BICLUSTER_ID : UPREG-208
PATHOGENS /2/ : helicobacter pylori,ehrlichia chaffeensis
TARGETS /17/ : BCL2, CD40, TNFRSF1B, VCAM1, CD86, GZMB, STAT1, IL2RB, LTB, ITGB2, IL2RG, CSF2RA, ICAM1, CASP1, CXCR4, ITGA4, TNF
Gene SetLeading Edge Genes
NETPATH IL 2 PATHWAY UPPRF1, BCL2, IL18RAP, PTPN22, TNFRSF1B, TLR4, SOCS3, SLAMF1, GZMB, STK17B, STAT1, IL2RB, IL12RB1, CSF1, LTB, CCR1, PTPRC, IL2RG, CCR2, TNFRSF11A, CD53, ICAM1, CASP1, PBEF1, IRF1, TNF, GZMA
NCI IL12 2PATHWAYSTAT1, IL2RB, IL12RB1, NFKB2, IL18RAP, CD3G, IL2RG, RELB, GZMA, GZMB
NCI IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELLVCAM1, SELL, CD40, ITGB2, ITGB7, ITGA4
NETPATH IL 7 PATHWAY UPCXCL5, FAS, CXCL1, BCL2, CCL19, CD86, CXCL2, CXCR4
NCI AMB2 NEUTROPHILS PATHWAYICAM1, ITGB2, TNF
NETPATH IL 4 PATHWAY DOWNLTB, TLR4, TLR3, ICAM1, CXCL2, IRF1, GZMA, TNF
NETPATH IL 3 PATHWAY UPSOCS3, CSF2RA, CSF1, CD86, TNF, CCR1
NETPATH IL 5 PATHWAY UPTLR1, NFKBIE, LTB, ITGB2, CCR1, TLR4, TLR6, ICAM1, RELB
SA MMP CYTOKINE CONNECTIONCSF1, SELL, TNFRSF1B, TNF
NCI IL12 STAT4PATHWAYPRF1, IL18RAP, IRF1, CD86, CD3G
BIOCARTA PML PATHWAY
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
RASHI RESPONSE TO IONIZING RADIATION 6
BORCZUK MALIGNANT MESOTHELIOMA DN
LINDGREN BLADDER CANCER CLUSTER 2B
BIOCARTA TOB1 PATHWAY
HAHTOLA SEZARY SYNDROM DN
KEGG GRAFT VERSUS HOST DISEASE
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
BIOCARTA TCYTOTOXIC PATHWAY
HELLER HDAC TARGETS SILENCED BY METHYLATION DN
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
RASHI RESPONSE TO IONIZING RADIATION 2
MORI LARGE PRE BII LYMPHOCYTE DN
BIOCARTA NKT PATHWAY
BIOCARTA THELPER PATHWAY
ZHAN EARLY DIFFERENTIATION GENES DN
NCI GENERATION OF SECOND MESSENGER MOLECULES
MORI MATURE B LYMPHOCYTE UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN
REACTOME SIGNALING IN IMMUNE SYSTEM
LENAOUR DENDRITIC CELL MATURATION DN
BIOCARTA LAIR PATHWAY
MILICIC FAMILIAL ADENOMATOUS POLYPOSIS DN
RUTELLA RESPONSE TO CSF2RB AND IL4 UP
MARKEY RB1 ACUTE LOF UP
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS
BIOCARTA LYM PATHWAY
PAL PRMT5 TARGETS DN
POOLA INVASIVE BREAST CANCER UP
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION
NCI INTEGRIN CELL SURFACE INTERACTIONS
LIU VAV3 PROSTATE CARCINOGENESIS UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN
TARTE PLASMA CELL VS B LYMPHOCYTE DN
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP
LIAN LIPA TARGETS 6M
MCLACHLAN DENTAL CARIES UP
HOSHIDA LIVER CANCER SUBCLASS S1
JAATINEN HEMATOPOIETIC STEM CELL DN
WANG SMARCE1 TARGETS DN
GAURNIER PSMD4 TARGETS
HELLER SILENCED BY METHYLATION UP
FARMER BREAST CANCER CLUSTER 1
KEGG CELL ADHESION MOLECULES CAMS
HADDAD T LYMPHOCYTE AND NK PROGENITOR DN
SMID BREAST CANCER LUMINAL B DN
NCI CD8TCRDOWNSTREAMPATHWAY
BIOCARTA MONOCYTE PATHWAY
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
BROWNE HCMV INFECTION 2HR UP
STEARMAN LUNG CANCER EARLY VS LATE DN
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME GENERATION OF SECOND MESSENGER MOLECULES
REACTOME G ALPHA I SIGNALLING EVENTS
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
BIOCARTA TCAPOPTOSIS PATHWAY
REACTOME GPCR LIGAND BINDING
TIAN TNF SIGNALING VIA NFKB
GAL LEUKEMIC STEM CELL DN
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
SMID BREAST CANCER RELAPSE IN PLEURA DN
LEE EARLY T LYMPHOCYTE DN
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
RHEIN ALL GLUCOCORTICOID THERAPY UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
RODWELL AGING KIDNEY NO BLOOD UP
KEGG PRIMARY IMMUNODEFICIENCY
KEGG ASTHMA
AUJLA IL22 AND IL17A SIGNALING
REACTOME DOWNSTREAM EVENTS IN GPCR SIGNALING
WALLACE PROSTATE CANCER RACE UP
HORIUCHI WTAP TARGETS UP
WIELAND UP BY HBV INFECTION
SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN
REACTOME INTEGRIN CELL SURFACE INTERACTIONS
RUTELLA RESPONSE TO CSF2RB AND IL4 DN
EHRLICH ICF SYNDROM DN
BIOCARTA TH1TH2 PATHWAY
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN
BASSO CD40 SIGNALING UP
BIOCARTA BLYMPHOCYTE PATHWAY
BIOCARTA DC PATHWAY
MAHADEVAN RESPONSE TO MP470 UP
SMID BREAST CANCER NORMAL LIKE UP
KEGG AUTOIMMUNE THYROID DISEASE
GOLDRATH ANTIGEN RESPONSE
FERRARI RESPONSE TO FENRETINIDE UP
BIOCARTA TCRA PATHWAY
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP
KEGG VIRAL MYOCARDITIS
BIOCARTA CTL PATHWAY
REACTOME COSTIMULATION BY THE CD28 FAMILY
YU MYC TARGETS DN
BOYLAN MULTIPLE MYELOMA PCA1 UP
MCLACHLAN DENTAL CARIES DN
KEGG ALLOGRAFT REJECTION
AMIT SERUM RESPONSE 40 MCF10A
PUJANA ATM PCC NETWORK
SEKI INFLAMMATORY RESPONSE LPS UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
THUM SYSTOLIC HEART FAILURE UP
SANA TNF SIGNALING UP
LEE DIFFERENTIATING T LYMPHOCYTE
FOSTER INFLAMMATORY RESPONSE LPS UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN
BASSO CD40 SIGNALING DN
RODWELL AGING KIDNEY UP
KEGG HEMATOPOIETIC CELL LINEAGE
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2
NCI A4B1 PAXDEP PATHWAY
HOLLMAN APOPTOSIS VIA CD40 UP
BIOCARTA GRANULOCYTES PATHWAY
MORI IMMATURE B LYMPHOCYTE UP
NETPATH T CELL RECEPTOR PATHWAY UP
NCI PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LU IL4 SIGNALING
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
RUTELLA RESPONSE TO HGF UP
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis arkansaehrlichia chaffeensis wakullahelicobacter pyloriGeneSet Name
0.00029 0.00006 0.02714NETPATH_IL_2_PATHWAY_UP
0.00000 0.00000 0.10271NCI_IL12_2PATHWAY
0.00005 0.00007 0.00010NCI_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
0.00034 0.00004 0.06443NETPATH_IL_7_PATHWAY_UP
0.00021 0.00002 0.08456NCI_AMB2_NEUTROPHILS_PATHWAY
0.00001 0.00000 0.00844NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.00000 0.15967NETPATH_IL_3_PATHWAY_UP
0.00007 0.00000 0.03211NETPATH_IL_5_PATHWAY_UP
0.00037 0.00000 0.01625SA_MMP_CYTOKINE_CONNECTION
0.00000 0.00001 0.12199NCI_IL12_STAT4PATHWAY
0.01308 0.00285 0.06304BIOCARTA_PML_PATHWAY
0.00021 0.00547 0.01575GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00000 0.02545RASHI_RESPONSE_TO_IONIZING_RADIATION_6
0.18336 0.19698 0.10777BORCZUK_MALIGNANT_MESOTHELIOMA_DN
0.00000 0.00000 0.16246LINDGREN_BLADDER_CANCER_CLUSTER_2B
0.02812 0.01391 0.12301BIOCARTA_TOB1_PATHWAY
0.00000 0.00000 0.17352HAHTOLA_SEZARY_SYNDROM_DN
0.00000 0.00000 0.16793KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00034 0.00004 0.01598REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.00000 0.00000 0.01211ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00093 0.00082 0.00446BIOCARTA_TCYTOTOXIC_PATHWAY
0.04351 0.01520 0.19971HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN
0.00094 0.00014 0.03448REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.00307 0.00001 0.15090RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00000 0.00823MORI_LARGE_PRE_BII_LYMPHOCYTE_DN
0.00005 0.00002 0.09183BIOCARTA_NKT_PATHWAY
0.00016 0.00111 0.00109BIOCARTA_THELPER_PATHWAY
0.13166 0.01695 0.18871ZHAN_EARLY_DIFFERENTIATION_GENES_DN
0.03100 0.07745 0.13838NCI_GENERATION_OF_SECOND_MESSENGER_MOLECULES
0.00000 0.00000 0.00110MORI_MATURE_B_LYMPHOCYTE_UP
0.00003 0.00000 0.05510TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN
0.00000 0.00000 0.03692REACTOME_SIGNALING_IN_IMMUNE_SYSTEM
0.00000 0.00000 0.00109LENAOUR_DENDRITIC_CELL_MATURATION_DN
0.00046 0.00063 0.00998BIOCARTA_LAIR_PATHWAY
0.17468 0.07544 0.10703MILICIC_FAMILIAL_ADENOMATOUS_POLYPOSIS_DN
0.08512 0.04484 0.10621RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP
0.00000 0.00000 0.03172MARKEY_RB1_ACUTE_LOF_UP
0.00904 0.02045 0.04622REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS
0.00036 0.00068 0.04199BIOCARTA_LYM_PATHWAY
0.01020 0.00109 0.15995PAL_PRMT5_TARGETS_DN
0.00000 0.00000 0.00000POOLA_INVASIVE_BREAST_CANCER_UP
0.00899 0.00181 0.04674KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
0.01350 0.03886 0.14070NCI_INTEGRIN_CELL_SURFACE_INTERACTIONS
0.00000 0.00000 0.01222LIU_VAV3_PROSTATE_CARCINOGENESIS_UP
0.00000 0.00000 0.00967REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00123 0.00006 0.06401RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP
0.00181 0.00031 0.15939RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN
0.00017 0.00000 0.13579TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN
0.00000 0.00000 0.13518NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.00549 0.00161 0.02703FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP
0.00000 0.00000 0.13986LIAN_LIPA_TARGETS_6M
0.00000 0.00000 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.00000 0.00000 0.00675HOSHIDA_LIVER_CANCER_SUBCLASS_S1
0.00000 0.00000 0.00000JAATINEN_HEMATOPOIETIC_STEM_CELL_DN
0.19486 0.12698 0.02925WANG_SMARCE1_TARGETS_DN
0.00000 0.00000 0.00123GAURNIER_PSMD4_TARGETS
0.00000 0.00000 0.00668HELLER_SILENCED_BY_METHYLATION_UP
0.00000 0.00000 0.04805FARMER_BREAST_CANCER_CLUSTER_1
0.03115 0.01808 0.01423KEGG_CELL_ADHESION_MOLECULES_CAMS
0.00000 0.00000 0.05335HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN
0.00000 0.00000 0.00142SMID_BREAST_CANCER_LUMINAL_B_DN
0.02138 0.00730 0.00727NCI_CD8TCRDOWNSTREAMPATHWAY
0.00013 0.00002 0.04624BIOCARTA_MONOCYTE_PATHWAY
0.00000 0.00000 0.00022ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.15614 0.11885 0.06309BROWNE_HCMV_INFECTION_2HR_UP
0.00142 0.00064 0.07230STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN
0.00000 0.00005 0.00037REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
0.00000 0.00000 0.19207VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00013 0.00009 0.16075REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES
0.00009 0.00052 0.00115REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.00000 0.00000 0.06219TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN
0.00015 0.00030 0.00409GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.00174 0.04195 0.01987BIOCARTA_TCAPOPTOSIS_PATHWAY
0.01722 0.01107 0.08093REACTOME_GPCR_LIGAND_BINDING
0.00003 0.00000 0.02721TIAN_TNF_SIGNALING_VIA_NFKB
0.00000 0.00000 0.02723GAL_LEUKEMIC_STEM_CELL_DN
0.01775 0.06977 0.10298KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.00000 0.00000 0.15392KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.02259 0.00056 0.05344SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_DN
0.00000 0.00005 0.06128LEE_EARLY_T_LYMPHOCYTE_DN
0.00212 0.00020 0.13793TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN
0.00000 0.00000 0.01320KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00610 0.00170 0.17130RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP
0.00488 0.00301 0.06395OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00255 0.00025 0.10255RODWELL_AGING_KIDNEY_NO_BLOOD_UP
0.00075 0.00103 0.01196KEGG_PRIMARY_IMMUNODEFICIENCY
0.06161 0.00288 0.13902KEGG_ASTHMA
0.00697 0.01045 0.12378AUJLA_IL22_AND_IL17A_SIGNALING
0.00379 0.00095 0.02766REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING
0.00000 0.00000 0.00000WALLACE_PROSTATE_CANCER_RACE_UP
0.00147 0.00059 0.13802HORIUCHI_WTAP_TARGETS_UP
0.00000 0.00000 0.00139WIELAND_UP_BY_HBV_INFECTION
0.01407 0.04480 0.06357SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_DN
0.00309 0.00627 0.07860REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS
0.00000 0.00000 0.13865RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN
0.00931 0.01539 0.11284EHRLICH_ICF_SYNDROM_DN
0.00111 0.00009 0.04641BIOCARTA_TH1TH2_PATHWAY
0.00053 0.00000 0.13511TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN
0.00000 0.00000 0.00046BASSO_CD40_SIGNALING_UP
0.00871 0.00448 0.00123BIOCARTA_BLYMPHOCYTE_PATHWAY
0.00147 0.01675 0.06449BIOCARTA_DC_PATHWAY
0.00029 0.00001 0.15994MAHADEVAN_RESPONSE_TO_MP470_UP
0.00000 0.00000 0.00012SMID_BREAST_CANCER_NORMAL_LIKE_UP
0.01760 0.00607 0.05509KEGG_AUTOIMMUNE_THYROID_DISEASE
0.00000 0.00000 0.01292GOLDRATH_ANTIGEN_RESPONSE
0.00947 0.00156 0.03414FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00550 0.07643 0.06349BIOCARTA_TCRA_PATHWAY
0.00000 0.00000 0.00145FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP
0.07943 0.02560 0.13897KEGG_VIRAL_MYOCARDITIS
0.00004 0.00603 0.00043BIOCARTA_CTL_PATHWAY
0.00274 0.01167 0.11722REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY
0.00006 0.00023 0.05539YU_MYC_TARGETS_DN
0.00000 0.00000 0.08203BOYLAN_MULTIPLE_MYELOMA_PCA1_UP
0.00000 0.00000 0.00000MCLACHLAN_DENTAL_CARIES_DN
0.00009 0.00014 0.02721KEGG_ALLOGRAFT_REJECTION
0.00705 0.00005 0.17677AMIT_SERUM_RESPONSE_40_MCF10A
0.04611 0.00734 0.10710PUJANA_ATM_PCC_NETWORK
0.00000 0.00000 0.00826SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00007 0.00003 0.07962GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.12811ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00454 0.00085 0.13840THUM_SYSTOLIC_HEART_FAILURE_UP
0.00000 0.00000 0.02871SANA_TNF_SIGNALING_UP
0.00000 0.00000 0.00013LEE_DIFFERENTIATING_T_LYMPHOCYTE
0.00000 0.00000 0.03242FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00030 0.00003 0.14547TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN
0.00610 0.01035 0.17145BASSO_CD40_SIGNALING_DN
0.00000 0.00000 0.00000RODWELL_AGING_KIDNEY_UP
0.00000 0.00000 0.06394KEGG_HEMATOPOIETIC_CELL_LINEAGE
0.00029 0.00974 0.11188SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2
0.14544 0.03885 0.01430NCI_A4B1_PAXDEP_PATHWAY
0.19139 0.09651 0.17473HOLLMAN_APOPTOSIS_VIA_CD40_UP
0.00024 0.00012 0.03459BIOCARTA_GRANULOCYTES_PATHWAY
0.00000 0.00000 0.02454MORI_IMMATURE_B_LYMPHOCYTE_UP
0.01014 0.01174 0.08386NETPATH_T_CELL_RECEPTOR_PATHWAY_UP
0.00890 0.02221 0.05269NCI_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS
0.00511 0.00265 0.05967OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00276 0.00009 0.14149LU_IL4_SIGNALING
0.00000 0.00001 0.00012BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP
0.01712 0.00473 0.02572RUTELLA_RESPONSE_TO_HGF_UP
0.00001 0.00007 0.02735DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN