BICLUSTER_ID : UPREG-204
PATHOGENS /3/ : streptococcus pneumoniae,streptococcus pyogenes,ehrlichia chaffeensis
TARGETS /10/ : PLA2G4A, ANXA3, STAT1, LCN2, WARS, CCL8, IL6, ICAM1, PIM1, DNMT1
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPANXA3, BIRC3, LCN2, CXCL1, WARS, CCL8, IL6, ICAM1, MT2A, CXCL2, DNMT1, PTX3
NETPATH IL 5 PATHWAYPLA2G4A, STAT1, NFKBIA
NETPATH IL 6 PATHWAY UPSTAT1, GADD45B, CEBPD, LOH11CR2A, CEBPB, MAP3K8, NMI, FOS, IRF1, PIM1
TURJANSKI MAPK7 TARGETS
MAHAJAN RESPONSE TO IL1A UP
BIOCARTA IL6 PATHWAY
RODRIGUES NTN1 AND DCC TARGETS
MUELLER COMMON TARGETS OF AML FUSIONS DN
TENEDINI MEGAKARYOCYTE MARKERS
LINDSTEDT DENDRITIC CELL MATURATION B
MCBRYAN PUBERTAL BREAST 4 5WK UP
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
NETPATH T CELL RECEPTOR PATHWAY DOWN
NETPATH IL 7 PATHWAY UP
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
NCI IL6 7PATHWAY
BROWNE INTERFERON RESPONSIVE GENES
KLEIN PRIMARY EFFUSION LYMPHOMA DN
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
ST TYPE I INTERFERON PATHWAY
BOYAULT LIVER CANCER SUBCLASS G56 DN
HINATA NFKB TARGETS KERATINOCYTE UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
OSADA ASCL1 TARGETS DN
NUYTTEN EZH2 TARGETS UP
DUTTA APOPTOSIS VIA NFKB
TSAI RESPONSE TO IONIZING RADIATION
DELYS THYROID CANCER UP
KRISHNAN FURIN TARGETS UP
DIRMEIER LMP1 RESPONSE EARLY
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP
TARTE PLASMA CELL VS B LYMPHOCYTE DN
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN 2FC DN
BIOCARTA RANKL PATHWAY
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
HOSHIDA LIVER CANCER SUBCLASS S1
TAVOR CEBPA TARGETS UP
BIOCARTA TCR PATHWAY
FOSTER INFLAMMATORY RESPONSE LPS DN
LEE LIVER CANCER E2F1 UP
HELLER SILENCED BY METHYLATION UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP
NETPATH TNF ALPHA PATHWAY UP
GESERICK TERT TARGETS DN
KEGG T CELL RECEPTOR SIGNALING PATHWAY
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN
AMIT SERUM RESPONSE 120 MCF10A
CORUM REL-MAP3K8-RELA-TNIP2-PAPOLA COMPLEX
NCI IL1PATHWAY
VERHAAK AML WITH NPM1 MUTATED UP
BROCKE APOPTOSIS REVERSED BY IL6
GEISS RESPONSE TO DSRNA UP
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
GERY CEBP TARGETS
ZHAN MULTIPLE MYELOMA DN
NETPATH IL 2 PATHWAY
BIOCARTA P38MAPK PATHWAY
TIAN TNF SIGNALING VIA NFKB
GRUETZMANN PANCREATIC CANCER UP
HUMMEL BURKITTS LYMPHOMA DN
AMIT DELAYED EARLY GENES
LEE EARLY T LYMPHOCYTE DN
BIOCARTA CASPASE PATHWAY
HUANG DASATINIB RESISTANCE UP
HINATA NFKB TARGETS FIBROBLAST UP
NOJIMA SFRP2 TARGETS UP
RHEIN ALL GLUCOCORTICOID THERAPY UP
CHEN HOXA5 TARGETS 6HR UP
MISSIAGLIA REGULATED BY METHYLATION UP
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE UP
NCI NFKAPPABATYPICALPATHWAY
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 9
WU CELL MIGRATION
KHETCHOUMIAN TRIM24 TARGETS UP
OUYANG PROSTATE CANCER PROGRESSION UP
CASORELLI APL SECONDARY VS DE NOVO UP
ST INTERFERON GAMMA PATHWAY
RUTELLA RESPONSE TO CSF2RB AND IL4 DN
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
HARRIS HYPOXIA
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN
DER IFN BETA RESPONSE UP
MORI PRE BI LYMPHOCYTE DN
SCHAVOLT TARGETS OF TP53 AND TP63
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
NETPATH IL 6 PATHWAY
GILDEA METASTASIS
AMIT EGF RESPONSE 20 HELA
GALI TP53 TARGETS APOPTOTIC UP
BASSO CD40 SIGNALING UP
XU RESPONSE TO TRETINOIN AND NSC682994 UP
MARZEC IL2 SIGNALING UP
SOUCEK MYC TARGETS
WANG ESOPHAGUS CANCER VS NORMAL UP
BILBAN B CLL LPL DN
ZHAN MULTIPLE MYELOMA LB DN
GOLDRATH ANTIGEN RESPONSE
SANA RESPONSE TO IFNG UP
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NUTT GBM VS AO GLIOMA UP
DER IFN ALPHA RESPONSE UP
LEE LIVER CANCER ACOX1 UP
RUTELLA RESPONSE TO HGF DN
WU HBX TARGETS 1 UP
NETPATH IL 5 PATHWAY UP
SEKI INFLAMMATORY RESPONSE LPS UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
PARK TRETINOIN RESPONSE AND PML RARA FUSION
SANA TNF SIGNALING UP
THUM SYSTOLIC HEART FAILURE UP
LEE DIFFERENTIATING T LYMPHOCYTE
FONTAINE FOLLICULAR THYROID ADENOMA DN
MULLIGHAN MLL SIGNATURE 1 UP
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP
ONDER CDH1 TARGETS 2 DN
HOLLMAN APOPTOSIS VIA CD40 DN
REACTOME TOLL RECEPTOR CASCADES
INGA TP53 TARGETS
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
CASTELLANO NRAS TARGETS UP
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN
BIOCARTA IL7 PATHWAY
JISON SICKLE CELL DISEASE UP
LINDSTEDT DENDRITIC CELL MATURATION C
HESS TARGETS OF HOXA9 AND MEIS1 DN
DASU IL6 SIGNALING UP
NETPATH IL 2 PATHWAY UP
BIOCARTA IL2RB PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
NETPATH IL 4 PATHWAY
ZUCCHI METASTASIS DN
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
NCI XANTHINE FORMATION
PRAMOONJAGO SOX4 TARGETS UP
OKAMOTO LIVER CANCER MULTICENTRIC OCCURRENCE UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis wakullastreptococcus pneumoniae g54streptococcus pyogenesGeneSet Name
0.00022 0.02186 0.03192NETPATH_IL_1_PATHWAY_UP
0.00075 0.04700 0.11209NETPATH_IL_5_PATHWAY
0.00000 0.01842 0.00001NETPATH_IL_6_PATHWAY_UP
0.06383 0.11975 0.11230TURJANSKI_MAPK7_TARGETS
0.00447 0.08911 0.17839MAHAJAN_RESPONSE_TO_IL1A_UP
0.12285 0.06093 0.00482BIOCARTA_IL6_PATHWAY
0.16874 0.00522 0.03026RODRIGUES_NTN1_AND_DCC_TARGETS
0.03586 0.13820 0.04812MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_DN
0.00000 0.11247 0.00784TENEDINI_MEGAKARYOCYTE_MARKERS
0.00000 0.00817 0.02304LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00085 0.03294 0.13511MCBRYAN_PUBERTAL_BREAST_4_5WK_UP
0.00001 0.00271 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.16372 0.00032LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00007 0.09456 0.13300NETPATH_T_CELL_RECEPTOR_PATHWAY_DOWN
0.00004 0.11486 0.04416NETPATH_IL_7_PATHWAY_UP
0.00174 0.09013 0.11415THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00000 0.10802 0.00000NCI_IL6_7PATHWAY
0.00000 0.11107 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00039 0.12095 0.10898KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN
0.00001 0.13995 0.13253TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.16006 0.04474 0.10462ST_TYPE_I_INTERFERON_PATHWAY
0.00184 0.12091 0.05417BOYAULT_LIVER_CANCER_SUBCLASS_G56_DN
0.00001 0.00568 0.05930HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00000 0.10730 0.00000MARKEY_RB1_ACUTE_LOF_UP
0.00000 0.17463 0.02604KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00002 0.03295 0.03178OSADA_ASCL1_TARGETS_DN
0.00144 0.00276 0.10005NUYTTEN_EZH2_TARGETS_UP
0.00000 0.05455 0.02575DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.03105 0.02653TSAI_RESPONSE_TO_IONIZING_RADIATION
0.00000 0.05377 0.13519DELYS_THYROID_CANCER_UP
0.00348 0.11205 0.01866KRISHNAN_FURIN_TARGETS_UP
0.00000 0.08905 0.00616DIRMEIER_LMP1_RESPONSE_EARLY
0.00006 0.01828 0.18510RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP
0.00000 0.07358 0.01882TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN
0.15100 0.02410 0.02319SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_DN
0.01515 0.11238 0.08751BIOCARTA_RANKL_PATHWAY
0.00276 0.13119 0.01028NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.00000 0.08375 0.00019HOSHIDA_LIVER_CANCER_SUBCLASS_S1
0.00085 0.04868 0.00445TAVOR_CEBPA_TARGETS_UP
0.04541 0.19144 0.03038BIOCARTA_TCR_PATHWAY
0.00000 0.01680 0.00568FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.05639 0.01561LEE_LIVER_CANCER_E2F1_UP
0.00000 0.17361 0.00113HELLER_SILENCED_BY_METHYLATION_UP
0.00161 0.09361 0.08503PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP
0.11655 0.07319 0.03392NETPATH_TNF_ALPHA_PATHWAY_UP
0.00032 0.00310 0.01538GESERICK_TERT_TARGETS_DN
0.00014 0.17024 0.15091KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY
0.12994 0.02013 0.05200NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN
0.00009 0.00320 0.09332AMIT_SERUM_RESPONSE_120_MCF10A
0.16009 0.08343 0.04834CORUM_REL-MAP3K8-RELA-TNIP2-PAPOLA_COMPLEX
0.06247 0.18632 0.19947NCI_IL1PATHWAY
0.00000 0.12533 0.01128VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00000 0.09635 0.00074BROCKE_APOPTOSIS_REVERSED_BY_IL6
0.00022 0.03258 0.01876GEISS_RESPONSE_TO_DSRNA_UP
0.00030 0.03598 0.19908GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.00116 0.12493 0.01652GERY_CEBP_TARGETS
0.00014 0.10196 0.00392ZHAN_MULTIPLE_MYELOMA_DN
0.02892 0.04610 0.01425NETPATH_IL_2_PATHWAY
0.01959 0.06101 0.09327BIOCARTA_P38MAPK_PATHWAY
0.00000 0.16057 0.00455TIAN_TNF_SIGNALING_VIA_NFKB
0.00009 0.00920 0.02643GRUETZMANN_PANCREATIC_CANCER_UP
0.00020 0.05491 0.02106HUMMEL_BURKITTS_LYMPHOMA_DN
0.00462 0.01300 0.11718AMIT_DELAYED_EARLY_GENES
0.00005 0.06967 0.05939LEE_EARLY_T_LYMPHOCYTE_DN
0.00291 0.07295 0.02556BIOCARTA_CASPASE_PATHWAY
0.00093 0.00242 0.04595HUANG_DASATINIB_RESISTANCE_UP
0.00151 0.02432 0.14412HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00340 0.17017 0.08281NOJIMA_SFRP2_TARGETS_UP
0.00170 0.05094 0.01655RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP
0.01388 0.01846 0.12534CHEN_HOXA5_TARGETS_6HR_UP
0.00006 0.00810 0.01557MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.01189 0.01265SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP
0.01784 0.10854 0.06911PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_UP
0.03445 0.11228 0.01125NCI_NFKAPPABATYPICALPATHWAY
0.00855 0.16355 0.03584YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9
0.00166 0.00050 0.05956WU_CELL_MIGRATION
0.00000 0.02156 0.00010KHETCHOUMIAN_TRIM24_TARGETS_UP
0.04529 0.04482 0.01033OUYANG_PROSTATE_CANCER_PROGRESSION_UP
0.00518 0.00977 0.04346CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP
0.02959 0.09655 0.02104ST_INTERFERON_GAMMA_PATHWAY
0.00000 0.03089 0.02986RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN
0.00022 0.02167 0.01836CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN
0.00000 0.08161 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.00025 0.10031 0.15102HARRIS_HYPOXIA
0.00000 0.12500 0.00016FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN
0.00214 0.11870 0.00032DER_IFN_BETA_RESPONSE_UP
0.00003 0.00687 0.06972MORI_PRE_BI_LYMPHOCYTE_DN
0.14927 0.16976 0.14369SCHAVOLT_TARGETS_OF_TP53_AND_TP63
0.00056 0.01803 0.19929DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.04314 0.03948 0.14953NETPATH_IL_6_PATHWAY
0.00141 0.10751 0.04336GILDEA_METASTASIS
0.00184 0.04591 0.10732AMIT_EGF_RESPONSE_20_HELA
0.01408 0.11520 0.04180GALI_TP53_TARGETS_APOPTOTIC_UP
0.00000 0.03498 0.00023BASSO_CD40_SIGNALING_UP
0.00274 0.13879 0.00327XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_UP
0.00004 0.16651 0.13526MARZEC_IL2_SIGNALING_UP
0.00027 0.08229 0.00021SOUCEK_MYC_TARGETS
0.00010 0.10110 0.02328WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP
0.00005 0.05066 0.04441BILBAN_B_CLL_LPL_DN
0.00000 0.08960 0.00000ZHAN_MULTIPLE_MYELOMA_LB_DN
0.00000 0.18885 0.04429GOLDRATH_ANTIGEN_RESPONSE
0.00000 0.15101 0.00000SANA_RESPONSE_TO_IFNG_UP
0.00307 0.03237 0.00038DAUER_STAT3_TARGETS_UP
0.00000 0.01216 0.00099LIANG_SILENCED_BY_METHYLATION_2
0.01090 0.17218 0.18434NUTT_GBM_VS_AO_GLIOMA_UP
0.00122 0.11860 0.00000DER_IFN_ALPHA_RESPONSE_UP
0.00000 0.05921 0.17117LEE_LIVER_CANCER_ACOX1_UP
0.00000 0.00674 0.15257RUTELLA_RESPONSE_TO_HGF_DN
0.11208 0.07559 0.18465WU_HBX_TARGETS_1_UP
0.00000 0.07746 0.03974NETPATH_IL_5_PATHWAY_UP
0.00000 0.02093 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00003 0.11160 0.05533GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00231 0.00019ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00001 0.15242 0.00624PARK_TRETINOIN_RESPONSE_AND_PML_RARA_FUSION
0.00000 0.15203 0.00000SANA_TNF_SIGNALING_UP
0.00085 0.19736 0.18498THUM_SYSTOLIC_HEART_FAILURE_UP
0.00000 0.18334 0.01087LEE_DIFFERENTIATING_T_LYMPHOCYTE
0.00276 0.12710 0.08194FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN
0.00001 0.13871 0.13395MULLIGHAN_MLL_SIGNATURE_1_UP
0.00000 0.13731 0.11584SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP
0.00036 0.00297 0.16233ONDER_CDH1_TARGETS_2_DN
0.08701 0.02451 0.04321HOLLMAN_APOPTOSIS_VIA_CD40_DN
0.00067 0.15988 0.12834REACTOME_TOLL_RECEPTOR_CASCADES
0.00111 0.13640 0.02844INGA_TP53_TARGETS
0.00004 0.00067 0.09492HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00260 0.11522 0.00217CASTELLANO_NRAS_TARGETS_UP
0.00103 0.14422 0.09594HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN
0.06001 0.09084 0.00958BIOCARTA_IL7_PATHWAY
0.00000 0.04179 0.00066JISON_SICKLE_CELL_DISEASE_UP
0.11084 0.00761 0.00756LINDSTEDT_DENDRITIC_CELL_MATURATION_C
0.00000 0.13868 0.00000HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.03956 0.09369 0.04449DASU_IL6_SIGNALING_UP
0.00006 0.16635 0.01602NETPATH_IL_2_PATHWAY_UP
0.01445 0.01752 0.05196BIOCARTA_IL2RB_PATHWAY
0.00009 0.03864 0.05507GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00029 0.07835 0.13277NETPATH_IL_4_PATHWAY
0.00899 0.01824 0.01684ZUCCHI_METASTASIS_DN
0.00001 0.10106 0.01025BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP
0.03882 0.19352 0.04960NCI_XANTHINE_FORMATION
0.00099 0.00000 0.19931PRAMOONJAGO_SOX4_TARGETS_UP
0.01564 0.08991 0.02426OKAMOTO_LIVER_CANCER_MULTICENTRIC_OCCURRENCE_UP