BICLUSTER_ID : UPREG-238
PATHOGENS /5/ : listeria monocytogenes,streptococcus pneumoniae,streptococcus pyogenes,brucella melitensis,ehrlichia chaffeensis
TARGETS /1/ : IL6
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPIL6, MT2A, CXCL2
MISSIAGLIA REGULATED BY METHYLATION UP
LINDSTEDT DENDRITIC CELL MATURATION B
NCI HOST INTERACTIONS OF HIV FACTORS
RASHI RESPONSE TO IONIZING RADIATION 2
WU CELL MIGRATION
LINDSTEDT DENDRITIC CELL MATURATION A
NCI APC C CDC20 MEDIATED DEGRADATION OF SECURIN
KHETCHOUMIAN TRIM24 TARGETS UP
NETPATH IL 7 PATHWAY UP
CORUM PA28-20S PROTEASOME
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21
NCI SCF SKP2 MEDIATED DEGRADATION OF P27 P21
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
HARRIS HYPOXIA
DER IFN BETA RESPONSE UP
HINATA NFKB TARGETS KERATINOCYTE UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
MARZEC IL2 SIGNALING UP
DUTTA APOPTOSIS VIA NFKB
BILBAN B CLL LPL DN
DIRMEIER LMP1 RESPONSE EARLY
NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
NCI VPU MEDIATED DEGRADATION OF CD4
GOLDRATH ANTIGEN RESPONSE
NCI AUTODEGRADATION OF CDH1 BY CDH1 APC C
REACTOME CDC20 PHOSPHO APC MEDIATED DEGRADATION OF CYCLIN A
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G
NETPATH IL 6 PATHWAY UPGADD45B
NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6
DER IFN ALPHA RESPONSE UP
WU HBX TARGETS 1 UP
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN
NETPATH IL 5 PATHWAY UP
FOSTER INFLAMMATORY RESPONSE LPS DN
LEE LIVER CANCER E2F1 UP
SEKI INFLAMMATORY RESPONSE LPS UP
REACTOME P53 INDEPENDENT DNA DAMAGE RESPONSE
NCI CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
NETPATH TNF ALPHA PATHWAY UP
SANA TNF SIGNALING UP
GESERICK TERT TARGETS DN
AMIT SERUM RESPONSE 120 MCF10A
NCI UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D1
NCI CDC20 PHOSPHO APC C MEDIATED DEGRADATION OF CYCLIN A
NCI REGULATION OF ORNITHINE DECARBOXYLASE ODC
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE
REACTOME STABILIZATION OF P53
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC
GEISS RESPONSE TO DSRNA UP
HESS TARGETS OF HOXA9 AND MEIS1 DN
TIAN TNF SIGNALING VIA NFKB
HUMMEL BURKITTS LYMPHOMA DN
NETPATH IL 2 PATHWAY UP
NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
NCI VIF MEDIATED DEGRADATION OF APOBEC3G
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION1
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
KEGG PROTEASOME
NCI SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION
NCI DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX
NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION
HINATA NFKB TARGETS FIBROBLAST UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis arkansabrucella melitensisstreptococcus pneumoniae g54listeria monocytogenesstreptococcus pyogenesGeneSet Name
0.00744 0.00061 0.02186 0.00000 0.03192NETPATH_IL_1_PATHWAY_UP
0.00123 0.05845 0.00810 0.00001 0.01557MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00007 0.01411 0.00817 0.00437 0.02304LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.03268 0.00509 0.04816 0.00045 0.00865NCI_HOST_INTERACTIONS_OF_HIV_FACTORS
0.00307 0.03255 0.00271 0.04054 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.01150 0.19091 0.00050 0.00267 0.05956WU_CELL_MIGRATION
0.00000 0.00644 0.16372 0.00000 0.00032LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.09958 0.01361 0.04423 0.00482 0.11025NCI_APC_C_CDC20_MEDIATED_DEGRADATION_OF_SECURIN
0.00000 0.13823 0.02156 0.10702 0.00010KHETCHOUMIAN_TRIM24_TARGETS_UP
0.00034 0.02550 0.11486 0.09197 0.04416NETPATH_IL_7_PATHWAY_UP
0.00680 0.02407 0.08304 0.00254 0.05659CORUM_PA28-20S_PROTEASOME
0.09686 0.00499 0.09247 0.00028 0.07566REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21
0.07195 0.00816 0.08690 0.00110 0.02955NCI_SCF_SKP2__MEDIATED_DEGRADATION_OF_P27_P21
0.01384 0.00944 0.09013 0.00000 0.11415THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00000 0.06677 0.08161 0.00000 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.06648 0.00836 0.05313 0.00013 0.02309REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.00160 0.04905 0.10031 0.00000 0.15102HARRIS_HYPOXIA
0.00030 0.03901 0.11870 0.00000 0.00032DER_IFN_BETA_RESPONSE_UP
0.00055 0.05127 0.00568 0.00001 0.05930HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00013 0.03717 0.17463 0.00736 0.02604KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.04270 0.03498 0.00020 0.00023BASSO_CD40_SIGNALING_UP
0.00003 0.00824 0.08229 0.09270 0.00021SOUCEK_MYC_TARGETS
0.00161 0.01700 0.16651 0.00507 0.13526MARZEC_IL2_SIGNALING_UP
0.00000 0.00246 0.05455 0.01422 0.02575DUTTA_APOPTOSIS_VIA_NFKB
0.00034 0.10240 0.05066 0.01132 0.04441BILBAN_B_CLL_LPL_DN
0.00000 0.00015 0.08905 0.00199 0.00616DIRMEIER_LMP1_RESPONSE_EARLY
0.09494 0.01608 0.04220 0.00178 0.06946NCI_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
0.07748 0.00625 0.07354 0.00119 0.01662NCI_VPU_MEDIATED_DEGRADATION_OF_CD4
0.00000 0.03198 0.18885 0.04561 0.04429GOLDRATH_ANTIGEN_RESPONSE
0.09820 0.01494 0.04350 0.00143 0.07133NCI_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
0.12269 0.01290 0.03006 0.00091 0.12054REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A
0.01097 0.00563 0.03237 0.00016 0.00038DAUER_STAT3_TARGETS_UP
0.00001 0.18585 0.01216 0.00001 0.00099LIANG_SILENCED_BY_METHYLATION_2
0.06904 0.00544 0.05320 0.00069 0.01918REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.00003 0.00163 0.01842 0.00233 0.00001NETPATH_IL_6_PATHWAY_UP
0.05794 0.00670 0.15941 0.00070 0.01320NCI_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
0.00000 0.18592 0.11860 0.00000 0.00000DER_IFN_ALPHA_RESPONSE_UP
0.02293 0.08096 0.07559 0.08533 0.18465WU_HBX_TARGETS_1_UP
0.02780 0.00728 0.04093 0.00306 0.00128PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN
0.00007 0.01177 0.07746 0.00007 0.03974NETPATH_IL_5_PATHWAY_UP
0.00000 0.00031 0.01680 0.00001 0.00568FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.14155 0.05639 0.02021 0.01561LEE_LIVER_CANCER_E2F1_UP
0.00000 0.00010 0.02093 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.03913 0.00576 0.05824 0.00031 0.01656REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE
0.06653 0.02209 0.15800 0.01511 0.07371NCI_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX
0.00007 0.02218 0.11160 0.00097 0.05533GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00017 0.00231 0.00000 0.00019ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.04059 0.09797 0.07319 0.00123 0.03392NETPATH_TNF_ALPHA_PATHWAY_UP
0.00000 0.00362 0.15203 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.00047 0.04550 0.00310 0.02216 0.01538GESERICK_TERT_TARGETS_DN
0.04018 0.00478 0.00320 0.00040 0.09332AMIT_SERUM_RESPONSE_120_MCF10A
0.04561 0.00535 0.04818 0.00081 0.02264NCI_UBIQUITIN_DEPENDENT_DEGRADATION_OF_CYCLIN_D1
0.10676 0.01697 0.02613 0.00272 0.09431NCI_CDC20_PHOSPHO_APC_C_MEDIATED_DEGRADATION_OF_CYCLIN_A
0.01628 0.00707 0.05117 0.00061 0.01121NCI_REGULATION_OF_ORNITHINE_DECARBOXYLASE__ODC_
0.02844 0.02111 0.11131 0.00069 0.03648REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE
0.05325 0.01983 0.13021 0.00163 0.02658REACTOME_STABILIZATION_OF_P53
0.00262 0.00468 0.00067 0.00000 0.09492HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.01897 0.12533 0.00000 0.01128VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.08549 0.01139 0.05319 0.00111 0.09468REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC
0.00175 0.09792 0.03258 0.00027 0.01876GEISS_RESPONSE_TO_DSRNA_UP
0.00000 0.14126 0.13868 0.00001 0.00000HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.00003 0.00659 0.16057 0.00054 0.00455TIAN_TNF_SIGNALING_VIA_NFKB
0.00212 0.05051 0.05491 0.17259 0.02106HUMMEL_BURKITTS_LYMPHOMA_DN
0.00029 0.03203 0.16635 0.00068 0.01602NETPATH_IL_2_PATHWAY_UP
0.07201 0.00899 0.03767 0.00045 0.01835NCI_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.07820 0.00472 0.03365 0.00069 0.01028NCI_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.02845 0.00824 0.04333 0.00062 0.01268NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION1
0.00001 0.00050 0.03864 0.00001 0.05507GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.03642 0.00674 0.05741 0.00038 0.01420KEGG_PROTEASOME
0.04102 0.00677 0.09866 0.01012 0.02961NCI_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE
0.02962 0.00456 0.04796 0.00056 0.00873NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION
0.10740 0.03915 0.05961 0.00037 0.01881NCI_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX
0.04449 0.00640 0.04458 0.00046 0.01493NCI_UBIQUITIN_MEDIATED_DEGRADATION_OF_PHOSPHORYLATED_CDC25A
0.19922 0.01568 0.06251 0.00007 0.18549REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_
0.00358 0.15037 0.02432 0.00031 0.14412HINATA_NFKB_TARGETS_FIBROBLAST_UP