WEINMANN ADAPTATION TO HYPOXIA DN
BIOCARTA EPONFKB PATHWAY
KEGG GRAFT VERSUS HOST DISEASE
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
CROONQUIST STROMAL STIMULATION UP
LEE LIVER CANCER MYC TGFA UP
LINDSTEDT DENDRITIC CELL MATURATION B
BIOCARTA IL1R PATHWAY
BIOCARTA RELA PATHWAY
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
NETPATH IL 1 PATHWAY
RADAEVA RESPONSE TO IFNA1 UP
SIMBULAN UV RESPONSE NORMAL UP
AMIT EGF RESPONSE 40 HELA
BIOCARTA SODD PATHWAY
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
HARRIS HYPOXIA
DER IFN BETA RESPONSE UP
DIRMEIER LMP1 RESPONSE LATE UP
HINATA NFKB TARGETS KERATINOCYTE UP
KEGG ADIPOCYTOKINE SIGNALING PATHWAY
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
VART KSHV INFECTION ANGIOGENIC MARKERS UP
MARZEC IL2 SIGNALING UP
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
BIOCARTA BLYMPHOCYTE PATHWAY
GILMORE CORE NFKB PATHWAY
DUTTA APOPTOSIS VIA NFKB
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN
COULOUARN TEMPORAL TGFB1 SIGNATURE UP
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS MAGENTA UP
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
MAHADEVAN RESPONSE TO MP470 UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA TID PATHWAY
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP
LIANG SILENCED BY METHYLATION 2
DAUER STAT3 TARGETS UP
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN
KEGG LEISHMANIA INFECTION
DER IFN ALPHA RESPONSE UP
MCLACHLAN DENTAL CARIES UP
WINTER HYPOXIA METAGENE
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE
DAZARD UV RESPONSE CLUSTER G2
CHEN HOXA5 TARGETS 9HR UP
LEE LIVER CANCER E2F1 UP
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
REACTOME HUMAN TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BROWNE HCMV INFECTION 4HR UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
NETPATH TNF ALPHA PATHWAY UP
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
SENESE HDAC1 AND HDAC2 TARGETS UP
FOSTER INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 120 MCF10A
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME DEATH RECEPTOR SIGNALLING
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1
BIOCARTA TNFR2 PATHWAY
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX RPL6 RPL30 RPS13 CHUK DDX3X NFKB2 NFKBIB REL IKBKG NFKB1 MAP3K8 RELB GLG1 NFKBIA RELA TNIP2 GTF2I
ZHOU INFLAMMATORY RESPONSE FIMA UP
HESS TARGETS OF HOXA9 AND MEIS1 DN
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
HUMMEL BURKITTS LYMPHOMA DN
ZHU CMV ALL UP
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OKUMURA INFLAMMATORY RESPONSE LPS
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
SUH COEXPRESSED WITH ID1 AND ID2 UP
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
NAGASHIMA EGF SIGNALING UP
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
helicobacter pylori kx1 mgepbrucella melitensisbifidobacterium bifidummycobacterium tuberculosisGeneSet Name
0.00065 0.02966 0.08735 0.00019NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.02575 0.03203 0.07512 0.00008NETPATH_IL_2_PATHWAY_UP
0.00000 0.00061 0.00007 0.00602NETPATH_IL_1_PATHWAY_UP
0.00024 0.11377 0.00099 0.01252NCI_TNFPATHWAY
0.00032 0.00659 0.00028 0.00010ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.00002 0.00471 0.00103 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00236 0.00163 0.00007 0.00000NETPATH_IL_6_PATHWAY_UP
0.00012 0.18357 0.01529 0.01575NCI_CD40_PATHWAY
0.00021 0.01177 0.11144 0.00000NETPATH_IL_5_PATHWAY_UP
0.00589 0.03782 0.00000 0.00126NCI_IL23PATHWAY
0.00294 0.02550 0.01764 0.00856NETPATH_IL_7_PATHWAY_UP
0.01282 0.03884 0.07888 0.00431CORUM_CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2_COMPLEX
0.03326 0.00052 0.01084 0.00171NETPATH_IL_3_PATHWAY_UP
0.02218 0.10177 0.00000 0.00225KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00725 0.05845 0.00000 0.00000MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00008 0.00628 0.01391 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.03509 0.03113 0.00214 0.00002GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00013 0.00000 0.00572 0.08229NETPATH_IL_9_PATHWAY_UP
0.00155 0.00822 0.00950 0.00073BIOCARTA_NFKB_PATHWAY
0.07109 0.03080 0.01898 0.03354WEINMANN_ADAPTATION_TO_HYPOXIA_DN
0.00105 0.06482 0.06360 0.00738BIOCARTA_EPONFKB_PATHWAY
0.02385 0.00487 0.00101 0.02321KEGG_GRAFT_VERSUS_HOST_DISEASE
0.02414 0.03772 0.00000 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.03674 0.07941 0.01386 0.00025CROONQUIST_STROMAL_STIMULATION_UP
0.11284 0.19382 0.13364 0.00029LEE_LIVER_CANCER_MYC_TGFA_UP
0.00000 0.01411 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00078 0.01663 0.01532 0.00118BIOCARTA_IL1R_PATHWAY
0.03110 0.04753 0.00440 0.03322BIOCARTA_RELA_PATHWAY
0.00000 0.03255 0.00098 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00015 0.00644 0.00005 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00053 0.02567 0.03028 0.03544NETPATH_IL_1_PATHWAY
0.08041 0.09499 0.00000 0.00000RADAEVA_RESPONSE_TO_IFNA1_UP
0.02203 0.02965 0.02109 0.04602SIMBULAN_UV_RESPONSE_NORMAL_UP
0.00125 0.03181 0.00190 0.00000AMIT_EGF_RESPONSE_40_HELA
0.04850 0.04158 0.01392 0.10024BIOCARTA_SODD_PATHWAY
0.00000 0.00944 0.07330 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00027 0.04905 0.05400 0.00067HARRIS_HYPOXIA
0.04581 0.03901 0.02261 0.00000DER_IFN_BETA_RESPONSE_UP
0.00800 0.04289 0.10056 0.00003DIRMEIER_LMP1_RESPONSE_LATE_UP
0.00002 0.05127 0.00013 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.12789 0.10770 0.07910 0.13484KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY
0.00005 0.03717 0.00000 0.00060KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00077 0.04270 0.00006 0.00000BASSO_CD40_SIGNALING_UP
0.18244 0.05150 0.00397 0.01566VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP
0.04862 0.01700 0.02397 0.00127MARZEC_IL2_SIGNALING_UP
0.00000 0.13564 0.05507 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.00011 0.00824 0.00012 0.02521SOUCEK_MYC_TARGETS
0.09108 0.16123 0.04026 0.04300BIOCARTA_BLYMPHOCYTE_PATHWAY
0.00003 0.01568 0.06213 0.00092GILMORE_CORE_NFKB_PATHWAY
0.00000 0.00246 0.00215 0.00002DUTTA_APOPTOSIS_VIA_NFKB
0.00543 0.18025 0.00389 0.00228TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN
0.02584 0.03253 0.02296 0.02560COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP
0.04809 0.18428 0.00919 0.00022GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_UP
0.00157 0.00015 0.00294 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.03795 0.02211 0.00551 0.00000DER_IFN_GAMMA_RESPONSE_UP
0.00002 0.15514 0.00318 0.00004MAHADEVAN_RESPONSE_TO_MP470_UP
0.00018 0.02236 0.00006 0.00176REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00325 0.09531 0.06186 0.01104BIOCARTA_TID_PATHWAY
0.00095 0.15400 0.00015 0.00002KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00029 0.15734 0.00118 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.00000 0.00487 0.00000 0.00002ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00085 0.00670 0.01033 0.10086ONDER_CDH1_TARGETS_3_DN
0.00007 0.05136 0.00015 0.00000GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP
0.00031 0.18585 0.00000 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.00067 0.00563 0.00011 0.00000DAUER_STAT3_TARGETS_UP
0.05403 0.18787 0.05362 0.00534ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN
0.00031 0.01414 0.00573 0.00007KEGG_LEISHMANIA_INFECTION
0.14451 0.18592 0.00081 0.00000DER_IFN_ALPHA_RESPONSE_UP
0.00018 0.01108 0.00155 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.00017 0.07019 0.01386 0.00019WINTER_HYPOXIA_METAGENE
0.00204 0.06656 0.00667 0.00136CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_CHUK_KPNA3_NFKB2_NFKBIB_REL_IKBKG__NFKB1_NFKBIE_RELB__NFKBIA_RELA_TNIP2
0.17649 0.05776 0.06171 0.00911SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE
0.00079 0.06885 0.03296 0.01541DAZARD_UV_RESPONSE_CLUSTER_G2
0.00000 0.08869 0.07447 0.00006CHEN_HOXA5_TARGETS_9HR_UP
0.17072 0.14155 0.00724 0.00014LEE_LIVER_CANCER_E2F1_UP
0.00006 0.00031 0.00000 0.00000FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00030 0.01946 0.00444 0.00001MCLACHLAN_DENTAL_CARIES_DN
0.00874 0.19786 0.01845 0.00000AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00010 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00002 0.00642 0.00007 0.00000GAURNIER_PSMD4_TARGETS
0.06009 0.09916 0.01857 0.00246REACTOME_HUMAN_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX
0.00937 0.02218 0.00000 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00261 0.13602 0.10226 0.00024BROWNE_HCMV_INFECTION_4HR_UP
0.00000 0.00017 0.00000 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.10562 0.09797 0.11156 0.00534NETPATH_TNF_ALPHA_PATHWAY_UP
0.00307 0.02743 0.00000 0.00000ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00257 0.04550 0.05480 0.00002GESERICK_TERT_TARGETS_DN
0.05381 0.03484 0.00002 0.05068BIOCARTA_INFLAM_PATHWAY
0.00000 0.00362 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.02541 0.17504 0.19319 0.01303SENESE_HDAC1_AND_HDAC2_TARGETS_UP
0.00587 0.09817 0.00000 0.00000FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00289 0.00478 0.07807 0.00013AMIT_SERUM_RESPONSE_120_MCF10A
0.00215 0.00468 0.02116 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00438 0.04719 0.00136 0.00000SESTO_RESPONSE_TO_UV_C3
0.01185 0.08894 0.00313 0.04041SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2
0.00063 0.01897 0.02011 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.03102 0.09794 0.00063 0.01374REACTOME_DEATH_RECEPTOR_SIGNALLING
0.00000 0.09792 0.00426 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.03185 0.05929 0.00006 0.00059KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00000 0.05866 0.08234 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.15849 0.13111 0.14936 0.00666SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1
0.00067 0.18375 0.00048 0.00388BIOCARTA_TNFR2_PATHWAY
0.03787 0.06374 0.09338 0.00487CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_RPL6_RPL30_RPS13_CHUK_DDX3X_NFKB2_NFKBIB_REL_IKBKG_NFKB1_MAP3K8_RELB_GLG1_NFKBIA_RELA_TNIP2__GTF2I
0.00157 0.00643 0.00015 0.00047ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.04632 0.14126 0.09533 0.00000HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.02386 0.03700 0.01036 0.03451AMIT_EGF_RESPONSE_120_MCF10A
0.00000 0.00659 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.02445 0.05051 0.06060 0.00035HUMMEL_BURKITTS_LYMPHOMA_DN
0.01293 0.10116 0.03180 0.00000ZHU_CMV_ALL_UP
0.00000 0.00050 0.00000 0.00002GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.13309 0.19376 0.17661 0.04117OKUMURA_INFLAMMATORY_RESPONSE_LPS
0.00010 0.00613 0.01525 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.07700 0.04602 0.02142 0.13990LEE_LIVER_CANCER_HEPATOBLAST
0.01235 0.18598 0.11596 0.05414SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP
0.01985 0.08892 0.11780 0.00002BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP
0.00000 0.04193 0.09324 0.00000NAGASHIMA_EGF_SIGNALING_UP
0.00000 0.15037 0.05376 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00002 0.02006 0.00467 0.00004AMIT_EGF_RESPONSE_60_MCF10A