BICLUSTER_ID : UPREG-198
PATHOGENS /5/ : bifidobacterium bifidum,lactobacillus acidophilus,yersinia enterocolitica,mycobacterium tuberculosis,porphyromonas gingivalis
TARGETS /6/ : IL6, IL12B, PTGS2, CCL2, PIM1, CD86
Gene SetLeading Edge Genes
NETPATH IL 4 PATHWAY UPIL6, REL, IBRDC3, CCL2, RIPK2, CD86
NCI IL23PATHWAYIL6, IL12B, CXCL1, CCL2
NETPATH IL 4 PATHWAY DOWNGADD45B, PTGS2, CCL2
NETPATH IL 3 PATHWAY UPCCL2, CD86
NETPATH IL 7 PATHWAY UPCXCL1, CD86
NETPATH IL 6 PATHWAY UPGADD45B, CXCL1, ZFP36, PIM1
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
NCI ATF2 PATHWAY
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
NETPATH IL 9 PATHWAY UP
KEGG GRAFT VERSUS HOST DISEASE
LINDSTEDT DENDRITIC CELL MATURATION B
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
WALLACE PROSTATE CANCER RACE UP
ODONNELL TFRC TARGETS UP
IYENGAR RESPONSE TO ADIPOCYTE FACTORS
AMIT EGF RESPONSE 40 HELA
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
MAHADEVAN RESPONSE TO MP470 DN
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
HARRIS HYPOXIA
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP
HINATA NFKB TARGETS KERATINOCYTE UP
VART KSHV INFECTION ANGIOGENIC MARKERS UP
SOUCEK MYC TARGETS
NAGASHIMA NRG1 SIGNALING UP
AMIT SERUM RESPONSE 60 MCF10A
BIOCARTA IL5 PATHWAY
BIOCARTA IL22BP PATHWAY
ZERBINI RESPONSE TO SULINDAC UP
DIRMEIER LMP1 RESPONSE EARLY
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION
MAHADEVAN RESPONSE TO MP470 UP
SMID BREAST CANCER NORMAL LIKE UP
SHAFFER IRF4 MULTIPLE MYELOMA PROGRAM
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
DAUER STAT3 TARGETS UP
LIAN LIPA TARGETS 6M
WINTER HYPOXIA METAGENE
MCLACHLAN DENTAL CARIES UP
DAZARD UV RESPONSE CLUSTER G2
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
SMID BREAST CANCER LUMINAL B DN
NCI IL27PATHWAY
FURUKAWA DUSP6 TARGETS PCI35 UP
AMIT SERUM RESPONSE 120 MCF10A
RICKMAN HEAD AND NECK CANCER C
ONDER CDH1 TARGETS 2 DN
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KEGG HEMATOPOIETIC CELL LINEAGE
BROCKE APOPTOSIS REVERSED BY IL6
REACTOME G ALPHA I SIGNALLING EVENTS
GEISS RESPONSE TO DSRNA UP
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
BOYLAN MULTIPLE MYELOMA C CLUSTER DN
TIAN TNF SIGNALING VIA NFKB
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
NAGASHIMA EGF SIGNALING UP
LU IL4 SIGNALING
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN
AMIT EGF RESPONSE 60 MCF10A
HINATA NFKB TARGETS FIBROBLAST UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6yersinia enterocolitica p60 bclactobacillus acidophilusbifidobacterium bifidumporphyromonas gingivalismycobacterium tuberculosisGeneSet Name
0.00016 0.00000 0.01511 0.05727 0.03326 0.01106NETPATH_IL_4_PATHWAY_UP
0.00000 0.00000 0.00000 0.00000 0.00584 0.00126NCI_IL23PATHWAY
0.00145 0.00040 0.00012 0.00103 0.00395 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.00000 0.00372 0.01084 0.12641 0.00171NETPATH_IL_3_PATHWAY_UP
0.00623 0.00028 0.06237 0.01764 0.01741 0.00856NETPATH_IL_7_PATHWAY_UP
0.00000 0.00000 0.00006 0.00007 0.09273 0.00000NETPATH_IL_6_PATHWAY_UP
0.00000 0.00000 0.00000 0.00000 0.00839 0.00225KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00172 0.00304 0.00685 0.00005 0.11857 0.00000NOJIMA_SFRP2_TARGETS_UP
0.00000 0.00000 0.00598 0.01391 0.03623 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.19595 0.00891 0.14551 0.19891 0.00897 0.06127NCI_ATF2_PATHWAY
0.00000 0.00000 0.00008 0.00214 0.02363 0.00002GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00016 0.00009 0.01316 0.00572 0.01126 0.08229NETPATH_IL_9_PATHWAY_UP
0.00424 0.00055 0.00180 0.00101 0.15597 0.02321KEGG_GRAFT_VERSUS_HOST_DISEASE
0.04571 0.00237 0.00000 0.00000 0.02335 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00427 0.00008 0.00034 0.00098 0.02386 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00011 0.00000 0.00000 0.00005 0.00457 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00001 0.00000 0.00000 0.00167 0.19031 0.00000WALLACE_PROSTATE_CANCER_RACE_UP
0.15209 0.08984 0.10276 0.10883 0.06632 0.03217ODONNELL_TFRC_TARGETS_UP
0.05090 0.00492 0.00648 0.01539 0.04059 0.00217IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS
0.01474 0.00031 0.00081 0.00190 0.00131 0.00000AMIT_EGF_RESPONSE_40_HELA
0.01516 0.02619 0.02475 0.02725 0.04210 0.01382GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.00031 0.00009 0.00321 0.00016 0.01107 0.00000MAHADEVAN_RESPONSE_TO_MP470_DN
0.01109 0.00004 0.00372 0.00139 0.12409 0.00000TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.00250 0.00029 0.18721 0.05400 0.08079 0.00067HARRIS_HYPOXIA
0.00998 0.00729 0.06413 0.02138 0.07753 0.00199TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP
0.00000 0.00000 0.00000 0.00013 0.00133 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.01528 0.00016 0.00138 0.00397 0.19275 0.01566VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP
0.00000 0.00008 0.00010 0.00012 0.03916 0.02521SOUCEK_MYC_TARGETS
0.00002 0.00000 0.02256 0.05507 0.00124 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.00000 0.00000 0.17039 0.15969 0.00000 0.00001AMIT_SERUM_RESPONSE_60_MCF10A
0.00281 0.01283 0.02266 0.05458 0.01916 0.05187BIOCARTA_IL5_PATHWAY
0.17972 0.06295 0.00107 0.00102 0.06447 0.01147BIOCARTA_IL22BP_PATHWAY
0.13677 0.12784 0.18728 0.11328 0.02341 0.04554ZERBINI_RESPONSE_TO_SULINDAC_UP
0.00000 0.00000 0.00007 0.00294 0.00483 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.10664 0.13189 0.00200 0.00179 0.07224 0.00469KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
0.00025 0.00000 0.00272 0.00318 0.18333 0.00004MAHADEVAN_RESPONSE_TO_MP470_UP
0.00889 0.09807 0.19514 0.17152 0.12023 0.15473SMID_BREAST_CANCER_NORMAL_LIKE_UP
0.01088 0.00353 0.00812 0.00315 0.00825 0.00240SHAFFER_IRF4_MULTIPLE_MYELOMA_PROGRAM
0.00000 0.00000 0.00000 0.00000 0.12784 0.00002ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00150 0.00099 0.00174 0.01033 0.00916 0.10086ONDER_CDH1_TARGETS_3_DN
0.05660 0.02597 0.00259 0.00011 0.00811 0.00000DAUER_STAT3_TARGETS_UP
0.00491 0.02049 0.01844 0.04912 0.09798 0.00002LIAN_LIPA_TARGETS_6M
0.06926 0.00442 0.11168 0.01386 0.16096 0.00019WINTER_HYPOXIA_METAGENE
0.00049 0.00008 0.00667 0.00155 0.08054 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.11521 0.01385 0.06213 0.03296 0.01540 0.01541DAZARD_UV_RESPONSE_CLUSTER_G2
0.00078 0.00014 0.01242 0.00444 0.08235 0.00001MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000 0.00000 0.00125 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00000 0.00000 0.00127 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00087 0.00148 0.07352 0.13028 0.04544 0.07952SMID_BREAST_CANCER_LUMINAL_B_DN
0.02027 0.00318 0.00000 0.00000 0.07257 0.04359NCI_IL27PATHWAY
0.07691 0.17340 0.00918 0.05128 0.18949 0.00001FURUKAWA_DUSP6_TARGETS_PCI35_UP
0.00013 0.00000 0.01424 0.07807 0.00000 0.00013AMIT_SERUM_RESPONSE_120_MCF10A
0.03323 0.00731 0.08904 0.05166 0.16035 0.09262RICKMAN_HEAD_AND_NECK_CANCER_C
0.00065 0.00011 0.02211 0.09938 0.07092 0.00500ONDER_CDH1_TARGETS_2_DN
0.00080 0.00006 0.11701 0.02116 0.05737 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00757 0.00270 0.02540 0.00136 0.00266 0.00000SESTO_RESPONSE_TO_UV_C3
0.00000 0.00057 0.02072 0.03856 0.02431 0.11260KEGG_HEMATOPOIETIC_CELL_LINEAGE
0.01123 0.00068 0.03083 0.02793 0.14398 0.00000BROCKE_APOPTOSIS_REVERSED_BY_IL6
0.02054 0.01232 0.04481 0.09003 0.15518 0.10331REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.00179 0.00000 0.00027 0.00426 0.12681 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.00000 0.00000 0.03748 0.08234 0.00000 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00514 0.00007 0.00001 0.00145 0.01492 0.00000GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.01366 0.01229 0.01867 0.05463 0.12675 0.04451BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_DN
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.00024 0.00000 0.00000 0.00000 0.09753 0.00002GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00000 0.00475 0.01525 0.03617 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00139 0.00168 0.04137 0.02142 0.11913 0.13990LEE_LIVER_CANCER_HEPATOBLAST
0.00000 0.00000 0.05878 0.09324 0.00025 0.00000NAGASHIMA_EGF_SIGNALING_UP
0.00017 0.00004 0.00007 0.01831 0.06609 0.02153LU_IL4_SIGNALING
0.00000 0.00000 0.00034 0.00605 0.10670 0.00000PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.00032 0.00004 0.03196 0.05799 0.09026 0.00205CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN
0.00000 0.00000 0.00978 0.00467 0.00000 0.00004AMIT_EGF_RESPONSE_60_MCF10A
0.03435 0.00008 0.01167 0.05376 0.03916 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP