BICLUSTER_ID : UPREG-190
PATHOGENS /3/ : listeria monocytogenes,bacillus anthracis,ehrlichia chaffeensis
TARGETS /7/ : IL1B, CCL8, SAT1, LTB, CD55, TNF, PLAUR
Gene SetLeading Edge Genes
NETPATH IL 2 PATHWAY UPPFKFB3, GBP1, SLC2A3, PMAIP1, CCL4, IER3, FUBP1, KLF6, LTB, GADD45G, SRC, LCP2, RGS1, IL1B, SLC7A5, CTSC, PLAUR, TNF
NETPATH IL 5 PATHWAY UPPLSCR1, IL1B, LTB, CD55, IL1A, IER3, CASP4
NETPATH IL 4 PATHWAY DOWNNFKBIA, GADD45B, LTB, CXCL2, TNF, GBP2
NETPATH IL 3 PATHWAY UPIL1B, TNF, CCL4
GERY CEBP TARGETSGADD45B, CXCL1, GADD45G, RGS16, IFRD1, SAT1, BTG2, PLAUR
NETPATH IL 1 PATHWAY UPNFKBIA, IL1B, CXCL1, CCL8, CXCL2, IL1A, CCL4
NCI IL23PATHWAYNFKBIA, IL1B, CXCL1, CXCL9
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
CHEN HOXA5 TARGETS 6HR UP
GRAHAM CML QUIESCENT VS NORMAL DIVIDING DN
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
BIOCARTA PML PATHWAY
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
LEONARD HYPOXIA
KEGG GRAFT VERSUS HOST DISEASE
KEGG ASTHMA
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
CROONQUIST STROMAL STIMULATION UP
LEE LIVER CANCER MYC TGFA UP
LINDSTEDT DENDRITIC CELL MATURATION B
BIOCARTA IL1R PATHWAY
SA MMP CYTOKINE CONNECTION
HALMOS CEBPA TARGETS UP
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
NCI SIGNALING BY PDGF
KHETCHOUMIAN TRIM24 TARGETS UP
KIM LRRC3B TARGETS
DACOSTA ERCC3 ALLELE XPCS VS TTD UP
AMIT EGF RESPONSE 40 HELA
NETPATH IL 7 PATHWAY UP
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
BROWNE INTERFERON RESPONSIVE GENES
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
BIOCARTA TH1TH2 PATHWAY
BUDHU LIVER CANCER METASTASIS DN
KEGG JAK STAT SIGNALING PATHWAY
HARRIS HYPOXIA
NETPATH KIT RECEPTOR PATHWAY UP
HINATA NFKB TARGETS KERATINOCYTE UP
BIOCARTA CYTOKINE PATHWAY
SEIKE LUNG CANCER POOR SURVIVAL
AMIT EGF RESPONSE 20 HELA
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
TIAN TNF SIGNALING NOT VIA NFKB
MARZEC IL2 SIGNALING UP
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
MAHADEVAN RESPONSE TO MP470 UP
KEGG AUTOIMMUNE THYROID DISEASE
FERRARI RESPONSE TO FENRETINIDE UP
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
SANA RESPONSE TO IFNG UP
ONDER CDH1 TARGETS 3 DN
AMIT EGF RESPONSE 120 HELA
DAUER STAT3 TARGETS UP
KEGG LEISHMANIA INFECTION
MCLACHLAN DENTAL CARIES UP
WANG ESOPHAGUS CANCER PROGRESSION UP
DAZARD UV RESPONSE CLUSTER G2
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
TAVOR CEBPA TARGETS UP
KEGG ALLOGRAFT REJECTION
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
NCI AMB2 NEUTROPHILS PATHWAY
SMID BREAST CANCER LUMINAL B DN
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP
NCI IL27PATHWAY
FOSTER INFLAMMATORY RESPONSE LPS UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN
BIOCARTA ASBCELL PATHWAY
FINAK BREAST CANCER SDPP SIGNATURE
VANTVEER BREAST CANCER ESR1 DN
ONDER CDH1 TARGETS 2 DN
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
VERHAAK AML WITH NPM1 MUTATED UP
BROCKE APOPTOSIS REVERSED BY IL6
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
SPIRA SMOKERS LUNG CANCER UP
NCI IL12 STAT4PATHWAY
NCI IL12 2PATHWAY
HESS TARGETS OF HOXA9 AND MEIS1 DN
CROONQUIST NRAS SIGNALING UP
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
GOUYER TATI TARGETS UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
KEGG TYPE I DIABETES MELLITUS
PRAMOONJAGO SOX4 TARGETS UP
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis arkansabacillus anthracislisteria monocytogenesehrlichia chaffeensis libertyGeneSet Name
0.00029 0.18345 0.00068 0.01786NETPATH_IL_2_PATHWAY_UP
0.00007 0.00652 0.00007 0.05924NETPATH_IL_5_PATHWAY_UP
0.00001 0.12825 0.00001 0.00340NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.19023 0.00553 0.00030NETPATH_IL_3_PATHWAY_UP
0.01308 0.01488 0.00163 0.05794GERY_CEBP_TARGETS
0.00744 0.00738 0.00000 0.04640NETPATH_IL_1_PATHWAY_UP
0.00000 0.00010 0.00100 0.00440NCI_IL23PATHWAY
0.00000 0.00020 0.02915 0.00077KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.01170 0.04547 0.00069 0.13502CHEN_HOXA5_TARGETS_6HR_UP
0.02322 0.12198 0.06543 0.08806GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_DN
0.00488 0.01784 0.00001 0.09755OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.01308 0.18545 0.00624 0.13171BIOCARTA_PML_PATHWAY
0.00021 0.15911 0.00023 0.01105GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.01232 0.03520 0.00328 0.02395LEONARD_HYPOXIA
0.00000 0.03120 0.00003 0.00002KEGG_GRAFT_VERSUS_HOST_DISEASE
0.06161 0.11139 0.00022 0.02389KEGG_ASTHMA
0.00697 0.19473 0.00510 0.12142AUJLA_IL22_AND_IL17A_SIGNALING
0.00000 0.00986 0.00001 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00000 0.03531 0.05925 0.00903CROONQUIST_STROMAL_STIMULATION_UP
0.00006 0.17312 0.00938 0.02710LEE_LIVER_CANCER_MYC_TGFA_UP
0.00007 0.00000 0.00437 0.02223LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.17481 0.00016 0.00776 0.06455BIOCARTA_IL1R_PATHWAY
0.00037 0.15130 0.04438 0.00029SA_MMP_CYTOKINE_CONNECTION
0.03101 0.00725 0.01542 0.03077HALMOS_CEBPA_TARGETS_UP
0.00307 0.00554 0.04054 0.09956RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00000 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.07595 0.10769 0.04836 0.17619NCI_SIGNALING_BY_PDGF
0.00000 0.17189 0.10702 0.00030KHETCHOUMIAN_TRIM24_TARGETS_UP
0.00000 0.15773 0.00001 0.00144KIM_LRRC3B_TARGETS
0.11533 0.06390 0.10505 0.07388DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_UP
0.03874 0.00021 0.00068 0.15480AMIT_EGF_RESPONSE_40_HELA
0.00034 0.04896 0.09197 0.00005NETPATH_IL_7_PATHWAY_UP
0.00697 0.02634 0.15820 0.03802YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.00000 0.15574 0.00000 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.01384 0.00240 0.00000 0.01294THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00111 0.04671 0.02563 0.01423BIOCARTA_TH1TH2_PATHWAY
0.01307 0.00779 0.03733 0.05362BUDHU_LIVER_CANCER_METASTASIS_DN
0.01019 0.18321 0.17844 0.18395KEGG_JAK_STAT_SIGNALING_PATHWAY
0.00160 0.07884 0.00000 0.03906HARRIS_HYPOXIA
0.02531 0.01116 0.05671 0.05936NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00055 0.00000 0.00001 0.00058HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.04697 0.00101 0.02298 0.02223BIOCARTA_CYTOKINE_PATHWAY
0.01151 0.00417 0.00438 0.01750SEIKE_LUNG_CANCER_POOR_SURVIVAL
0.00013 0.14256 0.02894 0.00673AMIT_EGF_RESPONSE_20_HELA
0.00013 0.00215 0.00736 0.00966KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.00020 0.00000BASSO_CD40_SIGNALING_UP
0.09628 0.08646 0.01298 0.02313TIAN_TNF_SIGNALING_NOT_VIA_NFKB
0.00161 0.05995 0.00507 0.04723MARZEC_IL2_SIGNALING_UP
0.00648 0.00590 0.00045 0.00351NAGASHIMA_NRG1_SIGNALING_UP
0.00003 0.00345 0.09270 0.00038SOUCEK_MYC_TARGETS
0.00000 0.01600 0.01422 0.00023DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.00000 0.00199 0.00342DIRMEIER_LMP1_RESPONSE_EARLY
0.00029 0.00593 0.00004 0.00131MAHADEVAN_RESPONSE_TO_MP470_UP
0.01760 0.12994 0.00296 0.08016KEGG_AUTOIMMUNE_THYROID_DISEASE
0.00947 0.01068 0.06128 0.18558FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00696 0.13675 0.00000 0.05938BILD_HRAS_ONCOGENIC_SIGNATURE
0.01092 0.00000 0.00000 0.05362ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00000 0.09919 0.00000 0.00245SANA_RESPONSE_TO_IFNG_UP
0.02809 0.00403 0.00011 0.16184ONDER_CDH1_TARGETS_3_DN
0.07404 0.08697 0.02592 0.00639AMIT_EGF_RESPONSE_120_HELA
0.01097 0.00062 0.00016 0.06350DAUER_STAT3_TARGETS_UP
0.00000 0.01847 0.00055 0.00000KEGG_LEISHMANIA_INFECTION
0.00000 0.11704 0.00000 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.08841 0.17122 0.19686 0.07674WANG_ESOPHAGUS_CANCER_PROGRESSION_UP
0.03944 0.15429 0.04745 0.05324DAZARD_UV_RESPONSE_CLUSTER_G2
0.00000 0.09653 0.00001 0.00078FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.12968 0.00000 0.00000MCLACHLAN_DENTAL_CARIES_DN
0.00572 0.17277 0.00125 0.04493TAVOR_CEBPA_TARGETS_UP
0.00009 0.03072 0.00001 0.00019KEGG_ALLOGRAFT_REJECTION
0.00705 0.00325 0.00799 0.03677AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00001 0.00000GAURNIER_PSMD4_TARGETS
0.00007 0.00009 0.00097 0.00022GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00000 0.00059ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.07377 0.00000 0.00029ZHU_CMV_8_HR_UP
0.00000 0.11881 0.00011 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.00021 0.18280 0.18259 0.01327NCI_AMB2_NEUTROPHILS_PATHWAY
0.00000 0.02727 0.12803 0.00253SMID_BREAST_CANCER_LUMINAL_B_DN
0.00269 0.00000 0.00000 0.03822ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00047 0.00454 0.02216 0.00164GESERICK_TERT_TARGETS_DN
0.03146 0.00049 0.00012 0.02390BIOCARTA_INFLAM_PATHWAY
0.00000 0.00096 0.00000 0.00008SANA_TNF_SIGNALING_UP
0.00104 0.16722 0.00004 0.00351TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP
0.00000 0.00412 0.04900 0.03237NCI_IL27PATHWAY
0.00000 0.19461 0.00000 0.00000FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00030 0.03058 0.00310 0.00033TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN
0.00639 0.09695 0.00550 0.00506BIOCARTA_ASBCELL_PATHWAY
0.00638 0.03057 0.16995 0.06018FINAK_BREAST_CANCER_SDPP_SIGNATURE
0.00020 0.06027 0.02711 0.07784VANTVEER_BREAST_CANCER_ESR1_DN
0.00757 0.14327 0.00554 0.03586ONDER_CDH1_TARGETS_2_DN
0.00262 0.00029 0.00000 0.02652HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.17152 0.00327 0.00002 0.11456SESTO_RESPONSE_TO_UV_C3
0.00000 0.00551 0.00000 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00000 0.17260 0.00001 0.00011BROCKE_APOPTOSIS_REVERSED_BY_IL6
0.00175 0.03512 0.00027 0.01274GEISS_RESPONSE_TO_DSRNA_UP
0.01044 0.02609 0.00588 0.05665KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.02814 0.00003 0.00007 0.10221UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.11439 0.19956 0.07678 0.03806SPIRA_SMOKERS_LUNG_CANCER_UP
0.00000 0.17208 0.03297 0.00901NCI_IL12_STAT4PATHWAY
0.00000 0.00781 0.04187 0.00032NCI_IL12_2PATHWAY
0.00000 0.13442 0.00001 0.00000HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.00000 0.12604 0.08123 0.00000CROONQUIST_NRAS_SIGNALING_UP
0.00003 0.00000 0.00054 0.02222TIAN_TNF_SIGNALING_VIA_NFKB
0.00053 0.14821 0.00000 0.06440ZHU_CMV_ALL_UP
0.00000 0.15813 0.02242 0.00866KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00001 0.00000 0.00001 0.00033GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.05925 0.19346 0.06660 0.06698GOUYER_TATI_TARGETS_UP
0.00511 0.01781 0.00001 0.10357OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00021 0.00308 0.02848 0.02333LEE_LIVER_CANCER_HEPATOBLAST
0.10538 0.00000 0.00518 0.05374ZUCCHI_METASTASIS_DN
0.00040 0.00009 0.00001 0.01422NAGASHIMA_EGF_SIGNALING_UP
0.00153 0.00422 0.00007 0.01050KEGG_TYPE_I_DIABETES_MELLITUS
0.07569 0.08362 0.01526 0.12936PRAMOONJAGO_SOX4_TARGETS_UP
0.00358 0.00000 0.00031 0.00960HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.02646 0.00559 0.01523 0.06686AMIT_EGF_RESPONSE_60_MCF10A