BICLUSTER_ID : UPREG-182
PATHOGENS /5/ : brucella neotomae,brucella ovis,mycobacterium tuberculosis,streptococcus pyogenes,ehrlichia chaffeensis
TARGETS /9/ : STAT1, IL6, IL1B, CCL8, CCL5, CCL2, CD86, ANXA2, TNFRSF1B
Gene SetLeading Edge Genes
NETPATH IL 3 PATHWAY UPIL1B, CCL2, CD86, ANXA2
NETPATH IL 1 PATHWAY UPIL6, BIRC3, IL1B, CCL2, CCL8, CXCL2
NETPATH IL 7 PATHWAY UPCCL8, CCL5, CD86, CXCL2
SA MMP CYTOKINE CONNECTIONIL1B, TNFRSF1B
NETPATH IL 4 PATHWAY DOWNSTAT1, NFKBIA, GADD45B, CCL2, CXCL2
NETPATH IL 5 PATHWAY UPBIRC3, NFKB2, IL1B, CCL2, IER3
NCI IL23PATHWAYNFKBIA, IL1B, CCL2
NETPATH IL 6 PATHWAY UPSTAT1, GADD45B, CEBPD, JUNB, NMI
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NETPATH IL 9 PATHWAY UP
BIOCARTA NFKB PATHWAY
MAHAJAN RESPONSE TO IL1A UP
ZHANG INTERFERON RESPONSE
KEGG GRAFT VERSUS HOST DISEASE
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
LINDSTEDT DENDRITIC CELL MATURATION B
NCI HOST INTERACTIONS OF HIV FACTORS
LINDSTEDT DENDRITIC CELL MATURATION A
NCI APC C CDC20 MEDIATED DEGRADATION OF SECURIN
RADAEVA RESPONSE TO IFNA1 UP
BOWIE RESPONSE TO EXTRACELLULAR MATRIX
CORUM PA28-20S PROTEASOME
UROSEVIC RESPONSE TO IMIQUIMOD
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21
NCI SCF SKP2 MEDIATED DEGRADATION OF P27 P21
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
BROWNE INTERFERON RESPONSIVE GENES
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
NETPATH KIT RECEPTOR PATHWAY UP
LENAOUR DENDRITIC CELL MATURATION DN
HINATA NFKB TARGETS KERATINOCYTE UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
MARZEC IL2 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
NCI VPU MEDIATED DEGRADATION OF CD4
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS
BIOCARTA TID PATHWAY
NCI AUTODEGRADATION OF CDH1 BY CDH1 APC C
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G
NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6
MCLACHLAN DENTAL CARIES UP
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
KEGG ALLOGRAFT REJECTION
SEKI INFLAMMATORY RESPONSE LPS UP
REACTOME P53 INDEPENDENT DNA DAMAGE RESPONSE
GAURNIER PSMD4 TARGETS
HELLER SILENCED BY METHYLATION UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
BOWIE RESPONSE TO TAMOXIFEN
NETPATH TNF ALPHA PATHWAY UP
ZHOU INFLAMMATORY RESPONSE LPS UP
SMID BREAST CANCER LUMINAL B DN
SANA TNF SIGNALING UP
MOSERLE IFNA RESPONSE
NCI UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D1
AMIT SERUM RESPONSE 120 MCF10A
FOSTER INFLAMMATORY RESPONSE LPS UP
NCI REGULATION OF ORNITHINE DECARBOXYLASE ODC
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE
REACTOME STABILIZATION OF P53
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1
DASU IL6 SIGNALING UP
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
NETPATH IL 2 PATHWAY UP
NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
NCI VIF MEDIATED DEGRADATION OF APOBEC3G
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION1
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
KEGG PROTEASOME
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION
NCI DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX
ZUCCHI METASTASIS DN
NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis arkansastreptococcus pyogenesmycobacterium tuberculosisbrucella ovisbrucella neotomaeGeneSet Name
0.00000 0.00095 0.00171 0.00156 0.00000NETPATH_IL_3_PATHWAY_UP
0.00744 0.03192 0.00602 0.01452 0.00114NETPATH_IL_1_PATHWAY_UP
0.00034 0.04416 0.00856 0.01316 0.01290NETPATH_IL_7_PATHWAY_UP
0.00037 0.02244 0.00814 0.18285 0.10715SA_MMP_CYTOKINE_CONNECTION
0.00001 0.00471 0.00000 0.00062 0.00269NETPATH_IL_4_PATHWAY_DOWN
0.00007 0.03974 0.00000 0.03173 0.12369NETPATH_IL_5_PATHWAY_UP
0.00000 0.00014 0.00126 0.05836 0.04130NCI_IL23PATHWAY
0.00003 0.00001 0.00000 0.01065 0.01660NETPATH_IL_6_PATHWAY_UP
0.00000 0.00010 0.00225 0.03342 0.17773KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00097 0.00011 0.08229 0.00706 0.00066NETPATH_IL_9_PATHWAY_UP
0.06659 0.16684 0.00073 0.12428 0.17568BIOCARTA_NFKB_PATHWAY
0.01198 0.17839 0.00132 0.08148 0.16767MAHAJAN_RESPONSE_TO_IL1A_UP
0.00000 0.00000 0.00000 0.14676 0.02415ZHANG_INTERFERON_RESPONSE
0.00000 0.01019 0.02321 0.01234 0.06507KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00000 0.00000 0.00000 0.03248 0.00537ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00007 0.02304 0.00000 0.02851 0.02410LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.03268 0.00865 0.00787 0.03263 0.00221NCI_HOST_INTERACTIONS_OF_HIV_FACTORS
0.00000 0.00032 0.00000 0.00044 0.00010LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.09958 0.11025 0.17875 0.03969 0.00375NCI_APC_C_CDC20_MEDIATED_DEGRADATION_OF_SECURIN
0.00000 0.00000 0.00000 0.11979 0.14758RADAEVA_RESPONSE_TO_IFNA1_UP
0.00254 0.00020 0.00000 0.19318 0.17499BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX
0.00680 0.05659 0.01169 0.01964 0.00236CORUM_PA28-20S_PROTEASOME
0.00000 0.00001 0.00000 0.06159 0.03804UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.09686 0.07566 0.07509 0.03357 0.00119REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21
0.07195 0.02955 0.01422 0.08116 0.00381NCI_SCF_SKP2__MEDIATED_DEGRADATION_OF_P27_P21
0.01384 0.11415 0.00000 0.06140 0.01038THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00000 0.00000 0.00000 0.12548 0.00715BROWNE_INTERFERON_RESPONSIVE_GENES
0.00000 0.00000 0.00000 0.04753 0.02175TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.06648 0.02309 0.03860 0.03302 0.00216REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.02531 0.02708 0.00019 0.17580 0.05217NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00000 0.00204 0.00000 0.11409 0.13798LENAOUR_DENDRITIC_CELL_MATURATION_DN
0.00055 0.05930 0.00000 0.03817 0.09086HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00013 0.02604 0.00060 0.05857 0.00378KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00023 0.00000 0.08843 0.03927BASSO_CD40_SIGNALING_UP
0.00161 0.13526 0.00127 0.05261 0.08610MARZEC_IL2_SIGNALING_UP
0.00003 0.00021 0.02521 0.00716 0.01093SOUCEK_MYC_TARGETS
0.00000 0.02575 0.00002 0.01264 0.00644DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.00616 0.00000 0.01330 0.00214DIRMEIER_LMP1_RESPONSE_EARLY
0.09494 0.06946 0.08118 0.05732 0.00390NCI_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
0.07748 0.01662 0.00707 0.08155 0.00369NCI_VPU_MEDIATED_DEGRADATION_OF_CD4
0.00000 0.00007 0.00176 0.05049 0.00575REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00001 0.00000 0.00000 0.03492 0.00947SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
0.00000 0.00004 0.00000 0.05898 0.07917BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.01590 0.02287 0.01104 0.16728 0.16198BIOCARTA_TID_PATHWAY
0.09820 0.07133 0.08317 0.05755 0.00352NCI_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
0.01097 0.00038 0.00000 0.10980 0.00155DAUER_STAT3_TARGETS_UP
0.00001 0.00099 0.00000 0.03860 0.01035LIANG_SILENCED_BY_METHYLATION_2
0.06904 0.01918 0.00468 0.03399 0.00129REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.05794 0.01320 0.03019 0.05538 0.00247NCI_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
0.00000 0.00000 0.00000 0.03202 0.00479MCLACHLAN_DENTAL_CARIES_UP
0.02780 0.00128 0.00008 0.04589 0.00660PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN
0.00000 0.00568 0.00000 0.01159 0.00621FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.00000 0.00001 0.04417 0.00595MCLACHLAN_DENTAL_CARIES_DN
0.00009 0.03176 0.00549 0.13146 0.14303KEGG_ALLOGRAFT_REJECTION
0.00000 0.00000 0.00000 0.00076 0.00041SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.03913 0.01656 0.01493 0.03125 0.00150REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE
0.00000 0.00000 0.00000 0.00581 0.00119GAURNIER_PSMD4_TARGETS
0.00000 0.00113 0.00000 0.11472 0.10277HELLER_SILENCED_BY_METHYLATION_UP
0.00007 0.05533 0.00000 0.05672 0.07552GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00019 0.00000 0.00055 0.00387ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00015 0.00016 0.00000 0.09220 0.04685BOWIE_RESPONSE_TO_TAMOXIFEN
0.04059 0.03392 0.00534 0.15651 0.10261NETPATH_TNF_ALPHA_PATHWAY_UP
0.00269 0.06782 0.00000 0.04278 0.02297ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.05508 0.07952 0.19116 0.18528SMID_BREAST_CANCER_LUMINAL_B_DN
0.00000 0.00000 0.00000 0.01931 0.00058SANA_TNF_SIGNALING_UP
0.00000 0.00000 0.00000 0.05076 0.02846MOSERLE_IFNA_RESPONSE
0.04561 0.02264 0.00551 0.02768 0.00204NCI_UBIQUITIN_DEPENDENT_DEGRADATION_OF_CYCLIN_D1
0.04018 0.09332 0.00013 0.01293 0.11404AMIT_SERUM_RESPONSE_120_MCF10A
0.00000 0.00000 0.00000 0.08922 0.09836FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.01628 0.01121 0.02665 0.03307 0.00259NCI_REGULATION_OF_ORNITHINE_DECARBOXYLASE__ODC_
0.02844 0.03648 0.02161 0.13579 0.00938REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE
0.05325 0.02658 0.00975 0.07503 0.00387REACTOME_STABILIZATION_OF_P53
0.00262 0.09492 0.00000 0.00038 0.00059HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.01128 0.00000 0.08159 0.03242VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.08549 0.09468 0.07867 0.05286 0.00237REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC
0.00175 0.01876 0.00000 0.08028 0.01183GEISS_RESPONSE_TO_DSRNA_UP
0.01044 0.04007 0.00059 0.03178 0.00835KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00221 0.01687 0.00666 0.19115 0.11004SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1
0.14492 0.04449 0.00006 0.14484 0.12777DASU_IL6_SIGNALING_UP
0.00003 0.00455 0.00000 0.02617 0.05899TIAN_TNF_SIGNALING_VIA_NFKB
0.00053 0.06342 0.00000 0.06104 0.00066ZHU_CMV_ALL_UP
0.00029 0.01602 0.00008 0.18663 0.17779NETPATH_IL_2_PATHWAY_UP
0.07201 0.01835 0.00570 0.08031 0.00384NCI_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.07820 0.01028 0.00789 0.03866 0.00197NCI_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.02845 0.01268 0.00809 0.04956 0.00256NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION1
0.00001 0.05507 0.00002 0.00040 0.00010GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.03642 0.01420 0.00367 0.03342 0.00158KEGG_PROTEASOME
0.00000 0.00011 0.00000 0.13418 0.05099KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.02962 0.00873 0.00636 0.03113 0.00221NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION
0.10740 0.01881 0.00348 0.18023 0.00597NCI_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX
0.10538 0.01684 0.00039 0.10002 0.01371ZUCCHI_METASTASIS_DN
0.04449 0.01493 0.01224 0.04348 0.00234NCI_UBIQUITIN_MEDIATED_DEGRADATION_OF_PHOSPHORYLATED_CDC25A
0.19922 0.18549 0.13943 0.10691 0.00372REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_