BICLUSTER_ID : UPREG-234
PATHOGENS /5/ : brucella neotomae,listeria monocytogenes,streptococcus pneumoniae,yersinia enterocolitica,brucella melitensis
TARGETS /3/ : IL6, PTGS2, PIM1
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPIL6, PTGS2, ZFP36, INHBA, CXCL2, HBEGF
NETPATH IL 4 PATHWAY DOWNGADD45B, PTGS2, CXCL2
NETPATH IL 3 PATHWAY UPSOCS3, PIM1
NETPATH IL 6 PATHWAY UPSOCS3, GADD45B, ZFP36, JUNB, PIM1, HBEGF
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
DORN ADENOVIRUS INFECTION 32HR DN
SESTO RESPONSE TO UV C1
LY AGING OLD DN
LINDSTEDT DENDRITIC CELL MATURATION B
CROONQUIST STROMAL STIMULATION UP
LINDSTEDT DENDRITIC CELL MATURATION A
SIMBULAN UV RESPONSE NORMAL UP
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE
AMIT EGF RESPONSE 40 HELA
NETPATH IL 7 PATHWAY UP
DORN ADENOVIRUS INFECTION 12HR UP
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
NETPATH KIT RECEPTOR PATHWAY UP
HARRIS HYPOXIA
HINATA NFKB TARGETS KERATINOCYTE UP
DORN ADENOVIRUS INFECTION 48HR DN
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
NAGASHIMA NRG1 SIGNALING UP
MARZEC IL2 SIGNALING UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN
BIOCARTA PPARA PATHWAY
DUTTA APOPTOSIS VIA NFKB
BILBAN B CLL LPL DN
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
MAHADEVAN RESPONSE TO MP470 UP
ZHOU INFLAMMATORY RESPONSE LIVE UP
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP
ONDER CDH1 TARGETS 3 DN
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
DAZARD RESPONSE TO UV NHEK UP
MCLACHLAN DENTAL CARIES UP
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE
AMIT EGF RESPONSE 60 HELA
DAZARD UV RESPONSE CLUSTER G2
CHEN HOXA5 TARGETS 9HR UP
MARKS HDAC TARGETS DN
NETPATH IL 5 PATHWAY UPEGR1, IER3
FOSTER INFLAMMATORY RESPONSE LPS DN
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHOU INFLAMMATORY RESPONSE LPS UP
BOQUEST STEM CELL CULTURED VS FRESH DN
AMIT SERUM RESPONSE 120 MCF10A
BERENJENO TRANSFORMED BY RHOA UP
DORN ADENOVIRUS INFECTION 24HR DN
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
VERHAAK AML WITH NPM1 MUTATED UP
KIM WT1 TARGETS UP
GEISS RESPONSE TO DSRNA UP
ONDER CDH1 TARGETS 1 DN
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
ZHOU INFLAMMATORY RESPONSE FIMA UP
HESS TARGETS OF HOXA9 AND MEIS1 DN
TIAN TNF SIGNALING VIA NFKB
ZHANG PROLIFERATING VS QUIESCENT
NETPATH IL 2 PATHWAY UP
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
GOUYER TATI TARGETS UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
NAGASHIMA EGF SIGNALING UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica p60 bl6brucella melitensislisteria monocytogenesbrucella neotomaestreptococcus pneumoniae tigr4GeneSet Name
0.00000 0.00061 0.00000 0.00114 0.00001NETPATH_IL_1_PATHWAY_UP
0.00146 0.00471 0.00001 0.00269 0.01938NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.00052 0.00553 0.00000 0.00810NETPATH_IL_3_PATHWAY_UP
0.00000 0.00163 0.00233 0.01660 0.00000NETPATH_IL_6_PATHWAY_UP
0.00000 0.00628 0.00001 0.00128 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00021 0.03113 0.00023 0.03682 0.00058GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00369 0.00667 0.01095 0.06343 0.00000DORN_ADENOVIRUS_INFECTION_32HR_DN
0.01204 0.05889 0.00001 0.03217 0.00117SESTO_RESPONSE_TO_UV_C1
0.16294 0.05192 0.09782 0.02651 0.11206LY_AGING_OLD_DN
0.04591 0.01411 0.00437 0.02410 0.00796LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00954 0.07941 0.05925 0.00132 0.00000CROONQUIST_STROMAL_STIMULATION_UP
0.00029 0.00644 0.00000 0.00010 0.15403LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.13433 0.02965 0.04183 0.01104 0.00048SIMBULAN_UV_RESPONSE_NORMAL_UP
0.09938 0.16503 0.06270 0.11444 0.00103SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE
0.00021 0.03181 0.00068 0.01260 0.00000AMIT_EGF_RESPONSE_40_HELA
0.00709 0.02550 0.09197 0.01290 0.00009NETPATH_IL_7_PATHWAY_UP
0.00175 0.01408 0.02117 0.02401 0.00004DORN_ADENOVIRUS_INFECTION_12HR_UP
0.00184 0.00944 0.00000 0.01038 0.00077THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00015 0.02966 0.05671 0.05217 0.00001NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00029 0.04905 0.00000 0.17495 0.00000HARRIS_HYPOXIA
0.00000 0.05127 0.00001 0.09086 0.00741HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00341 0.02820 0.00579 0.11822 0.00001DORN_ADENOVIRUS_INFECTION_48HR_DN
0.00058 0.03717 0.00736 0.00378 0.02561KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00018 0.04270 0.00020 0.03927 0.01887BASSO_CD40_SIGNALING_UP
0.00018 0.00824 0.09270 0.01093 0.02991SOUCEK_MYC_TARGETS
0.00000 0.13564 0.00045 0.06679 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.00021 0.01700 0.00507 0.08610 0.01084MARZEC_IL2_SIGNALING_UP
0.00000 0.18025 0.00142 0.01515 0.04093TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN
0.02843 0.06653 0.13158 0.14321 0.01946BIOCARTA_PPARA_PATHWAY
0.00201 0.00246 0.01422 0.00644 0.00090DUTTA_APOPTOSIS_VIA_NFKB
0.00270 0.10240 0.01132 0.03678 0.00001BILBAN_B_CLL_LPL_DN
0.00018 0.00015 0.00199 0.00214 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.14426 0.02211 0.00068 0.08485 0.17933DER_IFN_GAMMA_RESPONSE_UP
0.00018 0.15514 0.00004 0.09849 0.05724MAHADEVAN_RESPONSE_TO_MP470_UP
0.00000 0.00487 0.00000 0.01309 0.00172ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00032 0.05136 0.00000 0.01477 0.00000GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP
0.00026 0.00670 0.00011 0.01819 0.00000ONDER_CDH1_TARGETS_3_DN
0.06189 0.00563 0.00016 0.00155 0.00000DAUER_STAT3_TARGETS_UP
0.00000 0.18585 0.00001 0.01035 0.13850LIANG_SILENCED_BY_METHYLATION_2
0.01128 0.10000 0.01225 0.11484 0.00000DAZARD_RESPONSE_TO_UV_NHEK_UP
0.00050 0.01108 0.00000 0.00479 0.18322MCLACHLAN_DENTAL_CARIES_UP
0.00305 0.05776 0.01078 0.13954 0.00114SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE
0.00019 0.04947 0.02795 0.04600 0.00000AMIT_EGF_RESPONSE_60_HELA
0.01250 0.06885 0.04745 0.00657 0.00000DAZARD_UV_RESPONSE_CLUSTER_G2
0.00807 0.08869 0.00000 0.02011 0.00003CHEN_HOXA5_TARGETS_9HR_UP
0.02398 0.01578 0.01133 0.06194 0.15432MARKS_HDAC_TARGETS_DN
0.00711 0.01177 0.00007 0.12369 0.00002NETPATH_IL_5_PATHWAY_UP
0.00000 0.00031 0.00001 0.00621 0.01424FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.19786 0.00799 0.03264 0.00000AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00010 0.00000 0.00041 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00642 0.00001 0.00119 0.09452GAURNIER_PSMD4_TARGETS
0.00398 0.02218 0.00097 0.07552 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00017 0.00000 0.00387 0.00001ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.02743 0.00000 0.02297 0.05005ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.09376 0.02099 0.05101 0.00234 0.04615BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN
0.00007 0.00478 0.00040 0.11404 0.00000AMIT_SERUM_RESPONSE_120_MCF10A
0.06247 0.01394 0.13680 0.00234 0.02776BERENJENO_TRANSFORMED_BY_RHOA_UP
0.00061 0.02672 0.00441 0.10827 0.00000DORN_ADENOVIRUS_INFECTION_24HR_DN
0.00030 0.00468 0.00000 0.00059 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00078 0.04719 0.00002 0.04591 0.00000SESTO_RESPONSE_TO_UV_C3
0.00000 0.01897 0.00000 0.03242 0.01022VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00039 0.10192 0.01564 0.10627 0.00001KIM_WT1_TARGETS_UP
0.00109 0.09792 0.00027 0.01183 0.03793GEISS_RESPONSE_TO_DSRNA_UP
0.00405 0.09382 0.00003 0.17331 0.00114ONDER_CDH1_TARGETS_1_DN
0.00000 0.05866 0.00007 0.00256 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00000 0.00643 0.00125 0.05928 0.02569ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.00006 0.14126 0.00001 0.15914 0.00000HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.00016 0.00659 0.00054 0.05899 0.00001TIAN_TNF_SIGNALING_VIA_NFKB
0.09313 0.06613 0.12224 0.14382 0.00064ZHANG_PROLIFERATING_VS_QUIESCENT
0.00994 0.03203 0.00068 0.17779 0.07061NETPATH_IL_2_PATHWAY_UP
0.00037 0.00050 0.00001 0.00010 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.08058 0.14149 0.06660 0.03209 0.15861GOUYER_TATI_TARGETS_UP
0.00000 0.00613 0.00001 0.00123 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00058 0.04602 0.02848 0.17189 0.01752LEE_LIVER_CANCER_HEPATOBLAST
0.00000 0.04193 0.00001 0.01336 0.00000NAGASHIMA_EGF_SIGNALING_UP
0.00000 0.02006 0.01523 0.02489 0.00000AMIT_EGF_RESPONSE_60_MCF10A