BICLUSTER_ID : UPREG-250
PATHOGENS /4/ : pseudomonas aeruginosa,mycobacterium tuberculosis,streptococcus pyogenes,shigella dysenteriae
TARGETS /8/ : NFKB1, CCL20, CCL2, CASP7, IL6, IL1B, ICAM1, PLAUR
Gene SetLeading Edge Genes
NETPATH TNF ALPHA PATHWAY UPNFKB2, CCL2, NFKBIE, CASP7, TRAF1, NFKBIA, CXCL2, IER3, BIRC3, CSF1, CXCL1, KLF10, BCL3, TNFAIP2, IL6, IL1B, IL15RA, ZFP36, ICAM1, IRF1, PLAUR
NETPATH IL 5 PATHWAY UPNFKB1, BIRC3, NFKB2, IL1B, NFKBIE, CCL2, ICAM1, IER3
NETPATH IL 2 PATHWAY UPNFKB1, KLF6, CSF1, GADD45G, IL1B, ICAM1, FOS, IER3, PLAUR
NETPATH IL 1 PATHWAY UPBIRC3, CCL20, CXCL1, CCL2, IL1B, ICAM1, ZFP36, CXCL2
NETPATH IL 3 PATHWAY UPIL1B, CCL2, FOS
NETPATH KIT RECEPTOR PATHWAY UPCCL2, FOS, IER3
NOJIMA SFRP2 TARGETS UP
RHEIN ALL GLUCOCORTICOID THERAPY UP
ST B CELL ANTIGEN RECEPTOR
MISSIAGLIA REGULATED BY METHYLATION UP
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP
NETPATH IL 5 PATHWAY
NETPATH IL 9 PATHWAY UP
BIOCARTA NFKB PATHWAY
MAHAJAN RESPONSE TO IL1A UP
BIOCARTA IL6 PATHWAY
MUELLER COMMON TARGETS OF AML FUSIONS DN
TENEDINI MEGAKARYOCYTE MARKERS
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
BIOCARTA CCR5 PATHWAY
SIMBULAN UV RESPONSE NORMAL UP
KIM LRRC3B TARGETS
NETPATH T CELL RECEPTOR PATHWAY DOWN
NETPATH IL 4 PATHWAY DOWN
NETPATH IL 7 PATHWAY UPCXCL1, CXCL2
BROWNE HCMV INFECTION 30MIN UP
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
NCI IL6 7PATHWAYCEBPD, CEBPB, IRF1, FOS
HARRIS HYPOXIA
LENAOUR DENDRITIC CELL MATURATION DN
HINATA NFKB TARGETS KERATINOCYTE UP
NETPATH IL 6 PATHWAY
AMIT EGF RESPONSE 20 HELA
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
GILMORE CORE NFKB PATHWAY
DUTTA APOPTOSIS VIA NFKB
WANG ESOPHAGUS CANCER VS NORMAL UP
DELYS THYROID CANCER UP
TSAI RESPONSE TO IONIZING RADIATION
DIRMEIER LMP1 RESPONSE EARLY
NETPATH B CELL RECEPTOR PATHWAY UP
MAHADEVAN RESPONSE TO MP470 UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA TID PATHWAY
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
BIOCARTA RANKL PATHWAY
KEGG LEISHMANIA INFECTION
NETPATH IL 6 PATHWAY UPCEBPD, ZFP36, CEBPB, BCL3, FOS, MAP3K8
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
MCLACHLAN DENTAL CARIES UP
BROWNE HCMV INFECTION 8HR UP
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
NCI IL23PATHWAY
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
SANA TNF SIGNALING UP
KEGG T CELL RECEPTOR SIGNALING PATHWAY
NCI IL1PATHWAY
REACTOME TOLL RECEPTOR CASCADES
INGA TP53 TARGETS
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
GERY CEBP TARGETSFOS, GADD45G
HESS TARGETS OF HOXA9 AND MEIS1 DN
TARTE PLASMA CELL VS PLASMABLAST UP
DASU IL6 SIGNALING UP
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
HUMMEL BURKITTS LYMPHOMA DN
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
GOLUB ALL VS AML DNNFKBIA
CORUM NFKB1-NFKB2-REL-RELA-RELB COMPLEX
ZUCCHI METASTASIS DN
AMIT DELAYED EARLY GENES
PRAMOONJAGO SOX4 TARGETS UP
HINATA NFKB TARGETS FIBROBLAST UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
streptococcus pyogenespseudomonas aeruginosamycobacterium tuberculosisshigella dysenteriaeGeneSet Name
0.03392 0.01390 0.00534 0.07626NETPATH_TNF_ALPHA_PATHWAY_UP
0.03974 0.00238 0.00000 0.00014NETPATH_IL_5_PATHWAY_UP
0.01602 0.11013 0.00008 0.08636NETPATH_IL_2_PATHWAY_UP
0.03192 0.00004 0.00602 0.00030NETPATH_IL_1_PATHWAY_UP
0.00095 0.01596 0.00171 0.00147NETPATH_IL_3_PATHWAY_UP
0.02708 0.05123 0.00019 0.00112NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.08281 0.06631 0.00000 0.00035NOJIMA_SFRP2_TARGETS_UP
0.01655 0.03016 0.00003 0.04471RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP
0.07888 0.00000 0.02207 0.16351ST_B_CELL_ANTIGEN_RECEPTOR
0.01557 0.00002 0.00000 0.00484MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.01265 0.02594 0.00000 0.05182SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP
0.11209 0.11369 0.02988 0.18397NETPATH_IL_5_PATHWAY
0.00011 0.06627 0.08229 0.05058NETPATH_IL_9_PATHWAY_UP
0.16684 0.04067 0.00073 0.01398BIOCARTA_NFKB_PATHWAY
0.17839 0.00000 0.00132 0.00316MAHAJAN_RESPONSE_TO_IL1A_UP
0.00482 0.03352 0.06335 0.05423BIOCARTA_IL6_PATHWAY
0.04812 0.01543 0.00165 0.12756MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_DN
0.00784 0.09360 0.13556 0.08527TENEDINI_MEGAKARYOCYTE_MARKERS
0.02304 0.00005 0.00000 0.00053LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.02244 0.04053 0.00814 0.10485SA_MMP_CYTOKINE_CONNECTION
0.00000 0.00000 0.00000 0.00004RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00032 0.00387 0.00000 0.00034LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.12801 0.15535 0.05863 0.01069BIOCARTA_CCR5_PATHWAY
0.01756 0.00361 0.04602 0.03162SIMBULAN_UV_RESPONSE_NORMAL_UP
0.00000 0.03852 0.00000 0.07873KIM_LRRC3B_TARGETS
0.13300 0.15620 0.00067 0.18264NETPATH_T_CELL_RECEPTOR_PATHWAY_DOWN
0.00471 0.00000 0.00000 0.16501NETPATH_IL_4_PATHWAY_DOWN
0.04416 0.00151 0.00856 0.04120NETPATH_IL_7_PATHWAY_UP
0.19834 0.02842 0.00010 0.00103BROWNE_HCMV_INFECTION_30MIN_UP
0.11415 0.00381 0.00000 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00000 0.09153 0.00288 0.00624NCI_IL6_7PATHWAY
0.15102 0.00391 0.00067 0.00501HARRIS_HYPOXIA
0.00204 0.02052 0.00000 0.02446LENAOUR_DENDRITIC_CELL_MATURATION_DN
0.05930 0.00000 0.00000 0.00078HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.14953 0.07441 0.04845 0.06607NETPATH_IL_6_PATHWAY
0.10732 0.00091 0.00486 0.00013AMIT_EGF_RESPONSE_20_HELA
0.00000 0.02176 0.00000 0.14227MARKEY_RB1_ACUTE_LOF_UP
0.02604 0.00004 0.00060 0.00096KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00023 0.00006 0.00000 0.00004BASSO_CD40_SIGNALING_UP
0.00021 0.00251 0.02521 0.02047SOUCEK_MYC_TARGETS
0.06138 0.00340 0.00092 0.02153GILMORE_CORE_NFKB_PATHWAY
0.02575 0.00086 0.00002 0.02611DUTTA_APOPTOSIS_VIA_NFKB
0.02328 0.06142 0.00019 0.12426WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP
0.13519 0.03069 0.00018 0.12700DELYS_THYROID_CANCER_UP
0.02653 0.03182 0.00008 0.00016TSAI_RESPONSE_TO_IONIZING_RADIATION
0.00616 0.00000 0.00000 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.08745 0.10186 0.00218 0.09708NETPATH_B_CELL_RECEPTOR_PATHWAY_UP
0.01593 0.00009 0.00004 0.06328MAHADEVAN_RESPONSE_TO_MP470_UP
0.00007 0.00003 0.00176 0.17156REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.02287 0.01521 0.01104 0.02606BIOCARTA_TID_PATHWAY
0.00038 0.00006 0.00000 0.00005DAUER_STAT3_TARGETS_UP
0.00099 0.00126 0.00000 0.00396LIANG_SILENCED_BY_METHYLATION_2
0.08751 0.01532 0.03099 0.15704BIOCARTA_RANKL_PATHWAY
0.00061 0.00366 0.00007 0.00317KEGG_LEISHMANIA_INFECTION
0.00001 0.01244 0.00000 0.00000NETPATH_IL_6_PATHWAY_UP
0.01028 0.00593 0.02002 0.13279NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.00000 0.00000 0.00000 0.01598MCLACHLAN_DENTAL_CARIES_UP
0.14519 0.10159 0.00000 0.03443BROWNE_HCMV_INFECTION_8HR_UP
0.00568 0.00185 0.00000 0.00236FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.00005 0.00001 0.02949MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00036 0.00000 0.04466GAURNIER_PSMD4_TARGETS
0.05533 0.00000 0.00000 0.00003GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00019 0.00000 0.00000 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00014 0.00049 0.00126 0.09953NCI_IL23PATHWAY
0.06782 0.00043 0.00000 0.03754ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.01538 0.00178 0.00002 0.00000GESERICK_TERT_TARGETS_DN
0.00000 0.00000 0.00000 0.00530SANA_TNF_SIGNALING_UP
0.15091 0.03351 0.03737 0.13251KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY
0.19947 0.07942 0.01300 0.02440NCI_IL1PATHWAY
0.12834 0.02046 0.00015 0.15216REACTOME_TOLL_RECEPTOR_CASCADES
0.02844 0.00399 0.12410 0.10402INGA_TP53_TARGETS
0.09492 0.00000 0.00000 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.01128 0.00267 0.00000 0.00095VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.01876 0.00051 0.00000 0.01687GEISS_RESPONSE_TO_DSRNA_UP
0.01652 0.00843 0.00000 0.00067GERY_CEBP_TARGETS
0.00000 0.15886 0.00000 0.00054HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.13540 0.02025 0.00261 0.04650TARTE_PLASMA_CELL_VS_PLASMABLAST_UP
0.04449 0.00000 0.00006 0.00099DASU_IL6_SIGNALING_UP
0.12740 0.00069 0.03451 0.02002AMIT_EGF_RESPONSE_120_MCF10A
0.00455 0.00000 0.00000 0.00005TIAN_TNF_SIGNALING_VIA_NFKB
0.02106 0.00598 0.00035 0.03331HUMMEL_BURKITTS_LYMPHOMA_DN
0.05507 0.00000 0.00002 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00828 0.03983 0.03548 0.00784GOLUB_ALL_VS_AML_DN
0.17781 0.06462 0.05523 0.19006CORUM_NFKB1-NFKB2-REL-RELA-RELB_COMPLEX
0.01684 0.00002 0.00039 0.00013ZUCCHI_METASTASIS_DN
0.11718 0.04481 0.00001 0.00000AMIT_DELAYED_EARLY_GENES
0.19931 0.00151 0.00000 0.00000PRAMOONJAGO_SOX4_TARGETS_UP
0.14412 0.00000 0.00000 0.00153HINATA_NFKB_TARGETS_FIBROBLAST_UP