BICLUSTER_ID : UPREG-226
PATHOGENS /4/ : pseudomonas aeruginosa,listeria monocytogenes,escherichia coli,helicobacter pylori
TARGETS /6/ : MMP3, IL6, CCL20, PTGS2, GCH1, CFB
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPCCL20, CXCL1, TNFAIP6, NFKBIA, MMP3, IL6, PTGS2, CXCL2, SOD2, CSF2, CCL4, PTX3, CFB
NETPATH IL 4 PATHWAY DOWNMMP3, NFKBIA, IL6, CCL20, PTGS2, CXCL2
NETPATH IL 6 PATHWAY UPMMP3, MAFF, CXCL1, CEBPB, MAP3K8
NCI IL23PATHWAYNFKBIA, IL6, CXCL1
GERY CEBP TARGETSCXCL1, EREG, GADD45G, TNFAIP6, ATF3, GCH1, PTX3, DUSP1
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
BIOCARTA STEM PATHWAY
MAHAJAN RESPONSE TO IL1A UP
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
WALLACE PROSTATE CANCER RACE UP
ELVIDGE HYPOXIA UP
KIM LRRC3B TARGETS
IYENGAR RESPONSE TO ADIPOCYTE FACTORS
AMIT EGF RESPONSE 40 HELA
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
DORN ADENOVIRUS INFECTION 12HR UP
MAHADEVAN RESPONSE TO MP470 DN
KEGG COMPLEMENT AND COAGULATION CASCADES
BROWNE INTERFERON RESPONSIVE GENES
NCI DISSOLUTION OF FIBRIN CLOT
HARRIS HYPOXIA
NETPATH KIT RECEPTOR PATHWAY UP
HINATA NFKB TARGETS KERATINOCYTE UP
GENTILE UV HIGH DOSE UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
ZERBINI RESPONSE TO SULINDAC UP
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
MAHADEVAN RESPONSE TO MP470 UP
FERRARI RESPONSE TO FENRETINIDE UP
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
ONDER CDH1 TARGETS 3 DN
NETPATH IL 3 PATHWAY UPCCL4
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
BIOCARTA RANKL PATHWAY
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
MCLACHLAN DENTAL CARIES UP
NCI NF KB IS ACTIVATED AND SIGNALS SURVIVAL
MENSE HYPOXIA UP
CHEN HOXA5 TARGETS 9HR UP
DAZARD UV RESPONSE CLUSTER G2
ISHIKAWA STING SIGNALING
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
FARMER BREAST CANCER CLUSTER 1
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BROWNE HCMV INFECTION 4HR UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
BIERIE INFLAMMATORY RESPONSE TGFB1
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
BROWNE HCMV INFECTION 2HR UP
LEE LIVER CANCER MYC E2F1 UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
KOBAYASHI EGFR SIGNALING 6HR DN
XU HGF SIGNALING NOT VIA AKT1 48HR UP
ELVIDGE HYPOXIA BY DMOG UP
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
PRAMOONJAGO SOX4 TARGETS UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
listeria monocytogenespseudomonas aeruginosahelicobacter pylori kx1 npgecescherichia coliGeneSet Name
0.00000 0.00004 0.00201 0.00000NETPATH_IL_1_PATHWAY_UP
0.00001 0.00000 0.00644 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00233 0.01244 0.02074 0.00000NETPATH_IL_6_PATHWAY_UP
0.00100 0.00049 0.14576 0.00000NCI_IL23PATHWAY
0.00163 0.00843 0.04422 0.01389GERY_CEBP_TARGETS
0.02915 0.00066 0.06985 0.00000KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.02668 0.06631 0.01127 0.00018NOJIMA_SFRP2_TARGETS_UP
0.00001 0.00002 0.00255 0.00000MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00001 0.00003 0.09695 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00023 0.01558 0.18497 0.00000GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.05829 0.17647 0.01484 0.00008BIOCARTA_STEM_PATHWAY
0.00046 0.00000 0.00083 0.00000MAHAJAN_RESPONSE_TO_IL1A_UP
0.00510 0.04032 0.04599 0.00129AUJLA_IL22_AND_IL17A_SIGNALING
0.00001 0.00016 0.00000 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00437 0.00005 0.00011 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.04438 0.04053 0.13965 0.00133SA_MMP_CYTOKINE_CONNECTION
0.04054 0.00000 0.10813 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00387 0.00003 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00031 0.03564 0.03695 0.00004WALLACE_PROSTATE_CANCER_RACE_UP
0.00023 0.10177 0.11617 0.01124ELVIDGE_HYPOXIA_UP
0.00001 0.03852 0.00152 0.00004KIM_LRRC3B_TARGETS
0.01417 0.00802 0.00098 0.00026IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS
0.00068 0.00000 0.12195 0.00000AMIT_EGF_RESPONSE_40_HELA
0.00298 0.04274 0.09623 0.01179GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.15820 0.00150 0.02657 0.03327YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.02117 0.19042 0.05966 0.04767DORN_ADENOVIRUS_INFECTION_12HR_UP
0.01146 0.00187 0.09518 0.00317MAHADEVAN_RESPONSE_TO_MP470_DN
0.00615 0.00314 0.00989 0.00386KEGG_COMPLEMENT_AND_COAGULATION_CASCADES
0.00000 0.10336 0.00000 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.17554 0.02604 0.04592 0.12964NCI_DISSOLUTION_OF_FIBRIN_CLOT
0.00000 0.00391 0.08612 0.00034HARRIS_HYPOXIA
0.05671 0.05123 0.09166 0.00023NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00001 0.00000 0.00256 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.05348 0.01593 0.12131 0.00081GENTILE_UV_HIGH_DOSE_UP
0.00004 0.02176 0.00008 0.00000MARKEY_RB1_ACUTE_LOF_UP
0.00736 0.00004 0.06948 0.00000KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00020 0.00006 0.12757 0.00000BASSO_CD40_SIGNALING_UP
0.09270 0.00251 0.00009 0.00037SOUCEK_MYC_TARGETS
0.01422 0.00086 0.05736 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.05033 0.08983 0.06538 0.02814ZERBINI_RESPONSE_TO_SULINDAC_UP
0.00199 0.00000 0.06932 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00068 0.01592 0.00454 0.00000DER_IFN_GAMMA_RESPONSE_UP
0.00004 0.00009 0.00000 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.06128 0.00003 0.11271 0.00016FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.05669 0.00026 0.14476 0.00000KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00110 0.16783 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.00011 0.00003 0.06938 0.00000ONDER_CDH1_TARGETS_3_DN
0.00553 0.01596 0.05322 0.00000NETPATH_IL_3_PATHWAY_UP
0.00016 0.00006 0.01934 0.00003DAUER_STAT3_TARGETS_UP
0.00001 0.00126 0.00000 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.17317 0.01532 0.04517 0.05932BIOCARTA_RANKL_PATHWAY
0.00001 0.01171 0.10968 0.04537NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.01127 0.00593 0.14559 0.00438NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.00000 0.00000 0.02102 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.07063 0.00190 0.19145 0.00474NCI_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL
0.01410 0.10399 0.00732 0.09188MENSE_HYPOXIA_UP
0.00000 0.00776 0.00899 0.00050CHEN_HOXA5_TARGETS_9HR_UP
0.04745 0.01158 0.15355 0.00004DAZARD_UV_RESPONSE_CLUSTER_G2
0.02022 0.10531 0.00285 0.00301ISHIKAWA_STING_SIGNALING
0.00000 0.00005 0.06509 0.00002MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00799 0.00028 0.13910 0.00142AMIT_SERUM_RESPONSE_40_MCF10A
0.00001 0.00036 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00001 0.03450 0.00000 0.00000FARMER_BREAST_CANCER_CLUSTER_1
0.00097 0.00000 0.00796 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00001 0.06023 0.06493 0.00000BROWNE_HCMV_INFECTION_4HR_UP
0.00000 0.00000 0.00002 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.02114 0.00000 0.00000ZHU_CMV_8_HR_UP
0.00011 0.00725 0.15656 0.00769ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.05971 0.00508 0.00805 0.01522BIERIE_INFLAMMATORY_RESPONSE_TGFB1
0.00000 0.00043 0.00001 0.00000ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.02216 0.00178 0.01048 0.00083GESERICK_TERT_TARGETS_DN
0.00012 0.08424 0.04107 0.00000BIOCARTA_INFLAM_PATHWAY
0.00000 0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.02059 0.00000 0.02678 0.00014BROWNE_HCMV_INFECTION_2HR_UP
0.02477 0.16348 0.16806 0.08000LEE_LIVER_CANCER_MYC_E2F1_UP
0.00000 0.00000 0.06147 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.00267 0.06454 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00027 0.00051 0.00002 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.00588 0.00006 0.00515 0.00000KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00007 0.00002 0.00603 0.00044UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.01417 0.00269 0.10830 0.00015KOBAYASHI_EGFR_SIGNALING_6HR_DN
0.00850 0.04449 0.18936 0.05998XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_UP
0.00142 0.03582 0.06336 0.01098ELVIDGE_HYPOXIA_BY_DMOG_UP
0.00423 0.00069 0.19126 0.00004AMIT_EGF_RESPONSE_120_MCF10A
0.00054 0.00000 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.00000 0.13854 0.00201 0.00000ZHU_CMV_ALL_UP
0.02242 0.00027 0.14588 0.00000KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00001 0.00000 0.00039 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00001 0.00003 0.10013 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.02848 0.00093 0.18870 0.00010LEE_LIVER_CANCER_HEPATOBLAST
0.00518 0.00002 0.02425 0.00000ZUCCHI_METASTASIS_DN
0.00001 0.00102 0.01564 0.00003NAGASHIMA_EGF_SIGNALING_UP
0.01526 0.00151 0.00004 0.00005PRAMOONJAGO_SOX4_TARGETS_UP
0.00887 0.04258 0.15432 0.02690PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.00031 0.00000 0.05134 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.01523 0.00367 0.04711 0.00000AMIT_EGF_RESPONSE_60_MCF10A